CovidV2, PubMed, Corpus, bibRecord, 000D81

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies.

Identifieur interne : 000D81 ( PubMed/Corpus ); précédent : 000D80; suivant : 000D82

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies.

Auteurs : H. Kasai ; E. Morita ; K. Hatakeyama ; K. Sugiyama

Source :

Archives of virology [ 0304-8608 ] ; 1998.

RBID : pubmed:9856082

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Coronavirus (chemistry), Coronavirus (physiology), Hemagglutinins, Viral (analysis), Hemagglutinins, Viral (immunology), Hemagglutinins, Viral (physiology), Mice, Viral Fusion Proteins, Viral Proteins (analysis), Viral Proteins (immunology), Viral Proteins (physiology).
MESH :
- chemical , analysis : Hemagglutinins, Viral, Viral Proteins.
- chemical , immunology : Antibodies, Monoclonal, Hemagglutinins, Viral, Viral Proteins.
- chemistry : Coronavirus.
- physiology : Coronavirus, Hemagglutinins, Viral, Viral Proteins.
- Animals, Mice, Viral Fusion Proteins.

Abstract

We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.

DOI: 10.1007/s007050050431
PubMed: 9856082

Links to Exploration step

pubmed:9856082

Le document en format XML

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<author><name sortKey="Kasai, H" sort="Kasai, H" uniqKey="Kasai H" first="H" last="Kasai">H. Kasai</name>
<affiliation><nlm:affiliation>Department of Biology, Faculty of Science, Hirosaki University, Japan.</nlm:affiliation>
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<author><name sortKey="Morita, E" sort="Morita, E" uniqKey="Morita E" first="E" last="Morita">E. Morita</name>
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<author><name sortKey="Hatakeyama, K" sort="Hatakeyama, K" uniqKey="Hatakeyama K" first="K" last="Hatakeyama">K. Hatakeyama</name>
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<author><name sortKey="Sugiyama, K" sort="Sugiyama, K" uniqKey="Sugiyama K" first="K" last="Sugiyama">K. Sugiyama</name>
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<term>Hemagglutinins, Viral (analysis)</term>
<term>Hemagglutinins, Viral (immunology)</term>
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<term>Viral Fusion Proteins</term>
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<term>Viral Proteins (immunology)</term>
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<front><div type="abstract" xml:lang="en">We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</div>
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<Abstract><AbstractText>We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3a28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5a3, 6a6, 13a4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</AbstractText>
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Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies.

Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki