Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity††Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00508g
Identifieur interne : 000955 ( Pmc/Curation ); précédent : 000954; suivant : 000956Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity††Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00508g
Auteurs : Ana C. S. Gondim [Brésil] ; Suzete Roberta Da Silva [Brésil] ; Leen Mathys ; Sam Noppen ; Sandra Liekens ; Alexandre Holanda Sampaio [Brésil] ; Celso S. Nagano [Brésil] ; Cintia Renata Costa Rocha [Brésil] ; Kyria S. Nascimento ; Benildo S. Cavada ; Peter J. Sadler ; Jan BalzariniSource :
- MedChemComm [ 2040-2503 ] ; 2019.
Abstract
Brazilian legumes and algae contain potent antiviral lectins.
Url:
DOI: 10.1039/c8md00508g
PubMed: 30996857
PubMed Central: 6430086
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity<xref ref-type="fn" rid="fn1">†</xref><fn id="fn1"><p>†Electronic supplementary information (ESI) available. See DOI: <uri xlink:type="simple" xlink:href="https://doi.org/10.1039/c8md00508g">10.1039/c8md00508g</uri></p></fn></title><author><name sortKey="Gondim, Ana C S" sort="Gondim, Ana C S" uniqKey="Gondim A" first="Ana C. S." last="Gondim">Ana C. S. Gondim</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation><affiliation><nlm:aff id="affb"> Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email:<email>P.J.Sadler@warwick.ac.uk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="affc"> Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Roberta Da Silva, Suzete" sort="Roberta Da Silva, Suzete" uniqKey="Roberta Da Silva S" first="Suzete" last="Roberta Da Silva">Suzete Roberta Da Silva</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="affg"> Para West Federal University , 68220-000 , Monte Alegre , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Para West Federal University , 68220-000 , Monte Alegre </wicri:regionArea></affiliation></author><author><name sortKey="Mathys, Leen" sort="Mathys, Leen" uniqKey="Mathys L" first="Leen" last="Mathys">Leen Mathys</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Noppen, Sam" sort="Noppen, Sam" uniqKey="Noppen S" first="Sam" last="Noppen">Sam Noppen</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Liekens, Sandra" sort="Liekens, Sandra" uniqKey="Liekens S" first="Sandra" last="Liekens">Sandra Liekens</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Holanda Sampaio, Alexandre" sort="Holanda Sampaio, Alexandre" uniqKey="Holanda Sampaio A" first="Alexandre" last="Holanda Sampaio">Alexandre Holanda Sampaio</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Nagano, Celso S" sort="Nagano, Celso S" uniqKey="Nagano C" first="Celso S." last="Nagano">Celso S. Nagano</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Renata Costa Rocha, Cintia" sort="Renata Costa Rocha, Cintia" uniqKey="Renata Costa Rocha C" first="Cintia" last="Renata Costa Rocha">Cintia Renata Costa Rocha</name><affiliation wicri:level="1"><nlm:aff id="afff"> Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco </wicri:regionArea></affiliation></author><author><name sortKey="Nascimento, Kyria S" sort="Nascimento, Kyria S" uniqKey="Nascimento K" first="Kyria S." last="Nascimento">Kyria S. Nascimento</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Cavada, Benildo S" sort="Cavada, Benildo S" uniqKey="Cavada B" first="Benildo S." last="Cavada">Benildo S. Cavada</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Sadler, Peter J" sort="Sadler, Peter J" uniqKey="Sadler P" first="Peter J." last="Sadler">Peter J. Sadler</name><affiliation><nlm:aff id="affb"> Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email:<email>P.J.Sadler@warwick.ac.uk</email></nlm:aff></affiliation></author><author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . 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See DOI: <uri xlink:type="simple" xlink:href="https://doi.org/10.1039/c8md00508g">10.1039/c8md00508g</uri></p></fn></title><author><name sortKey="Gondim, Ana C S" sort="Gondim, Ana C S" uniqKey="Gondim A" first="Ana C. S." last="Gondim">Ana C. S. Gondim</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation><affiliation><nlm:aff id="affb"> Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email:<email>P.J.Sadler@warwick.ac.uk</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="affc"> Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Roberta Da Silva, Suzete" sort="Roberta Da Silva, Suzete" uniqKey="Roberta Da Silva S" first="Suzete" last="Roberta Da Silva">Suzete Roberta Da Silva</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="affg"> Para West Federal University , 68220-000 , Monte Alegre , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Para West Federal University , 68220-000 , Monte Alegre </wicri:regionArea></affiliation></author><author><name