Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial
Identifieur interne : 000527 ( Istex/Corpus ); précédent : 000526; suivant : 000528Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial
Auteurs : Yvonne C. M. De Waal ; Gerry M. Raghoebar ; James J. R. Huddleston Slater ; Henny J. A. Meijer ; Edwin G. Winkel ; Arie Jan Van WinkelhoffSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2013-02.
English descriptors
- KwdEn :
- Anaerobic, Anaerobic bacteria, Antibiotic therapy, Average differences, Bacterial load, Bactericidal effect, Baseline, Baseline value, Baseline values, Bone loss, Campylobacter rectus, Center groningen, Cetylpyridinium chloride, Chlorhexidine, Chlorhexidine digluconate, Citric acid, Clin periodontol, Clinical epidemiology, Clinical microbiology, Clinical outcome, Clinical outcomes, Clinical parameters, Clinical periodontology, Clinical trial, Debridement, Decontamination, Decontamination procedure, Decontamination procedures, Dental status, Descriptive statistics, Different protocols, Essential oils, Exclusion criteria, Fusobacterium nucleatum, Granulation tissue, Granulation tissue removal, Greater reduction, Groningen, Hydrogen peroxide, Implant, Implant decontamination, Implant fracture, Implant level, Implant placement, Implant surface, Implant surface decontamination, Implant surface roughness, Implant surfaces, Implants culture, Implants research, International journal, John wiley sons, John wiley sons implant surface decontamination, Lindhe meyle, Linear regression analysis, Marginal bone loss, Mcnemar test, Mechanical debridement, Microbiological, Microbiological effect, Microbiological parameters, Microbiological samples, Multilevel, Multilevel analysis, Multilevel modelling, Nobel biocare, Null hypothesis, Other studies, Parallel group randomised trials, Parvimonas micra, Periimplantitis, Periodontal pathogens, Periodontology, Pitten kramer, Placebo, Plaque, Pocket depth, Porphyromonas gingivalis, Prevotella intermedia, Primary outcome, Radiograph, Radiographical, Radiographical effect, Radiographical outcomes, Randomized, Resective, Resective surgery, Same site, Secondary outcomes, Serino turri, Sodium hypochlorite, Suppuration, Surface debridement, Surgical, Surgical assistant, Surgical gauzes, Surgical procedure, Surgical therapy, Surgical treatment, Tannerella forsythia, Titanium surfaces, Tpost, Tpre, Treatment allocation, Treatment protocol, Vivo study, Wound area.
- Teeft :
- Anaerobic, Anaerobic bacteria, Antibiotic therapy, Average differences, Bacterial load, Bactericidal effect, Baseline, Baseline value, Baseline values, Bone loss, Campylobacter rectus, Center groningen, Cetylpyridinium chloride, Chlorhexidine, Chlorhexidine digluconate, Citric acid, Clin periodontol, Clinical epidemiology, Clinical microbiology, Clinical outcome, Clinical outcomes, Clinical parameters, Clinical periodontology, Clinical trial, Debridement, Decontamination, Decontamination procedure, Decontamination procedures, Dental status, Descriptive statistics, Different protocols, Essential oils, Exclusion criteria, Fusobacterium nucleatum, Granulation tissue, Granulation tissue removal, Greater reduction, Groningen, Hydrogen peroxide, Implant, Implant decontamination, Implant fracture, Implant level, Implant placement, Implant surface, Implant surface decontamination, Implant surface roughness, Implant surfaces, Implants culture, Implants research, International journal, John wiley sons, John wiley sons implant surface decontamination, Lindhe meyle, Linear regression analysis, Marginal bone loss, Mcnemar test, Mechanical debridement, Microbiological, Microbiological effect, Microbiological parameters, Microbiological samples, Multilevel, Multilevel analysis, Multilevel modelling, Nobel biocare, Null hypothesis, Other studies, Parallel group randomised trials, Parvimonas micra, Periimplantitis, Periodontal pathogens, Periodontology, Pitten kramer, Placebo, Plaque, Pocket depth, Porphyromonas gingivalis, Prevotella intermedia, Primary outcome, Radiograph, Radiographical, Radiographical effect, Radiographical outcomes, Randomized, Resective, Resective surgery, Same site, Secondary outcomes, Serino turri, Sodium hypochlorite, Suppuration, Surface debridement, Surgical, Surgical assistant, Surgical gauzes, Surgical procedure, Surgical therapy, Surgical treatment, Tannerella forsythia, Titanium surfaces, Tpost, Tpre, Treatment allocation, Treatment protocol, Vivo study, Wound area.
