Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis
Identifieur interne : 000771 ( new/Analysis ); précédent : 000770; suivant : 000772Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis
Auteurs : Masaru Iwai ; Masatsugu HoriuchiSource :
- Hypertension Research [ 0916-9636 ] ; 2009.
Abstract
Recent studies have established a new regulatory axis in the renin–angiotensin system (RAS). In this axis, angiotensin (Ang)-(1–7) is finally produced from Ang I or Ang II by the catalytic activity of angiotensin-converting enzyme 2 (ACE2). Ang-(1–7) shows actions different from those of AT1 receptor stimulation, such as vasodilatation, natriuresis, anti-proliferation and an increase in the bradykinin–NO (nitric oxide) system. As the catalytic efficiency of ACE2 is approximately 400-fold higher with Ang II as a substrate than with Ang I, this axis is possibly acting as a counter-regulatory system against the ACE/Ang II/AT1 receptor axis. The signaling pathway of the ACE2–Ang-(1–7) axis has not yet been totally and clearly understood. However, a recent report suggests that the Mas oncogene acts as a receptor for Ang-(1–7). Intracellular signaling through Mas is not clear yet. Several factors such as Akt phosphorylation, protein kinase C activation and mitogen-activated protein (MAP) kinase inhibition seem to be involved in this signaling pathway. Further investigations are needed to clarify the regulation and mechanism of action of ACE2 and Ang-(1–7). However, this second axis through ACE2 and Ang-(1–7) in RAS can be an important target for the therapy of cardiovascular and metabolic disorders.
Url:
DOI: 10.1038/hr.2009.74
PubMed: 19461648
PubMed Central: 7091931
Affiliations:
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PMC:7091931Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT<sub>1</sub> receptor axis <italic>vs</italic>. ACE2–angiotensin-(1–7)–Mas receptor axis</title><author><name sortKey="Iwai, Masaru" sort="Iwai, Masaru" uniqKey="Iwai M" first="Masaru" last="Iwai">Masaru Iwai</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Horiuchi, Masatsugu" sort="Horiuchi, Masatsugu" uniqKey="Horiuchi M" first="Masatsugu" last="Horiuchi">Masatsugu Horiuchi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19461648</idno><idno type="pmc">7091931</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091931</idno><idno type="RBID">PMC:7091931</idno><idno type="doi">10.1038/hr.2009.74</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000383</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000383</idno><idno type="wicri:Area/Pmc/Curation">000383</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000383</idno><idno type="wicri:Area/Pmc/Checkpoint">000897</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000897</idno><idno type="wicri:Area/Ncbi/Merge">000176</idno><idno type="wicri:Area/Ncbi/Curation">000176</idno><idno type="wicri:Area/Ncbi/Checkpoint">000176</idno><idno type="wicri:doubleKey">0916-9636:2009:Iwai M:devil:and:angel</idno><idno type="wicri:Area/Main/Merge">001533</idno><idno type="wicri:Area/Main/Curation">001531</idno><idno type="wicri:Area/Main/Exploration">001531</idno><idno type="wicri:Area/new/Extraction">000771</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT<sub>1</sub> receptor axis <italic>vs</italic>. ACE2–angiotensin-(1–7)–Mas receptor axis</title><author><name sortKey="Iwai, Masaru" sort="Iwai, Masaru" uniqKey="Iwai M" first="Masaru" last="Iwai">Masaru Iwai</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Horiuchi, Masatsugu" sort="Horiuchi, Masatsugu" uniqKey="Horiuchi M" first="Masatsugu" last="Horiuchi">Masatsugu Horiuchi</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Hypertension Research</title><idno type="ISSN">0916-9636</idno><idno type="eISSN">1348-4214</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Recent studies have established a new regulatory axis in the renin–angiotensin system (RAS). In this axis, angiotensin (Ang)-(1–7) is finally produced from Ang I or Ang II by the catalytic activity of angiotensin-converting enzyme 2 (ACE2). Ang-(1–7) shows actions different from those of AT<sub>1</sub> receptor stimulation, such as vasodilatation, natriuresis, anti-proliferation and an increase in the bradykinin–NO (nitric oxide) system. As the catalytic efficiency of ACE2 is approximately 400-fold higher with Ang II as a substrate than with Ang I, this axis is possibly acting as a counter-regulatory system against the ACE/Ang II/AT<sub>1</sub> receptor axis. The signaling pathway of the ACE2–Ang-(1–7) axis has not yet been totally and clearly understood. However, a recent report suggests that the Mas oncogene acts as a receptor for Ang-(1–7). Intracellular signaling through Mas is not clear yet. Several factors such as Akt phosphorylation, protein kinase C activation and mitogen-activated protein (MAP) kinase inhibition seem to be involved in this signaling pathway. Further investigations are needed to clarify the regulation and mechanism of action of ACE2 and Ang-(1–7). However, this second axis through ACE2 and Ang-(1–7) in RAS can be an important target for the therapy of cardiovascular and metabolic disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Gasparo, M" uniqKey="De Gasparo M">M de Gasparo</name></author><author><name sortKey="Catt, Kj" uniqKey="Catt K">KJ Catt</name></author><author><name sortKey="Inagami, T" uniqKey="Inagami T">T Inagami</name></author><author><name sortKey="Wright, Jw" uniqKey="Wright J">JW Wright</name></author><author><name sortKey="Unger, T" uniqKey="Unger T">T Unger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daviet, L" uniqKey="Daviet L">L Daviet</name></author><author><name sortKey="Lehtonen, Jy" uniqKey="Lehtonen J">JY Lehtonen</name></author><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name></author><author><name sortKey="Griese, Dp" uniqKey="Griese D">DP Griese</name></author><author><name 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sortKey="Cruz, Js" uniqKey="Cruz J">JS Cruz</name></author><author><name sortKey="Ramos, As" uniqKey="Ramos A">AS Ramos</name></author><author><name sortKey="Rosa, Kt" uniqKey="Rosa K">KT Rosa</name></author><author><name sortKey="Irigoyen, Mc" uniqKey="Irigoyen M">MC Irigoyen</name></author><author><name sortKey="Bader, M" uniqKey="Bader M">M Bader</name></author><author><name sortKey="Alenina, N" uniqKey="Alenina N">N Alenina</name></author><author><name sortKey="Kitten, Gt" uniqKey="Kitten G">GT Kitten</name></author><author><name sortKey="Ferreira, Aj" uniqKey="Ferreira A">AJ Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castro, Ch" uniqKey="Castro C">CH Castro</name></author><author><name sortKey="Santos, Ra" uniqKey="Santos R">RA Santos</name></author><author><name sortKey="Ferreira, Aj" uniqKey="Ferreira A">AJ Ferreira</name></author><author><name sortKey="Bader, M" uniqKey="Bader M">M Bader</name></author><author><name sortKey="Alenina, N" uniqKey="Alenina N">N Alenina</name></author><author><name sortKey="Almeida, Ap" uniqKey="Almeida A">AP Almeida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tallant, Ea" uniqKey="Tallant E">EA Tallant</name></author><author><name sortKey="Ferrario, Cm" uniqKey="Ferrario C">CM Ferrario</name></author><author><name sortKey="Gallagher, Pe" uniqKey="Gallagher P">PE Gallagher</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Horiuchi, Masatsugu" sort="Horiuchi, Masatsugu" uniqKey="Horiuchi M" first="Masatsugu" last="Horiuchi">Masatsugu Horiuchi</name><name sortKey="Iwai, Masaru" sort="Iwai, Masaru" uniqKey="Iwai M" first="Masaru" last="Iwai">Masaru Iwai</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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