CovidV2, new, Analysis, bibRecord, 000436

Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID-19.

Identifieur interne : 000436 ( new/Analysis ); précédent : 000435; suivant : 000437

Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID-19.

Auteurs : Yong Gao [République populaire de Chine] ; Tuantuan Li [République populaire de Chine] ; Mingfeng Han [République populaire de Chine] ; Xiuyong Li [République populaire de Chine] ; Dong Wu [République populaire de Chine] ; Yuanhong Xu [République populaire de Chine] ; Yulin Zhu [République populaire de Chine] ; Yan Liu [République populaire de Chine] ; Xiaowu Wang [République populaire de Chine] ; Linding Wang [République populaire de Chine]

Source :

Journal of medical virology [ 1096-9071 ] ; 2020.

RBID : pubmed:32181911

Abstract

The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID-19 patients. We investigated forty-three adult patients with COVID-19. The patients were classified into mild group (28 patients) and severe group (15 patients). Comparison of the haematological parameters between the mild and severe groups showed significant differences in IL-6, D-Dimer, GLU, TT, FIB and CRP (P <0.05). The optimal threshold and area under the ROC curve of IL-6 were 24.3 pg/mL and 0.795 respectively, while those of D-Dimer were 0.28 µg/L and 0.750, respectively. The area under the ROC curve (AUC) of IL-6 combined with D-Dimer was 0.840. The specificity of predicting the severity of COVID-19 during IL-6 and D-Dimer tandem testing was up to 93.3%, while the sensitivity of IL-6 and D-Dimer by parallel test in the severe COVID-19 was 96.4%. IL-6 and D-Dimer were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. This article is protected by copyright. All rights reserved.

DOI: 10.1002/jmv.25770
PubMed: 32181911

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pubmed:32181911

Le document en format XML

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<front><div type="abstract" xml:lang="en">The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID-19 patients. We investigated forty-three adult patients with COVID-19. The patients were classified into mild group (28 patients) and severe group (15 patients). Comparison of the haematological parameters between the mild and severe groups showed significant differences in IL-6, D-Dimer, GLU, TT, FIB and CRP (P <0.05). The optimal threshold and area under the ROC curve of IL-6 were 24.3 pg/mL and 0.795 respectively, while those of D-Dimer were 0.28 µg/L and 0.750, respectively. The area under the ROC curve (AUC) of IL-6 combined with D-Dimer was 0.840. The specificity of predicting the severity of COVID-19 during IL-6 and D-Dimer tandem testing was up to 93.3%, while the sensitivity of IL-6 and D-Dimer by parallel test in the severe COVID-19 was 96.4%. IL-6 and D-Dimer were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. This article is protected by copyright. All rights reserved.</div>
</front>
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Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID-19.

Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID-19.

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Abstract

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