Abstract
The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.
Url:
DOI: 10.1111/jcpe.12034
Links to Exploration step
ISTEX:8A5E6B1F80D19DE474CB3F082412524ED3E4683CLe document en format XML
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M." last="De Waal">Yvonne C. M. De Waal</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Address:E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: y.c.m.de.waal@umcg.nl</mods:affiliation></affiliation></author><author><name sortKey="Raghoebar, Gerry M" sort="Raghoebar, Gerry M" uniqKey="Raghoebar G" first="Gerry M." last="Raghoebar">Gerry M. Raghoebar</name><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Huddleston Slater, James J R" sort="Huddleston Slater, James J R" uniqKey="Huddleston Slater J" first="James J. R." last="Huddleston Slater">James J. R. Huddleston Slater</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Meijer, Henny J A" sort="Meijer, Henny J A" uniqKey="Meijer H" first="Henny J. A." last="Meijer">Henny J. A. Meijer</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Winkel, Edwin G" sort="Winkel, Edwin G" uniqKey="Winkel E" first="Edwin G." last="Winkel">Edwin G. Winkel</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Winkelhoff, Arie Jan" sort="Van Winkelhoff, Arie Jan" uniqKey="Van Winkelhoff A" first="Arie Jan" last="Van Winkelhoff">Arie Jan Van Winkelhoff</name><affiliation><mods:affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical and Oral Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="186">186</biblScope><biblScope unit="page" to="195">195</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2013-02">2013-02</date></imprint><idno type="ISSN">0303-6979</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6979</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anaerobic</term><term>Anaerobic bacteria</term><term>Antibiotic therapy</term><term>Average differences</term><term>Bacterial load</term><term>Bactericidal effect</term><term>Baseline</term><term>Baseline value</term><term>Baseline values</term><term>Bone loss</term><term>Campylobacter rectus</term><term>Center groningen</term><term>Cetylpyridinium chloride</term><term>Chlorhexidine</term><term>Chlorhexidine digluconate</term><term>Citric acid</term><term>Clin periodontol</term><term>Clinical epidemiology</term><term>Clinical microbiology</term><term>Clinical outcome</term><term>Clinical outcomes</term><term>Clinical parameters</term><term>Clinical periodontology</term><term>Clinical trial</term><term>Debridement</term><term>Decontamination</term><term>Decontamination procedure</term><term>Decontamination procedures</term><term>Dental status</term><term>Descriptive statistics</term><term>Different protocols</term><term>Essential oils</term><term>Exclusion criteria</term><term>Fusobacterium nucleatum</term><term>Granulation tissue</term><term>Granulation tissue removal</term><term>Greater reduction</term><term>Groningen</term><term>Hydrogen peroxide</term><term>Implant</term><term>Implant decontamination</term><term>Implant fracture</term><term>Implant level</term><term>Implant placement</term><term>Implant surface</term><term>Implant surface decontamination</term><term>Implant surface roughness</term><term>Implant surfaces</term><term>Implants culture</term><term>Implants research</term><term>International journal</term><term>John wiley sons</term><term>John wiley sons implant surface decontamination</term><term>Lindhe meyle</term><term>Linear regression analysis</term><term>Marginal bone loss</term><term>Mcnemar test</term><term>Mechanical debridement</term><term>Microbiological</term><term>Microbiological effect</term><term>Microbiological parameters</term><term>Microbiological samples</term><term>Multilevel</term><term>Multilevel analysis</term><term>Multilevel modelling</term><term>Nobel biocare</term><term>Null hypothesis</term><term>Other studies</term><term>Parallel group randomised trials</term><term>Parvimonas micra</term><term>Periimplantitis</term><term>Periodontal pathogens</term><term>Periodontology</term><term>Pitten kramer</term><term>Placebo</term><term>Plaque</term><term>Pocket depth</term><term>Porphyromonas gingivalis</term><term>Prevotella intermedia</term><term>Primary outcome</term><term>Radiograph</term><term>Radiographical</term><term>Radiographical effect</term><term>Radiographical outcomes</term><term>Randomized</term><term>Resective</term><term>Resective surgery</term><term>Same site</term><term>Secondary outcomes</term><term>Serino turri</term><term>Sodium hypochlorite</term><term>Suppuration</term><term>Surface debridement</term><term>Surgical</term><term>Surgical assistant</term><term>Surgical gauzes</term><term>Surgical procedure</term><term>Surgical therapy</term><term>Surgical treatment</term><term>Tannerella