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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiorespiratory Fitness is Associated with Atrophy in Alzheimer’s and Aging Over Two Years</title><author><name sortKey="Vidoni, Eric D" sort="Vidoni, Eric D" uniqKey="Vidoni E" first="Eric D." last="Vidoni">Eric D. Vidoni</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Honea, Robyn A" sort="Honea, Robyn A" uniqKey="Honea R" first="Robyn A." last="Honea">Robyn A. Honea</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Billinger, Sandra A" sort="Billinger, Sandra A" uniqKey="Billinger S" first="Sandra A." last="Billinger">Sandra A. Billinger</name><affiliation><nlm:aff id="A2"> Dept. of Physical Therapy and Rehabilitation Science</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Russel H" sort="Swerdlow, Russel H" uniqKey="Swerdlow R" first="Russel H." last="Swerdlow">Russel H. Swerdlow</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Burns, Jeffrey M" sort="Burns, Jeffrey M" uniqKey="Burns J" first="Jeffrey M." last="Burns">Jeffrey M. Burns</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21531480</idno><idno type="pmc">3156963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156963</idno><idno type="RBID">PMC:3156963</idno><idno type="doi">10.1016/j.neurobiolaging.2011.03.016</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000262</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cardiorespiratory Fitness is Associated with Atrophy in Alzheimer’s and Aging Over Two Years</title><author><name sortKey="Vidoni, Eric D" sort="Vidoni, Eric D" uniqKey="Vidoni E" first="Eric D." last="Vidoni">Eric D. Vidoni</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Honea, Robyn A" sort="Honea, Robyn A" uniqKey="Honea R" first="Robyn A." last="Honea">Robyn A. Honea</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Billinger, Sandra A" sort="Billinger, Sandra A" uniqKey="Billinger S" first="Sandra A." last="Billinger">Sandra A. Billinger</name><affiliation><nlm:aff id="A2"> Dept. of Physical Therapy and Rehabilitation Science</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Russel H" sort="Swerdlow, Russel H" uniqKey="Swerdlow R" first="Russel H." last="Swerdlow">Russel H. Swerdlow</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author><author><name sortKey="Burns, Jeffrey M" sort="Burns, Jeffrey M" uniqKey="Burns J" first="Jeffrey M." last="Burns">Jeffrey M. Burns</name><affiliation><nlm:aff id="A1"> Dept. of Neurology</nlm:aff></affiliation></author></analytic><series><title level="j">Neurobiology of Aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early–stage Alzheimer’s disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy and dementia progression. Individuals with early-stage AD (n=37) and without dementia (n=53) attended clinical evaluations, cognitive and exercise tests, and MRI at baseline and 2 years later. CR fitness was lower in those with AD over the study period. Lower baseline CR fitness was associated with progression of dementia severity in AD. Declining CR fitness over 2 years was associated with brain atrophy in AD, especially in the parahippocampus. In nondemented participants, there was a trend for lower baseline fitness to be related to cognitive decline. Both lower baseline CR fitness and declining CR fitness over 2 years were associated with regional brain atrophy. We conclude that CR fitness is chronically reduced in those with AD. Further in those with AD, CR fitness is associated with progression of dementia severity and brain atrophy in AD, suggesting a link between progression of dementia severity and cardiorespiratory health.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8100437</journal-id><journal-id journal-id-type="pubmed-jr-id">6047</journal-id><journal-id journal-id-type="nlm-ta">Neurobiol Aging</journal-id><journal-id journal-id-type="iso-abbrev">Neurobiol. Aging</journal-id><journal-title-group><journal-title>Neurobiology of Aging</journal-title></journal-title-group><issn pub-type="ppub">0197-4580</issn><issn pub-type="epub">1558-1497</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21531480</article-id><article-id pub-id-type="pmc">3156963</article-id><article-id pub-id-type="doi">10.1016/j.neurobiolaging.2011.03.016</article-id><article-id pub-id-type="manuscript">NIHMS285716</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cardiorespiratory Fitness is Associated with Atrophy in Alzheimer’s and Aging Over Two Years</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vidoni</surname><given-names>Eric D.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Honea</surname><given-names>Robyn A.</given-names></name><degrees>DPhil</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Billinger</surname><given-names>Sandra A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Russel H.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Burns</surname><given-names>Jeffrey M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label> Dept. of Neurology</aff><aff id="A2"><label>2</label> Dept. of Physical Therapy and Rehabilitation Science</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: Department of Neurology, KU Alzheimer and Memory Program, University of Kansas Medical Center, MS 1063, 3901 Rainbow Blvd. Kansas City, KS 66160, (p) 913-588-0555, (f) 913-945-5035, (e) <email>jburns2@kumc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>04</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2013</year></pub-date><volume>33</volume><issue>8</issue><fpage>1624</fpage><lpage>1632</lpage><permissions><copyright-statement>© 2011 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P2">We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early–stage Alzheimer’s disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy and dementia progression. Individuals with early-stage AD (n=37) and without dementia (n=53) attended clinical evaluations, cognitive and exercise tests, and MRI at baseline and 2 years later. CR fitness was lower in those with AD over the study period. Lower baseline CR fitness was associated with progression of dementia severity in AD. Declining CR fitness over 2 years was associated with brain atrophy in AD, especially in the parahippocampus. In nondemented participants, there was a trend for lower baseline fitness to be related to cognitive decline. Both lower baseline CR fitness and declining CR fitness over 2 years were associated with regional brain atrophy. We conclude that CR fitness is chronically reduced in those with AD. Further in those with AD, CR fitness is associated with progression of dementia severity and brain atrophy in AD, suggesting a link between progression of dementia severity and cardiorespiratory health.</p></abstract><kwd-group><kwd>dementia</kwd><kwd>DARTEL</kwd><kwd>maximal exercise test</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R21 AG029615-01A1 || AG</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R03 AG026374-01 || AG</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>M01 RR023940-01 || RR</award-id></award-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>K23 NS058252-01A2 || NS</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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