The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.
Auteurs : Danielle C. Groves [Royaume-Uni] ; Sarah L. Rowland-Jones [Royaume-Uni] ; Adrienn Angyal [Royaume-Uni]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2020.
Abstract
The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
DOI: 10.1016/j.bbrc.2020.10.109
PubMed: 33199022
PubMed Central: PMC7643658
Affiliations:
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Groves</name></noRegion><name sortKey="Angyal, Adrienn" sort="Angyal, Adrienn" uniqKey="Angyal A" first="Adrienn" last="Angyal">Adrienn Angyal</name><name sortKey="Rowland Jones, Sarah L" sort="Rowland Jones, Sarah L" uniqKey="Rowland Jones S" first="Sarah L" last="Rowland-Jones">Sarah L. Rowland-Jones</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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