Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study.
Identifieur interne : 000B53 ( PubMed/Checkpoint ); précédent : 000B52; suivant : 000B54Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study.
Auteurs : Lisi Deng [République populaire de Chine] ; Chunna Li [République populaire de Chine] ; Qi Zeng [République populaire de Chine] ; Xi Liu [République populaire de Chine] ; Xinghua Li [République populaire de Chine] ; Haitang Zhang [République populaire de Chine] ; Zhongsi Hong [République populaire de Chine] ; Jinyu Xia [République populaire de Chine]Source :
- The Journal of infection [ 1532-2742 ] ; 2020.
Abstract
Corona Virus Disease 2019 (COVID-19) due to the 2019 novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only.
DOI: 10.1016/j.jinf.2020.03.002
PubMed: 32171872
Affiliations:
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<front><div type="abstract" xml:lang="en">Corona Virus Disease 2019 (COVID-19) due to the 2019 novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only.</div>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>23</Day>
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<Day>11</Day>
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<ArticleTitle>Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Corona Virus Disease 2019 (COVID-19) due to the 2019 novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In this retrospective cohort study, we included adults (age≥18years) with laboratory-confirmed COVID-19 without Invasive ventilation, diagnosed between Jan 17, 2020, and Feb 13, 2020. Patients, diagnosed after Jan 17, 2020, were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5-21 days. The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We analyzed 16 patients who received oral arbidol and LPV/r in the combination group and 17 who oral LPV/r only in the monotherapy group, and both initiated after diagnosis. Baseline clinical, laboratory, and chest CT characteristics were similar between groups. The SARS-CoV-2 could not be detected for 12(75%) of 16 patients' nasopharyngeal specimens in the combination group after seven days, compared with 6 (35%) of 17 in the monotherapy group (p < 0·05). After 14 days, 15 (94%) of 16 and 9 (52·9%) of 17, respectively, SARS-CoV-2 could not be detected (p < 0·05). The chest CT scans were improving for 11(69%) of 16 patients in the combination group after seven days, compared with 5(29%) of 17 in the monotherapy group (p < 0·05).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV/r only.</AbstractText>
<CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation>
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<CoiStatement>Declaration of Competing Interest The authors declare no conflict of interest.</CoiStatement>
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