Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.
Identifieur interne : 000D14 ( PubMed/Curation ); précédent : 000D13; suivant : 000D15Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.
Auteurs : Won-Kyung Cho [Corée du Sud] ; Hyunil Kim ; Yu Jeong Choi ; Nam-Hui Yim ; Hye Jin Yang ; Jin Yeul MaSource :
- Evidence-based complementary and alternative medicine : eCAM [ 1741-4288 ] ; 2012.
Abstract
Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.
DOI: 10.1155/2012/985151
PubMed: 23259003
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000D14
Links to Exploration step
pubmed:23259003Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.</title><author><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name><affiliation wicri:level="1"><nlm:affiliation>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Hyunil" sort="Kim, Hyunil" uniqKey="Kim H" first="Hyunil" last="Kim">Hyunil Kim</name></author><author><name sortKey="Choi, Yu Jeong" sort="Choi, Yu Jeong" uniqKey="Choi Y" first="Yu Jeong" last="Choi">Yu Jeong Choi</name></author><author><name sortKey="Yim, Nam Hui" sort="Yim, Nam Hui" uniqKey="Yim N" first="Nam-Hui" last="Yim">Nam-Hui Yim</name></author><author><name sortKey="Yang, Hye Jin" sort="Yang, Hye Jin" uniqKey="Yang H" first="Hye Jin" last="Yang">Hye Jin Yang</name></author><author><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23259003</idno><idno type="pmid">23259003</idno><idno type="doi">10.1155/2012/985151</idno><idno type="wicri:Area/PubMed/Corpus">000D14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D14</idno><idno type="wicri:Area/PubMed/Curation">000D14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.</title><author><name sortKey="Cho, Won Kyung" sort="Cho, Won Kyung" uniqKey="Cho W" first="Won-Kyung" last="Cho">Won-Kyung Cho</name><affiliation wicri:level="1"><nlm:affiliation>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Hyunil" sort="Kim, Hyunil" uniqKey="Kim H" first="Hyunil" last="Kim">Hyunil Kim</name></author><author><name sortKey="Choi, Yu Jeong" sort="Choi, Yu Jeong" uniqKey="Choi Y" first="Yu Jeong" last="Choi">Yu Jeong Choi</name></author><author><name sortKey="Yim, Nam Hui" sort="Yim, Nam Hui" uniqKey="Yim N" first="Nam-Hui" last="Yim">Nam-Hui Yim</name></author><author><name sortKey="Yang, Hye Jin" sort="Yang, Hye Jin" uniqKey="Yang H" first="Hye Jin" last="Yang">Hye Jin Yang</name></author><author><name sortKey="Ma, Jin Yeul" sort="Ma, Jin Yeul" uniqKey="Ma J" first="Jin Yeul" last="Ma">Jin Yeul Ma</name></author></analytic><series><title level="j">Evidence-based complementary and alternative medicine : eCAM</title><idno type="eISSN">1741-4288</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">23259003</PMID><DateCompleted><Year>2012</Year><Month>12</Month><Day>24</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1741-4288</ISSN><JournalIssue CitedMedium="Internet"><Volume>2012</Volume><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Evidence-based complementary and alternative medicine : eCAM</Title><ISOAbbreviation>Evid Based Complement Alternat Med</ISOAbbreviation></Journal><ArticleTitle>Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.</ArticleTitle><Pagination><MedlinePgn>985151</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2012/985151</ELocationID><Abstract><AbstractText>Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Won-Kyung</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Korean Medicine (KM)-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305-811, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyunil</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Yu Jeong</ForeName><Initials>YJ</Initials></Author><Author ValidYN="Y"><LastName>Yim</LastName><ForeName>Nam-Hui</ForeName><Initials>NH</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hye Jin</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jin Yeul</ForeName><Initials>JY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Evid Based Complement Alternat Med</MedlineTA><NlmUniqueID>101215021</NlmUniqueID><ISSNLinking>1741-427X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>10</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>11</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23259003</ArticleId><ArticleId IdType="doi">10.1155/2012/985151</ArticleId><ArticleId IdType="pmc">PMC3521454</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Ethnopharmacol. 2000 Sep;72(1-2):317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">10967489</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2012 Nov;96(2):260-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22985631</ArticleId></ArticleIdList></Reference><Reference><Citation>J Ethnopharmacol. 2002 Feb;79(2):273-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11801392</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2003 May;77(10):5933-47</Citation><ArticleIdList><ArticleId IdType="pubmed">12719586</ArticleId></ArticleIdList></Reference><Reference><Citation>Biosci Biotechnol Biochem. 2003 May;67(5):1071-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12834285</ArticleId></ArticleIdList></Reference><Reference><Citation>J Appl Microbiol. 2003;95(3):412-27</Citation><ArticleIdList><ArticleId IdType="pubmed">12911688</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2004 Nov;64(2):93-102</Citation><ArticleIdList><ArticleId IdType="pubmed">15498604</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Rec. 1977 Mar 19;100(12):243-4</Citation><ArticleIdList><ArticleId IdType="pubmed">888300</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 1978;58(3):243-7</Citation><ArticleIdList><ArticleId IdType="pubmed">83132</ArticleId></ArticleIdList></Reference><Reference><Citation>Can Vet J. 1980 Mar;21(3):100-xxiii</Citation><ArticleIdList><ArticleId IdType="pubmed">7363267</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Vet Res. 1980 Feb;41(2):219-23</Citation><ArticleIdList><ArticleId IdType="pubmed">6245603</ArticleId></ArticleIdList></Reference><Reference><Citation>Chemotherapy. 1981;27(2):139-45</Citation><ArticleIdList><ArticleId IdType="pubmed">7009087</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Virol. 1981;68(1):35-44</Citation><ArticleIdList><ArticleId IdType="pubmed">7247728</ArticleId></ArticleIdList></Reference><Reference><Citation>J Ethnopharmacol. 1991 Apr;32(1-3):141-53</Citation><ArticleIdList><ArticleId IdType="pubmed">1652667</ArticleId></ArticleIdList></Reference><Reference><Citation>AIDS Res Hum Retroviruses. 1993 Apr;9(4):291-7</Citation><ArticleIdList><ArticleId IdType="pubmed">8390276</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2004 Dec;64(3):195-201</Citation><ArticleIdList><ArticleId IdType="pubmed">15550273</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2005 Apr;66(1):29-34</Citation><ArticleIdList><ArticleId IdType="pubmed">15781129</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2005 Jun;66(2-3):159-63</Citation><ArticleIdList><ArticleId IdType="pubmed">15911031</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2005 Oct;68(1):10-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16087250</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2005 Nov;68(2):66-74</Citation><ArticleIdList><ArticleId IdType="pubmed">16137775</ArticleId></ArticleIdList></Reference><Reference><Citation>Antivir Chem Chemother. 2005;16(6):393-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16329286</ArticleId></ArticleIdList></Reference><Reference><Citation>J Ethnopharmacol. 2006 Mar 8;104(1-2):92-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16198524</ArticleId></ArticleIdList></Reference><Reference><Citation>Biol Pharm Bull. 2006 Jun;29(6):1092-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16754999</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2007 Apr;74(1):1-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17303260</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytother Res. 2007 May;21(5):466-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17357972</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol Methods. 2007 Dec;146(1-2):172-7</Citation><ArticleIdList><ArticleId IdType="pubmed">17697717</ArticleId></ArticleIdList></Reference><Reference><Citation>Phytomedicine. 2008 Jan;15(1-2):55-61</Citation><ArticleIdList><ArticleId IdType="pubmed">17482445</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2008 Feb;131(2):111-20</Citation><ArticleIdList><ArticleId IdType="pubmed">17981353</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2008 Feb;41(2):122-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18036887</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2008 Nov 14;376(2):404-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18789310</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2009 Jan;81(1):77-81</Citation><ArticleIdList><ArticleId IdType="pubmed">18992773</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Lett. 2009 Jul 18;280(1):93-100</Citation><ArticleIdList><ArticleId IdType="pubmed">19289254</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pharmacol Exp Ther. 2010 Jun;333(3):816-21</Citation><ArticleIdList><ArticleId IdType="pubmed">20194528</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2011;8:460</Citation><ArticleIdList><ArticleId IdType="pubmed">21967756</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2000 Oct;124(2):507-14</Citation><ArticleIdList><ArticleId IdType="pubmed">11027701</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000D14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:23259003
|texte= Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:23259003" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |