Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Identifieur interne : 000A10 ( PubMed/Corpus ); précédent : 000A09; suivant : 000A11Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Auteurs : Weilie Chen ; Yun Lan ; Xiaozhen Yuan ; Xilong Deng ; Yueping Li ; Xiaoli Cai ; Liya Li ; Ruiying He ; Yizhou Tan ; Xizi Deng ; Ming Gao ; Guofang Tang ; Lingzhai Zhao ; Jinlin Wang ; Qinghong Fan ; Chunyan Wen ; Yuwei Tong ; Yangbo Tang ; Fengyu Hu ; Feng Li ; Xiaoping TangSource :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : RNA, Viral.
- genetics : Betacoronavirus, RNA, Viral.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Humans, Real-Time Polymerase Chain Reaction, Retrospective Studies, Severity of Illness Index.
Abstract
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
DOI: 10.1080/22221751.2020.1732837
PubMed: 32102625
Links to Exploration step
pubmed:32102625Le document en format XML
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China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32102625</idno><idno type="pmid">32102625</idno><idno type="doi">10.1080/22221751.2020.1732837</idno><idno type="wicri:Area/PubMed/Corpus">000A10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.</title><author><name sortKey="Chen, Weilie" sort="Chen, Weilie" uniqKey="Chen W" first="Weilie" last="Chen">Weilie Chen</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name><affiliation><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Pneumonia, Viral (virology)</term><term>RNA, Viral (blood)</term><term>RNA, Viral (genetics)</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (<i>p</i>-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32102625</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Emerging microbes & infections</Title><ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation></Journal><ArticleTitle>Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.</ArticleTitle><Pagination><MedlinePgn>469-473</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1732837</ELocationID><Abstract><AbstractText>The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (<i>p</i>-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Weilie</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lan</LastName><ForeName>Yun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Xiaozhen</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Xilong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yueping</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Xiaoli</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Liya</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Ruiying</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Yizhou</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Xizi</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Ming</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Guofang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Lingzhai</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jinlin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Qinghong</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Chunyan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Yuwei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Yangbo</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Fengyu</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Feng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Xiaoping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Microbes Infect</MedlineTA><NlmUniqueID>101594885</NlmUniqueID><ISSNLinking>2222-1751</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">2019-ncov</Keyword><Keyword MajorTopicYN="Y">anal swab</Keyword><Keyword MajorTopicYN="Y">blood viral RNA</Keyword><Keyword MajorTopicYN="Y">laboratory test</Keyword><Keyword MajorTopicYN="Y">pharyngeal swab</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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