Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial
Identifieur interne : 000618 ( Istex/Corpus ); précédent : 000617; suivant : 000619Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial
Auteurs : Dorothee Sch R ; Christoph A. Ramseier ; Sigrun Eick ; Nicole B. Arweiler ; Anton Sculean ; Giovanni E. SalviSource :
- Clinical Oral Implants Research [ 0905-7161 ] ; 2013-01.
English descriptors
- KwdEn :
- Adjunctive, Adjunctive delivery, Adjunctive therapies, Baseline, Bone loss, Chlorhexidine, Chronic periodontitis, Clin, Clinical attachment level, Clinical parameters, Clinical periodontology, Clinical study, Colonization, Complete resolution, Control group, Control groups, Debridement, Dental implants, Hydrogen peroxide, Impl, Implant, Implant surface, Implant therapy, Implants research, International journal, John wiley sons schar, Lang, Laser, Local delivery, Local drug delivery, Mechanical debridement, Microspheres, Minocycline, Minocycline microspheres, Modality, Mombelli, Mombelli lang, Months baseline, Mucosal, Mucosal recession, Oral impl, Oral maxillofacial implants, Other hand, Periodontal, Periodontal disease, Periodontal treatment, Periodontitis, Periodontology, Photodynamic, Photodynamic systems gmbh, Photodynamic therapy, Plaque, Plaque index, Powder airpolishing, Present study, Prospective randomized, Randomized, Regular maintenance care program, Renvert, Salvi, Sculean, Secondary outcome variables, Standard deviation, Test group, Titanium, Treatment modalities, Treatment protocols.
- Teeft :
- Adjunctive, Adjunctive delivery, Adjunctive therapies, Baseline, Bone loss, Chlorhexidine, Chronic periodontitis, Clin, Clinical attachment level, Clinical parameters, Clinical periodontology, Clinical study, Colonization, Complete resolution, Control group, Control groups, Debridement, Dental implants, Hydrogen peroxide, Impl, Implant, Implant surface, Implant therapy, Implants research, International journal, John wiley sons schar, Lang, Laser, Local delivery, Local drug delivery, Mechanical debridement, Microspheres, Minocycline, Minocycline microspheres, Modality, Mombelli, Mombelli lang, Months baseline, Mucosal, Mucosal recession, Oral impl, Oral maxillofacial implants, Other hand, Periodontal, Periodontal disease, Periodontal treatment, Periodontitis, Periodontology, Photodynamic, Photodynamic systems gmbh, Photodynamic therapy, Plaque, Plaque index, Powder airpolishing, Present study, Prospective randomized, Randomized, Regular maintenance care program, Renvert, Salvi, Sculean, Secondary outcome variables, Standard deviation, Test group, Titanium, Treatment modalities, Treatment protocols.
Abstract
To compare the adjunctive clinical effects in the non‐surgical treatment of peri‐implantitis with either local drug delivery (LDD) or photodynamic therapy (PDT).
