Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
Identifieur interne : 000140 ( new/Analysis ); précédent : 000139; suivant : 000141Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
Auteurs : Zhilian Jia [République populaire de Chine] ; Jingwei Li [République populaire de Chine] ; Xiao Ge [République populaire de Chine] ; Yonghu Wu [République populaire de Chine] ; Ya Guo [République populaire de Chine] ; Qiang Wu [République populaire de Chine]Source :
- Genome Biology [ 1474-7596 ] ; 2020.
Abstract
CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem.
Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and promoters in the protocadherin (
These findings have interesting implications on the role of topological chromatin insulators in 3D genome folding and developmental gene regulation.
Url:
DOI: 10.1186/s13059-020-01984-7
PubMed: NONE
PubMed Central: 7087399
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000259
- to stream Pmc, to step Curation: 000259
- to stream Pmc, to step Checkpoint: 000035
- to stream Ncbi, to step Merge: 001767
- to stream Ncbi, to step Curation: 001767
- to stream Ncbi, to step Checkpoint: 001767
- to stream Main, to step Merge: 000310
- to stream Main, to step Curation: 000308
- to stream Main, to step Exploration: 000308
- to stream new, to step Extraction: 000140
Links to Exploration step
PMC:7087399Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection</title><author><name sortKey="Jia, Zhilian" sort="Jia, Zhilian" uniqKey="Jia Z" first="Zhilian" last="Jia">Zhilian Jia</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingwei" sort="Li, Jingwei" uniqKey="Li J" first="Jingwei" last="Li">Jingwei Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Ge, Xiao" sort="Ge, Xiao" uniqKey="Ge X" first="Xiao" last="Ge">Xiao Ge</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Yonghu" sort="Wu, Yonghu" uniqKey="Wu Y" first="Yonghu" last="Wu">Yonghu Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Ya" sort="Guo, Ya" uniqKey="Guo Y" first="Ya" last="Guo">Ya Guo</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Qiang" sort="Wu, Qiang" uniqKey="Wu Q" first="Qiang" last="Wu">Qiang Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.417009.b</institution-id><institution-id institution-id-type="ISNI">0000 0004 1758 4591</institution-id><institution>The Third Affiliated Hospital of Guangzhou Medical University,</institution></institution-wrap>Guangzhou, 510150 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7087399</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087399</idno><idno type="RBID">PMC:7087399</idno><idno type="doi">10.1186/s13059-020-01984-7</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000259</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000259</idno><idno type="wicri:Area/Pmc/Curation">000259</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000259</idno><idno type="wicri:Area/Pmc/Checkpoint">000035</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000035</idno><idno type="wicri:Area/Ncbi/Merge">001767</idno><idno type="wicri:Area/Ncbi/Curation">001767</idno><idno type="wicri:Area/Ncbi/Checkpoint">001767</idno><idno type="wicri:doubleKey">1474-7596:2020:Jia Z:tandem:ctcf:sites</idno><idno type="wicri:Area/Main/Merge">000310</idno><idno type="wicri:Area/Main/Curation">000308</idno><idno type="wicri:Area/Main/Exploration">000308</idno><idno type="wicri:Area/new/Extraction">000140</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection</title><author><name sortKey="Jia, Zhilian" sort="Jia, Zhilian" uniqKey="Jia Z" first="Zhilian" last="Jia">Zhilian Jia</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingwei" sort="Li, Jingwei" uniqKey="Li J" first="Jingwei" last="Li">Jingwei Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Ge, Xiao" sort="Ge, Xiao" uniqKey="Ge X" first="Xiao" last="Ge">Xiao Ge</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Yonghu" sort="Wu, Yonghu" uniqKey="Wu Y" first="Yonghu" last="Wu">Yonghu Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Ya" sort="Guo, Ya" uniqKey="Guo Y" first="Ya" last="Guo">Ya Guo</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Qiang" sort="Wu, Qiang" uniqKey="Wu Q" first="Qiang" last="Wu">Qiang Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.16821.3c</institution-id><institution-id