Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Identifieur interne : 000D30 ( PubMed/Corpus ); précédent : 000D29; suivant : 000D31Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Auteurs : Krishnan Suresh Kumar ; Swastika Ganguly ; Ravichandran Veerasamy ; Erik De ClercqSource :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2010.
English descriptors
- KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Quinazolines (chemical synthesis), Quinazolines (chemistry), Quinazolines (pharmacology), Schiff Bases (chemistry), Spectrophotometry, Infrared.
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quinazolines.
- chemical , chemistry : Antiviral Agents, Quinazolines, Schiff Bases.
- chemical , pharmacology : Antiviral Agents, Quinazolines.
- Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared.
Abstract
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.
DOI: 10.1016/j.ejmech.2010.07.058
PubMed: 20724039
Links to Exploration step
pubmed:20724039Le document en format XML
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<author><name sortKey="Kumar, Krishnan Suresh" sort="Kumar, Krishnan Suresh" uniqKey="Kumar K" first="Krishnan Suresh" last="Kumar">Krishnan Suresh Kumar</name>
<affiliation><nlm:affiliation>Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com</nlm:affiliation>
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<author><name sortKey="Ganguly, Swastika" sort="Ganguly, Swastika" uniqKey="Ganguly S" first="Swastika" last="Ganguly">Swastika Ganguly</name>
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<author><name sortKey="Veerasamy, Ravichandran" sort="Veerasamy, Ravichandran" uniqKey="Veerasamy R" first="Ravichandran" last="Veerasamy">Ravichandran Veerasamy</name>
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<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
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<term>Cell Line</term>
<term>Drug Evaluation, Preclinical</term>
<term>Humans</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Quinazolines (chemical synthesis)</term>
<term>Quinazolines (chemistry)</term>
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<term>Schiff Bases (chemistry)</term>
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<front><div type="abstract" xml:lang="en">A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</div>
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<Title>European journal of medicinal chemistry</Title>
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<Abstract><AbstractText>A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</AbstractText>
<CopyrightInformation>Crown Copyright © 2010. Published by Elsevier Masson SAS. All rights reserved.</CopyrightInformation>
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