Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical recordings.
Identifieur interne : 000024 ( PubMed/Corpus ); précédent : 000023; suivant : 000025Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical recordings.
Auteurs : Agustín Ibá Ez ; Juan F. Cardona ; Yamil Vidal Dos Santos ; Alejandro Blenkmann ; Pía Aravena ; María Roca ; Esteban Hurtado ; Mirna Nerguizian ; Lucía Amoruso ; Gonzalo G Mez-Arévalo ; Anabel Chade ; Alberto Dubrovsky ; Oscar Gershanik ; Silvia Kochen ; Arthur Glenberg ; Facundo Manes ; Tristán BekinschteinSource :
- Cortex; a journal devoted to the study of the nervous system and behavior [ 1973-8102 ] ; 2013.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Antiparkinson Agents (therapeutic use), Cerebral Cortex (physiopathology), Cognition Disorders (etiology), Cognition Disorders (psychology), Comprehension (physiology), Data Interpretation, Statistical (MeSH), Educational Status (MeSH), Electroencephalography (MeSH), Evoked Potentials, Motor (physiology), Female (MeSH), Hand (physiology), Humans (MeSH), Image Processing, Computer-Assisted (MeSH), Language (MeSH), Magnetic Resonance Imaging (MeSH), Male (MeSH), Middle Aged (MeSH), Motor Cortex (physiopathology), Movement (physiology), Nervous System Diseases (physiopathology), Nervous System Diseases (psychology), Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (psychology), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Reaction Time (physiology), Transcranial Magnetic Stimulation (MeSH).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- etiology : Cognition Disorders.
- physiology : Comprehension, Evoked Potentials, Motor, Hand, Movement, Reaction Time.
- physiopathology : Cerebral Cortex, Motor Cortex, Nervous System Diseases, Neurodegenerative Diseases, Parkinson Disease.
- psychology : Cognition Disorders, Nervous System Diseases, Neurodegenerative Diseases, Parkinson Disease.
- Analysis of Variance, Data Interpretation, Statistical, Educational Status, Electroencephalography, Female, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.
DOI: 10.1016/j.cortex.2012.02.014
PubMed: 22482695
Links to Exploration step
pubmed:22482695Le document en format XML
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Cardona</name></author><author><name sortKey="Dos Santos, Yamil Vidal" sort="Dos Santos, Yamil Vidal" uniqKey="Dos Santos Y" first="Yamil Vidal" last="Dos Santos">Yamil Vidal Dos Santos</name></author><author><name sortKey="Blenkmann, Alejandro" sort="Blenkmann, Alejandro" uniqKey="Blenkmann A" first="Alejandro" last="Blenkmann">Alejandro Blenkmann</name></author><author><name sortKey="Aravena, Pia" sort="Aravena, Pia" uniqKey="Aravena P" first="Pía" last="Aravena">Pía Aravena</name></author><author><name sortKey="Roca, Maria" sort="Roca, Maria" uniqKey="Roca M" first="María" last="Roca">María Roca</name></author><author><name sortKey="Hurtado, Esteban" sort="Hurtado, Esteban" uniqKey="Hurtado E" first="Esteban" last="Hurtado">Esteban Hurtado</name></author><author><name sortKey="Nerguizian, Mirna" sort="Nerguizian, Mirna" uniqKey="Nerguizian M" first="Mirna" last="Nerguizian">Mirna Nerguizian</name></author><author><name sortKey="Amoruso, Lucia" sort="Amoruso, Lucia" uniqKey="Amoruso L" first="Lucía" last="Amoruso">Lucía Amoruso</name></author><author><name sortKey="G Mez Arevalo, Gonzalo" sort="G Mez Arevalo, Gonzalo" uniqKey="G Mez Arevalo G" first="Gonzalo" last="G Mez-Arévalo">Gonzalo G Mez-Arévalo</name></author><author><name sortKey="Chade, Anabel" sort="Chade, Anabel" uniqKey="Chade A" first="Anabel" last="Chade">Anabel Chade</name></author><author><name sortKey="Dubrovsky, Alberto" sort="Dubrovsky, Alberto" uniqKey="Dubrovsky A" first="Alberto" last="Dubrovsky">Alberto Dubrovsky</name></author><author><name sortKey="Gershanik, Oscar" sort="Gershanik, Oscar" uniqKey="Gershanik O" first="Oscar" last="Gershanik">Oscar Gershanik</name></author><author><name sortKey="Kochen, Silvia" sort="Kochen, Silvia" uniqKey="Kochen S" first="Silvia" last="Kochen">Silvia Kochen</name></author><author><name sortKey="Glenberg, Arthur" sort="Glenberg, Arthur" uniqKey="Glenberg A" first="Arthur" last="Glenberg">Arthur Glenberg</name></author><author><name sortKey="Manes, Facundo" sort="Manes, Facundo" uniqKey="Manes F" first="Facundo" last="Manes">Facundo Manes</name></author><author><name sortKey="Bekinschtein, Tristan" sort="Bekinschtein, Tristan" uniqKey="Bekinschtein T" first="Tristán" last="Bekinschtein">Tristán Bekinschtein</name></author></analytic><series><title level="j">Cortex; a journal devoted to the study of the nervous system and behavior</title><idno type="eISSN">1973-8102</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cerebral Cortex (physiopathology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (psychology)</term><term>Comprehension (physiology)</term><term>Data Interpretation, Statistical (MeSH)</term><term>Educational Status (MeSH)</term><term>Electroencephalography (MeSH)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female (MeSH)</term><term>Hand (physiology)</term><term>Humans (MeSH)</term><term>Image Processing, Computer-Assisted (MeSH)</term><term>Language (MeSH)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Motor Cortex (physiopathology)</term><term>Movement (physiology)</term><term>Nervous System Diseases (physiopathology)</term><term>Nervous System Diseases (psychology)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurodegenerative Diseases (psychology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Reaction Time (physiology)</term><term>Transcranial Magnetic Stimulation (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Comprehension</term><term>Evoked Potentials, Motor</term><term>Hand</term><term>Movement</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Motor Cortex</term><term>Nervous System Diseases</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term><term>Nervous System Diseases</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Data Interpretation, Statistical</term><term>Educational Status</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Language</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22482695</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2013</Year><Month>09</Month><Day>25</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1973-8102</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Cortex; a journal devoted to the study of the nervous system and behavior</Title><ISOAbbreviation>Cortex</ISOAbbreviation></Journal><ArticleTitle>Motor-language coupling: direct evidence from early Parkinson's disease and intracranial cortical recordings.</ArticleTitle><Pagination><MedlinePgn>968-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cortex.2012.02.014</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0010-9452(12)00083-4</ELocationID><Abstract><AbstractText>Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson's disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ibáñez</LastName><ForeName>Agustín</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO); Favaloro University, Buenos Aires, Argentina. aibanez@ineco.org.ar</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cardona</LastName><ForeName>Juan F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Dos Santos</LastName><ForeName>Yamil Vidal</ForeName><Initials>YV</Initials></Author><Author ValidYN="Y"><LastName>Blenkmann</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Aravena</LastName><ForeName>Pía</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Roca</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hurtado</LastName><ForeName>Esteban</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Nerguizian</LastName><ForeName>Mirna</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Amoruso</LastName><ForeName>Lucía</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Gómez-Arévalo</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Chade</LastName><ForeName>Anabel</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dubrovsky</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gershanik</LastName><ForeName>Oscar</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Kochen</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Glenberg</LastName><ForeName>Arthur</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Manes</LastName><ForeName>Facundo</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bekinschtein</LastName><ForeName>Tristán</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>03</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Cortex</MedlineTA><NlmUniqueID>0100725</NlmUniqueID><ISSNLinking>0010-9452</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D032882">Comprehension</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003627">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004522">Educational Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019054">Evoked Potentials, Motor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006225">Hand</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D007802">Language</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009068">Movement</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009422">Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019636">Neurodegenerative Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050781">Transcranial Magnetic Stimulation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>1</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>2</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>2</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>3</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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