forsythia</term><term>Titanium surfaces</term><term>Tpost</term><term>Tpre</term><term>Treatment allocation</term><term>Treatment protocol</term><term>Vivo study</term><term>Wound area</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anaerobic</term><term>Anaerobic bacteria</term><term>Antibiotic therapy</term><term>Average differences</term><term>Bacterial load</term><term>Bactericidal 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reduction</term><term>Groningen</term><term>Hydrogen peroxide</term><term>Implant</term><term>Implant decontamination</term><term>Implant fracture</term><term>Implant level</term><term>Implant placement</term><term>Implant surface</term><term>Implant surface decontamination</term><term>Implant surface roughness</term><term>Implant surfaces</term><term>Implants culture</term><term>Implants research</term><term>International journal</term><term>John wiley sons</term><term>John wiley sons implant surface decontamination</term><term>Lindhe meyle</term><term>Linear regression analysis</term><term>Marginal bone loss</term><term>Mcnemar test</term><term>Mechanical debridement</term><term>Microbiological</term><term>Microbiological effect</term><term>Microbiological parameters</term><term>Microbiological samples</term><term>Multilevel</term><term>Multilevel analysis</term><term>Multilevel modelling</term><term>Nobel biocare</term><term>Null hypothesis</term><term>Other studies</term><term>Parallel group randomised trials</term><term>Parvimonas micra</term><term>Periimplantitis</term><term>Periodontal pathogens</term><term>Periodontology</term><term>Pitten kramer</term><term>Placebo</term><term>Plaque</term><term>Pocket depth</term><term>Porphyromonas gingivalis</term><term>Prevotella intermedia</term><term>Primary outcome</term><term>Radiograph</term><term>Radiographical</term><term>Radiographical effect</term><term>Radiographical outcomes</term><term>Randomized</term><term>Resective</term><term>Resective surgery</term><term>Same site</term><term>Secondary outcomes</term><term>Serino turri</term><term>Sodium hypochlorite</term><term>Suppuration</term><term>Surface debridement</term><term>Surgical</term><term>Surgical assistant</term><term>Surgical gauzes</term><term>Surgical procedure</term><term>Surgical therapy</term><term>Surgical treatment</term><term>Tannerella forsythia</term><term>Titanium surfaces</term><term>Tpost</term><term>Tpre</term><term>Treatment allocation</term><term>Treatment protocol</term><term>Vivo study</term><term>Wound area</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>implant</json:string><json:string>decontamination</json:string><json:string>implant 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M. de Waal</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string><json:string>Address:E‐mail:</json:string><json:string>E-mail: y.c.m.de.waal@umcg.nl</json:string></affiliations></json:item><json:item><name>Gerry M. Raghoebar</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>James J. R. Huddleston Slater</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string><json:string>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Henny J. A. Meijer</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string><json:string>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Edwin G. Winkel</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Arie Jan van Winkelhoff</name><affiliations><json:string>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string><json:string>Department of Medical and Oral Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cetylpyridinium chloride</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chlorhexidine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>decontamination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microbiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peri‐implantitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>resective surgery</value></json:item></subject><articleId><json:string>JCPE12034</json:string></articleId><arkIstex>ark:/67375/WNG-XNWCQJDK-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>27</abstractWordCount><abstractCharCount>231</abstractCharCount><keywordCount>6</keywordCount><score>7.324</score><pdfWordCount>5724</pdfWordCount><pdfCharCount>40827</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize></qualityIndicators><title>Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title><pmid><json:string>23211012</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Clinical Periodontology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-051X</json:string></doi><issn><json:string>0303-6979</json:string></issn><eissn><json:string>1600-051X</json:string></eissn><publisherId><json:string>JCPE</json:string></publisherId><volume>40</volume><issue>2</issue><pages><first>186</first><last>195</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Randomized Clinical Trial</value></json:item></subject></host><namedEntities><unitex><date><json:string>between October 2009 and September 2011</json:string><json:string>from October 2009 to September 2010</json:string><json:string>2012-11-06</json:string></date><geogName></geogName><orgName><json:string>Department of Medical and Oral Microbiology</json:string><json:string>Consolidated Standards of Reporting Trials Group</json:string><json:string>University of Kiel</json:string><json:string>Ethicon Inc.