Url:
DOI: 10.1111/j.1600-0501.2012.02494.x
Links to Exploration step
ISTEX:A22D2146738E6FD61A9DC03595CCFE90443A9625Le document en format XML
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debridement</term><term>Microspheres</term><term>Minocycline</term><term>Minocycline microspheres</term><term>Modality</term><term>Mombelli</term><term>Mombelli lang</term><term>Months baseline</term><term>Mucosal</term><term>Mucosal recession</term><term>Oral impl</term><term>Oral maxillofacial implants</term><term>Other hand</term><term>Periodontal</term><term>Periodontal disease</term><term>Periodontal treatment</term><term>Periodontitis</term><term>Periodontology</term><term>Photodynamic</term><term>Photodynamic systems gmbh</term><term>Photodynamic therapy</term><term>Plaque</term><term>Plaque index</term><term>Powder airpolishing</term><term>Present study</term><term>Prospective randomized</term><term>Randomized</term><term>Regular maintenance care program</term><term>Renvert</term><term>Salvi</term><term>Sculean</term><term>Secondary outcome variables</term><term>Standard deviation</term><term>Test group</term><term>Titanium</term><term>Treatment modalities</term><term>Treatment 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Ramseier</name><affiliations><json:string>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</json:string></affiliations></json:item><json:item><name>Sigrun Eick</name><affiliations><json:string>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</json:string></affiliations></json:item><json:item><name>Nicole B. Arweiler</name><affiliations><json:string>Department of Periodontology, Philipps University, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Anton Sculean</name><affiliations><json:string>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</json:string></affiliations></json:item><json:item><name>Giovanni E. Salvi</name><affiliations><json:string>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</json:string><json:string>Giovanni E. Salvi, University of Bern, School of Dental Medicine, Department of Periodontology, Freiburgstrasse 7, CH‐3010, Bern, SwitzerlandTel.: + 41 31 632 25 89Fax: + 41 31 632 49 15e‐mail:</json:string><json:string>E-mail: giovanni.salvi@zmk.unibe.ch</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dental implants</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>laser</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>local antibiotics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>local drug delivery</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peri‐implantitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>photodynamic therapy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>surface decontamination</value></json:item></subject><articleId><json:string>CLR2494</json:string></articleId><arkIstex>ark:/67375/WNG-HFP5GMG6-6</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>To compare the adjunctive clinical effects in the non‐surgical treatment of peri‐implantitis with either local drug delivery (LDD) or photodynamic therapy (PDT).</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>22</abstractWordCount><abstractCharCount>161</abstractCharCount><keywordCount>7</keywordCount><score>7.264</score><pdfWordCount>5714</pdfWordCount><pdfCharCount>37839</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize></qualityIndicators><title>Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title><pmid><json:string>22568744</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Clinical Oral Implants Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0501</json:string></doi><issn><json:string>0905-7161</json:string></issn><eissn><json:string>1600-0501</json:string></eissn><publisherId><json:string>CLR</json:string></publisherId><volume>24</volume><issue>1</issue><pages><first>104</first><last>110</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>from August 2010 to March 2011</json:string><json:string>2012-04-23</json:string></date><geogName></geogName><orgName><json:string>Photodynamic Systems</json:string><json:string>Ethical Committee of the Canton Bern</json:string><json:string>Electro Medical Systems</json:string><json:string>Department of Periodontology of the University of Bern, Switzerland and subjects</json:string><json:string>University of Bern</json:string><json:string>Switzerland Tel</json:string><json:string>Department of Periodontology, Philipps University, Marburg, Germany Anti</json:string><json:string>Department of Periodontology, Freiburgstrasse</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Anton Sculean</json:string><json:string>John Wiley</json:string><json:string>Dorothee Schar</json:string><json:string>Giovanni E. 