Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.
Identifieur interne : 000B47 ( PubMed/Corpus ); précédent : 000B46; suivant : 000B48Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.
Auteurs : Jaegyun Lim ; Seunghyun Jeon ; Hyun Young Shin ; Moon Jung Kim ; Yu Min Seong ; Wang Jun Lee ; Kang Won Choe ; Yu Min Kang ; Baeckseung Lee ; Sang Joon ParkSource :
- Journal of Korean medical science [ 1598-6357 ] ; 2020.
English descriptors
- KwdEn :
- Betacoronavirus (genetics), China, Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Coronavirus Infections (transmission), Cytochrome P-450 CYP3A Inhibitors (therapeutic use), Drug Combinations, Humans, Lopinavir (therapeutic use), Male, Middle Aged, Pneumonia (diagnosis), Pneumonia (drug therapy), Pneumonia (etiology), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy), Pneumonia, Viral (transmission), Real-Time Polymerase Chain Reaction, Republic of Korea, Ritonavir (therapeutic use), Viral Load.
- MESH :
- chemical , therapeutic use : Cytochrome P-450 CYP3A Inhibitors, Lopinavir, Ritonavir.
- geographic : China, Drug Combinations, Republic of Korea.
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Pneumonia.
- drug therapy : Coronavirus Infections, Pneumonia, Pneumonia, Viral.
- etiology : Pneumonia.
- genetics : Betacoronavirus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Viral Load.
Abstract
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
DOI: 10.3346/jkms.2020.35.e79
PubMed: 32056407
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Hanyang University College of Medicine, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Seunghyun" sort="Jeon, Seunghyun" uniqKey="Jeon S" first="Seunghyun" last="Jeon">Seunghyun Jeon</name><affiliation><nlm:affiliation>New Horizon Cancer Institute, Myongji Hospital, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Shin, Hyun Young" sort="Shin, Hyun Young" uniqKey="Shin H" first="Hyun Young" last="Shin">Hyun Young Shin</name><affiliation><nlm:affiliation>Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Moon Jung" sort="Kim, Moon Jung" uniqKey="Kim M" first="Moon Jung" last="Kim">Moon Jung Kim</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Seong, Yu Min" sort="Seong, Yu Min" uniqKey="Seong Y" first="Yu Min" last="Seong">Yu Min Seong</name><affiliation><nlm:affiliation>Department of Internal Medicine, Myongji Hospital, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Wang Jun" sort="Lee, Wang Jun" uniqKey="Lee W" first="Wang Jun" last="Lee">Wang Jun Lee</name><affiliation><nlm:affiliation>Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang Won" last="Choe">Kang Won Choe</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Yu Min" sort="Kang, Yu Min" uniqKey="Kang Y" first="Yu Min" last="Kang">Yu Min Kang</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Baeckseung" sort="Lee, Baeckseung" uniqKey="Lee B" first="Baeckseung" last="Lee">Baeckseung Lee</name><affiliation><nlm:affiliation>CancerROP, Seoul, Korea. baeckseung@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Sang Joon" sort="Park, Sang Joon" uniqKey="Park S" first="Sang Joon" last="Park">Sang Joon Park</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, Korea. drjoseph@mjh.or.kr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (genetics)</term><term>China</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (transmission)</term><term>Cytochrome P-450 CYP3A Inhibitors (therapeutic use)</term><term>Drug Combinations</term><term>Humans</term><term>Lopinavir (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Pneumonia (diagnosis)</term><term>Pneumonia (drug therapy)</term><term>Pneumonia (etiology)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (transmission)</term><term>Real-Time Polymerase Chain Reaction</term><term>Republic of Korea</term><term>Ritonavir (therapeutic use)</term><term>Viral Load</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Cytochrome P-450 CYP3A Inhibitors</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term><term>Drug Combinations</term><term>Republic of Korea</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32056407</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>Feb</Month><Day>17</Day></PubDate></JournalIssue><Title>Journal of Korean medical science</Title><ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation></Journal><ArticleTitle>Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.</ArticleTitle><Pagination><MedlinePgn>e79</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e79</ELocationID><Abstract><AbstractText>Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.</AbstractText><CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Jaegyun</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3553-0058</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Seunghyun</ForeName><Initials>S</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4320-2644</Identifier><AffiliationInfo><Affiliation>New Horizon Cancer Institute, Myongji Hospital, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Hyun Young</ForeName><Initials>HY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7261-3365</Identifier><AffiliationInfo><Affiliation>Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Moon Jung</ForeName><Initials>MJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4148-9116</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seong</LastName><ForeName>Yu Min</ForeName><Initials>YM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9650-6353</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Myongji Hospital, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Wang Jun</ForeName><Initials>WJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3042-1557</Identifier><AffiliationInfo><Affiliation>Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choe</LastName><ForeName>Kang Won</ForeName><Initials>KW</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2003-6492</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Yu Min</ForeName><Initials>YM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4368-9878</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Baeckseung</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7867-8434</Identifier><AffiliationInfo><Affiliation>CancerROP, Seoul, Korea. baeckseung@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sang Joon</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-3178-6272</Identifier><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, Korea. drjoseph@mjh.or.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Med Sci</MedlineTA><NlmUniqueID>8703518</NlmUniqueID><ISSNLinking>1011-8934</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065692">Cytochrome P-450 CYP3A Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C558899">lopinavir-ritonavir drug combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>2494G1JF75</RegistryNumber><NameOfSubstance UI="D061466">Lopinavir</NameOfSubstance></Chemical><Chemical><RegistryNumber>O3J8G9O825</RegistryNumber><NameOfSubstance UI="D019438">Ritonavir</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Korean Med Sci. 2020 Feb 24;35(7):e88</RefSource><PMID Version="1">32080992</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Korean Med Sci. 2020 Feb 24;35(7):e89</RefSource><PMID Version="1">32080993</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065692" MajorTopicYN="Y">Cytochrome P-450 CYP3A Inhibitors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061466" MajorTopicYN="Y">Lopinavir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011014" MajorTopicYN="Y">Pneumonia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N" Type="Geographic">Republic of Korea</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019438" MajorTopicYN="Y">Ritonavir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Pneumonia</Keyword><Keyword MajorTopicYN="N">Real-Time Reverse-Transcriptase Polymerase Chain Reaction</Keyword><Keyword MajorTopicYN="N">Tertiary Infection</Keyword><Keyword MajorTopicYN="N">Viral Load</Keyword></KeywordList><CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32056407</ArticleId><ArticleId IdType="pii">35.e79</ArticleId><ArticleId IdType="doi">10.3346/jkms.2020.35.e79</ArticleId><ArticleId IdType="pmc">PMC7025910</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Korean Med Sci. 2020 Feb 10;35(5):e61</Citation><ArticleIdList><ArticleId IdType="pubmed">32030925</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Brain Behav Immun. 2019 Feb;76:280-283</Citation><ArticleIdList><ArticleId 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