The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.
Identifieur interne : 000D62 ( PubMed/Corpus ); précédent : 000D61; suivant : 000D63The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.
Auteurs : Masaji Okada ; Yuji Takemoto ; Yoshinobu Okuno ; Satomi Hashimoto ; Shigeto Yoshida ; Yukari Fukunaga ; Takao Tanaka ; Yoko Kita ; Sachiko Kuwayama ; Yumiko Muraki ; Noriko Kanamaru ; Hiroko Takai ; Chika Okada ; Yayoi Sakaguchi ; Izumi Furukawa ; Kyoko Yamada ; Makoto Matsumoto ; Tetsuo Kase ; Daphne E. Demello ; J S M. Peiris ; Pei-Jer Chen ; Naoki Yamamoto ; Yoshiyuki Yoshinaka ; Tatsuji Nomura ; Isao Ishida ; Shigeru Morikawa ; Masato Tashiro ; Mitsunori SakataniSource :
- Vaccine [ 0264-410X ] ; 2005.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Antigens, Viral (genetics), Female, Humans, In Vitro Techniques, Lymphocyte Activation, Lymphocyte Transfusion, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, Neutralization Tests, SARS Virus (genetics), SARS Virus (immunology), T-Lymphocytes, Cytotoxic (immunology), Transplantation, Heterologous, Vaccines, DNA (genetics), Vaccines, DNA (pharmacology), Viral Proteins (genetics), Viral Proteins (immunology), Viral Vaccines (genetics), Viral Vaccines (isolation & purification).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Antigens, Viral, Vaccines, DNA, Viral Proteins, Viral Vaccines.
- genetics : SARS Virus.
- immunology : SARS Virus, T-Lymphocytes, Cytotoxic, Viral Proteins.
- chemical , isolation & purification : Viral Vaccines.
- chemical , pharmacology : Vaccines, DNA.
- Animals, Female, Humans, In Vitro Techniques, Lymphocyte Activation, Lymphocyte Transfusion, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, Neutralization Tests, Transplantation, Heterologous.
Abstract
We have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines.
DOI: 10.1016/j.vaccine.2005.01.036
PubMed: 15755609
Links to Exploration step
pubmed:15755609Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation><nlm:affiliation>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp</nlm:affiliation></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name></author><author><name sortKey="Fukunaga, Yukari" sort="Fukunaga, Yukari" uniqKey="Fukunaga Y" first="Yukari" last="Fukunaga">Yukari Fukunaga</name></author><author><name sortKey="Tanaka, Takao" sort="Tanaka, Takao" uniqKey="Tanaka T" first="Takao" last="Tanaka">Takao Tanaka</name></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name></author><author><name sortKey="Kuwayama, Sachiko" sort="Kuwayama, Sachiko" uniqKey="Kuwayama S" first="Sachiko" last="Kuwayama">Sachiko Kuwayama</name></author><author><name sortKey="Muraki, Yumiko" sort="Muraki, Yumiko" uniqKey="Muraki Y" first="Yumiko" last="Muraki">Yumiko Muraki</name></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name></author><author><name sortKey="Takai, Hiroko" sort="Takai, Hiroko" uniqKey="Takai H" first="Hiroko" last="Takai">Hiroko Takai</name></author><author><name sortKey="Okada, Chika" sort="Okada, Chika" uniqKey="Okada C" first="Chika" last="Okada">Chika Okada</name></author><author><name sortKey="Sakaguchi, Yayoi" sort="Sakaguchi, Yayoi" uniqKey="Sakaguchi Y" first="Yayoi" last="Sakaguchi">Yayoi Sakaguchi</name></author><author><name sortKey="Furukawa, Izumi" sort="Furukawa, Izumi" uniqKey="Furukawa I" first="Izumi" last="Furukawa">Izumi Furukawa</name></author><author><name sortKey="Yamada, Kyoko" sort="Yamada, Kyoko" uniqKey="Yamada K" first="Kyoko" last="Yamada">Kyoko Yamada</name></author><author><name sortKey="Matsumoto, Makoto" sort="Matsumoto, Makoto" uniqKey="Matsumoto M" first="Makoto" last="Matsumoto">Makoto Matsumoto</name></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name></author><author><name sortKey="Demello, Daphne E" sort="Demello, Daphne E" uniqKey="Demello D" first="Daphne E" last="Demello">Daphne E. Demello</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name></author><author><name sortKey="Yoshinaka, Yoshiyuki" sort="Yoshinaka, Yoshiyuki" uniqKey="Yoshinaka Y" first="Yoshiyuki" last="Yoshinaka">Yoshiyuki Yoshinaka</name></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15755609</idno><idno type="pmid">15755609</idno><idno type="doi">10.1016/j.vaccine.2005.01.036</idno><idno type="wicri:Area/PubMed/Corpus">000D62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.</title><author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name><affiliation><nlm:affiliation>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp</nlm:affiliation></affiliation></author><author><name sortKey="Takemoto, Yuji" sort="Takemoto, Yuji" uniqKey="Takemoto Y" first="Yuji" last="Takemoto">Yuji Takemoto</name></author><author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name></author><author><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name></author><author><name sortKey="Yoshida, Shigeto" sort="Yoshida, Shigeto" uniqKey="Yoshida S" first="Shigeto" last="Yoshida">Shigeto Yoshida</name></author><author><name sortKey="Fukunaga, Yukari" sort="Fukunaga, Yukari" uniqKey="Fukunaga Y" first="Yukari" last="Fukunaga">Yukari Fukunaga</name></author><author><name sortKey="Tanaka, Takao" sort="Tanaka, Takao" uniqKey="Tanaka T" first="Takao" last="Tanaka">Takao Tanaka</name></author><author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name></author><author><name sortKey="Kuwayama, Sachiko" sort="Kuwayama, Sachiko" uniqKey="Kuwayama S" first="Sachiko" last="Kuwayama">Sachiko Kuwayama</name></author><author><name sortKey="Muraki, Yumiko" sort="Muraki, Yumiko" uniqKey="Muraki Y" first="Yumiko" last="Muraki">Yumiko Muraki</name></author><author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name></author><author><name sortKey="Takai, Hiroko" sort="Takai, Hiroko" uniqKey="Takai H" first="Hiroko" last="Takai">Hiroko Takai</name></author><author><name sortKey="Okada, Chika" sort="Okada, Chika" uniqKey="Okada C" first="Chika" last="Okada">Chika Okada</name></author><author><name sortKey="Sakaguchi, Yayoi" sort="Sakaguchi, Yayoi" uniqKey="Sakaguchi Y" first="Yayoi" last="Sakaguchi">Yayoi Sakaguchi</name></author><author><name sortKey="Furukawa, Izumi" sort="Furukawa, Izumi" uniqKey="Furukawa I" first="Izumi" last="Furukawa">Izumi Furukawa</name></author><author><name sortKey="Yamada, Kyoko" sort="Yamada, Kyoko" uniqKey="Yamada K" first="Kyoko" last="Yamada">Kyoko Yamada</name></author><author><name sortKey="Matsumoto, Makoto" sort="Matsumoto, Makoto" uniqKey="Matsumoto M" first="Makoto" last="Matsumoto">Makoto Matsumoto</name></author><author><name sortKey="Kase, Tetsuo" sort="Kase, Tetsuo" uniqKey="Kase T" first="Tetsuo" last="Kase">Tetsuo Kase</name></author><author><name sortKey="Demello, Daphne E" sort="Demello, Daphne E" uniqKey="Demello D" first="Daphne E" last="Demello">Daphne E. Demello</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Chen, Pei Jer" sort="Chen, Pei Jer" uniqKey="Chen P" first="Pei-Jer" last="Chen">Pei-Jer Chen</name></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name></author><author><name sortKey="Yoshinaka, Yoshiyuki" sort="Yoshinaka, Yoshiyuki" uniqKey="Yoshinaka Y" first="Yoshiyuki" last="Yoshinaka">Yoshiyuki Yoshinaka</name></author><author><name sortKey="Nomura, Tatsuji" sort="Nomura, Tatsuji" uniqKey="Nomura T" first="Tatsuji" last="Nomura">Tatsuji Nomura</name></author><author><name sortKey="Ishida, Isao" sort="Ishida, Isao" uniqKey="Ishida I" first="Isao" last="Ishida">Isao Ishida</name></author><author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name></author><author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name></author><author><name sortKey="Sakatani, Mitsunori" sort="Sakatani, Mitsunori" uniqKey="Sakatani M" first="Mitsunori" last="Sakatani">Mitsunori Sakatani</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Antigens, Viral (genetics)</term><term>Female</term><term>Humans</term><term>In Vitro Techniques</term><term>Lymphocyte Activation</term><term>Lymphocyte Transfusion</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred NOD</term><term>Mice, Knockout</term><term>Mice, SCID</term><term>Neutralization Tests</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Transplantation, Heterologous</term><term>Vaccines, DNA (genetics)</term><term>Vaccines, DNA (pharmacology)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (immunology)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (isolation & purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Vaccines, DNA</term><term>Viral Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>T-Lymphocytes, Cytotoxic</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>In Vitro Techniques</term><term>Lymphocyte Activation</term><term>Lymphocyte Transfusion</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred NOD</term><term>Mice, Knockout</term><term>Mice, SCID</term><term>Neutralization Tests</term><term>Transplantation, Heterologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15755609</PMID><DateCompleted><Year>2005</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>23</Volume><Issue>17-18</Issue><PubDate><Year>2005</Year><Month>Mar</Month><Day>18</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.</ArticleTitle><Pagination><MedlinePgn>2269-72</MedlinePgn></Pagination><Abstract><AbstractText>We have investigated to develop novel vaccines against SARS CoV using cDNA constructs encoding the structural antigen; spike protein (S), membrane protein (M), envelope protein (E), or nucleocapsid (N) protein, derived from SARS CoV. Mice vaccinated with SARS-N or -M DNA using pcDNA 3.1(+) plasmid vector showed T cell immune responses (CTL induction and proliferation) against N or M protein, respectively. CTL responses were also detected to SARS DNA-transfected type II alveolar epithelial cells (T7 cell clone), which are thought to be initial target cells for SARS virus infection in human. To determine whether these DNA vaccines could induce T cell immune responses in humans as well as in mice, SCID-PBL/hu mice was immunized with these DNA vaccines. As expected, virus-specific CTL responses and T cell proliferation were induced from human T cells. SARS-N and SARS-M DNA vaccines and SCID-PBL/hu mouse model will be important in the development of protective vaccines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Okada</LastName><ForeName>Masaji</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, 1180 Nagasone, Sakai, Osaka 591-8555, Japan. okm@kch.hosp.go.jp</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takemoto</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Okuno</LastName><ForeName>Yoshinobu</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hashimoto</LastName><ForeName>Satomi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Yoshida</LastName><ForeName>Shigeto</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Fukunaga</LastName><ForeName>Yukari</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Takao</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kita</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kuwayama</LastName><ForeName>Sachiko</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Muraki</LastName><ForeName>Yumiko</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Kanamaru</LastName><ForeName>Noriko</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Takai</LastName><ForeName>Hiroko</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Okada</LastName><ForeName>Chika</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Sakaguchi</LastName><ForeName>Yayoi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Furukawa</LastName><ForeName>Izumi</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Yamada</LastName><ForeName>Kyoko</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Makoto</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kase</LastName><ForeName>Tetsuo</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Demello</LastName><ForeName>Daphne E</ForeName><Initials>DE</Initials></Author><Author ValidYN="Y"><LastName>Peiris</LastName><ForeName>J S M</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Pei-Jer</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Naoki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Yoshinaka</LastName><ForeName>Yoshiyuki</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Nomura</LastName><ForeName>Tatsuji</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Ishida</LastName><ForeName>Isao</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Morikawa</LastName><ForeName>Shigeru</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tashiro</LastName><ForeName>Masato</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Sakatani</LastName><ForeName>Mitsunori</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019444">Vaccines, DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017710" MajorTopicYN="N">Lymphocyte Transfusion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016688" MajorTopicYN="N">Mice, Inbred NOD</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016513" MajorTopicYN="N">Mice, SCID</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014183" MajorTopicYN="N">Transplantation, Heterologous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019444" MajorTopicYN="N">Vaccines, DNA</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>3</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>5</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>3</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15755609</ArticleId><ArticleId IdType="pii">S0264-410X(05)00039-3</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2005.01.036</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000D62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:15755609
|texte= The development of vaccines against SARS corona virus in mice and SCID-PBL/hu mice.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:15755609" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |