Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.
Identifieur interne : 000D21 ( PubMed/Curation ); précédent : 000D20; suivant : 000D22Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.
Auteurs : S K Krishnan [Inde] ; S. Ganguly ; R. Veerasamy ; B. JanSource :
- European review for medical and pharmacological sciences [ 1128-3602 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Antiviraux (toxicité), Cellules HeLa, Cellules Vero, Chats, Chiens, Humains, Lignée cellulaire, Maladies virales (traitement médicamenteux), Maladies virales (virologie), Quinazolinones (pharmacologie), Quinazolinones (synthèse chimique), Quinazolinones (toxicité), Relation structure-activité, Réplication virale ().
- MESH :
- pharmacologie : Antiviraux, Quinazolinones.
- synthèse chimique : Antiviraux, Quinazolinones.
- toxicité : Antiviraux, Quinazolinones.
- traitement médicamenteux : Maladies virales.
- virologie : Maladies virales.
- Animaux, Cellules HeLa, Cellules Vero, Chats, Chiens, Humains, Lignée cellulaire, Relation structure-activité, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemical synthesis), Antiviral Agents (pharmacology), Antiviral Agents (toxicity), Cats, Cell Line, Chlorocebus aethiops, Dogs, HeLa Cells, Humans, Quinazolinones (chemical synthesis), Quinazolinones (pharmacology), Quinazolinones (toxicity), Structure-Activity Relationship, Vero Cells, Virus Diseases (drug therapy), Virus Diseases (virology), Virus Replication (drug effects).
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quinazolinones.
- chemical , pharmacology : Antiviral Agents, Quinazolinones.
- chemical , toxicity : Antiviral Agents, Quinazolinones.
- drug effects : Virus Replication.
- drug therapy : Virus Diseases.
- virology : Virus Diseases.
- Animals, Cats, Cell Line, Chlorocebus aethiops, Dogs, HeLa Cells, Humans, Structure-Activity Relationship, Vero Cells.
Abstract
A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds.
PubMed: 21796872
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pubmed:21796872Le document en format XML
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<author><name sortKey="Krishnan, S K" sort="Krishnan, S K" uniqKey="Krishnan S" first="S K" last="Krishnan">S K Krishnan</name>
<affiliation wicri:level="1"><nlm:affiliation>Medicinal Chemistry Research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Medicinal Chemistry Research Laboratory, KMCH College of Pharmacy, Coimbatore</wicri:regionArea>
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<author><name sortKey="Ganguly, S" sort="Ganguly, S" uniqKey="Ganguly S" first="S" last="Ganguly">S. Ganguly</name>
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<author><name sortKey="Veerasamy, R" sort="Veerasamy, R" uniqKey="Veerasamy R" first="R" last="Veerasamy">R. Veerasamy</name>
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<author><name sortKey="Jan, B" sort="Jan, B" uniqKey="Jan B" first="B" last="Jan">B. Jan</name>
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<series><title level="j">European review for medical and pharmacological sciences</title>
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<term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (toxicity)</term>
<term>Cats</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Dogs</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Quinazolinones (chemical synthesis)</term>
<term>Quinazolinones (pharmacology)</term>
<term>Quinazolinones (toxicity)</term>
<term>Structure-Activity Relationship</term>
<term>Vero Cells</term>
<term>Virus Diseases (drug therapy)</term>
<term>Virus Diseases (virology)</term>
<term>Virus Replication (drug effects)</term>
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<term>Maladies virales (traitement médicamenteux)</term>
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<term>Quinazolinones (synthèse chimique)</term>
<term>Quinazolinones (toxicité)</term>
<term>Relation structure-activité</term>
<term>Réplication virale ()</term>
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<term>Quinazolinones</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Quinazolinones</term>
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<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antiviral Agents</term>
<term>Quinazolinones</term>
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<term>Cell Line</term>
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<term>Cellules Vero</term>
<term>Chats</term>
<term>Chiens</term>
<term>Humains</term>
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<term>Relation structure-activité</term>
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<front><div type="abstract" xml:lang="en">A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds.</div>
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<DateCompleted><Year>2011</Year>
<Month>08</Month>
<Day>11</Day>
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<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1128-3602</ISSN>
<JournalIssue CitedMedium="Print"><Volume>15</Volume>
<Issue>6</Issue>
<PubDate><Year>2011</Year>
<Month>Jun</Month>
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<Title>European review for medical and pharmacological sciences</Title>
<ISOAbbreviation>Eur Rev Med Pharmacol Sci</ISOAbbreviation>
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<ArticleTitle>Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.</ArticleTitle>
<Pagination><MedlinePgn>673-81</MedlinePgn>
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<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR and mass spectral analysis. Title compounds were investigated for cytotoxicity and antiviral activity against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK-KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1 N1 subtype, influenza A H3N2 subtype, influenza B and vesicular stomatitis virus.</AbstractText>
<AbstractText Label="RESULTS AND CONCLUSION" NlmCategory="CONCLUSIONS">Compound 3d was found inhibit viral replication of para influenza-3virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus in Vero cell cultures.</AbstractText>
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