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The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

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The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

Auteurs : Yan-Rong Guo [République populaire de Chine] ; Qing-Dong Cao [République populaire de Chine] ; Zhong-Si Hong [République populaire de Chine] ; Yuan-Yang Tan [République populaire de Chine] ; Shou-Deng Chen [République populaire de Chine] ; Hong-Jun Jin [République populaire de Chine] ; Kai-Sen Tan [Singapour] ; De-Yun Wang [Singapour] ; Yan Yan [République populaire de Chine]

Source :

Military Medical Research [ 2054-9369 ] ; 2020.

RBID : pubmed:32169119

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Chine (épidémiologie), Chiroptera, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Diarrhée (étiologie), Fatigue (étiologie), Femelle, Fièvre (étiologie), Flambées de maladies, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Mâle, Peptidyl-Dipeptidase A, Pneumopathie virale (), Pneumopathie virale (diagnostic), Pneumopathie virale (transmission), Pneumopathie virale (épidémiologie), Protéines de l'enveloppe virale, Réplication virale, Réservoirs d'agents pathogènes, Sujet âgé, Toux (étiologie), Virulence, Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- épidémiologie : Chine, Infections à coronavirus, Pneumopathie virale.
- étiologie : Diarrhée, Fatigue, Fièvre, Toux.
- Adulte, Adulte d'âge moyen, Animaux, Chiroptera, Femelle, Flambées de maladies, Humains, Infections à coronavirus, Mâle, Peptidyl-Dipeptidase A, Pneumopathie virale, Protéines de l'enveloppe virale, Réplication virale, Réservoirs d'agents pathogènes, Sujet âgé, Virulence.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adult, Aged, Alphacoronavirus (genetics), Animals, Betacoronavirus (genetics), Betacoronavirus (pathogenicity), China (epidemiology), Chiroptera, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Cough (etiology), Diarrhea (etiology), Disease Outbreaks, Disease Reservoirs, Fatigue (etiology), Female, Fever (etiology), Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Peptidyl-Dipeptidase A, Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Pneumonia, Viral (transmission), SARS Virus (genetics), SARS Virus (pathogenicity), Viral Envelope Proteins, Virulence, Virus Replication.
MESH :
- chemical : Peptidyl-Dipeptidase A, Viral Envelope Proteins.
- geographic , epidemiology : China.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- etiology : Cough, Diarrhea, Fatigue, Fever.
- genetics : Alphacoronavirus, Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Animals, Chiroptera, Disease Outbreaks, Disease Reservoirs, Female, Humans, Male, Middle Aged, Virulence, Virus Replication.

Abstract

An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.

DOI: 10.1186/s40779-020-00240-0
PubMed: 32169119

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<front><div type="abstract" xml:lang="en">An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>03</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2054-9369</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>03</Month>
<Day>13</Day>
</PubDate>
</JournalIssue>
<Title>Military Medical Research</Title>
<ISOAbbreviation>Mil Med Res</ISOAbbreviation>
</Journal>
<ArticleTitle>The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.</ArticleTitle>
<Pagination><MedlinePgn>11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s40779-020-00240-0</ELocationID>
<Abstract><AbstractText>An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Yan-Rong</ForeName>
<Initials>YR</Initials>
<AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Qing-Dong</ForeName>
<Initials>QD</Initials>
<AffiliationInfo><Affiliation>Department of Cardiothoracic Surgery, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hong</LastName>
<ForeName>Zhong-Si</ForeName>
<Initials>ZS</Initials>
<AffiliationInfo><Affiliation>Center of Infectious Disease, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Yuan-Yang</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Shou-Deng</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Jin</LastName>
<ForeName>Hong-Jun</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Kai-Sen</ForeName>
<Initials>KS</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>De-Yun</ForeName>
<Initials>DY</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, 119228, Singapore. entwdy@nus.edu.sg.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000, Guangdong, China. yanyan35@mail.sysu.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China. yanyan35@mail.sysu.edu.cn.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<Month>03</Month>
<Day>13</Day>
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The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

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