Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea
Identifieur interne : 000178 ( Pmc/Curation ); précédent : 000177; suivant : 000179Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea
Auteurs : Jianping Sha [République populaire de Chine] ; Yuan Li [République populaire de Chine] ; Xiaowen Chen [République populaire de Chine] ; Yan Hu [République populaire de Chine] ; Yajin Ren [République populaire de Chine] ; Xingyi Geng ; Zhiruo Zhang [République populaire de Chine] ; Shelan LiuSource :
- Archives of Virology [ 0304-8608 ] ; 2016.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012. The largest known outbreak outside the Middle East occurred in South Korea in 2015. As of 29 June 2016, 1769 laboratory-confirmed cases (630 deaths; 35.6 % case fatality rate [CFR]) had been reported from 26 countries, particularly in the Middle East. However, the CFR for hospital outbreaks was higher than that of family clusters in the Middle East and Korea. Here, we compared the mortality rates for 51 nosocomial outbreaks in the Middle East and one outbreak of MERS-CoV in South Korea. Our findings showed the CFR in the Middle East was much higher than that in South Korea (25.9 % [56/216] vs. 13.8 % [24/174],
The online version of this article (doi:10.1007/s00705-016-3062-x) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00705-016-3062-x
PubMed: 27664026
PubMed Central: 7087023
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Xingyi Geng<affiliation><nlm:aff id="Aff4">Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province China</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012. The largest known outbreak outside the Middle East occurred in South Korea in 2015. As of 29 June 2016, 1769 laboratory-confirmed cases (630 deaths; 35.6 % case fatality rate [CFR]) had been reported from 26 countries, particularly in the Middle East. However, the CFR for hospital outbreaks was higher than that of family clusters in the Middle East and Korea. Here, we compared the mortality rates for 51 nosocomial outbreaks in the Middle East and one outbreak of MERS-CoV in South Korea. Our findings showed the CFR in the Middle East was much higher than that in South Korea (25.9 % [56/216] vs. 13.8 % [24/174], <italic>p</italic>
= 0.003). Infected individuals who died were, on average, older than those who survived in both the Middle East (64 years [25–98] vs. 46 years [2–85], <italic>p</italic>
= 0.000) and South Korea (68 years [49–82] vs. 53.5 years [16–87], <italic>p</italic>
= 0.000). Similarly, the co-morbidity rates for the fatal cases were statistically higher than for the nonfatal cases in both the Middle East (64.3 % [36/56] vs. 28.1 % [45/160], <italic>p</italic>
= 0.000) and South Korea (45.8 % [11/24] vs. 12.0 % [18/150], <italic>p</italic>
= 0.000). The median number of days from onset to confirmation of infection in the fatal cases was longer than that for survivors from the Middle East (8 days [1–47] vs. 4 days [0–14], <italic>p</italic>
= 0.009). Thus, older age, pre-existing concurrent diseases, and delayed confirmation increase the odds of a fatal outcome in nosocomial MERS-CoV outbreaks in the Middle East and South Korea.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s00705-016-3062-x) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Arch Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">Arch. Virol</journal-id>
<journal-title-group><journal-title>Archives of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0304-8608</issn>
<issn pub-type="epub">1432-8798</issn>
<publisher><publisher-name>Springer Vienna</publisher-name>
<publisher-loc>Vienna</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27664026</article-id>
<article-id pub-id-type="pmc">7087023</article-id>
<article-id pub-id-type="publisher-id">3062</article-id>
<article-id pub-id-type="doi">10.1007/s00705-016-3062-x</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Sha</surname>
<given-names>Jianping</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Li</surname>
<given-names>Yuan</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Chen</surname>
<given-names>Xiaowen</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hu</surname>
<given-names>Yan</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ren</surname>
<given-names>Yajin</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Geng</surname>
<given-names>Xingyi</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zhang</surname>
<given-names>Zhiruo</given-names>
</name>
<address><phone>(+86) 15618977655</phone>
<email>zhangzhiruo@sjtu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Liu</surname>
<given-names>Shelan</given-names>
</name>
<address><phone>(+86) 571-87115137</phone>
<email>liushelan@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Endocrinology, The 421 Hospital of Chinese People’s Liberation Army, Guangzhou, China</aff>
<aff id="Aff2"><label>2</label>
Emergency Offices, Baoan District Centre for Disease Control and Prevention, Shenzhen, China</aff>
<aff id="Aff3"><label>3</label>
Department of Senior Cadres, The 421 Hospital of the Chinese People’s Liberation Army, Guangzhou, China</aff>
<aff id="Aff4"><label>4</label>
Emergency Offices, Jinan Centre for Disease Control and Prevention, Jinan, Shandong Province China</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.415869.7</institution-id>
<institution>School of Public Health,</institution>
<institution>Shanghai Jiaotong University School of Medicine,</institution>
</institution-wrap>
227 Chongqing South Road, Shanghai, 200025 China</aff>
<aff id="Aff6"><label>6</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.198530.6</institution-id>
<institution-id institution-id-type="ISNI">0000000088032373</institution-id>
<institution>Department of Infectious Diseases,</institution>
<institution>Zhejiang Provincial Centre for Disease Control and Prevention,</institution>
</institution-wrap>
3399 Binsheng Road, Binjiang District, Hangzhou, 310051 Zhejiang Province China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>23</day>
<month>9</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><year>2017</year>
</pub-date>
<volume>162</volume>
<issue>1</issue>
<fpage>33</fpage>
<lpage>44</lpage>
<history><date date-type="received"><day>25</day>
<month>7</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>12</day>
<month>9</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© Springer-Verlag Wien 2016</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012. The largest known outbreak outside the Middle East occurred in South Korea in 2015. As of 29 June 2016, 1769 laboratory-confirmed cases (630 deaths; 35.6 % case fatality rate [CFR]) had been reported from 26 countries, particularly in the Middle East. However, the CFR for hospital outbreaks was higher than that of family clusters in the Middle East and Korea. Here, we compared the mortality rates for 51 nosocomial outbreaks in the Middle East and one outbreak of MERS-CoV in South Korea. Our findings showed the CFR in the Middle East was much higher than that in South Korea (25.9 % [56/216] vs. 13.8 % [24/174], <italic>p</italic>
= 0.003). Infected individuals who died were, on average, older than those who survived in both the Middle East (64 years [25–98] vs. 46 years [2–85], <italic>p</italic>
= 0.000) and South Korea (68 years [49–82] vs. 53.5 years [16–87], <italic>p</italic>
= 0.000). Similarly, the co-morbidity rates for the fatal cases were statistically higher than for the nonfatal cases in both the Middle East (64.3 % [36/56] vs. 28.1 % [45/160], <italic>p</italic>
= 0.000) and South Korea (45.8 % [11/24] vs. 12.0 % [18/150], <italic>p</italic>
= 0.000). The median number of days from onset to confirmation of infection in the fatal cases was longer than that for survivors from the Middle East (8 days [1–47] vs. 4 days [0–14], <italic>p</italic>
= 0.009). Thus, older age, pre-existing concurrent diseases, and delayed confirmation increase the odds of a fatal outcome in nosocomial MERS-CoV outbreaks in the Middle East and South Korea.</p>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s00705-016-3062-x) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Fatal Case</kwd>
<kwd>Case Fatality Rate</kwd>
<kwd>Secondary Case</kwd>
<kwd>Middle East Respiratory Syndrome</kwd>
<kwd>Nosocomial Outbreak</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer-Verlag Wien 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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