Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes
Identifieur interne : 000050 ( Istex/Corpus ); précédent : 000049; suivant : 000051Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes
Auteurs : Petra Timonen ; Tuomas Saxlin ; Matti Knuuttila ; Anna Liisa Suominen ; Antti Jula ; Tellervo Tervonen ; Pekka YlöstaloSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2013-12.
English descriptors
- KwdEn :
- Baseline, Baseline examinations, Beta, Beta cell function, Blood pressure, Body mass index, Body weight, Chronic periodontitis, Clinical periodontology, Dental attendance pattern, Dental plaque, Diabetes, Diabetes care, Diabetes mellitus, Fasting, Fasting glucose, Finland, Finnish, Finnish adults, Genetic factors, Gingival, Gingival margins, Glucose, Glucose metabolism, Glucose regulation, Glucose tolerance, Health institute, Helsinki, Highest index tertile, Homa indices, Homeostasis, Homeostasis model assessment, Incidence rate ratios, Index values, Insulin, Insulin resistance, Insulin sensitivity, Intermediate index tertile, John wiley sons, Lowest index tertile, Metabolism, National institute, Ndings, Normoweight subjects, Oral health, Periodontal, Periodontal disease, Periodontal diseases, Periodontal pocket formation, Periodontal pockets, Periodontitis, Periodontium, Periodontology, Physical activity, Plaque, Pocket depth, Pocket formation, Severe periodontitis, Social insurance institution, Study population, Tertile, Timonen, Toothbrushing frequency, Vehkalahti, Visible plaque.
- Teeft :
- Baseline, Baseline examinations, Beta, Beta cell function, Blood pressure, Body mass index, Body weight, Chronic periodontitis, Clinical periodontology, Dental attendance pattern, Dental plaque, Diabetes, Diabetes care, Diabetes mellitus, Fasting, Fasting glucose, Finland, Finnish, Finnish adults, Genetic factors, Gingival, Gingival margins, Glucose, Glucose metabolism, Glucose regulation, Glucose tolerance, Health institute, Helsinki, Highest index tertile, Homa indices, Homeostasis, Homeostasis model assessment, Incidence rate ratios, Index values, Insulin, Insulin resistance, Insulin sensitivity, Intermediate index tertile, John wiley sons, Lowest index tertile, Metabolism, National institute, Ndings, Normoweight subjects, Oral health, Periodontal, Periodontal disease, Periodontal diseases, Periodontal pocket formation, Periodontal pockets, Periodontitis, Periodontium, Periodontology, Physical activity, Plaque, Pocket depth, Pocket formation, Severe periodontitis, Social insurance institution, Study population, Tertile, Timonen, Toothbrushing frequency, Vehkalahti, Visible plaque.
Abstract
The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non‐smoking adults without manifest diabetes.
Url:
DOI: 10.1111/jcpe.12162
Links to Exploration step
ISTEX:0E798B03D311DCC09A4812725CBC0852F49CF233Le document en format XML
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periodontitis</json:string></teeft></keywords><author><json:item><name>Petra Timonen</name><affiliations><json:string>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</json:string><json:string>Address:E‐mail:</json:string><json:string>E-mail: petra.timonen@oulu.fi</json:string></affiliations></json:item><json:item><name>Tuomas Saxlin</name><affiliations><json:string>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</json:string></affiliations></json:item><json:item><name>Matti Knuuttila</name><affiliations><json:string>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</json:string></affiliations></json:item><json:item><name>Anna Liisa Suominen</name><affiliations><json:string>National Institute for Health and Welfare (THL), Kuopio, Finland</json:string><json:string>Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</json:string><json:string>Oral and Maxillofacial Department, Kuopio University Hospital, Kuopio, Finland</json:string></affiliations></json:item><json:item><name>Antti Jula</name><affiliations><json:string>National Institute for Health and Welfare (THL), Turku, Finland</json:string></affiliations></json:item><json:item><name>Tellervo Tervonen</name><affiliations><json:string>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</json:string><json:string>Department of Oral and Maxillofacial, Oulu University Hospital, Oulu, Finland</json:string></affiliations></json:item><json:item><name>Pekka Ylöstalo</name><affiliations><json:string>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</json:string><json:string>Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</json:string><json:string>Oral and Maxillofacial 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Role</json:string><json:string>Matti Knuuttila</json:string><json:string>Orion Diagnostica</json:string><json:string>S. Published</json:string><json:string>Fisher Scienti</json:string></persName><placeName><json:string>Finland</json:string><json:string>Turku</json:string><json:string>Espoo</json:string><json:string>Vantaa</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Kiiskinen et al. 2005</json:string><json:string>Kumar et al. 2006</json:string><json:string>Balkau et al. 2008</json:string><json:string>Bonora et al. 2000</json:string><json:string>Saito et al. 2005</json:string><json:string>Matthews et al. 1985</json:string><json:string>Choi et al. 2011</json:string><json:string>Feskens et al. 1995</json:string><json:string>Hosker et al. 1985</json:string><json:string>Vehkalahti et al. 2004, p. 29</json:string><json:string>Ek et al. 2001</json:string><json:string>Dandona et al. 2004</json:string><json:string>Zadik et al. 2010</json:string><json:string>Faerch et al. 2009</json:string><json:string>Nibali et al. 2007</json:string><json:string>Schneir et al. 1988</json:string><json:string>Frantzis et al. 1971</json:string><json:string>Gyurko et al. 2006</json:string><json:string>Polonsky et al. 1996</json:string><json:string>Riordain et al. 1995</json:string><json:string>Hermans et al. 1999</json:string><json:string>Esposito et al. 2002</json:string><json:string>Pickup & Crook 1998</json:string><json:string>Suominen-Taipale 2005</json:string><json:string>Sima et al. 2010</json:string><json:string>Ding et al. 2006</json:string><json:string>Vehkalahti et al. 2008, p. 19</json:string><json:string>Lyssenko et al. 2005</json:string><json:string>Yoshida et al. 2009</json:string><json:string>Timonen et al. 2011</json:string><json:string>Haffner et al. 1997</json:string><json:string>Hockaday et al. 2007</json:string><json:string>Estvez et al. 2003</json:string><json:string>Genco et al. 2005</json:string><json:string>Benguigui et al. 2010</json:string><json:string>Noack et al. 2000</json:string><json:string>Aiuto et al. 2007</json:string><json:string>Suominen-Taipale et al.</json:string><json:string>Saito et al. 2006</json:string><json:string>Timonen et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-5MLMK6BT-2</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1111/jcpe.12162</json:string></doi><id>0E798B03D311DCC09A4812725CBC0852F49CF233</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/0E798B03D311DCC09A4812725CBC0852F49CF233/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/0E798B03D311DCC09A4812725CBC0852F49CF233/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0E798B03D311DCC09A4812725CBC0852F49CF233/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</licence></availability><date type="published" when="2013-12"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Petra</forename><surname>Timonen</surname></persName><affiliation><orgName>Department of Periodontology and Geriatric Dentistry</orgName><orgName>Institute of Dentistry</orgName><orgName>University of Oulu</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation><affiliation>Address: Petra Timonen Institute of Dentistry University of Oulu P.O. Box 5281 90014 University of Oulu Finland E‐mail: petra.timonen@oulu.fi</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tuomas</forename><surname>Saxlin</surname></persName><affiliation><orgName>Department of Periodontology and Geriatric Dentistry</orgName><orgName>Institute of Dentistry</orgName><orgName>University of Oulu</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Matti</forename><surname>Knuuttila</surname></persName><affiliation><orgName>Department of Periodontology and Geriatric Dentistry</orgName><orgName>Institute of Dentistry</orgName><orgName>University of Oulu</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Anna Liisa</forename><surname>Suominen</surname></persName><affiliation><orgName>National Institute for Health and Welfare (THL)</orgName><address><settlement type="city">Kuopio</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Eastern Finland</orgName><address><settlement type="city">Kuopio</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Oral and Maxillofacial Department</orgName><orgName>Kuopio University Hospital</orgName><address><settlement type="city">Kuopio</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Antti</forename><surname>Jula</surname></persName><affiliation><orgName>National Institute for Health and Welfare (THL)</orgName><address><settlement type="city">Turku</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Tellervo</forename><surname>Tervonen</surname></persName><affiliation><orgName>Department of Periodontology and Geriatric Dentistry</orgName><orgName>Institute of Dentistry</orgName><orgName>University of Oulu</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Department of Oral and Maxillofacial</orgName><orgName>Oulu University Hospital</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Pekka</forename><surname>Ylöstalo</surname></persName><affiliation><orgName>Department of Periodontology and Geriatric Dentistry</orgName><orgName>Institute of Dentistry</orgName><orgName>University of Oulu</orgName><address><settlement type="city">Oulu</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Institute of Dentistry</orgName><orgName>University of Eastern Finland</orgName><address><settlement type="city">Kuopio</settlement><country key="FI">Finland</country></address></affiliation><affiliation><orgName>Oral and Maxillofacial Department</orgName><orgName>Kuopio University Hospital</orgName><address><settlement type="city">Kuopio</settlement><country key="FI">Finland</country></address></affiliation></author><idno type="istex">0E798B03D311DCC09A4812725CBC0852F49CF233</idno><idno type="ark">ark:/67375/WNG-5MLMK6BT-2</idno><idno type="DOI">10.1111/jcpe.12162</idno><idno type="unit">JCPE12162</idno><idno type="toTypesetVersion">file:JCPE.JCPE12162.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/jcpe.2013.40.issue-12</idno><idno type="product">JCPE</idno><imprint><biblScope unit="vol">40</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1079">1079</biblScope><biblScope unit="page" to="1086">1086</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2013-12"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="jcpe12162-abs-0001"><head>Abstract</head>
Aim
<p>The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non‐smoking adults without manifest diabetes.</p>
Material and Methods
<p>We analysed data from a Health 2000 Survey consisting of dentate subjects without any indication of diabetes, aged between 30 and 64, who had never smoked and who had participated in the Follow‐up Study on Finnish Adults' Oral Health about 4 years later (<hi rend="italic">n</hi> = 157). The Homeostasis Model Assessment Indices were used to measure insulin resistance (<hi rend="fc">HOMA</hi>‐<hi rend="fc">IR</hi>) and β‐cell function (<hi rend="fc">HOMA</hi>‐B). The development of periodontal disease was measured by means of the incidence of deepened periodontal pockets (4 mm deep or deeper) during the follow‐up period. Incidence rate ratios (<hi rend="fc">IRR</hi>) were estimated using Poisson regression models.</p>
Results
<p>Both <hi rend="fc">HOMA</hi>‐<hi rend="fc">IR</hi> and <hi rend="fc">HOMA</hi>‐B indices were associated with periodontal pocket formation during the 4‐year follow‐up.</p>
Conclusion
<p>The results of this follow‐up study suggest that impaired glucose metabolism measured as insulin resistance and altered beta cell function predict the breakdown of periodontal tissues. Further studies about their role in the pathogenesis of periodontal diseases are needed.</p></abstract><textClass><keywords><term xml:id="jcpe12162-kwd-0001">beta cell function</term><term xml:id="jcpe12162-kwd-0002"><hi rend="fc">HOMA</hi>‐B</term><term xml:id="jcpe12162-kwd-0003"><hi rend="fc">HOMA</hi>‐<hi rend="fc">IR</hi></term><term xml:id="jcpe12162-kwd-0004">insulin resistance</term><term xml:id="jcpe12162-kwd-0005">periodontal infection</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Periodontal Diseases</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/0E798B03D311DCC09A4812725CBC0852F49CF233/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jcpe12162" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id></idGroup><titleGroup><title sort="JOURNAL OF CLINICAL PERIODONTOLOGY" type="main">Journal of Clinical Periodontology</title><title type="short">J Clin Periodontol</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley">10.1111/jcpe.2013.40.issue-12</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><numberingGroup><numbering number="40" type="journalVolume">40</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2013-12">December 2013</coverDate></publicationMeta><publicationMeta level="unit" position="40" status="forIssue" type="article"><doi>10.1111/jcpe.12162</doi><idGroup><id type="unit" value="JCPE12162"></id></idGroup><countGroup><count number="8" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Periodontal Diseases</title></titleGroup><copyright ownership="publisher">© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</copyright><eventGroup><event date="2013-09-01" type="manuscriptAccepted"></event><event agent="SPS" date="2013-09-19" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.6 mode:FullText" date="2013-11-06"></event><event type="publishedOnlineAccepted" date="2013-09-10"></event><event type="firstOnline" date="2013-11-06"></event><event type="publishedOnlineFinalForm" date="2013-11-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">1079</numbering><numbering type="pageLast">1086</numbering></numberingGroup><correspondenceTo><lineatedText><line>Address:</line><line><i>Petra Timonen</i></line><line><i>Institute of Dentistry</i></line><line><i>University of Oulu</i></line><line><i>P.O. Box 5281</i></line><line><i>90014 University of Oulu</i></line><line><i>Finland</i></line><line>E‐mail: <email>petra.timonen@oulu.fi</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="jcpe12162-cit-1001"><author><familyName>Timonen</familyName> <givenNames>P</givenNames></author>, <author><familyName>Saxlin</familyName> <givenNames>T</givenNames></author>, <author><familyName>Knuuttila</familyName> <givenNames>M</givenNames></author>, <author><familyName>Suominen</familyName> <givenNames>AL</givenNames></author>, <author><familyName>Jula</familyName> <givenNames>A</givenNames></author>, <author><familyName>Tervonen</familyName> <givenNames>T</givenNames></author>, <author><familyName>Ylöstalo</familyName> <givenNames>P</givenNames></author>. <articleTitle>Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</articleTitle>. <journalTitle>J Clin Periodontol</journalTitle> <pubYear year="2013">2013</pubYear>; <vol>40</vol>: <pageFirst>1079</pageFirst>–<pageLast>1086</pageLast>. doi: <accessionId ref="info:doi/10.1111/jcpe.12162">10.1111/jcpe.12162</accessionId></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE12162.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</title><title type="shortAuthors">Timonen et al.</title></titleGroup><creators><creator affiliationRef="#jcpe12162-aff-0001" corresponding="yes" creatorRole="author" xml:id="jcpe12162-cr-0001"><personName><givenNames>Petra</givenNames> <familyName>Timonen</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0001" creatorRole="author" xml:id="jcpe12162-cr-0002"><personName><givenNames>Tuomas</givenNames> <familyName>Saxlin</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0001" creatorRole="author" xml:id="jcpe12162-cr-0003"><personName><givenNames>Matti</givenNames> <familyName>Knuuttila</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0002 #jcpe12162-aff-0003 #jcpe12162-aff-0004" creatorRole="author" xml:id="jcpe12162-cr-0004"><personName><givenNames>Anna Liisa</givenNames> <familyName>Suominen</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0005" creatorRole="author" xml:id="jcpe12162-cr-0005"><personName><givenNames>Antti</givenNames> <familyName>Jula</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0001 #jcpe12162-aff-0006" creatorRole="author" xml:id="jcpe12162-cr-0006"><personName><givenNames>Tellervo</givenNames> <familyName>Tervonen</familyName></personName></creator><creator affiliationRef="#jcpe12162-aff-0001 #jcpe12162-aff-0003 #jcpe12162-aff-0004" creatorRole="author" xml:id="jcpe12162-cr-0007"><personName><givenNames>Pekka</givenNames> <familyName>Ylöstalo</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0001"><orgDiv>Department of Periodontology and Geriatric Dentistry</orgDiv> <orgName>Institute of Dentistry</orgName> <orgName>University of Oulu</orgName> <address><city>Oulu</city> <country>Finland</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0002"><orgName>National Institute for Health and Welfare (THL)</orgName> <address><city>Kuopio</city> <country>Finland</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0003"><orgName>Institute of Dentistry</orgName> <orgName>University of Eastern Finland</orgName> <address><city>Kuopio</city> <country>Finland</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0004"><orgDiv>Oral and Maxillofacial Department</orgDiv> <orgName>Kuopio University Hospital</orgName> <address><city>Kuopio</city> <country>Finland</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0005"><orgName>National Institute for Health and Welfare (THL)</orgName> <address><city>Turku</city> <country>Finland</country></address></affiliation><affiliation countryCode="FI" type="organization" xml:id="jcpe12162-aff-0006"><orgDiv>Department of Oral and Maxillofacial</orgDiv> <orgName>Oulu University Hospital</orgName> <address><city>Oulu</city> <country>Finland</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jcpe12162-kwd-0001">beta cell function</keyword><keyword xml:id="jcpe12162-kwd-0002"><fc>HOMA</fc>‐B</keyword><keyword xml:id="jcpe12162-kwd-0003"><fc>HOMA</fc>‐<fc>IR</fc></keyword><keyword xml:id="jcpe12162-kwd-0004">insulin resistance</keyword><keyword xml:id="jcpe12162-kwd-0005">periodontal infection</keyword></keywordGroup><fundingInfo><fundingAgency>National Institute for Health and Welfare</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Social Insurance Institution of Finland (KELA)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jcpe12162-abs-0001"><title type="main">Abstract</title><section xml:id="jcpe12162-sec-0001"><title type="main">Aim</title><p>The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non‐smoking adults without manifest diabetes.</p></section><section xml:id="jcpe12162-sec-0002"><title type="main">Material and Methods</title><p>We analysed data from a Health 2000 Survey consisting of dentate subjects without any indication of diabetes, aged between 30 and 64, who had never smoked and who had participated in the Follow‐up Study on Finnish Adults' Oral Health about 4 years later (<i>n</i> = 157). The Homeostasis Model Assessment Indices were used to measure insulin resistance (<fc>HOMA</fc>‐<fc>IR</fc>) and β‐cell function (<fc>HOMA</fc>‐B). The development of periodontal disease was measured by means of the incidence of deepened periodontal pockets (4 mm deep or deeper) during the follow‐up period. Incidence rate ratios (<fc>IRR</fc>) were estimated using Poisson regression models.</p></section><section xml:id="jcpe12162-sec-0003"><title type="main">Results</title><p>Both <fc>HOMA</fc>‐<fc>IR</fc> and <fc>HOMA</fc>‐B indices were associated with periodontal pocket formation during the 4‐year follow‐up.</p></section><section xml:id="jcpe12162-sec-0004"><title type="main">Conclusion</title><p>The results of this follow‐up study suggest that impaired glucose metabolism measured as insulin resistance and altered beta cell function predict the breakdown of periodontal tissues. Further studies about their role in the pathogenesis of periodontal diseases are needed.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jcpe12162-ntgp-0001"><note numbered="no" xml:id="jcpe12162-note-0001"><p><b>Conflict of interest and source of funding</b></p><p>The authors declare that there are no conflicts of interest in this study. This study is part of the Health 2000 Survey, organized by the National Institute for Health and Welfare (THL) (former National Public Health Institute (KTL) of Finland), and partly supported by the Finnish Dental Society Apollonia and the Finnish Dental Association. The personal grant received from the Finnish Dental Society Apollonia and the Finnish Dental Association is acknowledged by Petra Timonen. The follow‐up Study on Finnish Adults′ Oral Health was organized and funded by the National Institute for Health and Welfare and the Social Insurance Institution of Finland (KELA).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes</title></titleInfo><name type="personal"><namePart type="given">Petra</namePart><namePart type="family">Timonen</namePart><affiliation>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</affiliation><affiliation>Address:E‐mail:</affiliation><affiliation>E-mail: petra.timonen@oulu.fi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tuomas</namePart><namePart type="family">Saxlin</namePart><affiliation>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matti</namePart><namePart type="family">Knuuttila</namePart><affiliation>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna Liisa</namePart><namePart type="family">Suominen</namePart><affiliation>National Institute for Health and Welfare (THL), Kuopio, Finland</affiliation><affiliation>Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</affiliation><affiliation>Oral and Maxillofacial Department, Kuopio University Hospital, Kuopio, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antti</namePart><namePart type="family">Jula</namePart><affiliation>National Institute for Health and Welfare (THL), Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tellervo</namePart><namePart type="family">Tervonen</namePart><affiliation>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</affiliation><affiliation>Department of Oral and Maxillofacial, Oulu University Hospital, Oulu, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pekka</namePart><namePart type="family">Ylöstalo</namePart><affiliation>Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland</affiliation><affiliation>Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</affiliation><affiliation>Oral and Maxillofacial Department, Kuopio University Hospital, Kuopio, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-12</dateIssued><dateCreated encoding="w3cdtf">2013-09-19</dateCreated><dateValid encoding="w3cdtf">2013-09-01</dateValid><edition>Timonen P, Saxlin T, Knuuttila M, Suominen AL, Jula A, Tervonen T, Ylöstalo P. Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes. J Clin Periodontol 2013; 40: 1079–1086. doi: 10.1111/jcpe.12162</edition><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non‐smoking adults without manifest diabetes.</abstract><abstract>We analysed data from a Health 2000 Survey consisting of dentate subjects without any indication of diabetes, aged between 30 and 64, who had never smoked and who had participated in the Follow‐up Study on Finnish Adults' Oral Health about 4 years later (n = 157). The Homeostasis Model Assessment Indices were used to measure insulin resistance (HOMA‐IR) and β‐cell function (HOMA‐B). The development of periodontal disease was measured by means of the incidence of deepened periodontal pockets (4 mm deep or deeper) during the follow‐up period. Incidence rate ratios (IRR) were estimated using Poisson regression models.</abstract><abstract>Both HOMA‐IR and HOMA‐B indices were associated with periodontal pocket formation during the 4‐year follow‐up.</abstract><abstract>The results of this follow‐up study suggest that impaired glucose metabolism measured as insulin resistance and altered beta cell function predict the breakdown of periodontal tissues. Further studies about their role in the pathogenesis of periodontal diseases are needed.</abstract><note type="funding">National Institute for Health and Welfare</note><note type="funding">Social Insurance Institution of Finland (KELA)</note><subject><genre>keywords</genre><topic>beta cell function</topic><topic>HOMA‐B</topic><topic>HOMA‐IR</topic><topic>insulin resistance</topic><topic>periodontal infection</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><titleInfo type="abbreviated"><title>J Clin Periodontol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1079</start><end>1086</end><total>8</total></extent></part></relatedItem><identifier type="istex">0E798B03D311DCC09A4812725CBC0852F49CF233</identifier><identifier type="ark">ark:/67375/WNG-5MLMK6BT-2</identifier><identifier type="DOI">10.1111/jcpe.12162</identifier><identifier type="ArticleID">JCPE12162</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/S. 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