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Burgin</json:string></persName><placeName><json:string>IL</json:string><json:string>Switzerland</json:string><json:string>Germany</json:string><json:string>St. Stefan</json:string><json:string>Walldorf</json:string><json:string>Austria</json:string><json:string>Canada</json:string><json:string>Helsinki</json:string><json:string>USA</json:string><json:string>Basel</json:string><json:string>Chicago</json:string><json:string>Wels</json:string><json:string>Nyon</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Quirynen et al. 2006</json:string><json:string>Alcoforado et al. 1991</json:string><json:string>Haas et al. 1997</json:string><json:string>Azarpazhooh et al. 2011</json:string><json:string>Renvert et al. 2004, 2006, 2008</json:string><json:string>Ge et al. 2011</json:string><json:string>Hayek et al. 2005</json:string><json:string>Leonhardt et al. 1999</json:string><json:string>Lang et al. 1986</json:string><json:string>Salcetti et al. 1997</json:string><json:string>Chondros et al. 2009</json:string><json:string>Andersen et al. 2007</json:string><json:string>Christodoulides et al. 2008</json:string><json:string>Salvi et al. 2008</json:string><json:string>Albrektsson & Isidor 1994</json:string><json:string>Mombelli et al. 2001</json:string><json:string>Herrera 2011</json:string><json:string>Shibli et al. 2003</json:string><json:string>Mombelli et al. 1987</json:string><json:string>Quirynen et al. 1996, 2006</json:string><json:string>Salvi et al. 2007</json:string><json:string>Becker et al. 1990</json:string><json:string>Augthun & Conrads 1997</json:string><json:string>Renvert et al. 2009</json:string><json:string>Braun et al. 2008</json:string><json:string>Zablotsky et al. 1992</json:string><json:string>Salvi et al. 2012</json:string><json:string>Sumida et al. 2002</json:string><json:string>Renvert et al. 2008, 2009</json:string><json:string>Dobson & Wilson 1992</json:string><json:string>Scha et al</json:string><json:string>Sahm et al. 2011</json:string><json:string>Schwarz et al. (2005)</json:string><json:string>Quirynen et al. 2002, 2006</json:string><json:string>Karring et al. 2005</json:string><json:string>Renvert et al. 2008</json:string><json:string>Schar et al</json:string><json:string>Konopka & Goslinski 2007</json:string><json:string>Persson et al. 2006</json:string><json:string>Mombelli & Lang 1992</json:string><json:string>Furst et al. 2007</json:string><json:string>Pontoriero et al. 1994</json:string><json:string>Rams et al. 1991</json:string><json:string>Mombelli et al. 1987, 1988</json:string><json:string>van Winkelhoff et al. 2000</json:string><json:string>Mombelli et al. 1995</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-HFP5GMG6-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - engineering, biomedical</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/j.1600-0501.2012.02494.x</json:string></doi><id>A22D2146738E6FD61A9DC03595CCFE90443A9625</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/A22D2146738E6FD61A9DC03595CCFE90443A9625/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/A22D2146738E6FD61A9DC03595CCFE90443A9625/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A22D2146738E6FD61A9DC03595CCFE90443A9625/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2012 John Wiley & Sons A/S</licence></availability><date type="published" when="2013-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title><author xml:id="author-0000"><persName><forename type="first">Dorothee</forename><surname>Schär</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>School of Dental Medicine</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Christoph A.</forename><surname>Ramseier</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>School of Dental Medicine</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Sigrun</forename><surname>Eick</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>School of Dental Medicine</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Nicole B.</forename><surname>Arweiler</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>Philipps University</orgName><address><settlement type="city">Marburg</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Anton</forename><surname>Sculean</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>School of Dental Medicine</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation></author><author xml:id="author-0005" role="corresp"><persName><forename type="first">Giovanni E.</forename><surname>Salvi</surname></persName><affiliation><orgName>Department of Periodontology</orgName><orgName>School of Dental Medicine</orgName><orgName>University of Bern</orgName><address><settlement type="city">Bern</settlement><country key="CH">Switzerland</country></address></affiliation><affiliation>Corresponding author: Giovanni E. Salvi, University of Bern, School of Dental Medicine, Department of Periodontology, Freiburgstrasse 7, CH‐3010, Bern, Switzerland Tel.: + 41 31 632 25 89 Fax: + 41 31 632 49 15 e‐mail: giovanni.salvi@zmk.unibe.ch</affiliation></author><idno type="istex">A22D2146738E6FD61A9DC03595CCFE90443A9625</idno><idno type="ark">ark:/67375/WNG-HFP5GMG6-6</idno><idno type="DOI">10.1111/j.1600-0501.2012.02494.x</idno><idno type="unit">CLR2494</idno><idno type="toTypesetVersion">file:CLR.CLR2494.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Oral Implants Research</title><title level="j" type="alt">CLINICAL ORAL IMPLANTS RESEARCH</title><idno type="pISSN">0905-7161</idno><idno type="eISSN">1600-0501</idno><idno type="book-DOI">10.1111/(ISSN)1600-0501</idno><idno type="book-part-DOI">10.1111/clr.2012.24.issue-1</idno><idno type="product">CLR</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="104">104</biblScope><biblScope unit="page" to="110">110</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2013-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="clr2494-abs-0001"><head>Abstract</head>
Objective
<p>To compare the adjunctive clinical effects in the non‐surgical treatment of peri‐implantitis with either local drug delivery (<hi rend="fc">LDD</hi>) or photodynamic therapy (<hi rend="fc">PDT</hi>).</p>
Material and methods
<p>Forty subjects with initial peri‐implantitis, i.e. pocket probing depths (<hi rend="fc">PPD</hi>) 4–6 mm with concomitant bleeding on probing (<hi rend="fc">BoP</hi>) and marginal bone loss ranging from 0.5 to 2 mm between delivery of the reconstruction and pre‐screening appointment were randomly assigned to two treatment groups. All implants underwent mechanical debridement with titanium curettes, followed by a glycine‐based powder airpolishing. Implants in the test group (<hi rend="italic">n</hi> = 20) received adjunctive <hi rend="fc">PDT</hi>, whereas minocycline microspheres were locally delivered into the peri‐implant pockets of control implants (<hi rend="italic">n</hi> = 20). At sites with residual <hi rend="fc">BoP</hi>, treatment was repeated after 3 and 6 months. The primary outcome variable was the change in the number of sites with <hi rend="fc">BoP</hi>. Secondary outcome variables were changes in <hi rend="fc">PPD</hi>, in clinical attachment level (<hi rend="fc">CAL</hi>), and in mucosal recession (<hi rend="fc">REC</hi>).</p>
Results
<p>After 3 months, implants of both groups yielded a statistically significant reduction (<hi rend="italic">P</hi> < 0.0001) in the number of <hi rend="fc">BoP</hi>‐positive sites compared with baseline (<hi rend="fc">LDD</hi>: from 4.41 ± 1.47 to 2.20 ± 1.28, <hi rend="fc">PDT</hi>: from 4.03 ± 1.66 to 2.26 ± 1.28). After 6 months, complete resolution of mucosal inflammation was obtained in 15% of the implants in the control group and in 30% of the implants in the test group (<hi rend="italic">P</hi> = 0.16). After 3 months, changes in <hi rend="fc">PPD</hi>,<hi rend="fc"> REC</hi>, and modified Plaque Index (mPlI) were statistically significantly different from baseline (<hi rend="italic">P</hi> < 0.05). No statistically significant changes (<hi rend="italic">P</hi> > 0.05) occurred between 3 and 6 months. <hi rend="fc">CAL</hi> measurements did not yield statistically significant changes (<hi rend="italic">P</hi> > 0.05) in both groups during the 6‐month observation time. Between‐group comparisons revealed no statistically significant differences (<hi rend="italic">P</hi> > 0.05) at baseline, 3 and 6 months with the exception of the mPlI after 6 months.</p>
Conclusions
