Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Identifieur interne : 000B99 ( PubMed/Curation ); précédent : 000B98; suivant : 000C00Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Auteurs : Manli Wang [République populaire de Chine] ; Ruiyuan Cao [République populaire de Chine] ; Leike Zhang [République populaire de Chine] ; Xinglou Yang [République populaire de Chine] ; Jia Liu [République populaire de Chine] ; Mingyue Xu [République populaire de Chine] ; Zhengli Shi [République populaire de Chine] ; Zhihong Hu [République populaire de Chine] ; Wu Zhong [République populaire de Chine] ; Gengfu Xiao [République populaire de Chine]Source :
- Cell research [ 1748-7838 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (pharmacologie), AMP (usage thérapeutique), Alanine (analogues et dérivés), Alanine (pharmacologie), Alanine (usage thérapeutique), Animaux, Antipaludiques (pharmacologie), Antipaludiques (usage thérapeutique), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cellules Vero, Chloroquine (pharmacologie), Chloroquine (usage thérapeutique), Coronavirus du syndrome respiratoire du Moyen-Orient (), Dosage biologique, Découverte de médicament, Humains, Infections à coronavirus (traitement médicamenteux), Pneumopathie virale (traitement médicamenteux), Sincalide, Virus du SRAS (), Évaluation préclinique de médicament.
- MESH :
- analogues et dérivés : AMP, Alanine.
- pharmacologie : AMP, Alanine, Antipaludiques, Antiviraux, Chloroquine.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : AMP, Alanine, Antipaludiques, Antiviraux, Chloroquine.
- Animaux, Cellules Vero, Coronavirus du syndrome respiratoire du Moyen-Orient, Dosage biologique, Découverte de médicament, Humains, Sincalide, Virus du SRAS, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (pharmacology), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (pharmacology), Alanine (therapeutic use), Animals, Antimalarials (pharmacology), Antimalarials (therapeutic use), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (pathogenicity), Biological Assay, Chlorocebus aethiops, Chloroquine (pharmacology), Chloroquine (therapeutic use), Coronavirus Infections (drug therapy), Drug Discovery, Drug Evaluation, Preclinical, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Pneumonia, Viral (drug therapy), SARS Virus (drug effects), Sincalide, Vero Cells.
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , pharmacology : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Chloroquine.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Chloroquine.
- drug effects : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- Animals, Biological Assay, Chlorocebus aethiops, Drug Discovery, Drug Evaluation, Preclinical, Humans, Sincalide, Vero Cells.
DOI: 10.1038/s41422-020-0282-0
PubMed: 32020029
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<term>Adenosine Monophosphate (pharmacology)</term>
<term>Adenosine Monophosphate (therapeutic use)</term>
<term>Alanine (analogs & derivatives)</term>
<term>Alanine (pharmacology)</term>
<term>Alanine (therapeutic use)</term>
<term>Animals</term>
<term>Antimalarials (pharmacology)</term>
<term>Antimalarials (therapeutic use)</term>
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<term>Biological Assay</term>
<term>Chlorocebus aethiops</term>
<term>Chloroquine (pharmacology)</term>
<term>Chloroquine (therapeutic use)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Drug Discovery</term>
<term>Drug Evaluation, Preclinical</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Pneumonia, Viral (drug therapy)</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Dosage biologique</term>
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<Agency>National Natural Science Foundation of China (National Science Foundation of China)</Agency>
<Country>International</Country>
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