Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012
Identifieur interne : 000792 ( Pmc/Curation ); précédent : 000791; suivant : 000793Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012
Auteurs : N. Khuri-Bulos [États-Unis, Jordanie] ; D. C. Payne [États-Unis] ; X. Lu [États-Unis] ; D. Erdman [États-Unis] ; L. Wang [États-Unis] ; S. Faouri [Jordanie] ; A. Shehabi [Jordanie] ; M. Johnson [États-Unis] ; M. M. Becker [États-Unis] ; M. R. Denison [États-Unis] ; J. V. Williams [États-Unis] ; N. B. Halasa [États-Unis]Source :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1198-743X ] ; 2013.
Abstract
Hospitalized children < 2 years of age in Amman, Jordan, admitted for fever and/or respiratory symptoms, were tested for Middle East respiratory syndrome coronavirus (MERS-CoV): MERS-CoV by real-time RT-PCR (rRT-PCR). This was a prospective year-round viral surveillance study in children <2 years of age admitted with acute respiratory symptoms and/or fever from March 2010 to September 2012 and enrolled from a government-run hospital, Al-Bashir in Amman, Jordan. Clinical and demographic data, including antibiotic use, were collected. Combined nasal/throat swabs were collected, aliquoted, and frozen at −80°C. Specimen aliquots were shipped to Vanderbilt University and the Centers for Disease Control and Prevention (CDC), and tested by rRT-PCR for MERS-CoV. Of the 2433 subjects enrolled from 16 March 2010 to 10 September 2012, 2427 subjects had viral testing and clinical data. Of 1898 specimens prospectively tested for other viruses between 16 March 2010 and 18 March 2012, 474 samples did not have other common respiratory viruses detected. These samples were tested at CDC for MERS-CoV and all were negative by rRT-PCR for MERS-CoV. Of the remaining 531 samples, collected from 19 March 2012 to 10 September 2012 and tested at Vanderbilt, none were positive for MERS-CoV. Our negative findings from a large sample of young Jordanian children hospitalized with fever and/or respiratory symptoms suggest that MERS-CoV was not widely circulating in Amman, Jordan, during the 30-month period of prospective, active surveillance occurring before and after the first documented MERS-CoV outbreak in the Middle East region.
Url:
DOI: 10.1111/1469-0691.12438
PubMed: 24313317
PubMed Central: 4618562
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<front><div type="abstract" xml:lang="en"><p id="P1">Hospitalized children < 2 years of age in Amman, Jordan, admitted for fever and/or respiratory symptoms, were tested for Middle East respiratory syndrome coronavirus (MERS-CoV): MERS-CoV by real-time RT-PCR (rRT-PCR). This was a prospective year-round viral surveillance study in children <2 years of age admitted with acute respiratory symptoms and/or fever from March 2010 to September 2012 and enrolled from a government-run hospital, Al-Bashir in Amman, Jordan. Clinical and demographic data, including antibiotic use, were collected. Combined nasal/throat swabs were collected, aliquoted, and frozen at −80°C. Specimen aliquots were shipped to Vanderbilt University and the Centers for Disease Control and Prevention (CDC), and tested by rRT-PCR for MERS-CoV. Of the 2433 subjects enrolled from 16 March 2010 to 10 September 2012, 2427 subjects had viral testing and clinical data. Of 1898 specimens prospectively tested for other viruses between 16 March 2010 and 18 March 2012, 474 samples did not have other common respiratory viruses detected. These samples were tested at CDC for MERS-CoV and all were negative by rRT-PCR for MERS-CoV. Of the remaining 531 samples, collected from 19 March 2012 to 10 September 2012 and tested at Vanderbilt, none were positive for MERS-CoV. Our negative findings from a large sample of young Jordanian children hospitalized with fever and/or respiratory symptoms suggest that MERS-CoV was not widely circulating in Amman, Jordan, during the 30-month period of prospective, active surveillance occurring before and after the first documented MERS-CoV outbreak in the Middle East region.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Khuri-Bulos</surname>
<given-names>N.</given-names>
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<xref rid="FN2" ref-type="author-notes">*</xref>
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<aff id="A1"><label>1</label>
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA</aff>
<aff id="A2"><label>2</label>
Department of Pediatrics, The Jordan University, Amman, Jordan</aff>
<aff id="A3"><label>3</label>
Centers for Disease Control and Prevention, Atlanta, GA</aff>
<aff id="A4"><label>4</label>
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA</aff>
<aff id="A5"><label>5</label>
Al Basheer, Amman, Jordan</aff>
<aff id="A6"><label>6</label>
Department of Microbiology, The Jordan University, Amman, Jordan</aff>
<author-notes><corresp id="FN1">Corresponding author: N. Halasa, Pediatric Infectious Diseases, 1161 21st Ave South, D7232 MCN, Nashville, TN 37232, USA, <email>natasha.halasa@vanderbilt.edu</email>
</corresp>
<fn id="FN2"><label>*</label>
<p>This article was amended on 12/12/2013 after initial online publication 09/12/2013. The author X. Lu was incorrectly cited as L. Xiaoyan.</p>
</fn>
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<pub-date pub-type="nihms-submitted"><day>24</day>
<month>9</month>
<year>2015</year>
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<pub-date pub-type="epub"><day>09</day>
<month>12</month>
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<pub-date pub-type="ppub"><month>7</month>
<year>2014</year>
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<month>10</month>
<year>2015</year>
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<volume>20</volume>
<issue>7</issue>
<fpage>678</fpage>
<lpage>682</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/1469-0691.12438</pmc-comment>
<abstract><p id="P1">Hospitalized children < 2 years of age in Amman, Jordan, admitted for fever and/or respiratory symptoms, were tested for Middle East respiratory syndrome coronavirus (MERS-CoV): MERS-CoV by real-time RT-PCR (rRT-PCR). This was a prospective year-round viral surveillance study in children <2 years of age admitted with acute respiratory symptoms and/or fever from March 2010 to September 2012 and enrolled from a government-run hospital, Al-Bashir in Amman, Jordan. Clinical and demographic data, including antibiotic use, were collected. Combined nasal/throat swabs were collected, aliquoted, and frozen at −80°C. Specimen aliquots were shipped to Vanderbilt University and the Centers for Disease Control and Prevention (CDC), and tested by rRT-PCR for MERS-CoV. Of the 2433 subjects enrolled from 16 March 2010 to 10 September 2012, 2427 subjects had viral testing and clinical data. Of 1898 specimens prospectively tested for other viruses between 16 March 2010 and 18 March 2012, 474 samples did not have other common respiratory viruses detected. These samples were tested at CDC for MERS-CoV and all were negative by rRT-PCR for MERS-CoV. Of the remaining 531 samples, collected from 19 March 2012 to 10 September 2012 and tested at Vanderbilt, none were positive for MERS-CoV. Our negative findings from a large sample of young Jordanian children hospitalized with fever and/or respiratory symptoms suggest that MERS-CoV was not widely circulating in Amman, Jordan, during the 30-month period of prospective, active surveillance occurring before and after the first documented MERS-CoV outbreak in the Middle East region.</p>
</abstract>
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