<p>In cases of initial peri‐implantitis, non‐surgical mechanical debridement with adjunctive use of <hi rend="fc">PDT</hi> is equally effective in the reduction of mucosal inflammation as with the adjunctive use of minocycline microspheres up to 6 months. Adjunctive <hi rend="fc">PDT</hi> may represent an alternative treatment modality in the non‐surgical management of initial peri‐implantitis. Complete resolution of inflammation, however, was not routinely achieved with either of the adjunctive therapies.</p></abstract><textClass><keywords><term xml:id="clr2494-kwd-0001">dental implants</term><term xml:id="clr2494-kwd-0002">laser</term><term xml:id="clr2494-kwd-0003">local antibiotics</term><term xml:id="clr2494-kwd-0004">local drug delivery</term><term xml:id="clr2494-kwd-0005">peri‐implantitis</term><term xml:id="clr2494-kwd-0006">photodynamic therapy</term><term xml:id="clr2494-kwd-0007">surface decontamination</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A22D2146738E6FD61A9DC03595CCFE90443A9625/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="clr2494" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0501</doi><issn type="print">0905-7161</issn><issn type="electronic">1600-0501</issn><idGroup><id type="product" value="CLR"></id></idGroup><titleGroup><title sort="CLINICAL ORAL IMPLANTS RESEARCH" type="main">Clinical Oral Implants Research</title><title type="short">Clin. Oral Impl. Res.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley">10.1111/clr.2012.24.issue-1</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2013-01">January 2013</coverDate></publicationMeta><publicationMeta level="unit" position="160" status="forIssue" type="article"><doi>10.1111/j.1600-0501.2012.02494.x</doi><idGroup><id type="unit" value="CLR2494"></id></idGroup><countGroup><count number="7" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">© 2012 John Wiley & Sons A/S</copyright><eventGroup><event date="2012-04-10" type="manuscriptAccepted"></event><event agent="SPS" date="2012-04-23" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-05-09"></event><event type="firstOnline" date="2012-05-09"></event><event type="publishedOnlineFinalForm" date="2012-12-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">104</numbering><numbering type="pageLast">110</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Corresponding author:</b></line><line>Giovanni E. Salvi, University of Bern, School of Dental Medicine, Department of Periodontology, Freiburgstrasse 7, CH‐3010, Bern, Switzerland</line><line>Tel.: + 41 31 632 25 89</line><line>Fax: + 41 31 632 49 15</line><line>e‐mail: <email>giovanni.salvi@zmk.unibe.ch</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="clr2494-cit-0500">Sch_r, D., Ramseier, C.A., Eick, S., Arweiler, N.B., Sculean, A. & Salvi, G.E. (2013). Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial. Clinical Oral Implants Research, 24(1), 104–110. doi: 10.1111/j.1600-0501.2012.02494.x</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:CLR.CLR2494.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title><title type="shortAuthors">Schär et al</title></titleGroup><creators><creator affiliationRef="#clr2494-aff-0001" creatorRole="author" xml:id="clr2494-cr-0001"><personName><givenNames>Dorothee</givenNames> <familyName>Schär</familyName></personName></creator><creator affiliationRef="#clr2494-aff-0001" creatorRole="author" xml:id="clr2494-cr-0002"><personName><givenNames>Christoph A.</givenNames> <familyName>Ramseier</familyName></personName></creator><creator affiliationRef="#clr2494-aff-0001" creatorRole="author" xml:id="clr2494-cr-0003"><personName><givenNames>Sigrun</givenNames> <familyName>Eick</familyName></personName></creator><creator affiliationRef="#clr2494-aff-0002" creatorRole="author" xml:id="clr2494-cr-0004"><personName><givenNames>Nicole B.</givenNames> <familyName>Arweiler</familyName></personName></creator><creator affiliationRef="#clr2494-aff-0001" creatorRole="author" xml:id="clr2494-cr-0005"><personName><givenNames>Anton</givenNames> <familyName>Sculean</familyName></personName></creator><creator affiliationRef="#clr2494-aff-0001" corresponding="yes" creatorRole="author" xml:id="clr2494-cr-0006"><personName><givenNames>Giovanni E.