Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
Identifieur interne : 000323 ( Pmc/Curation ); précédent : 000322; suivant : 000324Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
Auteurs : Yingxia Liu [République populaire de Chine] ; Yang Yang [République populaire de Chine] ; Cong Zhang [République populaire de Chine] ; Fengming Huang [République populaire de Chine] ; Fuxiang Wang [République populaire de Chine] ; Jing Yuan [République populaire de Chine] ; Zhaoqin Wang [République populaire de Chine] ; Jinxiu Li [République populaire de Chine] ; Jianming Li [République populaire de Chine] ; Cheng Feng [République populaire de Chine] ; Zheng Zhang [République populaire de Chine] ; Lifei Wang [République populaire de Chine] ; Ling Peng [République populaire de Chine] ; Li Chen [République populaire de Chine] ; Yuhao Qin [République populaire de Chine] ; Dandan Zhao [République populaire de Chine] ; Shuguang Tan [République populaire de Chine] ; Lu Yin [République populaire de Chine] ; Jun Xu [République populaire de Chine] ; Congzhao Zhou [République populaire de Chine] ; Chengyu Jiang [République populaire de Chine] ; Lei Liu [République populaire de Chine]Source :
- Science China. Life Sciences [ 1674-7305 ] ; 2020.
Abstract
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.
Supplementary material is available for this article at 10.1007/s11427-020-1643-8 and is accessible for authorized users.
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DOI: 10.1007/s11427-020-1643-8
PubMed: 32048163
PubMed Central: 7088566
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institution-id-type="ISNI">0000000121679639</institution-id><institution>Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,</institution><institution>University of Science and Technology of China,</institution></institution-wrap>Hefei, 230027 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hefei</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Lei" sort="Liu, Lei" uniqKey="Liu L" first="Lei" last="Liu">Lei Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno 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institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Cong" sort="Zhang, Cong" uniqKey="Zhang C" first="Cong" last="Zhang">Cong Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.59053.3a</institution-id><institution-id institution-id-type="ISNI">0000000121679639</institution-id><institution>Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,</institution><institution>University of Science and Technology of China,</institution></institution-wrap>Hefei, 230027 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hefei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Fengming" sort="Huang, Fengming" uniqKey="Huang F" first="Fengming" last="Huang">Fengming Huang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Fuxiang" sort="Wang, Fuxiang" uniqKey="Wang F" first="Fuxiang" last="Wang">Fuxiang Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Jing" sort="Yuan, Jing" uniqKey="Yuan J" first="Jing" last="Yuan">Jing Yuan</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Zhaoqin" sort="Wang, Zhaoqin" uniqKey="Wang Z" first="Zhaoqin" last="Wang">Zhaoqin Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jianming" sort="Li, Jianming" uniqKey="Li J" first="Jianming" last="Li">Jianming Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Cheng" sort="Feng, Cheng" uniqKey="Feng C" first="Cheng" last="Feng">Cheng Feng</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Lifei" sort="Wang, Lifei" uniqKey="Wang L" first="Lifei" last="Wang">Lifei Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Peng, Ling" sort="Peng, Ling" uniqKey="Peng L" first="Ling" last="Peng">Ling Peng</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li" sort="Chen, Li" uniqKey="Chen L" first="Li" last="Chen">Li Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Yuhao" sort="Qin, Yuhao" uniqKey="Qin Y" first="Yuhao" last="Qin">Yuhao Qin</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Dandan" sort="Zhao, Dandan" uniqKey="Zhao D" first="Dandan" last="Zhao">Dandan Zhao</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Shuguang" sort="Tan, Shuguang" uniqKey="Tan S" first="Shuguang" last="Tan">Shuguang Tan</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Lu" sort="Yin, Lu" uniqKey="Yin L" first="Lu" last="Yin">Lu Yin</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.413106.1</institution-id><institution-id institution-id-type="ISNI">0000 0000 9889 6335</institution-id><institution>Emergence Department Peking Union Medical College Hospital,</institution></institution-wrap>Beijing, 100731 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Jun" sort="Xu, Jun" uniqKey="Xu J" first="Jun" last="Xu">Jun Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.413106.1</institution-id><institution-id institution-id-type="ISNI">0000 0000 9889 6335</institution-id><institution>Emergence Department Peking Union Medical College Hospital,</institution></institution-wrap>Beijing, 100731 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Congzhao" sort="Zhou, Congzhao" uniqKey="Zhou C" first="Congzhao" last="Zhou">Congzhao Zhou</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.59053.3a</institution-id><institution-id institution-id-type="ISNI">0000000121679639</institution-id><institution>Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,</institution><institution>University of Science and Technology of China,</institution></institution-wrap>Hefei, 230027 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hefei</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Chengyu" sort="Jiang, Chengyu" uniqKey="Jiang C" first="Chengyu" last="Jiang">Chengyu Jiang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Lei" sort="Liu, Lei" uniqKey="Liu L" first="Lei" last="Liu">Lei Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen</wicri:regionArea></affiliation></author></analytic><series><title level="j">Science China. Life Sciences</title><idno type="ISSN">1674-7305</idno><idno type="eISSN">1869-1889</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.</p><sec><title>Electronic Supplementary Material</title><p>Supplementary material is available for this article at 10.1007/s11427-020-1643-8 and is accessible for authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bi, Y" uniqKey="Bi Y">Y Bi</name></author><author><name sortKey="Tan, S" uniqKey="Tan S">S Tan</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci China Life Sci</journal-id><journal-id journal-id-type="iso-abbrev">Sci China Life Sci</journal-id><journal-title-group><journal-title>Science China. Life Sciences</journal-title></journal-title-group><issn pub-type="ppub">1674-7305</issn><issn pub-type="epub">1869-1889</issn><publisher><publisher-name>Science China Press</publisher-name><publisher-loc>Beijing</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32048163</article-id><article-id pub-id-type="pmc">7088566</article-id><article-id pub-id-type="publisher-id">1643</article-id><article-id pub-id-type="doi">10.1007/s11427-020-1643-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name><surname>Liu</surname><given-names>Yingxia</given-names></name><address><email>yingxialiu@hotmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Yang</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zhang</surname><given-names>Cong</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Huang</surname><given-names>Fengming</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Fuxiang</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Zhaoqin</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jinxiu</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jianming</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Cheng</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Zheng</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Lifei</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Peng</surname><given-names>Ling</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Qin</surname><given-names>Yuhao</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Dandan</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Shuguang</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Lu</given-names></name><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Congzhao</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jiang</surname><given-names>Chengyu</given-names></name><address><email>jiang@pumc.edu.cn</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Liu</surname><given-names>Lei</given-names></name><address><email>liulei3322@aliyun.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.410741.7</institution-id><institution>Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease,</institution><institution>Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology,</institution></institution-wrap>Shenzhen, 518112 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.59053.3a</institution-id><institution-id institution-id-type="ISNI">0000000121679639</institution-id><institution>Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,</institution><institution>University of Science and Technology of China,</institution></institution-wrap>Hefei, 230027 China</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.12527.33</institution-id><institution-id institution-id-type="ISNI">0000 0001 0662 3178</institution-id><institution>State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry,</institution><institution>Peking Union Medical College,</institution></institution-wrap>Beijing, 100005 China</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.9227.e</institution-id><institution-id institution-id-type="ISNI">0000000119573309</institution-id><institution>Institute of Microbiology,</institution><institution>Chinese Academy of Sciences,</institution></institution-wrap>Beijing, 100101 China</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.413106.1</institution-id><institution-id institution-id-type="ISNI">0000 0000 9889 6335</institution-id><institution>Emergence Department Peking Union Medical College Hospital,</institution></institution-wrap>Beijing, 100731 China</aff></contrib-group><pub-date pub-type="epub"><day>9</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="ppub"><year>2020</year></pub-date><volume>63</volume><issue>3</issue><fpage>364</fpage><lpage>374</lpage><history><date date-type="received"><day>5</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>8</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.</p><sec><title>Electronic Supplementary Material</title><p>Supplementary material is available for this article at 10.1007/s11427-020-1643-8 and is accessible for authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>2019-nCoV</kwd><kwd>Angiotensin II</kwd><kwd>ARDS</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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