Systematic review of COVID-19 in children show milder cases and a better prognosis than adults.
Identifieur interne : 000289 ( PubMed/Checkpoint ); précédent : 000288; suivant : 000290Systematic review of COVID-19 in children show milder cases and a better prognosis than adults.
Auteurs : Jonas F. Ludvigsson [Suède]Source :
- Acta paediatrica (Oslo, Norway : 1992) [ 1651-2227 ] ; 2020.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognoses in children are rare.
DOI: 10.1111/apa.15270
PubMed: 32202343
Affiliations:
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Ludvigsson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32202343</idno><idno type="pmid">32202343</idno><idno type="doi">10.1111/apa.15270</idno><idno type="wicri:Area/PubMed/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000111</idno><idno type="wicri:Area/PubMed/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000111</idno><idno type="wicri:Area/PubMed/Checkpoint">000289</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000289</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Systematic review of COVID-19 in children show milder cases and a better prognosis than adults.</title><author><name sortKey="Ludvigsson, Jonas F" sort="Ludvigsson, Jonas F" uniqKey="Ludvigsson J" first="Jonas F" last="Ludvigsson">Jonas F. Ludvigsson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">Acta paediatrica (Oslo, Norway : 1992)</title><idno type="eISSN">1651-2227</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognoses in children are rare.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32202343</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1651-2227</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>23</Day></PubDate></JournalIssue><Title>Acta paediatrica (Oslo, Norway : 1992)</Title><ISOAbbreviation>Acta Paediatr.</ISOAbbreviation></Journal><ArticleTitle>Systematic review of COVID-19 in children show milder cases and a better prognosis than adults.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/apa.15270</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognoses in children are rare.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the Medline and EMBASE databases between 1 January and 18 March 2020.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">COVID-19 has occurred in children, but they seemed to have a milder disease course and better prognoses than adults. Deaths were extremely rare.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ludvigsson</LastName><ForeName>Jonas F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, Orebro University Hospital, Orebro, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingha, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Norway</Country><MedlineTA>Acta Paediatr</MedlineTA><NlmUniqueID>9205968</NlmUniqueID><ISSNLinking>0803-5253</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-nCoV</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Children</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">SARS-CoV2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32202343</ArticleId><ArticleId IdType="doi">10.1111/apa.15270</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Ludvigsson, Jonas F" sort="Ludvigsson, Jonas F" uniqKey="Ludvigsson J" first="Jonas F" last="Ludvigsson">Jonas F. 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