institution-id-type="ISNI">0000 0004 0368 8293</institution-id><institution>MOE Key Lab of Systems Biomedicine, Center for Comparative Biomedicine, State Key Lab of Oncogenes and Related Genes, Shanghai Cancer Institute, Joint International Research Laboratory of Metabolic & Developmental Sciences, Institute of Systems Biomedicine, Xin Hua Hospital,</institution><institution>Shanghai Jiao Tong University,</institution></institution-wrap>Shanghai, 200240 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.417009.b</institution-id><institution-id institution-id-type="ISNI">0000 0004 1758 4591</institution-id><institution>The Third Affiliated Hospital of Guangzhou Medical University,</institution></institution-wrap>Guangzhou, 510150 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author></analytic><series><title level="j">Genome Biology</title><idno type="ISSN">1474-7596</idno><idno type="eISSN">1474-760X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem.</p></sec><sec><title>Results</title><p id="Par2">Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and promoters in the protocadherin (<italic>Pcdh</italic>) and <italic>β-globin</italic> clusters, function as an enhancer-blocking insulator by forming distinct directional chromatin loops, regardless whether enhancers contain CTCF sites or not. Moreover, computational simulation in silico and genetic deletions in vivo as well as dCas9 blocking in vitro revealed balanced promoter usage in cell populations and stochastic monoallelic expression in single cells by large arrays of tandem CTCF sites in the <italic>Pcdh</italic> and immunoglobulin heavy chain (<italic>Igh</italic>) clusters. Furthermore, CTCF insulators promote, counter-intuitively, long-range chromatin interactions with distal directional CTCF sites, consistent with the cohesin “loop extrusion” model. Finally, gene expression levels are negatively correlated with CTCF insulators located between enhancers and promoters on a genome-wide scale. Thus, single CTCF insulators ensure proper enhancer insulation and promoter activation while tandem CTCF topological insulators determine balanced spatial contacts and promoter choice.</p></sec><sec><title>Conclusions</title><p id="Par3">These findings have interesting implications on the role of topological chromatin insulators in 3D genome folding and developmental gene regulation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Phillips Cremins, Je" uniqKey="Phillips Cremins J">JE Phillips-Cremins</name></author><author><name sortKey="Corces, Vg" uniqKey="Corces V">VG Corces</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author><author><name sortKey="Mirny, L" uniqKey="Mirny L">L Mirny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furlong, Eem" uniqKey="Furlong E">EEM Furlong</name></author><author><name sortKey="Levine, M" uniqKey="Levine M">M Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grosveld, F" uniqKey="Grosveld F">F Grosveld</name></author><author><name sortKey="Van Assendelft, Gb" uniqKey="Van Assendelft G">GB van Assendelft</name></author><author><name sortKey="Greaves, Dr" uniqKey="Greaves D">DR Greaves</name></author><author><name sortKey="Kollias, G" uniqKey="Kollias G">G Kollias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, Jh" uniqKey="Chung J">JH Chung</name></author><author><name sortKey="Whiteley, M" uniqKey="Whiteley M">M Whiteley</name></author><author><name sortKey="Felsenfeld, G" uniqKey="Felsenfeld G">G Felsenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Ac" uniqKey="Bell A">AC Bell</name></author><author><name sortKey="West, Ag" uniqKey="West A">AG West</name></author><author><name sortKey="Felsenfeld, G" uniqKey="Felsenfeld G">G Felsenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghirlando, R" uniqKey="Ghirlando R">R Ghirlando</name></author><author><name sortKey="Felsenfeld, G" uniqKey="Felsenfeld G">G Felsenfeld</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name></author><author><name sortKey="Ma, R" uniqKey="Ma R">R Ma</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author><author><name sortKey="Peng, J" uniqKey="Peng J">J Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Ssp" uniqKey="Rao S">SSP Rao</name></author><author><name sortKey="Huntley, Mh" uniqKey="Huntley M">MH Huntley</name></author><author><name sortKey="Durand, Nc" uniqKey="Durand N">NC Durand</name></author><author><name sortKey="Stamenova, Ek" uniqKey="Stamenova E">EK Stamenova</name></author><author><name sortKey="Bochkov, Id" uniqKey="Bochkov I">ID Bochkov</name></author><author><name sortKey="Robinson, Jt" uniqKey="Robinson J">JT Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name></author><author><name sortKey="Canzio, D" uniqKey="Canzio D">D Canzio</name></author><author><name sortKey="Shou, J" uniqKey="Shou J">J Shou</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Gorkin, Du" uniqKey="Gorkin D">DU Gorkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudan, Mv" uniqKey="Rudan M">MV Rudan</name></author><author><name sortKey="Barrington, C" uniqKey="Barrington C">C Barrington</name></author><author><name sortKey="Henderson, S" uniqKey="Henderson S">S Henderson</name></author><author><name sortKey="Ernst, C" uniqKey="Ernst C">C Ernst</name></author><author><name sortKey="Odom, Dt" uniqKey="Odom D">DT Odom</name></author><author><name sortKey="Tanay, A" uniqKey="Tanay A">A Tanay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Vos, Esm" uniqKey="Vos E">ESM Vos</name></author><author><name sortKey="Holwerda, Sjb" uniqKey="Holwerda S">SJB Holwerda</name></author><author><name sortKey="Valdes Quezada, C" uniqKey="Valdes Quezada C">C Valdes-Quezada</name></author><author><name sortKey="Verstegen, Mjam" uniqKey="Verstegen M">MJAM Verstegen</name></author><author><name sortKey="Teunissen, H" uniqKey="Teunissen H">H Teunissen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hnisz, D" uniqKey="Hnisz D">D Hnisz</name></author><author><name sortKey="Weintraub, As" uniqKey="Weintraub A">AS Weintraub</name></author><author><name sortKey="Day, Ds" uniqKey="Day D">DS Day</name></author><author><name sortKey="Valton, Al" uniqKey="Valton A">AL Valton</name></author><author><name sortKey="Bak, Ro" uniqKey="Bak R">RO Bak</name></author><author><name sortKey="Li, Ch" uniqKey="Li C">CH Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narendra, V" uniqKey="Narendra V">V Narendra</name></author><author><name sortKey="Bulajic, M" uniqKey="Bulajic M">M Bulajic</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author><author><name sortKey="Mazzoni, Eo" uniqKey="Mazzoni E">EO Mazzoni</name></author><author><name sortKey="Reinberg, D" uniqKey="Reinberg D">D Reinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merkenschlager, M" uniqKey="Merkenschlager M">M Merkenschlager</name></author><author><name sortKey="Nora, Ep" uniqKey="Nora E">EP Nora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanborn, Al" uniqKey="Sanborn A">AL Sanborn</name></author><author><name sortKey="Rao, Ssp" uniqKey="Rao S">SSP Rao</name></author><author><name sortKey="Huang, Sc" uniqKey="Huang S">SC Huang</name></author><author><name sortKey="Durand, Nc" uniqKey="Durand N">NC Durand</name></author><author><name sortKey="Huntley, Mh" uniqKey="Huntley M">MH Huntley</name></author><author><name sortKey="Jewett, Ai" uniqKey="Jewett A">AI Jewett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fudenberg, G" uniqKey="Fudenberg G">G Fudenberg</name></author><author><name sortKey="Imakaev, M" uniqKey="Imakaev M">M Imakaev</name></author><author><name sortKey="Lu, C" uniqKey="Lu C">C Lu</name></author><author><name sortKey="Goloborodko, A" uniqKey="Goloborodko A">A Goloborodko</name></author><author><name sortKey="Abdennur, N" uniqKey="Abdennur N">N Abdennur</name></author><author><name sortKey="Mirny, La" uniqKey="Mirny L">LA Mirny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nuebler, J" uniqKey="Nuebler J">J Nuebler</name></author><author><name sortKey="Fudenberg, G" uniqKey="Fudenberg G">G Fudenberg</name></author><author><name sortKey="Imakaev, M" uniqKey="Imakaev M">M Imakaev</name></author><author><name sortKey="Abdennur, N" uniqKey="Abdennur N">N Abdennur</name></author><author><name sortKey="Mirny, La" uniqKey="Mirny L">LA Mirny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nora, Ep" uniqKey="Nora E">EP Nora</name></author><author><name sortKey="Goloborodko, A" uniqKey="Goloborodko A">A Goloborodko</name></author><author><name sortKey="Valton, Al" uniqKey="Valton A">AL Valton</name></author><author><name sortKey="Gibcus, Jh" uniqKey="Gibcus J">JH Gibcus</name></author><author><name sortKey="Uebersohn, A" uniqKey="Uebersohn A">A Uebersohn</name></author><author><name sortKey="Abdennur, N" uniqKey="Abdennur N">N Abdennur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Ssp" uniqKey="Rao S">SSP Rao</name></author><author><name sortKey="Huang, Sc" uniqKey="Huang S">SC Huang</name></author><author><name sortKey="St Hilaire, Bg" uniqKey="St Hilaire B">BG St Hilaire</name></author><author><name sortKey="Engreitz, Jm" uniqKey="Engreitz J">JM Engreitz</name></author><author><name sortKey="Perez, Em" uniqKey="Perez E">EM Perez</name></author><author><name sortKey="Kieffer Kwon, Kr" uniqKey="Kieffer Kwon K">KR Kieffer-Kwon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lupianez, Dg" uniqKey="Lupianez D">DG Lupianez</name></author><author><name sortKey="Kraft, K" uniqKey="Kraft K">K Kraft</name></author><author><name sortKey="Heinrich, V" uniqKey="Heinrich V">V Heinrich</name></author><author><name sortKey="Krawitz, P" uniqKey="Krawitz P">P Krawitz</name></author><author><name sortKey="Brancati, F" uniqKey="Brancati F">F Brancati</name></author><author><name sortKey="Klopocki, E" uniqKey="Klopocki E">E Klopocki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, C" uniqKey="Hou C">C Hou</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Dean, A" uniqKey="Dean A">A Dean</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flavahan, Wa" uniqKey="Flavahan W">WA Flavahan</name></author><author><name sortKey="Drier, Y" uniqKey="Drier Y">Y Drier</name></author><author><name sortKey="Liau, Bb" uniqKey="Liau B">BB Liau</name></author><author><name sortKey="Gillespie, Sm" uniqKey="Gillespie S">SM Gillespie</name></author><author><name sortKey="Venteicher, As" uniqKey="Venteicher A">AS Venteicher</name></author><author><name sortKey="Stemmer Rachamimov, Ao" uniqKey="Stemmer Rachamimov A">AO Stemmer-Rachamimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefebvre, Jl" uniqKey="Lefebvre J">JL Lefebvre</name></author><author><name sortKey="Kostadinov, D" uniqKey="Kostadinov D">D Kostadinov</name></author><author><name sortKey="Chen, Wv" uniqKey="Chen W">WV Chen</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name></author><author><name sortKey="Sanes, Jr" uniqKey="Sanes J">JR Sanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toyoda, S" uniqKey="Toyoda S">S Toyoda</name></author><author><name sortKey="Kawaguchi, M" uniqKey="Kawaguchi M">M Kawaguchi</name></author><author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T Kobayashi</name></author><author><name sortKey="Tarusawa, E" uniqKey="Tarusawa E">E Tarusawa</name></author><author><name sortKey="Toyama, T" uniqKey="Toyama T">T Toyama</name></author><author><name sortKey="Okano, M" uniqKey="Okano M">M Okano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schreiner, D" uniqKey="Schreiner D">D Schreiner</name></author><author><name sortKey="Weiner, Ja" uniqKey="Weiner J">JA Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Wv" uniqKey="Chen W">WV Chen</name></author><author><name sortKey="Nwakeze, Cl" uniqKey="Nwakeze C">CL Nwakeze</name></author><author><name sortKey="Denny, Ca" uniqKey="Denny C">CA Denny</name></author><author><name sortKey="O Eeffe, S" uniqKey="O Eeffe S">S O’Keeffe</name></author><author><name sortKey="Rieger, Ma" uniqKey="Rieger M">MA Rieger</name></author><author><name sortKey="Mountoufaris, G" uniqKey="Mountoufaris G">G Mountoufaris</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mountoufaris, G" uniqKey="Mountoufaris G">G Mountoufaris</name></author><author><name sortKey="Canzio, D" uniqKey="Canzio D">D Canzio</name></author><author><name sortKey="Nwakeze, Cl" uniqKey="Nwakeze C">CL Nwakeze</name></author><author><name sortKey="Chen, Wv" uniqKey="Chen W">WV Chen</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Ba, Z" uniqKey="Ba Z">Z Ba</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Dai, Hq" uniqKey="Dai H">HQ Dai</name></author><author><name sortKey="Alt, Fw" uniqKey="Alt F">FW Alt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kehayova, P" uniqKey="Kehayova P">P Kehayova</name></author><author><name sortKey="Monahan, K" uniqKey="Monahan