In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces
Identifieur interne : 000235 ( Istex/Corpus ); précédent : 000234; suivant : 000236In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces
Auteurs : Ikiru Atsuta ; Yasunori Ayukawa ; Akihiro Furuhashi ; Yoichiro Ogino ; Yasuko Moriyama ; Yoshihiro Tsukiyama ; Kiyoshi KoyanoSource :
- Clinical Implant Dentistry and Related Research [ 1523-0899 ] ; 2014-10.
Abstract
The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.
Url:
DOI: 10.1111/cid.12043
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Ayukawa</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Furuhashi, Akihiro" sort="Furuhashi, Akihiro" uniqKey="Furuhashi A" first="Akihiro" last="Furuhashi">Akihiro Furuhashi</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ogino, Yoichiro" sort="Ogino, Yoichiro" uniqKey="Ogino Y" first="Yoichiro" last="Ogino">Yoichiro Ogino</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Moriyama, Yasuko" sort="Moriyama, Yasuko" uniqKey="Moriyama Y" first="Yasuko" last="Moriyama">Yasuko Moriyama</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tsukiyama, Yoshihiro" sort="Tsukiyama, Yoshihiro" uniqKey="Tsukiyama Y" first="Yoshihiro" last="Tsukiyama">Yoshihiro Tsukiyama</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Koyano, Kiyoshi" sort="Koyano, Kiyoshi" uniqKey="Koyano K" first="Kiyoshi" last="Koyano">Kiyoshi Koyano</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, 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Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, California, Los Angeles, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: atyuta@dent.kyushu-u.ac.jp</mods:affiliation></affiliation></author><author><name sortKey="Ayukawa, Yasunori" sort="Ayukawa, Yasunori" uniqKey="Ayukawa Y" first="Yasunori" last="Ayukawa">Yasunori Ayukawa</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Furuhashi, Akihiro" sort="Furuhashi, Akihiro" uniqKey="Furuhashi A" first="Akihiro" last="Furuhashi">Akihiro Furuhashi</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ogino, Yoichiro" sort="Ogino, Yoichiro" uniqKey="Ogino Y" first="Yoichiro" last="Ogino">Yoichiro Ogino</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Moriyama, Yasuko" sort="Moriyama, Yasuko" uniqKey="Moriyama Y" first="Yasuko" last="Moriyama">Yasuko Moriyama</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tsukiyama, Yoshihiro" sort="Tsukiyama, Yoshihiro" uniqKey="Tsukiyama Y" first="Yoshihiro" last="Tsukiyama">Yoshihiro Tsukiyama</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Koyano, Kiyoshi" sort="Koyano, Kiyoshi" uniqKey="Koyano K" first="Kiyoshi" last="Koyano">Kiyoshi Koyano</name><affiliation><mods:affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH</title><idno type="ISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="772">772</biblScope><biblScope unit="page" to="781">781</biblScope><biblScope 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atyuta@dent.kyushu-u.ac.jp</json:string></affiliations></json:item><json:item><name>Yasunori Ayukawa DDS, PhD</name><affiliations><json:string>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</json:string></affiliations></json:item><json:item><name>Akihiro Furuhashi DDS, PhD</name><affiliations><json:string>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</json:string></affiliations></json:item><json:item><name>Yoichiro Ogino DDS, PhD</name><affiliations><json:string>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</json:string></affiliations></json:item><json:item><name>Yasuko Moriyama DDS, PhD</name><affiliations><json:string>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, 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roughness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>titanium</value></json:item></subject><articleId><json:string>CID12043</json:string></articleId><arkIstex>ark:/67375/WNG-1PZCX567-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.</abstract><qualityIndicators><score>7.228</score><pdfWordCount>5195</pdfWordCount><pdfCharCount>33121</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>585 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>19</abstractWordCount><abstractCharCount>135</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough 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Rough Surfaces</title><title level="a" type="short">Epithelial Sealing around Rough Surface Implants</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Ikiru</forename><surname>Atsuta</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation><affiliation><orgName>Center for Craniofacial Molecular Biology</orgName><orgName>University of Southern California School of Dentistry</orgName><address><settlement type="city">Los Angeles</settlement><region>California</region><country key="US">USA</country></address></affiliation><affiliation>Reprint requests: Dr. Ikiru Atsuta, Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan; e‐mail: atyuta@dent.kyushu-u.ac.jp</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Yasunori</forename><surname>Ayukawa</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Akihiro</forename><surname>Furuhashi</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Yoichiro</forename><surname>Ogino</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Yasuko</forename><surname>Moriyama</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Yoshihiro</forename><surname>Tsukiyama</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Kiyoshi</forename><surname>Koyano</surname><roleName type="degree">DDS, PhD</roleName></persName><affiliation><orgName>Section of Implant and Rehabilitative Dentistry</orgName><orgName>Division of Oral Rehabilitation</orgName><orgName>Faculty of Dental Science</orgName><orgName>Kyushu University</orgName><address><settlement type="city">Fukuoka</settlement><country key="JP">Japan</country></address></affiliation></author><idno type="istex">4091F9A1FAA4E434FA3699A03E22268ED0EEEEB4</idno><idno type="ark">ark:/67375/WNG-1PZCX567-2</idno><idno type="DOI">10.1111/cid.12043</idno><idno type="unit">CID12043</idno><idno type="toTypesetVersion">file://CID.CID12043.pdf</idno></analytic><monogr><title level="j" type="main">Clinical Implant Dentistry and Related Research</title><title level="j" type="alt">CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH</title><idno type="pISSN">1523-0899</idno><idno type="eISSN">1708-8208</idno><idno type="book-DOI">10.1111/(ISSN)1708-8208</idno><idno type="book-part-DOI">10.1111/cid.2014.16.issue-5</idno><idno type="product">CID</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="772">772</biblScope><biblScope unit="page" to="781">781</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>Abstract</head>
Background
<p>The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.</p>
Purpose
<p>We explored the influence of surface roughness on peri‐implant epithelium (<hi rend="fc">PIE</hi>) sealing and down‐growth by comparing machine‐surfaced (<hi rend="fc">M</hi>s) and rough‐surfaced (<hi rend="fc">R</hi>s) implants.</p>
Materials and Methods
<p>(1) Maxillary first molars were extracted from rats and replaced with <hi rend="fc">M</hi>s or <hi rend="fc">R</hi>s implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells (<hi rend="fc">OECs</hi>) grown on <hi rend="fc">M</hi>s or <hi rend="fc">R</hi>s titanium (<hi rend="fc">T</hi>i) plates.</p>
Results
<p>(1) After 4 weeks, the <hi rend="fc">PIE</hi> around <hi rend="fc">M</hi>s and <hi rend="fc">R</hi>s implants showed a similar structure to junctional epithelium (<hi rend="fc">JE</hi>). At 16 weeks, <hi rend="fc">R</hi>s implants appeared to form a weak epithelial seal at the tissue‐implant interface and exhibited markedly less <hi rend="fc">PIE</hi> down‐growth than <hi rend="fc">M</hi>s implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in <hi rend="fc">OECs</hi> cultured on <hi rend="fc">R</hi>s plates than in cells grown on <hi rend="fc">M</hi>s plates. Additionally, cell adherence, migration, and proliferation on <hi rend="fc">R</hi>s plates were lower, whereas apoptosis was reduced on <hi rend="fc">M</hi>s plates.</p>
Conclusion
<p><hi rend="fc">M</hi>s implants are a better choice for integration with an epithelial wound healing process.</p></abstract><textClass><keywords><term xml:id="cid12043-kwd-0001">adhesion molecule</term><term xml:id="cid12043-kwd-0002">dental implant</term><term xml:id="cid12043-kwd-0003">epithelial cell</term><term xml:id="cid12043-kwd-0004">surface roughness</term><term xml:id="cid12043-kwd-0005">titanium</term></keywords><keywords rend="tocHeading1"><term>ARTICLES</term></keywords><keywords rend="articleCategory"><term>ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body" wicri:toSee="Element #text"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="cid12043" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley">10.1111/(ISSN)1708-8208</doi><issn type="print">1523-0899</issn><issn type="electronic">1708-8208</issn><idGroup><id type="product" value="CID"></id></idGroup><titleGroup><title sort="CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH" type="main">Clinical Implant Dentistry and Related Research</title><title type="short">Clinical Implant Dentistry and Related Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="10105"><doi>10.1111/cid.2014.16.issue-5</doi><copyright ownership="publisher">Copyright © 2014 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering number="16" type="journalVolume">16</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2014-10">October 2014</coverDate></publicationMeta><publicationMeta level="unit" status="forIssue" type="article" position="140"><doi>10.1111/cid.12043</doi><idGroup><id type="unit" value="CID12043"></id></idGroup><countGroup><count number="10" type="pageTotal"></count></countGroup><titleGroup><title type="tocHeading1">ARTICLES</title><title type="articleCategory">ARTICLE</title></titleGroup><copyright ownership="publisher">© 2013 Wiley Periodicals, Inc.</copyright><eventGroup><event agent="bestset" date="2013-01-21" type="xmlCreated"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-02-28"></event><event type="firstOnline" date="2013-02-28"></event><event type="publishedOnlineFinalForm" date="2014-10-21"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-06"></event></eventGroup><numberingGroup><numbering type="pageFirst">772</numbering><numbering type="pageLast">781</numbering></numberingGroup><correspondenceTo>Reprint requests: Dr. Ikiru Atsuta, Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3‐1‐1 Maidashi, Higashi‐ku, Fukuoka 812‐8582, Japan; e‐mail: <email>atyuta@dent.kyushu-u.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file://CID.CID12043.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="short">Epithelial Sealing around Rough Surface Implants</title><title type="shortAuthors">Clinical Implant Dentistry and Related Research, Volume 16, Number 5, 2014</title><title type="main">In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces</title></titleGroup><creators><creator affiliationRef="#cid12043-aff-0001 #cid12043-aff-0002" corresponding="yes" creatorRole="author" xml:id="cid12043-cr-0001"><personName><givenNames>Ikiru</givenNames><familyName>Atsuta</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>Assistant professor</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0002"><personName><givenNames>Yasunori</givenNames><familyName>Ayukawa</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>assistant professor</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0003"><personName><givenNames>Akihiro</givenNames><familyName>Furuhashi</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>clinical fellow</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0004"><personName><givenNames>Yoichiro</givenNames><familyName>Ogino</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>assistant professor</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0005"><personName><givenNames>Yasuko</givenNames><familyName>Moriyama</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>assistant professor</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0006"><personName><givenNames>Yoshihiro</givenNames><familyName>Tsukiyama</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>associate professor</jobTitle></creator><creator affiliationRef="#cid12043-aff-0001" creatorRole="author" xml:id="cid12043-cr-0007"><personName><givenNames>Kiyoshi</givenNames><familyName>Koyano</familyName><degrees>DDS, PhD</degrees></personName><jobTitle>professor</jobTitle></creator></creators><affiliationGroup><affiliation countryCode="JP" xml:id="cid12043-aff-0001"><orgDiv>Section of Implant and Rehabilitative Dentistry</orgDiv><orgDiv>Division of Oral Rehabilitation</orgDiv><orgDiv>Faculty of Dental Science</orgDiv><orgName>Kyushu University</orgName><address><city>Fukuoka</city><country>Japan</country></address></affiliation><affiliation countryCode="US" xml:id="cid12043-aff-0002"><orgDiv>Center for Craniofacial Molecular Biology</orgDiv><orgName>University of Southern California School of Dentistry</orgName><address><city>Los Angeles</city><countryPart>California</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="cid12043-kwd-0001">adhesion molecule</keyword><keyword xml:id="cid12043-kwd-0002">dental implant</keyword><keyword xml:id="cid12043-kwd-0003">epithelial cell</keyword><keyword xml:id="cid12043-kwd-0004">surface roughness</keyword><keyword xml:id="cid12043-kwd-0005">titanium</keyword></keywordGroup><fundingInfo><fundingAgency>Ministry of Education, Culture, Sports, Science and Technology of Japan</fundingAgency><fundingNumber>23592888</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><title type="main">Abstract</title><section xml:id="cid12043-sec-0001"><title type="main">Background</title><p>The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.</p></section><section xml:id="cid12043-sec-0002"><title type="main">Purpose</title><p>We explored the influence of surface roughness on peri‐implant epithelium (<fc>PIE</fc>) sealing and down‐growth by comparing machine‐surfaced (<fc>M</fc>s) and rough‐surfaced (<fc>R</fc>s) implants.</p></section><section xml:id="cid12043-sec-0003"><title type="main">Materials and Methods</title><p>(1) Maxillary first molars were extracted from rats and replaced with <fc>M</fc>s or <fc>R</fc>s implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells (<fc>OECs</fc>) grown on <fc>M</fc>s or <fc>R</fc>s titanium (<fc>T</fc>i) plates.</p></section><section xml:id="cid12043-sec-0004"><title type="main">Results</title><p>(1) After 4 weeks, the <fc>PIE</fc> around <fc>M</fc>s and <fc>R</fc>s implants showed a similar structure to junctional epithelium (<fc>JE</fc>). At 16 weeks, <fc>R</fc>s implants appeared to form a weak epithelial seal at the tissue‐implant interface and exhibited markedly less <fc>PIE</fc> down‐growth than <fc>M</fc>s implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in <fc>OECs</fc> cultured on <fc>R</fc>s plates than in cells grown on <fc>M</fc>s plates. Additionally, cell adherence, migration, and proliferation on <fc>R</fc>s plates were lower, whereas apoptosis was reduced on <fc>M</fc>s plates.