sortKey="Mathys, Leen" sort="Mathys, Leen" uniqKey="Mathys L" first="Leen" last="Mathys">Leen Mathys</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Noppen, Sam" sort="Noppen, Sam" uniqKey="Noppen S" first="Sam" last="Noppen">Sam Noppen</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Liekens, Sandra" sort="Liekens, Sandra" uniqKey="Liekens S" first="Sandra" last="Liekens">Sandra Liekens</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author><author><name sortKey="Holanda Sampaio, Alexandre" sort="Holanda Sampaio, Alexandre" uniqKey="Holanda Sampaio A" first="Alexandre" last="Holanda Sampaio">Alexandre Holanda Sampaio</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Nagano, Celso S" sort="Nagano, Celso S" uniqKey="Nagano C" first="Celso S." last="Nagano">Celso S. Nagano</name><affiliation wicri:level="1"><nlm:aff id="affd"> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará </wicri:regionArea></affiliation></author><author><name sortKey="Renata Costa Rocha, Cintia" sort="Renata Costa Rocha, Cintia" uniqKey="Renata Costa Rocha C" first="Cintia" last="Renata Costa Rocha">Cintia Renata Costa Rocha</name><affiliation wicri:level="1"><nlm:aff id="afff"> Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea> Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco </wicri:regionArea></affiliation></author><author><name sortKey="Nascimento, Kyria S" sort="Nascimento, Kyria S" uniqKey="Nascimento K" first="Kyria S." last="Nascimento">Kyria S. Nascimento</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Cavada, Benildo S" sort="Cavada, Benildo S" uniqKey="Cavada B" first="Benildo S." last="Cavada">Benildo S. Cavada</name><affiliation><nlm:aff id="affa"> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Sadler, Peter J" sort="Sadler, Peter J" uniqKey="Sadler P" first="Peter J." last="Sadler">Peter J. Sadler</name><affiliation><nlm:aff id="affb"> Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email:<email>P.J.Sadler@warwick.ac.uk</email></nlm:aff></affiliation></author><author><name sortKey="Balzarini, Jan" sort="Balzarini, Jan" uniqKey="Balzarini J" first="Jan" last="Balzarini">Jan Balzarini</name><affiliation><nlm:aff id="affe"> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></nlm:aff></affiliation></author></analytic><series><title level="j">MedChemComm</title><idno type="ISSN">2040-2503</idno><idno type="eISSN">2040-2511</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><graphic xlink:href="c8md00508g-ga.jpg" id="ga" position="float" orientation="portrait"></graphic>Brazilian legumes and algae contain potent antiviral lectins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gondim, A C S" uniqKey="Gondim A">A. C. S. Gondim</name></author><author><name sortKey="Romero Canelon, I" uniqKey="Romero Canelon I">I. Romero-Canelon</name></author><author><name sortKey="Sousa, E H S" uniqKey="Sousa E">E. H. S. Sousa</name></author><author><name sortKey="Blindauer, C A" uniqKey="Blindauer C">C. A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Medchemcomm</journal-id><journal-id journal-id-type="iso-abbrev">Medchemcomm</journal-id><journal-title-group><journal-title>MedChemComm</journal-title></journal-title-group><issn pub-type="ppub">2040-2503</issn><issn pub-type="epub">2040-2511</issn><publisher><publisher-name>Royal Society of Chemistry</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30996857</article-id><article-id pub-id-type="pmc">6430086</article-id><article-id pub-id-type="publisher-id">c8md00508g</article-id><article-id pub-id-type="doi">10.1039/c8md00508g</article-id><article-categories><subj-group subj-group-type="heading"><subject>Chemistry</subject></subj-group></article-categories><title-group><article-title>Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity<xref ref-type="fn" rid="fn1">†</xref><fn id="fn1"><p>†Electronic supplementary information (ESI) available. See DOI: <uri xlink:type="simple" xlink:href="https://doi.org/10.1039/c8md00508g">10.1039/c8md00508g</uri></p></fn></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gondim</surname><given-names>Ana C. S.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-3526-1203</contrib-id><xref ref-type="aff" rid="affa">a</xref><xref ref-type="aff" rid="affb">b</xref><xref ref-type="aff" rid="affc">c</xref><xref ref-type="author-notes" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Roberta da Silva</surname><given-names>Suzete</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-6254-1975</contrib-id><xref ref-type="aff" rid="affd">d</xref><xref ref-type="aff" rid="affg">g</xref></contrib><contrib contrib-type="author"><name><surname>Mathys</surname><given-names>Leen</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5123-8751</contrib-id><xref ref-type="aff" rid="affe">e</xref><xref ref-type="author-notes" rid="fn3">§</xref></contrib><contrib contrib-type="author"><name><surname>Noppen</surname><given-names>Sam</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-2831-5042</contrib-id><xref ref-type="aff" rid="affe">e</xref></contrib><contrib contrib-type="author"><name><surname>Liekens</surname><given-names>Sandra</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3529-8121</contrib-id><xref ref-type="aff" rid="affe">e</xref></contrib><contrib contrib-type="author"><name><surname>Holanda Sampaio</surname><given-names>Alexandre</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-3871-0502</contrib-id><xref ref-type="aff" rid="affd">d</xref></contrib><contrib contrib-type="author"><name><surname>Nagano</surname><given-names>Celso S.