</json:string><json:string>University of Groningen</json:string><json:string>Group D of European Workshop on Periodontology</json:string><json:string>University Medical Center Groningen</json:string><json:string>Implant Complication Research Group</json:string><json:string>US National Institutes of Health</json:string><json:string>CONSORT Group</json:string><json:string>Department of Oral and Maxillofacial Surgery</json:string><json:string>Adobe Systems Incorporated, San Jose</json:string><json:string>Institutional Review Board of the University Medical Center Groningen, the Netherlands</json:string><json:string>University of Bristol</json:string><json:string>Switzerland, TPS</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Age</json:string><json:string>John Wiley</json:string><json:string>Edwin G. Winkel</json:string><json:string>Fifteen</json:string><json:string>Jan van Winkelhoff</json:string><json:string>J. A. Meijer</json:string><json:string>Gerry M. Raghoebar</json:string></persName><placeName><json:string>Groningen</json:string><json:string>IL</json:string><json:string>Bristol</json:string><json:string>Switzerland</json:string><json:string>Germany</json:string><json:string>Kiel</json:string><json:string>UK</json:string><json:string>Helsinki</json:string><json:string>Somerville</json:string><json:string>USA</json:string><json:string>Basel</json:string><json:string>Chicago</json:string><json:string>NJ</json:string><json:string>Spain</json:string><json:string>Netherlands</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Syed & Loesche 1972</json:string><json:string>Twisk 2006</json:string><json:string>Schwarz et al. 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(1986)</json:string><json:string>Pitten & Kramer 1999</json:string><json:string>de Waal et al.</json:string><json:string>Cairo et al. 2012</json:string><json:string>[7]</json:string><json:string>Pitten & Kramer 2001</json:string><json:string>Leonhardt et al. 2003</json:string><json:string>[25]</json:string><json:string>Russell 1986</json:string><json:string>Gosau et al. 2010</json:string><json:string>[35]</json:string><json:string>Schwarz et al. 2011</json:string><json:string>Quirynen et al. 2001</json:string><json:string>Van Winkelhoff et al. (1985)</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-XNWCQJDK-Z</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/jcpe.12034</json:string></doi><id>8A5E6B1F80D19DE474CB3F082412524ED3E4683C</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/8A5E6B1F80D19DE474CB3F082412524ED3E4683C/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/8A5E6B1F80D19DE474CB3F082412524ED3E4683C/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8A5E6B1F80D19DE474CB3F082412524ED3E4683C/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2012 John Wiley & Sons A/S</licence></availability><date type="published" when="2013-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Yvonne C. M.</forename><surname>Waal</surname></persName><affiliation><orgName>Center for Dentistry and Oral Hygiene</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation><affiliation>Address: Yvonne de Waal Center for Dentistry and Oral Hygiene University Medical Center Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands E‐mail: y.c.m.de.waal@umcg.nl</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gerry M.</forename><surname>Raghoebar</surname></persName><affiliation><orgName>Department of Oral and Maxillofacial Surgery</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">James J. R.</forename><surname>Huddleston Slater</surname></persName><affiliation><orgName>Center for Dentistry and Oral Hygiene</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation><affiliation><orgName>Department of Oral and Maxillofacial Surgery</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Henny J. A.</forename><surname>Meijer</surname></persName><affiliation><orgName>Center for Dentistry and Oral Hygiene</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation><affiliation><orgName>Department of Oral and Maxillofacial Surgery</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Edwin G.