Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.
Identifieur interne : 000C52 ( PubMed/Corpus ); précédent : 000C51; suivant : 000C53Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.
Auteurs : Ana C S. Gondim ; Suzete Roberta Da Silva ; Leen Mathys ; Sam Noppen ; Sandra Liekens ; Alexandre Holanda Sampaio ; Celso S. Nagano ; Cintia Renata Costa Rocha ; Kyria S. Nascimento ; Benildo S. Cavada ; Peter J. Sadler ; Jan BalzariniSource :
- MedChemComm [ 2040-2511 ] ; 2019.
Abstract
Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: Canavalia brasiliensis (ConBr), C. maritima (ConM), Dioclea lasiocarpa (DLasiL) and D. sclerocarpa (DSclerL), and algae Amansia multifida (AML), Bryothamniom seaforthii (BSL), Hypnea musciformis (HML), Meristiella echinocarpa (MEL) and Solieria filiformis (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC50 values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC50 of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC50 values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC50 values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.
DOI: 10.1039/c8md00508g
PubMed: 30996857
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.</title><author><name sortKey="Gondim, Ana C S" sort="Gondim, Ana C S" uniqKey="Gondim A" first="Ana C S" last="Gondim">Ana C S. Gondim</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Roberta Da Silva, Suzete" sort="Roberta Da Silva, Suzete" uniqKey="Roberta Da Silva S" first="Suzete" last="Roberta Da Silva">Suzete Roberta Da Silva</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Mathys, Leen" sort="Mathys, Leen" uniqKey="Mathys L" first="Leen" last="Mathys">Leen Mathys</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Noppen, Sam" sort="Noppen, Sam" uniqKey="Noppen S" first="Sam" last="Noppen">Sam Noppen</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Liekens, Sandra" sort="Liekens, Sandra" uniqKey="Liekens S" first="Sandra" last="Liekens">Sandra Liekens</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Holanda Sampaio, Alexandre" sort="Holanda Sampaio, Alexandre" uniqKey="Holanda Sampaio A" first="Alexandre" last="Holanda Sampaio">Alexandre Holanda Sampaio</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Nagano, Celso S" sort="Nagano, Celso S" uniqKey="Nagano C" first="Celso S" last="Nagano">Celso S. Nagano</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Renata Costa Rocha, Cintia" sort="Renata Costa Rocha, Cintia" uniqKey="Renata Costa Rocha C" first="Cintia" last="Renata Costa Rocha">Cintia Renata Costa Rocha</name><affiliation><nlm:affiliation>Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Nascimento, Kyria S" sort="Nascimento, Kyria S" uniqKey="Nascimento K" first="Kyria S" last="Nascimento">Kyria S. Nascimento</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Cavada, Benildo S" sort="Cavada, Benildo S" uniqKey="Cavada B" first="Benildo S" last="Cavada">Benildo S. Cavada</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Sadler, Peter J" sort="Sadler, Peter J" uniqKey="Sadler P" first="Peter J" last="Sadler">Peter J. Sadler</name><affiliation><nlm:affiliation>Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email: P.J.Sadler@warwick.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30996857</idno><idno type="pmid">30996857</idno><idno type="doi">10.1039/c8md00508g</idno><idno type="wicri:Area/PubMed/Corpus">000C52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.</title><author><name sortKey="Gondim, Ana C S" sort="Gondim, Ana C S" uniqKey="Gondim A" first="Ana C S" last="Gondim">Ana C S. Gondim</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Roberta Da Silva, Suzete" sort="Roberta Da Silva, Suzete" uniqKey="Roberta Da Silva S" first="Suzete" last="Roberta Da Silva">Suzete Roberta Da Silva</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Mathys, Leen" sort="Mathys, Leen" uniqKey="Mathys L" first="Leen" last="Mathys">Leen Mathys</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Noppen, Sam" sort="Noppen, Sam" uniqKey="Noppen S" first="Sam" last="Noppen">Sam Noppen</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Liekens, Sandra" sort="Liekens, Sandra" uniqKey="Liekens S" first="Sandra" last="Liekens">Sandra Liekens</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Holanda