CovidV2, an2020, Analysis, bibRecord, 000449

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.

Identifieur interne : 000449 ( an2020/Analysis ); précédent : 000448; suivant : 000450

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.

Auteurs : Tao Zhang [République populaire de Chine] ; Qunfu Wu [République populaire de Chine] ; Zhigang Zhang [République populaire de Chine]

Source :

Current biology : CB [ 1879-0445 ] ; 2020.

RBID : pubmed:32197085

Abstract

An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2. The S1 protein of Pangolin-CoV is much more closely related to SARS-CoV-2 than to RaTG13. Five key amino acid residues involved in the interaction with human ACE2 are completely consistent between Pangolin-CoV and SARS-CoV-2, but four amino acid mutations are present in RaTG13. Both Pangolin-CoV and RaTG13 lost the putative furin recognition sequence motif at S1/S2 cleavage site that can be observed in the SARS-CoV-2. Conclusively, this study suggests that pangolin species are a natural reservoir of SARS-CoV-2-like CoVs.

DOI: 10.1016/j.cub.2020.03.022
PubMed: 32197085

Affiliations:

République populaire de Chine

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pubmed:32197085

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Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.

Source :

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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