NADPH Oxidase and Neurodegeneration
Identifieur interne : 000129 ( Ncbi/Merge ); précédent : 000128; suivant : 000130NADPH Oxidase and Neurodegeneration
Auteurs : Marina S. Hernandes ; Luiz R G. BrittoSource :
- Current Neuropharmacology [ 1570-159X ] ; 2012.
Abstract
NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide
Url:
DOI: 10.2174/157015912804143540
PubMed: 23730256
PubMed Central: 3520042
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NADPH Oxidase and Neurodegeneration</title><author><name sortKey="Hernandes, Marina S" sort="Hernandes, Marina S" uniqKey="Hernandes M" first="Marina S" last="Hernandes">Marina S. Hernandes</name></author><author><name sortKey="Britto, Luiz R G" sort="Britto, Luiz R G" uniqKey="Britto L" first="Luiz R G" last="Britto">Luiz R G. Britto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23730256</idno><idno type="pmc">3520042</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520042</idno><idno type="RBID">PMC:3520042</idno><idno type="doi">10.2174/157015912804143540</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno><idno type="wicri:Area/Pmc/Curation">000163</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000163</idno><idno type="wicri:Area/Pmc/Checkpoint">000104</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000104</idno><idno type="wicri:Area/Ncbi/Merge">000129</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NADPH Oxidase and Neurodegeneration</title><author><name sortKey="Hernandes, Marina S" sort="Hernandes, Marina S" uniqKey="Hernandes M" first="Marina S" last="Hernandes">Marina S. Hernandes</name></author><author><name sortKey="Britto, Luiz R G" sort="Britto, Luiz R G" uniqKey="Britto L" first="Luiz R G" last="Britto">Luiz R G. Britto</name></author></analytic><series><title level="j">Current Neuropharmacology</title><idno type="ISSN">1570-159X</idno><idno type="eISSN">1875-6190</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide <italic>via </italic>the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in the pathophysiology of several neurodegenerative diseases has been increasingly recognized. ROS produced by Nox proteins contribute to neurodegenerative diseases through distinct mechanisms, such as oxidation of DNA, proteins, lipids, amino acids and metals, in addition to activation of redox-sensitive signaling pathways. In this review, we discuss the recent literature on Nox involvement in neurodegeneration, focusing on Parkinson and Alzheimer diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wondrak, Gt" uniqKey="Wondrak G">GT Wondrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Di" uniqKey="Brown D">DI Brown</name></author><author><name sortKey="Griendling, Kk" uniqKey="Griendling K">KK Griendling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gobbo, Mg" uniqKey="Gobbo M">MG Gobbo</name></author><author><name sortKey="Ribeiro, Dl" uniqKey="Ribeiro D">DL Ribeiro</name></author><author><name sortKey="Taboga, Sr" uniqKey="Taboga S">SR Taboga</name></author><author><name sortKey="De Almeida, Ea" uniqKey="De Almeida E">EA de Almeida</name></author><author><name sortKey="G Es, Rm" uniqKey="G Es R">RM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Curr Neuropharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Curr Neuropharmacol</journal-id><journal-id journal-id-type="publisher-id">CN</journal-id><journal-title-group><journal-title>Current Neuropharmacology</journal-title></journal-title-group><issn pub-type="ppub">1570-159X</issn><issn pub-type="epub">1875-6190</issn><publisher><publisher-name>Bentham Science Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23730256</article-id><article-id pub-id-type="pmc">3520042</article-id><article-id pub-id-type="publisher-id">CN-10-321</article-id><article-id pub-id-type="doi">10.2174/157015912804143540</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>NADPH Oxidase and Neurodegeneration</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hernandes</surname><given-names>Marina S</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Britto</surname><given-names>Luiz R G</given-names></name></contrib></contrib-group><aff>Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas and Núcleo de Apoio à Pesquisa em Neurociência Aplicada, Universidade de São Paulo, SP, Brasil</aff><author-notes><corresp id="cor1"><label>*</label>Address correspondence to this author at the Laboratory of Cellular Neurobiology, Institute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 1524, CEP 05508-900 São Paulo - Brazil;
Tel: +55 11 3091 7242; E-mail: <email xlink:href="marinash@icb.usp.br">marinash@icb.usp.br</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="epub"><month>12</month><year>2012</year></pub-date><volume>10</volume><issue>4</issue><fpage>321</fpage><lpage>327</lpage><history><date date-type="received"><day>21</day><month>5</month><year>2012</year></date><date date-type="rev-recd"><day>22</day><month>7</month><year>2012</year></date><date date-type="accepted"><day>8</day><month>8</month><year>2012</year></date></history><permissions><copyright-statement>©2012 Bentham Science Publishers</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<uri xlink:type="simple" xlink:href="http://creativecommons.org/licenses/by/2.5/">http://creativecommons.org/licenses/by/2.5/</uri>), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide <italic>via </italic>the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in the pathophysiology of several neurodegenerative diseases has been increasingly recognized. ROS produced by Nox proteins contribute to neurodegenerative diseases through distinct mechanisms, such as oxidation of DNA, proteins, lipids, amino acids and metals, in addition to activation of redox-sensitive signaling pathways. In this review, we discuss the recent literature on Nox involvement in neurodegeneration, focusing on Parkinson and Alzheimer diseases.</p></abstract><kwd-group><title>Keywords</title><kwd>Alzheimer´s disease</kwd><kwd>neuroprotection</kwd><kwd>Nox enzymes</kwd><kwd>Parkinson´s disease</kwd><kwd>reactive oxygen species. </kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. (1)</label><caption><p>Nox activation, neurodegeneration and neuroprotection. In Parkinson´s and Alzheimer´s disease rodent models, increased activation of the Nox family of ROS-producing proteins contributes to neurodegeneration. Blockade of Nox generates neuroprotection in some instances. Abbreviations: 6-hydroxydopamine (6-OHDA); 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP); Lipopolysaccharide (LPS); amyloid-β peptide (Aβ); superoxide (O<sub>2</sub><sup>·−</sup>); hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and diphenyleneiodonium (DPI).</p></caption><graphic xlink:href="CN-10-321_F1"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1.</label><caption><p>NADPH Oxidases in the Brain</p></caption><table frame="border" rules="all" width="100%"><thead><tr><th rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1">Brain
Region</th><th align="left" rowspan="1" colspan="1">Specie</th><th rowspan="1" colspan="1">RNA</th><th rowspan="1" colspan="1">Protein</th><th align="left" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td rowspan="9" colspan="1"><bold>Nox1</bold></td><td rowspan="1" colspan="1">Medulla</td><td rowspan="1" colspan="1">Human</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R85">85</xref>]</td></tr><tr><td rowspan="1" colspan="1">Superior
colliculus</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R26">26</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hippocampus</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R84">84</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cerebellum</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R61">83</xref>]</td></tr><tr><td rowspan="1" colspan="1">Forebrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Midbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hindbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Dorsal root
ganglion</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R86">86</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hypothalamus</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R87">87</xref>]</td></tr><tr><td rowspan="15" colspan="1"><bold>Nox2</bold></td><td rowspan="1" colspan="1">Medulla</td><td rowspan="1" colspan="1">Human/Rat</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R74">74</xref>,<xref ref-type="bibr" rid="R83">83</xref>]</td></tr><tr><td rowspan="1" colspan="1">Superior
colliculus</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R26">26</xref>]</td></tr><tr><td rowspan="1" colspan="1">Thalamus</td><td rowspan="1" colspan="1">Mice/Rat</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R26">26</xref>, <xref ref-type="bibr" rid="R78">78</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hippocampus</td><td rowspan="1" colspan="1">Mice/Rat/Human</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R58">58</xref>, <xref ref-type="bibr" rid="R69">69</xref>, <xref ref-type="bibr" rid="R70">70</xref>,
<xref ref-type="bibr" rid="R88">88</xref>, <xref ref-type="bibr" rid="R90">90</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cerebellum</td><td rowspan="1" colspan="1">Mice</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R80">80</xref>]</td></tr><tr><td rowspan="1" colspan="1">Forebrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Midbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hindbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hypothalamus</td><td rowspan="1" colspan="1">Mice/Rat</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R73">73</xref>, <xref ref-type="bibr" rid="R74">74</xref>, <xref ref-type="bibr" rid="R76">76</xref>]</td></tr><tr><td rowspan="1" colspan="1">Substantia
nigra</td><td rowspan="1" colspan="1">Mice/Rat</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[ <xref ref-type="bibr" rid="R75">75</xref>, <xref ref-type="bibr" rid="R77">77</xref>]</td></tr><tr><td rowspan="1" colspan="1">Amygdala</td><td rowspan="1" colspan="1">Mice</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R78">78</xref>]</td></tr><tr><td rowspan="1" colspan="1">Nucleus of
the solitary tract</td><td rowspan="1" colspan="1">Rat</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R79">79</xref>]</td></tr><tr><td rowspan="1" colspan="1">Striatum</td><td rowspan="1" colspan="1">Mice/Rat</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R71">71</xref>, <xref ref-type="bibr" rid="R72">72</xref>,<xref ref-type="bibr" rid="R75">75</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cortex</td><td rowspan="1" colspan="1">Mice/Rat/Human</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R24">24</xref>, <xref ref-type="bibr" rid="R69">69</xref>, <xref ref-type="bibr" rid="R89">89</xref>,
<xref ref-type="bibr" rid="R90">90</xref>]</td></tr><tr><td rowspan="1" colspan="1">Brainstem</td><td rowspan="1" colspan="1">Mice</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R70">70</xref>]</td></tr><tr><td rowspan="3" colspan="1"><bold>Nox3</bold></td><td rowspan="1" colspan="1">Cerebellum</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R81">81</xref>, <xref ref-type="bibr" rid="R83">83</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hypothalamus</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R81">81</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cortex </td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R81">81</xref>]</td></tr><tr><td rowspan="8" colspan="1"><bold>Nox4</bold></td><td rowspan="1" colspan="1">Superior
colliculus</td><td rowspan="1" colspan="1">Rat</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R26">26</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hypothalamus</td><td rowspan="1" colspan="1">Mice</td><td rowspan="1" colspan="1"></td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R73">73</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cortex</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R61">61</xref>, <xref ref-type="bibr" rid="R82">82</xref>]</td></tr><tr><td rowspan="1" colspan="1">Forebrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Midbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hindbrain</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R25">25</xref>]</td></tr><tr><td rowspan="1" colspan="1">Hippocampus</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R82">82</xref>]</td></tr><tr><td rowspan="1" colspan="1">Cerebellum</td><td rowspan="1" colspan="1">Mice</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">+</td><td rowspan="1" colspan="1">[<xref ref-type="bibr" rid="R82">82</xref>]</td></tr></tbody></table><table-wrap-foot><fn id="T1F1"><p><underline>Observation</underline>: several studies that reported Nox protein occurrence by immunostaining have not actually used the appropriate negative controls, and therefore the data must be interpreted with caution.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list></list><tree><noCountry><name sortKey="Britto, Luiz R G" sort="Britto, Luiz R G" uniqKey="Britto L" first="Luiz R G" last="Britto">Luiz R G. Britto</name><name sortKey="Hernandes, Marina S" sort="Hernandes, Marina S" uniqKey="Hernandes M" first="Marina S" last="Hernandes">Marina S. Hernandes</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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