Sampaio, Alexandre" sort="Holanda Sampaio, Alexandre" uniqKey="Holanda Sampaio A" first="Alexandre" last="Holanda Sampaio">Alexandre Holanda Sampaio</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Nagano, Celso S" sort="Nagano, Celso S" uniqKey="Nagano C" first="Celso S" last="Nagano">Celso S. Nagano</name><affiliation><nlm:affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Renata Costa Rocha, Cintia" sort="Renata Costa Rocha, Cintia" uniqKey="Renata Costa Rocha C" first="Cintia" last="Renata Costa Rocha">Cintia Renata Costa Rocha</name><affiliation><nlm:affiliation>Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Nascimento, Kyria S" sort="Nascimento, Kyria S" uniqKey="Nascimento K" first="Kyria S" last="Nascimento">Kyria S. Nascimento</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Cavada, Benildo S" sort="Cavada, Benildo S" uniqKey="Cavada B" first="Benildo S" last="Cavada">Benildo S. Cavada</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Sadler, Peter J" sort="Sadler, Peter J" uniqKey="Sadler P" first="Peter J" last="Sadler">Peter J. Sadler</name><affiliation><nlm:affiliation>Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email: P.J.Sadler@warwick.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name><affiliation><nlm:affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</nlm:affiliation></affiliation></author></analytic><series><title level="j">MedChemComm</title><idno type="eISSN">2040-2511</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: <i>Canavalia brasiliensis</i> (ConBr), <i>C. maritima</i> (ConM), <i>Dioclea lasiocarpa</i> (DLasiL) and <i>D. sclerocarpa</i> (DSclerL), and algae <i>Amansia multifida</i> (AML), <i>Bryothamniom seaforthii</i> (BSL), <i>Hypnea musciformis</i> (HML), <i>Meristiella echinocarpa</i> (MEL) and <i>Solieria filiformis</i> (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC<sub>50</sub> values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC<sub>50</sub> of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC<sub>50</sub> values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC<sub>50</sub> values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30996857</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2040-2511</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>3</Issue><PubDate><Year>2019</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>MedChemComm</Title><ISOAbbreviation>Medchemcomm</ISOAbbreviation></Journal><ArticleTitle>Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.</ArticleTitle><Pagination><MedlinePgn>390-398</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c8md00508g</ELocationID><Abstract><AbstractText>Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: <i>Canavalia brasiliensis</i> (ConBr), <i>C. maritima</i> (ConM), <i>Dioclea lasiocarpa</i> (DLasiL) and <i>D. sclerocarpa</i> (DSclerL), and algae <i>Amansia multifida</i> (AML), <i>Bryothamniom seaforthii</i> (BSL), <i>Hypnea musciformis</i> (HML), <i>Meristiella echinocarpa</i> (MEL) and <i>Solieria filiformis</i> (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC<sub>50</sub> values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC<sub>50</sub> of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC<sub>50</sub> values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC<sub>50</sub> values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gondim</LastName><ForeName>Ana C S</ForeName><Initials>ACS</Initials><Identifier Source="ORCID">0000-0003-3526-1203</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email: P.J.Sadler@warwick.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roberta da Silva</LastName><ForeName>Suzete</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-6254-1975</Identifier><AffiliationInfo><Affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Para West Federal University , 68220-000 , Monte Alegre , Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mathys</LastName><ForeName>Leen</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0002-5123-8751</Identifier><AffiliationInfo><Affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noppen</LastName><ForeName>Sam</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-2831-5042</Identifier><AffiliationInfo><Affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liekens</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-3529-8121</Identifier><AffiliationInfo><Affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holanda