</givenNames> <familyName>Salvi</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="CH" type="organization" xml:id="clr2494-aff-0001"><orgDiv>Department of Periodontology</orgDiv> <orgDiv>School of Dental Medicine</orgDiv> <orgName>University of Bern</orgName> <address><city>Bern</city> <country>Switzerland</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="clr2494-aff-0002"><orgDiv>Department of Periodontology</orgDiv> <orgName>Philipps University</orgName> <address><city>Marburg</city> <country>Germany</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="clr2494-kwd-0001">dental implants</keyword><keyword xml:id="clr2494-kwd-0002">laser</keyword><keyword xml:id="clr2494-kwd-0003">local antibiotics</keyword><keyword xml:id="clr2494-kwd-0004">local drug delivery</keyword><keyword xml:id="clr2494-kwd-0005">peri‐implantitis</keyword><keyword xml:id="clr2494-kwd-0006">photodynamic therapy</keyword><keyword xml:id="clr2494-kwd-0007">surface decontamination</keyword></keywordGroup><fundingInfo><fundingAgency>Bredent Medical GmbH & Co. KG</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="clr2494-abs-0001"><title type="main">Abstract</title><section xml:id="clr2494-sec-0001"><title type="main">Objective</title><p>To compare the adjunctive clinical effects in the non‐surgical treatment of peri‐implantitis with either local drug delivery (<fc>LDD</fc>) or photodynamic therapy (<fc>PDT</fc>).</p></section><section xml:id="clr2494-sec-0002"><title type="main">Material and methods</title><p>Forty subjects with initial peri‐implantitis, i.e. pocket probing depths (<fc>PPD</fc>) 4–6 mm with concomitant bleeding on probing (<fc>BoP</fc>) and marginal bone loss ranging from 0.5 to 2 mm between delivery of the reconstruction and pre‐screening appointment were randomly assigned to two treatment groups. All implants underwent mechanical debridement with titanium curettes, followed by a glycine‐based powder airpolishing. Implants in the test group (<i>n</i> = 20) received adjunctive <fc>PDT</fc>, whereas minocycline microspheres were locally delivered into the peri‐implant pockets of control implants (<i>n</i> = 20). At sites with residual <fc>BoP</fc>, treatment was repeated after 3 and 6 months. The primary outcome variable was the change in the number of sites with <fc>BoP</fc>. Secondary outcome variables were changes in <fc>PPD</fc>, in clinical attachment level (<fc>CAL</fc>), and in mucosal recession (<fc>REC</fc>).</p></section><section xml:id="clr2494-sec-0003"><title type="main">Results</title><p>After 3 months, implants of both groups yielded a statistically significant reduction (<i>P</i> < 0.0001) in the number of <fc>BoP</fc>‐positive sites compared with baseline (<fc>LDD</fc>: from 4.41 ± 1.47 to 2.20 ± 1.28, <fc>PDT</fc>: from 4.03 ± 1.66 to 2.26 ± 1.28). After 6 months, complete resolution of mucosal inflammation was obtained in 15% of the implants in the control group and in 30% of the implants in the test group (<i>P</i> = 0.16). After 3 months, changes in <fc>PPD</fc>,<fc> REC</fc>, and modified Plaque Index (mPlI) were statistically significantly different from baseline (<i>P</i> < 0.05). No statistically significant changes (<i>P</i> > 0.05) occurred between 3 and 6 months. <fc>CAL</fc> measurements did not yield statistically significant changes (<i>P</i> > 0.05) in both groups during the 6‐month observation time. Between‐group comparisons revealed no statistically significant differences (<i>P</i> > 0.05) at baseline, 3 and 6 months with the exception of the mPlI after 6 months.</p></section><section xml:id="clr2494-sec-0004"><title type="main">Conclusions</title><p>In cases of initial peri‐implantitis, non‐surgical mechanical debridement with adjunctive use of <fc>PDT</fc> is equally effective in the reduction of mucosal inflammation as with the adjunctive use of minocycline microspheres up to 6 months. Adjunctive <fc>PDT</fc> may represent an alternative treatment modality in the non‐surgical management of initial peri‐implantitis. Complete resolution of inflammation, however, was not routinely achieved with either of the adjunctive therapies.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial</title></titleInfo><name type="personal"><namePart type="given">Dorothee</namePart><namePart type="family">Schär</namePart><affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph A.</namePart><namePart type="family">Ramseier</namePart><affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sigrun</namePart><namePart type="family">Eick</namePart><affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicole B.</namePart><namePart type="family">Arweiler</namePart><affiliation>Department of Periodontology, Philipps University, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anton</namePart><namePart type="family">Sculean</namePart><affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni E.