Gut microbiome and the risk factors in central nervous system autoimmunity
Identifieur interne : 000A86 ( Pmc/Curation ); précédent : 000A85; suivant : 000A87Gut microbiome and the risk factors in central nervous system autoimmunity
Auteurs : Javier Ochoa-Repáraz ; Lloyd H. KasperSource :
- Febs Letters [ 0014-5793 ] ; 2014.
Abstract
Humans are colonized after birth by microbial organisms that form a heterogeneous community, collectively termed microbiota. The genomic pool of this macro-community is named microbiome. The gut microbiota is essential for the complete development of the immune system, representing a binary network in which the microbiota interact with the host providing important immune and physiologic function and conversely the bacteria protect themselves from host immune defense. Alterations in the balance of the gut microbiome due to a combination of environmental and genetic factors can now be associated with detrimental or protective effects in experimental autoimmune diseases. These gut microbiome alterations can unbalance the gastrointestinal immune responses and influence distal effector sites leading to CNS disease including both demyelination and affective disorders. The current range of risk factors for MS includes genetic makeup and environmental elements. Of interest to this review is the consistency between this range of MS risk factors and the gut microbiome. We postulate that the gut microbiome serves as the niche where different MS risk factors merge, thereby influencing the disease process.
Url:
DOI: 10.1016/j.febslet.2014.09.024
PubMed: 25286403
PubMed Central: 4254300
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gut microbiome and the risk factors in central nervous system autoimmunity</title><author><name sortKey="Ochoa Reparaz, Javier" sort="Ochoa Reparaz, Javier" uniqKey="Ochoa Reparaz J" first="Javier" last="Ochoa-Repáraz">Javier Ochoa-Repáraz</name></author><author><name sortKey="Kasper, Lloyd H" sort="Kasper, Lloyd H" uniqKey="Kasper L" first="Lloyd H." last="Kasper">Lloyd H. Kasper</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25286403</idno><idno type="pmc">4254300</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254300</idno><idno type="RBID">PMC:4254300</idno><idno type="doi">10.1016/j.febslet.2014.09.024</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000A86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A86</idno><idno type="wicri:Area/Pmc/Curation">000A86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gut microbiome and the risk factors in central nervous system autoimmunity</title><author><name sortKey="Ochoa Reparaz, Javier" sort="Ochoa Reparaz, Javier" uniqKey="Ochoa Reparaz J" first="Javier" last="Ochoa-Repáraz">Javier Ochoa-Repáraz</name></author><author><name sortKey="Kasper, Lloyd H" sort="Kasper, Lloyd H" uniqKey="Kasper L" first="Lloyd H." last="Kasper">Lloyd H. Kasper</name></author></analytic><series><title level="j">Febs Letters</title><idno type="ISSN">0014-5793</idno><idno type="eISSN">1873-3468</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Humans are colonized after birth by microbial organisms that form a heterogeneous community, collectively termed microbiota. The genomic pool of this macro-community is named microbiome. The gut microbiota is essential for the complete development of the immune system, representing a binary network in which the microbiota interact with the host providing important immune and physiologic function and conversely the bacteria protect themselves from host immune defense. Alterations in the balance of the gut microbiome due to a combination of environmental and genetic factors can now be associated with detrimental or protective effects in experimental autoimmune diseases. These gut microbiome alterations can unbalance the gastrointestinal immune responses and influence distal effector sites leading to CNS disease including both demyelination and affective disorders. The current range of risk factors for MS includes genetic makeup and environmental elements. Of interest to this review is the consistency between this range of MS risk factors and the gut microbiome. We postulate that the gut microbiome serves as the niche where different MS risk factors merge, thereby influencing the disease process.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gandhi, R" uniqKey="Gandhi R">R. Gandhi</name></author><author><name sortKey="Laroni, A" uniqKey="Laroni A">A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">FEBS Lett</journal-id><journal-id journal-id-type="iso-abbrev">FEBS Lett</journal-id><journal-title-group><journal-title>Febs Letters</journal-title></journal-title-group><issn pub-type="ppub">0014-5793</issn><issn pub-type="epub">1873-3468</issn><publisher><publisher-name>John Wiley & Sons Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25286403</article-id><article-id pub-id-type="pmc">4254300</article-id><article-id pub-id-type="publisher-id">S0014-5793(14)00701-7</article-id><article-id pub-id-type="doi">10.1016/j.febslet.2014.09.024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Gut microbiome and the risk factors in central nervous system autoimmunity</article-title></title-group><contrib-group><contrib contrib-type="author" id="au005"><name><surname>Ochoa-Repáraz</surname><given-names>Javier</given-names></name><email>Javier.Ochoa-Reparaz@Dartmouth.edu</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="au010"><name><surname>Kasper</surname><given-names>Lloyd H.</given-names></name></contrib></contrib-group><aff id="af005">Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. <email>Javier.Ochoa-Reparaz@Dartmouth.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>5</day><month>10</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>17</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>5</day><month>10</month><year>2014</year></pub-date><volume>588</volume><issue>22</issue><fpage>4214</fpage><lpage>4222</lpage><history><date date-type="received"><day>15</day><month>8</month><year>2014</year></date><date date-type="rev-recd"><day>16</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>16</day><month>9</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Federation of European Biochemical Societies</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab005"><p>Humans are colonized after birth by microbial organisms that form a heterogeneous community, collectively termed microbiota. The genomic pool of this macro-community is named microbiome. The gut microbiota is essential for the complete development of the immune system, representing a binary network in which the microbiota interact with the host providing important immune and physiologic function and conversely the bacteria protect themselves from host immune defense. Alterations in the balance of the gut microbiome due to a combination of environmental and genetic factors can now be associated with detrimental or protective effects in experimental autoimmune diseases. These gut microbiome alterations can unbalance the gastrointestinal immune responses and influence distal effector sites leading to CNS disease including both demyelination and affective disorders. The current range of risk factors for MS includes genetic makeup and environmental elements. Of interest to this review is the consistency between this range of MS risk factors and the gut microbiome. We postulate that the gut microbiome serves as the niche where different MS risk factors merge, thereby influencing the disease process.</p></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>Risk factor</kwd><kwd>Autoimmunity</kwd><kwd>CNS</kwd><kwd>Gut</kwd><kwd>Microbiome</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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