Sampaio</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-3871-0502</Identifier><AffiliationInfo><Affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagano</LastName><ForeName>Celso S</ForeName><Initials>CS</Initials><Identifier Source="ORCID">0000-0001-5988-5868</Identifier><AffiliationInfo><Affiliation>Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renata Costa Rocha</LastName><ForeName>Cintia</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-3366-3615</Identifier><AffiliationInfo><Affiliation>Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nascimento</LastName><ForeName>Kyria S</ForeName><Initials>KS</Initials><Identifier Source="ORCID">0000-0002-2220-4552</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavada</LastName><ForeName>Benildo S</ForeName><Initials>BS</Initials><Identifier Source="ORCID">0000-0002-5791-6170</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email: bscavada@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadler</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><Identifier Source="ORCID">0000-0001-9160-1941</Identifier><AffiliationInfo><Affiliation>Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email: P.J.Sadler@warwick.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balzarini</LastName><ForeName>Jan</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-1144-1808</Identifier><AffiliationInfo><Affiliation>Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email: jan.balzarini@kuleuven.be.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Medchemcomm</MedlineTA><NlmUniqueID>101531525</NlmUniqueID><ISSNLinking>2040-2503</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30996857</ArticleId><ArticleId IdType="doi">10.1039/c8md00508g</ArticleId><ArticleId IdType="pii">c8md00508g</ArticleId><ArticleId IdType="pmc">PMC6430086</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2004 Oct;48(10):3858-70</Citation><ArticleIdList><ArticleId IdType="pubmed">15388446</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Sci. 2005 Aug;14(8):2167-76</Citation><ArticleIdList><ArticleId IdType="pubmed">16046632</ArticleId></ArticleIdList></Reference><Reference><Citation>Braz J Med Biol Res. 2005 Dec;38(12):1769-73</Citation><ArticleIdList><ArticleId IdType="pubmed">16302091</ArticleId></ArticleIdList></Reference><Reference><Citation>J Struct Biol. 2005 Dec;152(3):185-94</Citation><ArticleIdList><ArticleId IdType="pubmed">16337811</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2006 Sep;71(2-3):237-47</Citation><ArticleIdList><ArticleId IdType="pubmed">16569440</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(1):362-73</Citation><ArticleIdList><ArticleId IdType="pubmed">17050611</ArticleId></ArticleIdList></Reference><Reference><Citation>Antivir Chem Chemother. 2007;18(1):1-11</Citation><ArticleIdList><ArticleId IdType="pubmed">17354647</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2007 Aug;5(8):583-97</Citation><ArticleIdList><ArticleId IdType="pubmed">17632570</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1933 Dec 8;78(2032):532</Citation><ArticleIdList><ArticleId IdType="pubmed">17836764</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biochem Cell Biol. 2008;40(12):2802-14</Citation><ArticleIdList><ArticleId IdType="pubmed">18598778</ArticleId></ArticleIdList></Reference><Reference><Citation>Autophagy. 2009 Feb;5(2):253-5</Citation><ArticleIdList><ArticleId IdType="pubmed">19139634</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104</Citation><ArticleIdList><ArticleId IdType="pubmed">19332801</ArticleId></ArticleIdList></Reference><Reference><Citation>Naunyn Schmiedebergs Arch Pharmacol. 2009 Dec;380(6):509-21</Citation><ArticleIdList><ArticleId IdType="pubmed">19855960</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Mar;84(5):2511-21</Citation><ArticleIdList><ArticleId IdType="pubmed">20032190</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 Mar 19;285(12):8646-55</Citation><ArticleIdList><ArticleId IdType="pubmed">20080975</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 Apr 23;285(17):13057-65</Citation><ArticleIdList><ArticleId IdType="pubmed">20147291</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biosci. 