</namePart><namePart type="family">Salvi</namePart><affiliation>Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland</affiliation><affiliation>Giovanni E. Salvi, University of Bern, School of Dental Medicine, Department of Periodontology, Freiburgstrasse 7, CH‐3010, Bern, SwitzerlandTel.: + 41 31 632 25 89Fax: + 41 31 632 49 15e‐mail:</affiliation><affiliation>E-mail: giovanni.salvi@zmk.unibe.ch</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-01</dateIssued><dateCreated encoding="w3cdtf">2012-04-23</dateCreated><dateValid encoding="w3cdtf">2012-04-10</dateValid><edition>Sch_r, D., Ramseier, C.A., Eick, S., Arweiler, N.B., Sculean, A. & Salvi, G.E. (2013). Anti‐infective therapy of peri‐implantitis with adjunctive local drug delivery or photodynamic therapy: six‐month outcomes of a prospective randomized clinical trial. Clinical Oral Implants Research, 24(1), 104–110. doi: 10.1111/j.1600-0501.2012.02494.x</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>To compare the adjunctive clinical effects in the non‐surgical treatment of peri‐implantitis with either local drug delivery (LDD) or photodynamic therapy (PDT).</abstract><abstract>Forty subjects with initial peri‐implantitis, i.e. pocket probing depths (PPD) 4–6 mm with concomitant bleeding on probing (BoP) and marginal bone loss ranging from 0.5 to 2 mm between delivery of the reconstruction and pre‐screening appointment were randomly assigned to two treatment groups. All implants underwent mechanical debridement with titanium curettes, followed by a glycine‐based powder airpolishing. Implants in the test group (n = 20) received adjunctive PDT, whereas minocycline microspheres were locally delivered into the peri‐implant pockets of control implants (n = 20). At sites with residual BoP, treatment was repeated after 3 and 6 months. The primary outcome variable was the change in the number of sites with BoP. Secondary outcome variables were changes in PPD, in clinical attachment level (CAL), and in mucosal recession (REC).</abstract><abstract>After 3 months, implants of both groups yielded a statistically significant reduction (P < 0.0001) in the number of BoP‐positive sites compared with baseline (LDD: from 4.41 ± 1.47 to 2.20 ± 1.28, PDT: from 4.03 ± 1.66 to 2.26 ± 1.28). After 6 months, complete resolution of mucosal inflammation was obtained in 15% of the implants in the control group and in 30% of the implants in the test group (P = 0.16). After 3 months, changes in PPD, REC, and modified Plaque Index (mPlI) were statistically significantly different from baseline (P < 0.05). No statistically significant changes (P > 0.05) occurred between 3 and 6 months. CAL measurements did not yield statistically significant changes (P > 0.05) in both groups during the 6‐month observation time. Between‐group comparisons revealed no statistically significant differences (P > 0.05) at baseline, 3 and 6 months with the exception of the mPlI after 6 months.</abstract><abstract>In cases of initial peri‐implantitis, non‐surgical mechanical debridement with adjunctive use of PDT is equally effective in the reduction of mucosal inflammation as with the adjunctive use of minocycline microspheres up to 6 months. Adjunctive PDT may represent an alternative treatment modality in the non‐surgical management of initial peri‐implantitis. Complete resolution of inflammation, however, was not routinely achieved with either of the adjunctive therapies.</abstract><note type="funding">Bredent Medical GmbH & Co. KG</note><subject><genre>keywords</genre><topic>dental implants</topic><topic>laser</topic><topic>local antibiotics</topic><topic>local drug delivery</topic><topic>peri‐implantitis</topic><topic>photodynamic therapy</topic><topic>surface decontamination</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Oral Implants Research</title></titleInfo><titleInfo type="abbreviated"><title>Clin. Oral Impl. Res.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0905-7161</identifier><identifier type="eISSN">1600-0501</identifier><identifier type="DOI">10.1111/(ISSN)1600-0501</identifier><identifier type="PublisherID">CLR</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>104</start><end>110</end><total>7</total></extent></part></relatedItem><identifier type="istex">A22D2146738E6FD61A9DC03595CCFE90443A9625</identifier><identifier type="ark">ark:/67375/WNG-HFP5GMG6-6</identifier><identifier type="DOI">10.1111/j.1600-0501.2012.02494.x</identifier><identifier type="ArticleID">CLR2494</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/A22D2146738E6FD61A9DC03595CCFE90443A9625/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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