</forename><surname>Winkel</surname></persName><affiliation><orgName>Center for Dentistry and Oral Hygiene</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Arie Jan</forename><surname>Winkelhoff</surname></persName><affiliation><orgName>Center for Dentistry and Oral Hygiene</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation><affiliation><orgName>Department of Medical and Oral Microbiology</orgName><orgName>University Medical Center Groningen</orgName><orgName>University of Groningen</orgName><address><settlement type="city">Groningen</settlement><country key="NL">The Netherlands</country></address></affiliation></author><idno type="istex">8A5E6B1F80D19DE474CB3F082412524ED3E4683C</idno><idno type="ark">ark:/67375/WNG-XNWCQJDK-Z</idno><idno type="DOI">10.1111/jcpe.12034</idno><idno type="unit">JCPE12034</idno><idno type="toTypesetVersion">file:JCPE.JCPE12034.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/jcpe.2013.40.issue-2</idno><idno type="product">JCPE</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="186">186</biblScope><biblScope unit="page" to="195">195</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2013-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main" xml:id="jcpe12034-abs-0001"><head>Abstract</head>
Aim
<p>The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (<hi rend="fc">CHX</hi>)/cetylpyridinium chloride (<hi rend="fc">CPC</hi>) on microbiological and clinical parameters.</p>
Material & Methods
<p>Thirty patients (79 implants) with peri‐implantitis were treated with resective surgical treatment consisting of apically re‐positioned flap, bone re‐contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% <hi rend="fc">CHX</hi> + 0.05% <hi rend="fc">CPC</hi> (test‐group) or a placebo‐solution (without <hi rend="fc">CHX</hi>/<hi rend="fc">CPC</hi>, placebo‐group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre‐) treatment (baseline), and at 3, 6 and 12 months after treatment.</p>
Results
<p>Nine implants in two patients in the placebo‐group were lost due to severe persisting peri‐implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test‐group showed a significantly greater reduction than the placebo‐group (log 4.21 ± 1.89 <hi rend="italic">versus</hi> log 2.77 ± 2.12, <hi rend="italic">p </hi>=<hi rend="italic"> </hi>0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.</p>
Conclusion
<p>Implant surface decontamination with 0.12% <hi rend="fc">CHX</hi> + 0.05% <hi rend="fc">CPC</hi> in resective surgical treatment of peri‐implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo‐solution, but does not lead to superior clinical results. The long‐term microbiological effect remains unknown.</p></abstract><textClass><keywords><term xml:id="jcpe12034-kwd-0001">cetylpyridinium chloride</term><term xml:id="jcpe12034-kwd-0002">chlorhexidine</term><term xml:id="jcpe12034-kwd-0003">decontamination</term><term xml:id="jcpe12034-kwd-0004">microbiology</term><term xml:id="jcpe12034-kwd-0005">peri‐implantitis</term><term xml:id="jcpe12034-kwd-0006">resective surgery</term></keywords><keywords rend="articleCategory"><term>Randomized Clinical Trial</term></keywords><keywords rend="tocHeading1"><term>Implant Therapy</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/8A5E6B1F80D19DE474CB3F082412524ED3E4683C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12034" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley">10.1111/jcpe.2013.40.issue-2</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="40">40</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2013-02">February 2013</coverDate></publicationMeta><publicationMeta level="unit" position="110" status="forIssue" type="article"><doi>10.1111/jcpe.12034</doi><idGroup><id type="unit" value="JCPE12034"></id></idGroup><countGroup><count number="10" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Randomized Clinical Trial</title><title type="tocHeading1">Implant Therapy</title></titleGroup><copyright ownership="publisher">© 2012 John Wiley & Sons A/S</copyright><eventGroup><event date="2012-10-01" type="manuscriptAccepted"></event><event agent="SPS" date="2012-11-06" type="xmlCreated"></event><event type="publishedOnlineAccepted" date="2012-10-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-12-04"></event><event type="firstOnline" date="2012-12-04"></event><event type="publishedOnlineFinalForm" date="2013-01-11"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-02"></event></eventGroup><numberingGroup><numbering type="pageFirst">186</numbering><numbering type="pageLast">195</numbering></numberingGroup><correspondenceTo><lineatedText><line>Address:</line><line><i>Yvonne de Waal</i></line><line><i>Center for Dentistry and Oral Hygiene</i></line><line><i>University Medical Center Groningen</i></line><line><i>Antonius Deusinglaan 