2010 Mar;35(1):95-103</Citation><ArticleIdList><ArticleId IdType="pubmed">20413914</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 Aug 6;285(32):24845-54</Citation><ArticleIdList><ArticleId IdType="pubmed">20507987</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Pharmacol Sci. 2009;2009:862162</Citation><ArticleIdList><ArticleId IdType="pubmed">21152207</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2011;6(8):e22635</Citation><ArticleIdList><ArticleId IdType="pubmed">21829638</ArticleId></ArticleIdList></Reference><Reference><Citation>Molecules. 2011 Oct 28;16(11):9077-89</Citation><ArticleIdList><ArticleId IdType="pubmed">22037666</ArticleId></ArticleIdList></Reference><Reference><Citation>J Insect Physiol. 2012 Sep;58(9):1177-83</Citation><ArticleIdList><ArticleId IdType="pubmed">22677323</ArticleId></ArticleIdList></Reference><Reference><Citation>Mar Drugs. 2012 Sep;10(9):1936-54</Citation><ArticleIdList><ArticleId IdType="pubmed">23118713</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Recognit. 2012 Dec;25(12):657-64</Citation><ArticleIdList><ArticleId IdType="pubmed">23192963</ArticleId></ArticleIdList></Reference><Reference><Citation>Neurochem Int. 2013 May;62(6):836-42</Citation><ArticleIdList><ArticleId IdType="pubmed">23454192</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013 May 21;8(5):e64449</Citation><ArticleIdList><ArticleId IdType="pubmed">23700478</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Signal Behav. 2013;8(12):e26595</Citation><ArticleIdList><ArticleId IdType="pubmed">24084524</ArticleId></ArticleIdList></Reference><Reference><Citation>FEMS Microbiol Rev. 2014 Jul;38(4):598-632</Citation><ArticleIdList><ArticleId IdType="pubmed">24188132</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Feb;88(4):2327-32</Citation><ArticleIdList><ArticleId IdType="pubmed">24284326</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Biochem Biophys. 2014 Feb 1;543:31-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24361256</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1989 Oct 13;246(4927):227-34</Citation><ArticleIdList><ArticleId IdType="pubmed">2552581</ArticleId></ArticleIdList></Reference><Reference><Citation>Molecules. 2015 Jan 06;20(1):648-68</Citation><ArticleIdList><ArticleId IdType="pubmed">25569520</ArticleId></ArticleIdList></Reference><Reference><Citation>AIDS. 1989 Oct;3(10):635-41</Citation><ArticleIdList><ArticleId IdType="pubmed">2574581</ArticleId></ArticleIdList></Reference><Reference><Citation>Mar Drugs. 2015 May 29;13(6):3454-65</Citation><ArticleIdList><ArticleId IdType="pubmed">26035023</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Biotechnol J. 2015 Oct;13(8):1160-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26176205</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2015 Oct 22;163(3):746-58</Citation><ArticleIdList><ArticleId IdType="pubmed">26496612</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2016 Sep 23;12(9):e1005851</Citation><ArticleIdList><ArticleId IdType="pubmed">27662652</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2017 Jul;189(1):21-35</Citation><ArticleIdList><ArticleId IdType="pubmed">28268243</ArticleId></ArticleIdList></Reference><Reference><Citation>J Inorg Biochem. 2017 Oct;175:179-189</Citation><ArticleIdList><ArticleId IdType="pubmed">28756174</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol Methods. 2017 Nov;249:10-20</Citation><ArticleIdList><ArticleId IdType="pubmed">28797655</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biol Macromol. 2018 Feb;107(Pt A):1320-1329</Citation><ArticleIdList><ArticleId IdType="pubmed">28970169</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2018 Feb 12;8(1):2786</Citation><ArticleIdList><ArticleId IdType="pubmed">29434285</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2018 May 23;8(1):8059</Citation><ArticleIdList><ArticleId IdType="pubmed">29795295</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioimpacts. 2018;8(2):139-151</Citation><ArticleIdList><ArticleId IdType="pubmed">29977835</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Biochem. 1997 Aug 15;248(1):43-8</Citation><ArticleIdList><ArticleId 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