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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra</title><author><name sortKey="Jeong, Hey Kyeong" sort="Jeong, Hey Kyeong" uniqKey="Jeong H" first="Hey-Kyeong" last="Jeong">Hey-Kyeong Jeong</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jou, Ilo" sort="Jou, Ilo" uniqKey="Jou I" first="Ilo" last="Jou">Ilo Jou</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author><author><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20962566</idno><idno type="pmc">3015156</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015156</idno><idno type="RBID">PMC:3015156</idno><idno type="doi">10.3858/emm.2010.42.12.085</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra</title><author><name sortKey="Jeong, Hey Kyeong" sort="Jeong, Hey Kyeong" uniqKey="Jeong H" first="Hey-Kyeong" last="Jeong">Hey-Kyeong Jeong</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jou, Ilo" sort="Jou, Ilo" uniqKey="Jou I" first="Ilo" last="Jou">Ilo Jou</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author><author><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><affiliation><nlm:aff id="A1">Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff></affiliation></author></analytic><series><title level="j">Experimental & Molecular Medicine</title><idno type="ISSN">1226-3613</idno><idno type="eISSN">2092-6413</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Mol Med</journal-id><journal-id journal-id-type="publisher-id">EMM</journal-id><journal-title-group><journal-title>Experimental & Molecular Medicine</journal-title></journal-title-group><issn pub-type="ppub">1226-3613</issn><issn pub-type="epub">2092-6413</issn><publisher><publisher-name>Korean Society for Biochemistry and Molecular Biology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20962566</article-id><article-id pub-id-type="pmc">3015156</article-id><article-id pub-id-type="doi">10.3858/emm.2010.42.12.085</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Hey-Kyeong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jou</surname><given-names>Ilo</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Joe</surname><given-names>Eun-hye</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442-721, Korea.</aff><aff id="A2"><label>2</label>Department of Pharmacology, Ajou University School of Medicine, Suwon 442-721, Korea.</aff><aff id="A3"><label>3</label>Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</aff><aff id="A4"><label>4</label>Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</aff><author-notes><corresp>Corresponding author: Tel, 82-31-219-5062; Fax, 82-31-219-5069; <email>ehjoe@ajou.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><day>31</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2010</year></pub-date><volume>42</volume><issue>12</issue><fpage>823</fpage><lpage>832</lpage><history><date date-type="accepted"><day>18</day><month>10</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010 Korean Society for Biochemistry and Molecular Biology</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p>It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.</p></abstract><kwd-group><kwd>brain inflammation</kwd><kwd>neuronal damage</kwd><kwd>systemic inflammation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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