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-5988-5868</contrib-id><xref ref-type="aff" rid="affd">d</xref></contrib><contrib contrib-type="author"><name><surname>Renata Costa Rocha</surname><given-names>Cintia</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3366-3615</contrib-id><xref ref-type="aff" rid="afff">f</xref></contrib><contrib contrib-type="author"><name><surname>Nascimento</surname><given-names>Kyria S.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-2220-4552</contrib-id><xref ref-type="aff" rid="affa">a</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Cavada</surname><given-names>Benildo S.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5791-6170</contrib-id><xref ref-type="aff" rid="affa">a</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Sadler</surname><given-names>Peter J.</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-9160-1941</contrib-id><xref ref-type="aff" rid="affb">b</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Balzarini</surname><given-names>Jan</given-names></name><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-1144-1808</contrib-id><xref ref-type="aff" rid="affe">e</xref></contrib></contrib-group><aff id="affa"><label>a</label> Department of Biochemistry and Molecular Biology , Federal University of Ceará , 60455-760 , Fortaleza , Ceará , Brazil . Email:<email>bscavada@gmail.com</email></aff><aff id="affb"><label>b</label> Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK . Email:<email>P.J.Sadler@warwick.ac.uk</email></aff><aff id="affc"><label>c</label> Department of Organic and Inorganic Chemistry , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</aff><aff id="affd"><label>d</label> Department of Fishing and Engineering , Federal University of Ceará , 60455-900 , Fortaleza , Ceará , Brazil</aff><aff id="affe"><label>e</label> Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:<email>jan.balzarini@kuleuven.be</email></aff><aff id="afff"><label>f</label> Biochemistry Department , LINKA/UFPE , CEP 50670-901 , Recife , Pernambuco , Brazil</aff><aff id="affg"><label>g</label> Para West Federal University , 68220-000 , Monte Alegre , Brazil</aff><author-notes><fn id="fn2"><p>‡Current address: Department of Organic and Inorganic Chemistry, Federal University of Ceará, 60455-900, Fortaleza, Ceará, Brazil.</p></fn><fn id="fn3"><p>§Current address: Janssen Pharmaceutica, 2340 Beerse, Belgium.</p></fn></author-notes><pub-date pub-type="epub"><day>14</day><month>1</month><year>2019</year></pub-date><pub-date pub-type="collection"><day>1</day><month>3</month><year>2019</year></pub-date><volume>10</volume><issue>3</issue><fpage>390</fpage><lpage>398</lpage><history><date date-type="received"><day>8</day><month>10</month><year>2018</year></date><date date-type="accepted"><day>11</day><month>12</month><year>2018</year></date></history><permissions><copyright-statement>This journal is © The Royal Society of Chemistry 2019</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)</license-p></license></permissions><abstract abstract-type="toc"><p><graphic xlink:href="c8md00508g-ga.jpg" id="ga" position="float" orientation="portrait"></graphic>Brazilian legumes and algae contain potent antiviral lectins.</p></abstract><abstract><p>Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: <italic>Canavalia brasiliensis</italic> (ConBr), <italic>C. maritima</italic> (ConM), <italic>Dioclea lasiocarpa</italic> (DLasiL) and <italic>D. sclerocarpa</italic> (DSclerL), and algae <italic>Amansia multifida</italic> (AML), <italic>Bryothamniom seaforthii</italic> (BSL), <italic>Hypnea musciformis</italic> (HML), <italic>Meristiella echinocarpa</italic> (MEL) and <italic>Solieria filiformis</italic> (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC<sub>50</sub> values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC<sub>50</sub> of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC<sub>50</sub> values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC<sub>50</sub> values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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