1</i></line><line><i>9713 AV Groningen</i></line><line><i>The Netherlands</i></line><line>E‐mail: <email>y.c.m.de.waal@umcg.nl</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12034-cit-1001"><author><familyNamePrefix>de</familyNamePrefix> <familyName>Waal</familyName> <givenNames>YCM</givenNames></author>, <author><familyName>Raghoebar</familyName> <givenNames>GM</givenNames></author>, <author><familyName>Huddleston Slater</familyName> <givenNames>JJR</givenNames></author>, <author><familyName>Meijer</familyName> <givenNames>HJA</givenNames></author>, <author><familyName>Winkel</familyName> <givenNames>EG</givenNames></author>, <author><familyNamePrefix>Jan van</familyNamePrefix> <familyName>Winkelhoff</familyName> <givenNames>A.</givenNames></author> <articleTitle>Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</articleTitle>. <journalTitle>J Clin Periodontol</journalTitle> <pubYear year="2013">2013</pubYear>; <vol>40</vol>: <pageFirst>186</pageFirst>–<pageLast>195</pageLast>. doi: 10.1111/jcpe.12034</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE12034.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title><title type="shortAuthors">de Waal <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#jcpe12034-aff-0001" corresponding="yes" creatorRole="author" xml:id="jcpe12034-cr-0001"><personName><givenNames>Yvonne C. M.</givenNames> <familyNamePrefix>de</familyNamePrefix><familyName>Waal</familyName></personName></creator><creator affiliationRef="#jcpe12034-aff-0002" creatorRole="author" xml:id="jcpe12034-cr-0002"><personName><givenNames>Gerry M.</givenNames> <familyName>Raghoebar</familyName></personName></creator><creator affiliationRef="#jcpe12034-aff-0001 #jcpe12034-aff-0002" creatorRole="author" xml:id="jcpe12034-cr-0003"><personName><givenNames>James J. R.</givenNames> <familyName>Huddleston Slater</familyName></personName></creator><creator affiliationRef="#jcpe12034-aff-0001 #jcpe12034-aff-0002" creatorRole="author" xml:id="jcpe12034-cr-0004"><personName><givenNames>Henny J. A.</givenNames> <familyName>Meijer</familyName></personName></creator><creator affiliationRef="#jcpe12034-aff-0001" creatorRole="author" xml:id="jcpe12034-cr-0005"><personName><givenNames>Edwin G.</givenNames> <familyName>Winkel</familyName></personName></creator><creator affiliationRef="#jcpe12034-aff-0001 #jcpe12034-aff-0003" creatorRole="author" xml:id="jcpe12034-cr-0006"><personName><givenNames>Arie Jan</givenNames> <familyNamePrefix>van</familyNamePrefix> <familyName>Winkelhoff</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="NL" type="organization" xml:id="jcpe12034-aff-0001"><orgDiv>Center for Dentistry and Oral Hygiene</orgDiv> <orgDiv>University Medical Center Groningen</orgDiv> <orgName>University of Groningen</orgName> <address><city>Groningen</city> <country>The Netherlands</country></address></affiliation><affiliation countryCode="NL" type="organization" xml:id="jcpe12034-aff-0002"><orgDiv>Department of Oral and Maxillofacial Surgery</orgDiv> <orgDiv>University Medical Center Groningen</orgDiv> <orgName>University of Groningen</orgName> <address><city>Groningen</city> <country>The Netherlands</country></address></affiliation><affiliation countryCode="NL" type="organization" xml:id="jcpe12034-aff-0003"><orgDiv>Department of Medical and Oral Microbiology</orgDiv> <orgDiv>University Medical Center Groningen</orgDiv> <orgName>University of Groningen</orgName> <address><city>Groningen</city> <country>The Netherlands</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12034-kwd-0001">cetylpyridinium chloride</keyword><keyword xml:id="jcpe12034-kwd-0002">chlorhexidine</keyword><keyword xml:id="jcpe12034-kwd-0003">decontamination</keyword><keyword xml:id="jcpe12034-kwd-0004">microbiology</keyword><keyword xml:id="jcpe12034-kwd-0005">peri‐implantitis</keyword><keyword xml:id="jcpe12034-kwd-0006">resective surgery</keyword></keywordGroup><abstractGroup><abstract type="main" xml:id="jcpe12034-abs-0001" xml:lang="en"><title type="main">Abstract</title><section xml:id="jcpe12034-sec-0001"><title type="main">Aim</title><p>The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (<fc>CHX</fc>)/cetylpyridinium chloride (<fc>CPC</fc>) on microbiological and clinical parameters.</p></section><section xml:id="jcpe12034-sec-0002"><title type="main">Material & Methods</title><p>Thirty patients (79 implants) with peri‐implantitis were treated with resective surgical treatment consisting of apically re‐positioned flap, bone re‐contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% <fc>CHX</fc> + 0.05% <fc>CPC</fc> (test‐group) or a placebo‐solution (without <fc>CHX</fc>/<fc>CPC</fc>, placebo‐group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre‐) treatment (baseline), and at 3, 6 and 12 months after treatment.</p></section><section xml:id="jcpe12034-sec-0003"><title type="main">Results</title><p>Nine implants in two patients in the placebo‐group were lost due to severe persisting peri‐implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test‐group showed a significantly greater reduction than the placebo‐group (log 4.21 ± 1.89 <i>versus</i> log 2.77 ± 2.12, <i>p </i>=<i> </i>0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.</p></section><section xml:id="jcpe12034-sec-0004"><title type="main">Conclusion</title><p>Implant surface decontamination with 0.12% <fc>CHX</fc> + 0.05% <fc>CPC</fc> in resective surgical treatment of peri‐implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo‐solution, but does not lead to superior clinical results. The long‐term microbiological effect remains unknown.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12034-ntgp-0001"><note numbered="no" xml:id="jcpe12034-note-0001"><p><b>Conflict of interest and source of funding statement</b></p><p>The authors declare that they have no conflict of interest. The test‐ and placebo‐solutions were provided for free by Dentaid SL (Cerdanyola, Spain).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial</title></titleInfo><name type="personal"><namePart type="given">Yvonne C. M.</namePart><namePart type="family">de Waal</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Address:E‐mail:</affiliation><affiliation>E-mail: y.c.m.de.waal@umcg.nl</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerry M.</namePart><namePart type="family">Raghoebar</namePart><affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James J. R.</namePart><namePart type="family">Huddleston Slater</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henny J. A.</namePart><namePart type="family">Meijer</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edwin G.</namePart><namePart type="family">Winkel</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arie Jan</namePart><namePart type="family">van Winkelhoff</namePart><affiliation>Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><affiliation>Department of Medical and Oral Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-02</dateIssued><dateCreated encoding="w3cdtf">2012-11-06</dateCreated><dateValid encoding="w3cdtf">2012-10-01</dateValid><edition>de Waal YCM, Raghoebar GM, Huddleston Slater JJR, Meijer HJA, Winkel EG, Jan van Winkelhoff A. Implant decontamination during surgical peri‐implantitis treatment: a randomized, double‐blind, placebo‐controlled trial. J Clin Periodontol 2013; 40: 186–195. doi: 10.1111/jcpe.12034</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The objective of this randomized, double‐blind, placebo‐controlled trial was to study the effect of implant surface decontamination with chlorhexidine (CHX)/cetylpyridinium chloride (CPC) on microbiological and clinical parameters.</abstract><abstract>Thirty patients (79 implants) with peri‐implantitis were treated with resective surgical treatment consisting of apically re‐positioned flap, bone re‐contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% CHX + 0.05% CPC (test‐group) or a placebo‐solution (without CHX/CPC, placebo‐group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre‐) treatment (baseline), and at 3, 6 and 12 months after treatment.</abstract><abstract>Nine implants in two patients in the placebo‐group were lost due to severe persisting peri‐implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test‐group showed a significantly greater reduction than the placebo‐group (log 4.21 ± 1.89 versus log 2.77 ± 2.12, p = 0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.</abstract><abstract>Implant surface decontamination with 0.12% CHX + 0.05% CPC in resective surgical treatment of peri‐implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo‐solution, but does not lead to superior clinical results. The long‐term microbiological effect remains unknown.</abstract><subject><genre>keywords</genre><topic>cetylpyridinium chloride</topic><topic>chlorhexidine</topic><topic>decontamination</topic><topic>microbiology</topic><topic>peri‐implantitis</topic><topic>resective surgery</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Randomized Clinical Trial</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>186</start><end>195</end><total>10</total></extent></part></relatedItem><identifier type="istex">8A5E6B1F80D19DE474CB3F082412524ED3E4683C</identifier><identifier type="ark">ark:/67375/WNG-XNWCQJDK-Z</identifier><identifier type="DOI">10.1111/jcpe.12034</identifier><identifier type="ArticleID">JCPE12034</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/8A5E6B1F80D19DE474CB3F082412524ED3E4683C/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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