</p></section><section xml:id="cid12043-sec-0005"><title type="main">Conclusion</title><p><fc>M</fc>s implants are a better choice for integration with an epithelial wound healing process.</p></section></abstract></abstractGroup></contentMeta></header> </component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Epithelial Sealing around Rough Surface Implants</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces</title></titleInfo><name type="personal"><namePart type="given">Ikiru</namePart><namePart type="family">Atsuta</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><affiliation>Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, California, Los Angeles, USA</affiliation><affiliation>E-mail: atyuta@dent.kyushu-u.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Assistant professor</description></name><name type="personal"><namePart type="given">Yasunori</namePart><namePart type="family">Ayukawa</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>assistant professor</description></name><name type="personal"><namePart type="given">Akihiro</namePart><namePart type="family">Furuhashi</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>clinical fellow</description></name><name type="personal"><namePart type="given">Yoichiro</namePart><namePart type="family">Ogino</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>assistant professor</description></name><name type="personal"><namePart type="given">Yasuko</namePart><namePart type="family">Moriyama</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>assistant professor</description></name><name type="personal"><namePart type="given">Yoshihiro</namePart><namePart type="family">Tsukiyama</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>associate professor</description></name><name type="personal"><namePart type="given">Kiyoshi</namePart><namePart type="family">Koyano</namePart><namePart type="termsOfAddress">DDS, PhD</namePart><affiliation>Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role><description>professor</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-10</dateIssued><dateCreated encoding="w3cdtf">2013-01-21</dateCreated><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.</abstract><abstract>We explored the influence of surface roughness on peri‐implant epithelium (PIE) sealing and down‐growth by comparing machine‐surfaced (Ms) and rough‐surfaced (Rs) implants.</abstract><abstract>(1) Maxillary first molars were extracted from rats and replaced with Ms or Rs implants. (2) We also compared changes in the morphology of cultured rat oral epithelial cells (OECs) grown on Ms or Rs titanium (Ti) plates.</abstract><abstract>(1) After 4 weeks, the PIE around Ms and Rs implants showed a similar structure to junctional epithelium (JE). At 16 weeks, Rs implants appeared to form a weak epithelial seal at the tissue‐implant interface and exhibited markedly less PIE down‐growth than Ms implants but was deeper than that observed in natural teeth. (2) We observed less expression of adhesion proteins in OECs cultured on Rs plates than in cells grown on Ms plates. Additionally, cell adherence, migration, and proliferation on Rs plates were lower, whereas apoptosis was reduced on Ms plates.</abstract><abstract>Ms implants are a better choice for integration with an epithelial wound healing process.</abstract><note type="funding">Ministry of Education, Culture, Sports, Science and Technology of Japan - No. 23592888; </note><subject><genre>keywords</genre><topic>adhesion molecule</topic><topic>dental implant</topic><topic>epithelial cell</topic><topic>surface roughness</topic><topic>titanium</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Implant Dentistry and Related Research</title></titleInfo><titleInfo type="abbreviated"><title>Clinical Implant Dentistry and Related Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ARTICLE</topic></subject><identifier type="ISSN">1523-0899</identifier><identifier type="eISSN">1708-8208</identifier><identifier type="DOI">10.1111/(ISSN)1708-8208</identifier><identifier type="PublisherID">CID</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>772</start><end>781</end><total>10</total></extent></part></relatedItem><identifier type="istex">4091F9A1FAA4E434FA3699A03E22268ED0EEEEB4</identifier><identifier type="ark">ark:/67375/WNG-1PZCX567-2</identifier><identifier type="DOI">10.1111/cid.12043</identifier><identifier type="ArticleID">CID12043</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 Wiley Periodicals, Inc.© 2013 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/4091F9A1FAA4E434FA3699A03E22268ED0EEEEB4/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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