Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).
Identifieur interne : 000059 ( PubMed/Corpus ); précédent : 000058; suivant : 000060Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).
Auteurs : Li Runfeng ; Hou Yunlong ; Huang Jicheng ; Pan Weiqi ; Ma Qinhai ; Shi Yongxia ; Li Chufang ; Zhao Jin ; Jia Zhenhua ; Jiang Haiming ; Zheng Kui ; Huang Shuxiang ; Dai Jun ; Li Xiaobo ; Hou Xiaotao ; Wang Lin ; Zhong Nanshan ; Yang ZifengSource :
- Pharmacological research [ 1096-1186 ] ; 2020.
Abstract
Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.
DOI: 10.1016/j.phrs.2020.104761
PubMed: 32205232
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last="Jicheng">Huang Jicheng</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Weiqi, Pan" sort="Weiqi, Pan" uniqKey="Weiqi P" first="Pan" last="Weiqi">Pan Weiqi</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qinhai, Ma" sort="Qinhai, Ma" uniqKey="Qinhai M" first="Ma" last="Qinhai">Ma Qinhai</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yongxia, Shi" sort="Yongxia, Shi" uniqKey="Yongxia S" first="Shi" last="Yongxia">Shi Yongxia</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chufang, Li" sort="Chufang, Li" uniqKey="Chufang L" first="Li" last="Chufang">Li Chufang</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jin, Zhao" sort="Jin, Zhao" uniqKey="Jin Z" first="Zhao" last="Jin">Zhao Jin</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhenhua, Jia" sort="Zhenhua, Jia" uniqKey="Zhenhua J" first="Jia" last="Zhenhua">Jia Zhenhua</name><affiliation><nlm:affiliation>Hebei University of Chinese Medicine, College of Integrated Chinese and Western Medicine, China.</nlm:affiliation></affiliation></author><author><name sortKey="Haiming, Jiang" sort="Haiming, Jiang" uniqKey="Haiming J" first="Jiang" last="Haiming">Jiang Haiming</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kui, Zheng" sort="Kui, Zheng" uniqKey="Kui Z" first="Zheng" last="Kui">Zheng Kui</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shuxiang, Huang" sort="Shuxiang, Huang" uniqKey="Shuxiang H" first="Huang" last="Shuxiang">Huang Shuxiang</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jun, Dai" sort="Jun, Dai" uniqKey="Jun D" first="Dai" last="Jun">Dai Jun</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiaobo, Li" sort="Xiaobo, Li" uniqKey="Xiaobo L" first="Li" last="Xiaobo">Li Xiaobo</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiaotao, Hou" sort="Xiaotao, Hou" uniqKey="Xiaotao H" first="Hou" last="Xiaotao">Hou Xiaotao</name><affiliation><nlm:affiliation>KingMed Virology Diagnostic & Translational Center, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Wang" sort="Lin, Wang" uniqKey="Lin W" first="Wang" last="Lin">Wang Lin</name><affiliation><nlm:affiliation>KingMed Virology Diagnostic & Translational Center, China.</nlm:affiliation></affiliation></author><author><name sortKey="Nanshan, Zhong" sort="Nanshan, Zhong" uniqKey="Nanshan Z" first="Zhong" last="Nanshan">Zhong Nanshan</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zifeng, Yang" sort="Zifeng, Yang" uniqKey="Zifeng Y" first="Yang" last="Zifeng">Yang Zifeng</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; KingMed Virology Diagnostic & Translational Center, China. Electronic address: jeffyah@163.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32205232</idno><idno type="pmid">32205232</idno><idno type="doi">10.1016/j.phrs.2020.104761</idno><idno type="wicri:Area/PubMed/Corpus">000059</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).</title><author><name sortKey="Runfeng, Li" sort="Runfeng, Li" uniqKey="Runfeng L" first="Li" last="Runfeng">Li Runfeng</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yunlong, Hou" sort="Yunlong, Hou" uniqKey="Yunlong H" first="Hou" last="Yunlong">Hou Yunlong</name><affiliation><nlm:affiliation>Hebei University of Chinese Medicine, College of Integrated Chinese and Western Medicine, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jicheng, Huang" sort="Jicheng, Huang" uniqKey="Jicheng H" first="Huang" last="Jicheng">Huang Jicheng</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Weiqi, Pan" sort="Weiqi, Pan" uniqKey="Weiqi P" first="Pan" last="Weiqi">Pan Weiqi</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qinhai, Ma" sort="Qinhai, Ma" uniqKey="Qinhai M" first="Ma" last="Qinhai">Ma Qinhai</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yongxia, Shi" sort="Yongxia, Shi" uniqKey="Yongxia S" first="Shi" last="Yongxia">Shi Yongxia</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chufang, Li" sort="Chufang, Li" uniqKey="Chufang L" first="Li" last="Chufang">Li Chufang</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jin, Zhao" sort="Jin, Zhao" uniqKey="Jin Z" first="Zhao" last="Jin">Zhao Jin</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhenhua, Jia" sort="Zhenhua, Jia" uniqKey="Zhenhua J" first="Jia" last="Zhenhua">Jia Zhenhua</name><affiliation><nlm:affiliation>Hebei University of Chinese Medicine, College of Integrated Chinese and Western Medicine, China.</nlm:affiliation></affiliation></author><author><name sortKey="Haiming, Jiang" sort="Haiming, Jiang" uniqKey="Haiming J" first="Jiang" last="Haiming">Jiang Haiming</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kui, Zheng" sort="Kui, Zheng" uniqKey="Kui Z" first="Zheng" last="Kui">Zheng Kui</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shuxiang, Huang" sort="Shuxiang, Huang" uniqKey="Shuxiang H" first="Huang" last="Shuxiang">Huang Shuxiang</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jun, Dai" sort="Jun, Dai" uniqKey="Jun D" first="Dai" last="Jun">Dai Jun</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiaobo, Li" sort="Xiaobo, Li" uniqKey="Xiaobo L" first="Li" last="Xiaobo">Li Xiaobo</name><affiliation><nlm:affiliation>Technology Centre, Guangzhou Customs, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiaotao, Hou" sort="Xiaotao, Hou" uniqKey="Xiaotao H" first="Hou" last="Xiaotao">Hou Xiaotao</name><affiliation><nlm:affiliation>KingMed Virology Diagnostic & Translational Center, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Wang" sort="Lin, Wang" uniqKey="Lin W" first="Wang" last="Lin">Wang Lin</name><affiliation><nlm:affiliation>KingMed Virology Diagnostic & Translational Center, China.</nlm:affiliation></affiliation></author><author><name sortKey="Nanshan, Zhong" sort="Nanshan, Zhong" uniqKey="Nanshan Z" first="Zhong" last="Nanshan">Zhong Nanshan</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zifeng, Yang" sort="Zifeng, Yang" uniqKey="Zifeng Y" first="Yang" last="Zifeng">Yang Zifeng</name><affiliation><nlm:affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; KingMed Virology Diagnostic & Translational Center, China. Electronic address: jeffyah@163.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pharmacological research</title><idno type="eISSN">1096-1186</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32205232</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-1186</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>20</Day></PubDate></JournalIssue><Title>Pharmacological research</Title><ISOAbbreviation>Pharmacol. Res.</ISOAbbreviation></Journal><ArticleTitle>Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).</ArticleTitle><Pagination><MedlinePgn>104761</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1043-6618(20)30743-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.phrs.2020.104761</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The antiviral activity of LH against SARS-CoV-2 was assessed in Vero E6 cells using CPE and plaque reduction assay. The effect of LH on virion morphology was visualized under transmission electron microscope. Pro-inflammatory cytokine expression levels upon SARS-CoV-2 infection in Huh-7 cells were measured by real-time quantitative PCR assays.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">LH significantly inhibited SARS-CoV-2 replication in Vero E6 cells and markedly reduced pro-inflammatory cytokines (TNF-α, IL-6, CCL-2/MCP-1 and CXCL-10/IP-10) production at the mRNA levels. Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">LH significantly inhibits the SARS-COV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro. These findings indicate that LH protects against the virus attack, making its use a novel strategy for controlling the COVID-19 disease.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Runfeng</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yunlong</LastName><ForeName>Hou</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Hebei University of Chinese Medicine, College of Integrated Chinese and Western Medicine, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jicheng</LastName><ForeName>Huang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiqi</LastName><ForeName>Pan</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qinhai</LastName><ForeName>Ma</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yongxia</LastName><ForeName>Shi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chufang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Zhao</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhenhua</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hebei University of Chinese Medicine, College of Integrated Chinese and Western Medicine, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haiming</LastName><ForeName>Jiang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kui</LastName><ForeName>Zheng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shuxiang</LastName><ForeName>Huang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jun</LastName><ForeName>Dai</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiaobo</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Technology Centre, Guangzhou Customs, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiaotao</LastName><ForeName>Hou</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>KingMed Virology Diagnostic & Translational Center, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Wang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>KingMed Virology Diagnostic & Translational Center, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nanshan</LastName><ForeName>Zhong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zifeng</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; KingMed Virology Diagnostic & Translational Center, China. Electronic address: jeffyah@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Pharmacol Res</MedlineTA><NlmUniqueID>8907422</NlmUniqueID><ISSNLinking>1043-6618</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Lianhuaqingwen</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">anti-inflammatory</Keyword><Keyword MajorTopicYN="N">coronavirus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32205232</ArticleId><ArticleId IdType="pii">S1043-6618(20)30743-X</ArticleId><ArticleId IdType="doi">10.1016/j.phrs.2020.104761</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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