K">K Monahan</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Maniatis, T" uniqKey="Maniatis T">T Maniatis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Monahan, K" uniqKey="Monahan K">K Monahan</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Gertz, J" uniqKey="Gertz J">J Gertz</name></author><author><name sortKey="Varley, Ke" uniqKey="Varley K">KE Varley</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allahyar, A" uniqKey="Allahyar A">A Allahyar</name></author><author><name sortKey="Vermeulen, C" uniqKey="Vermeulen C">C Vermeulen</name></author><author><name sortKey="Bouwman, Bam" uniqKey="Bouwman B">BAM Bouwman</name></author><author><name sortKey="Krijger, Phl" uniqKey="Krijger P">PHL Krijger</name></author><author><name sortKey="Verstegen, M" uniqKey="Verstegen M">M Verstegen</name></author><author><name sortKey="Geeven, G" uniqKey="Geeven G">G Geeven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Shou, J" uniqKey="Shou J">J Shou</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shou, J" uniqKey="Shou J">J Shou</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esumi, S" uniqKey="Esumi S">S Esumi</name></author><author><name sortKey="Kakazu, N" uniqKey="Kakazu N">N Kakazu</name></author><author><name sortKey="Taguchi, Y" uniqKey="Taguchi Y">Y Taguchi</name></author><author><name sortKey="Hirayama, T" uniqKey="Hirayama T">T Hirayama</name></author><author><name sortKey="Sasaki, A" uniqKey="Sasaki A">A Sasaki</name></author><author><name sortKey="Hirabayashi, T" uniqKey="Hirabayashi T">T Hirabayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tasic, B" uniqKey="Tasic B">B Tasic</name></author><author><name sortKey="Yao, Z" uniqKey="Yao Z">Z Yao</name></author><author><name sortKey="Graybuck, Lt" uniqKey="Graybuck L">LT Graybuck</name></author><author><name sortKey="Smith, Ka" uniqKey="Smith K">KA Smith</name></author><author><name sortKey="Nguyen, Tn" uniqKey="Nguyen T">TN Nguyen</name></author><author><name sortKey="Bertagnolli, D" uniqKey="Bertagnolli D">D Bertagnolli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, Hn" uniqKey="Cai H">HN Cai</name></author><author><name sortKey="Shen, P" uniqKey="Shen P">P Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muravyova, E" uniqKey="Muravyova E">E Muravyova</name></author><author><name sortKey="Golovnin, A" uniqKey="Golovnin A">A Golovnin</name></author><author><name sortKey="Gracheva, E" uniqKey="Gracheva E">E Gracheva</name></author><author><name sortKey="Parshikov, A" uniqKey="Parshikov A">A Parshikov</name></author><author><name sortKey="Belenkaya, T" uniqKey="Belenkaya T">T Belenkaya</name></author><author><name sortKey="Pirrotta, V" uniqKey="Pirrotta V">V Pirrotta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srinivasan, M" uniqKey="Srinivasan M">M Srinivasan</name></author><author><name sortKey="Scheinost, Jc" uniqKey="Scheinost J">JC Scheinost</name></author><author><name sortKey="Petela, Nj" uniqKey="Petela N">NJ Petela</name></author><author><name sortKey="Gligoris, Tg" uniqKey="Gligoris T">TG Gligoris</name></author><author><name sortKey="Wissler, M" uniqKey="Wissler M">M Wissler</name></author><author><name sortKey="Ogushi, S" uniqKey="Ogushi S">S Ogushi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokota, S" uniqKey="Yokota S">S Yokota</name></author><author><name sortKey="Hirayama, T" uniqKey="Hirayama T">T Hirayama</name></author><author><name sortKey="Hirano, K" uniqKey="Hirano K">K Hirano</name></author><author><name sortKey="Kaneko, R" uniqKey="Kaneko R">R Kaneko</name></author><author><name sortKey="Toyoda, S" uniqKey="Toyoda S">S Toyoda</name></author><author><name sortKey="Kawamura, Y" uniqKey="Kawamura Y">Y Kawamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsamardinos, I" uniqKey="Tsamardinos I">I Tsamardinos</name></author><author><name sortKey="Brown, Le" uniqKey="Brown L">LE Brown</name></author><author><name sortKey="Aliferis, Cf" uniqKey="Aliferis C">CF Aliferis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubin, Aj" uniqKey="Rubin A">AJ Rubin</name></author><author><name sortKey="Barajas, Bc" uniqKey="Barajas B">BC Barajas</name></author><author><name sortKey="Furlan Magaril, M" uniqKey="Furlan Magaril M">M Furlan-Magaril</name></author><author><name sortKey="Lopez Pajares, V" uniqKey="Lopez Pajares V">V Lopez-Pajares</name></author><author><name sortKey="Mumbach, Mr" uniqKey="Mumbach M">MR Mumbach</name></author><author><name sortKey="Howard, I" uniqKey="Howard I">I Howard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monahan, K" uniqKey="Monahan K">K Monahan</name></author><author><name sortKey="Horta, A" uniqKey="Horta A">A Horta</name></author><author><name sortKey="Lomvardas, S" uniqKey="Lomvardas S">S Lomvardas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canzio, D" uniqKey="Canzio D">D Canzio</name></author><author><name sortKey="Nwakeze, Cl" uniqKey="Nwakeze C">CL Nwakeze</name></author><author><name sortKey="Horta, A" uniqKey="Horta A">A Horta</name></author><author><name sortKey="Rajkumar, Sm" uniqKey="Rajkumar S">SM Rajkumar</name></author><author><name sortKey="Coffey, El" uniqKey="Coffey E">EL Coffey</name></author><author><name sortKey="Duffy, Ee" uniqKey="Duffy E">EE Duffy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Cheng, Jf" uniqKey="Cheng J">JF Cheng</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name></author><author><name sortKey="Grimwood, J" uniqKey="Grimwood J">J Grimwood</name></author><author><name sortKey="Schmutz, J" uniqKey="Schmutz J">J Schmutz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanimoto, K" uniqKey="Tanimoto K">K Tanimoto</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Bungert, J" uniqKey="Bungert J">J Bungert</name></author><author><name sortKey="Engel, Jd" uniqKey="Engel J">JD Engel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Busslinger, Ga" uniqKey="Busslinger G">GA Busslinger</name></author><author><name sortKey="Stocsits, Rr" uniqKey="Stocsits R">RR Stocsits</name></author><author><name sortKey="Van Der Lelij, P" uniqKey="Van Der Lelij P">P van der Lelij</name></author><author><name sortKey="Axelsson, E" uniqKey="Axelsson E">E Axelsson</name></author><author><name sortKey="Tedeschi, A" uniqKey="Tedeschi A">A Tedeschi</name></author><author><name sortKey="Galjart, N" uniqKey="Galjart N">N Galjart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Z" uniqKey="Tang Z">Z Tang</name></author><author><name sortKey="Luo, Oj" uniqKey="Luo O">OJ Luo</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Zheng, M" uniqKey="Zheng M">M Zheng</name></author><author><name sortKey="Zhu, Jj" uniqKey="Zhu J">JJ Zhu</name></author><author><name sortKey="Szalaj, P" uniqKey="Szalaj P">P Szalaj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, Ls" uniqKey="Qi L">LS Qi</name></author><author><name sortKey="Larson, Mh" uniqKey="Larson M">MH Larson</name></author><author><name sortKey="Gilbert, La" uniqKey="Gilbert L">LA Gilbert</name></author><author><name sortKey="Doudna, Ja" uniqKey="Doudna J">JA Doudna</name></author><author><name sortKey="Weissman, Js" uniqKey="Weissman J">JS Weissman</name></author><author><name sortKey="Arkin, Ap" uniqKey="Arkin A">AP Arkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Ba, Z" uniqKey="Ba Z">Z Ba</name></author><author><name sortKey="Liang, Z" uniqKey="Liang Z">Z Liang</name></author><author><name sortKey="Dring, Ew" uniqKey="Dring E">EW Dring</name></author><author><name sortKey="Hu, H" uniqKey="Hu H">H Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarjan, Dr" uniqKey="Tarjan D">DR Tarjan</name></author><author><name sortKey="Flavahan, Wa" uniqKey="Flavahan W">WA Flavahan</name></author><author><name sortKey="Bernstein, Be" uniqKey="Bernstein B">BE Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashimoto, H" uniqKey="Hashimoto H">H Hashimoto</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Horton, Jr" uniqKey="Horton J">JR Horton</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Corces, Vg" uniqKey="Corces V">VG Corces</name></author><author><name sortKey="Cheng, X" uniqKey="Cheng X">X Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Ml" uniqKey="Yin M">ML Yin</name></author><author><name sortKey="Wang, Jy" uniqKey="Wang J">JY Wang</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Li, Xm" uniqKey="Li X">XM Li</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vian, L" uniqKey="Vian L">L Vian</name></author><author><name sortKey="Pekowska, A" uniqKey="Pekowska A">A Pekowska</name></author><author><name sortKey="Rao, Ssp" uniqKey="Rao S">SSP Rao</name></author><author><name sortKey="Kieffer Kwon, Kr" uniqKey="Kieffer Kwon K">KR Kieffer-Kwon</name></author><author><name sortKey="Jung, S" uniqKey="Jung S">S Jung</name></author><author><name sortKey="Baranello, L" uniqKey="Baranello L">L Baranello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartzman, O" uniqKey="Schwartzman O">O Schwartzman</name></author><author><name sortKey="Mukamel, Z" uniqKey="Mukamel Z">Z Mukamel</name></author><author><name sortKey="Oded Elkayam, N" uniqKey="Oded Elkayam N">N Oded-Elkayam</name></author><author><name sortKey="Olivares Chauvet, P" uniqKey="Olivares Chauvet P">P Olivares-Chauvet</name></author><author><name sortKey="Lubling, Y" uniqKey="Lubling Y">Y Lubling</name></author><author><name sortKey="Landan, G" uniqKey="Landan G">G Landan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dostie, J" uniqKey="Dostie J">J Dostie</name></author><author><name sortKey="Richmond, Ta" uniqKey="Richmond T">TA Richmond</name></author><author><name sortKey="Arnaout, Ra" uniqKey="Arnaout R">RA Arnaout</name></author><author><name sortKey="Selzer, Rr" uniqKey="Selzer R">RR Selzer</name></author><author><name sortKey="Lee, Wl" uniqKey="Lee W">WL Lee</name></author><author><name sortKey="Honan, Ta" uniqKey="Honan T">TA Honan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dostie, J" uniqKey="Dostie J">J Dostie</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lajoie, Br" uniqKey="Lajoie B">BR Lajoie</name></author><author><name sortKey="Van Berkum, Nl" uniqKey="Van Berkum N">NL van Berkum</name></author><author><name sortKey="Sanyal, A" uniqKey="Sanyal A">A Sanyal</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Shou, J" uniqKey="Shou J">J Shou</name></author><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z Jia</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cleveland, Ws" uniqKey="Cleveland W">WS Cleveland</name></author><author><name sortKey="Devlin, Sj" uniqKey="Devlin S">SJ Devlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanyal, A" uniqKey="Sanyal A">A Sanyal</name></author><author><name sortKey="Lajoie, Br" uniqKey="Lajoie B">BR Lajoie</name></author><author><name sortKey="Jain, G" uniqKey="Jain G">G Jain</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Em" uniqKey="Smith E">EM Smith</name></author><author><name sortKey="Lajoie, Br" uniqKey="Lajoie B">BR Lajoie</name></author><author><name sortKey="Jain, G" uniqKey="Jain G">G Jain</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kundu, S" uniqKey="Kundu S">S Kundu</name></author><author><name sortKey="Ji, F" uniqKey="Ji F">F Ji</name></author><author><name sortKey="Sunwoo, H" uniqKey="Sunwoo H">H Sunwoo</name></author><author><name sortKey="Jain, G" uniqKey="Jain G">G Jain</name></author><author><name sortKey="Lee, Jt" uniqKey="Lee J">JT Lee</name></author><author><name sortKey="Sadreyev, Ri" uniqKey="Sadreyev R">RI Sadreyev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Meyer, Ca" uniqKey="Meyer C">CA Meyer</name></author><author><name sortKey="Eeckhoute, J" uniqKey="Eeckhoute J">J Eeckhoute</name></author><author><name sortKey="Johnson, Ds" uniqKey="Johnson D">DS Johnson</name></author><author><name sortKey="Bernstein, Be" uniqKey="Bernstein B">BE Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dempster, Ap" uniqKey="Dempster A">AP Dempster</name></author><author><name sortKey="Laird, Nm" uniqKey="Laird N">NM Laird</name></author><author><name sortKey="Rubin, Db" uniqKey="Rubin D">DB Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, As" uniqKey="Hansen A">AS Hansen</name></author><author><name sortKey="Cattoglio, C" uniqKey="Cattoglio C">C Cattoglio</name></author><author><name sortKey="Darzacq, X" uniqKey="Darzacq X">X Darzacq</name></author><author><name sortKey="Tjian, R" uniqKey="Tjian R">R Tjian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichols, Mh" uniqKey="Nichols M">MH Nichols</name></author><author><name sortKey="Corces, Vg" uniqKey="Corces V">VG Corces</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yatskevich, S" uniqKey="Yatskevich S">S Yatskevich</name></author><author><name sortKey="Rhodes, J" uniqKey="Rhodes J">J Rhodes</name></author><author><name sortKey="Nasmyth, K" uniqKey="Nasmyth K">K Nasmyth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nichols, Mh" uniqKey="Nichols M">MH Nichols</name></author><author><name sortKey="Corces, Vg" uniqKey="Corces V">VG Corces</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naumova, N" uniqKey="Naumova N">N Naumova</name></author><author><name sortKey="Imakaev, M" uniqKey="Imakaev M">M Imakaev</name></author><author><name sortKey="Fudenberg, G" uniqKey="Fudenberg G">G Fudenberg</name></author><author><name sortKey="Zhan, Y" uniqKey="Zhan Y">Y Zhan</name></author><author><name sortKey="Lajoie, Br" uniqKey="Lajoie B">BR Lajoie</name></author><author><name sortKey="Mirny, La" uniqKey="Mirny L">LA Mirny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marko, Jf" uniqKey="Marko J">JF Marko</name></author><author><name sortKey="Siggia, Ed" uniqKey="Siggia E">ED Siggia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alipour, E" uniqKey="Alipour E">E Alipour</name></author><author><name sortKey="Marko, Jf" uniqKey="Marko J">JF Marko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarzer, W" uniqKey="Schwarzer W">W Schwarzer</name></author><author><name sortKey="Abdennur, N" uniqKey="Abdennur N">N Abdennur</name></author><author><name sortKey="Goloborodko, A" uniqKey="Goloborodko A">A Goloborodko</name></author><author><name sortKey="Pekowska, A" uniqKey="Pekowska A">A Pekowska</name></author><author><name sortKey="Fudenberg, G" uniqKey="Fudenberg G">G Fudenberg</name></author><author><name sortKey="Loe Mie, Y" uniqKey="Loe Mie Y">Y Loe-Mie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parelho, V" uniqKey="Parelho V">V Parelho</name></author><author><name sortKey="Hadjur, S" uniqKey="Hadjur S">S Hadjur</name></author><author><name sortKey="Spivakov, M" uniqKey="Spivakov M">M Spivakov</name></author><author><name sortKey="Leleu, M" uniqKey="Leleu M">M Leleu</name></author><author><name sortKey="Sauer, S" uniqKey="Sauer S">S Sauer</name></author><author><name sortKey="Gregson, Hc" uniqKey="Gregson H">HC Gregson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, Ce" uniqKey="Grant C">CE Grant</name></author><author><name sortKey="Bailey, Tl" uniqKey="Bailey T">TL Bailey</name></author><author><name sortKey="Noble, Ws" uniqKey="Noble W">WS Noble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langmead, B" uniqKey="Langmead B">B Langmead</name></author><author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rapaport, Dc" uniqKey="Rapaport D">DC Rapaport</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cesari, A" uniqKey="Cesari A">A Cesari</name></author><author><name sortKey="Rei Er, S" uniqKey="Rei Er S">S Reißer</name></author><author><name sortKey="Bussi, G" uniqKey="Bussi G">G Bussi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imakaev, Mv" uniqKey="Imakaev M">MV Imakaev</name></author><author><name sortKey="Tchourine, Km" uniqKey="Tchourine K">KM Tchourine</name></author><author><name sortKey="Nechaev, Sk" uniqKey="Nechaev S">SK Nechaev</name></author><author><name sortKey="Mirny, La" uniqKey="Mirny L">LA Mirny</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Jia, Zhilian" sort="Jia, Zhilian" uniqKey="Jia Z" first="Zhilian" last="Jia">Zhilian Jia</name></noRegion><name sortKey="Ge, Xiao" sort="Ge, Xiao" uniqKey="Ge X" first="Xiao" last="Ge">Xiao Ge</name><name sortKey="Guo, Ya" sort="Guo, Ya" uniqKey="Guo Y" first="Ya" last="Guo">Ya Guo</name><name sortKey="Li, Jingwei" sort="Li, Jingwei" uniqKey="Li J" first="Jingwei" last="Li">Jingwei Li</name><name sortKey="Wu, Qiang" sort="Wu, Qiang" uniqKey="Wu Q" first="Qiang" last="Wu">Qiang Wu</name><name sortKey="Wu, Qiang" sort="Wu, Qiang" uniqKey="Wu Q" first="Qiang" last="Wu">Qiang Wu</name><name sortKey="Wu, Yonghu" sort="Wu, Yonghu" uniqKey="Wu Y" first="Yonghu" last="Wu">Yonghu Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/new/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000140 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/new/Analysis/biblio.hfd -nk 000140 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= new
|étape= Analysis
|type= RBID
|clé= PMC:7087399
|texte= Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/new/Analysis/RBID.i -Sk "pubmed:NONE" \
| HfdSelect -Kh $EXPLOR_AREA/Data/new/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |