CovidV2, PubMed, Corpus, bibRecord, 000D40

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Identifieur interne : 000D40 ( PubMed/Corpus ); précédent : 000D39; suivant : 000D41

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Auteurs : Yoon-Suk Lee ; Sun Min Park ; Byeang Hyean Kim

Source :

Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2009.

RBID : pubmed:19147352

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Combinatorial Chemistry Techniques, Deoxyuridine (analogs & derivatives), Deoxyuridine (chemical synthesis), Deoxyuridine (chemistry), Deoxyuridine (pharmacology), Isoxazoles (chemical synthesis), Isoxazoles (chemistry), Isoxazoles (pharmacology), Microbial Sensitivity Tests, Molecular Structure, RNA Viruses (drug effects), Simplexvirus (drug effects).
MESH :
- chemical , analogs & derivatives : Deoxyuridine.
- chemical , chemical synthesis : Antiviral Agents, Deoxyuridine, Isoxazoles.
- chemical , chemistry : Antiviral Agents, Deoxyuridine, Isoxazoles.
- chemical , pharmacology : Antiviral Agents, Deoxyuridine, Isoxazoles.
- drug effects : RNA Viruses, Simplexvirus.
- Combinatorial Chemistry Techniques, Microbial Sensitivity Tests, Molecular Structure.

Abstract

This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2'-deoxyuridines from 5-iodo-2'-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2'-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV.

DOI: 10.1016/j.bmcl.2008.12.103
PubMed: 19147352

Links to Exploration step

pubmed:19147352

Le document en format XML

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<author><name sortKey="Lee, Yoon Suk" sort="Lee, Yoon Suk" uniqKey="Lee Y" first="Yoon-Suk" last="Lee">Yoon-Suk Lee</name>
<affiliation><nlm:affiliation>Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Park, Sun Min" sort="Park, Sun Min" uniqKey="Park S" first="Sun Min" last="Park">Sun Min Park</name>
</author>
<author><name sortKey="Kim, Byeang Hyean" sort="Kim, Byeang Hyean" uniqKey="Kim B" first="Byeang Hyean" last="Kim">Byeang Hyean Kim</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.</title>
<author><name sortKey="Lee, Yoon Suk" sort="Lee, Yoon Suk" uniqKey="Lee Y" first="Yoon-Suk" last="Lee">Yoon-Suk Lee</name>
<affiliation><nlm:affiliation>Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Park, Sun Min" sort="Park, Sun Min" uniqKey="Park S" first="Sun Min" last="Park">Sun Min Park</name>
</author>
<author><name sortKey="Kim, Byeang Hyean" sort="Kim, Byeang Hyean" uniqKey="Kim B" first="Byeang Hyean" last="Kim">Byeang Hyean Kim</name>
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<series><title level="j">Bioorganic & medicinal chemistry letters</title>
<idno type="eISSN">1464-3405</idno>
<imprint><date when="2009" type="published">2009</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Combinatorial Chemistry Techniques</term>
<term>Deoxyuridine (analogs & derivatives)</term>
<term>Deoxyuridine (chemical synthesis)</term>
<term>Deoxyuridine (chemistry)</term>
<term>Deoxyuridine (pharmacology)</term>
<term>Isoxazoles (chemical synthesis)</term>
<term>Isoxazoles (chemistry)</term>
<term>Isoxazoles (pharmacology)</term>
<term>Microbial Sensitivity Tests</term>
<term>Molecular Structure</term>
<term>RNA Viruses (drug effects)</term>
<term>Simplexvirus (drug effects)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxyuridine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term>
<term>Deoxyuridine</term>
<term>Isoxazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Deoxyuridine</term>
<term>Isoxazoles</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Deoxyuridine</term>
<term>Isoxazoles</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>RNA Viruses</term>
<term>Simplexvirus</term>
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<front><div type="abstract" xml:lang="en">This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2'-deoxyuridines from 5-iodo-2'-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2'-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV.</div>
</front>
</TEI>
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<DateCompleted><Year>2009</Year>
<Month>03</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1464-3405</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>4</Issue>
<PubDate><Year>2009</Year>
<Month>Feb</Month>
<Day>15</Day>
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<Title>Bioorganic & medicinal chemistry letters</Title>
<ISOAbbreviation>Bioorg. Med. Chem. Lett.</ISOAbbreviation>
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<ArticleTitle>Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.</ArticleTitle>
<Pagination><MedlinePgn>1126-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bmcl.2008.12.103</ELocationID>
<Abstract><AbstractText>This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2'-deoxyuridines from 5-iodo-2'-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2'-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Yoon-Suk</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea.</Affiliation>
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<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Sun Min</ForeName>
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<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Byeang Hyean</ForeName>
<Initials>BH</Initials>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D007555" MajorTopicYN="N">Isoxazoles</DescriptorName>
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<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
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<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="Y">Microbial Sensitivity Tests</DescriptorName>
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<MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName>
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<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018139" MajorTopicYN="N">Simplexvirus</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year>
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<PubMedPubDate PubStatus="revised"><Year>2008</Year>
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<Day>05</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2008</Year>
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Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki