The Utility of Preliminary Patient Evaluation in a Febrile Respiratory Infectious Disease Unit outside the Emergency Department
Identifieur interne : 000931 ( Pmc/Corpus ); précédent : 000930; suivant : 000932The Utility of Preliminary Patient Evaluation in a Febrile Respiratory Infectious Disease Unit outside the Emergency Department
Auteurs : Jun Sik Kang ; Byung Woo Jhun ; Hee Yoon ; Seong Mi Lim ; Eunsil Ko ; Joo Hyun Park ; Sung Yeon Hwang ; Se Uk Lee ; Tae Rim Lee ; Won Chul Cha ; Tae Gun Shin ; Min Seob Sim ; Ik Joon JoSource :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2017.
Abstract
A febrile respiratory infectious disease unit (FRIDU) with a negative pressure ventilation system was constructed outside the emergency department (ED) of the Samsung Medical Center in 2015, to screen for patients with contagious diseases requiring isolation. We evaluated the utility of the FRIDU during 1 year of operation. We analyzed 1,562 patients who were hospitalized after FRIDU screening between August 2015 and July 2016. The level of isolation recommended during their screening at the FRIDU was compared with the level deemed appropriate given their final diagnosis. Of the 1,562 patients screened at the FRIDU, 198 (13%) were isolated, 194 (12%) were reverse isolated, and 1,170 (75%) were not isolated. While hospitalized, 97 patients (6%) were confirmed to have a contagious disease requiring isolation, such as tuberculosis; 207 patients (13%) were confirmed to be immunocompromised and to require reverse isolation, mainly due to neutropenia; and the remaining 1,258 patients (81%) did not require isolation. The correlation coefficient for isolation consistency was 0.565 (
Url:
DOI: 10.3346/jkms.2017.32.9.1534
PubMed: 28776351
PubMed Central: 5546975
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PMC:5546975Le document en format XML
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<author><name sortKey="Kang, Jun Sik" sort="Kang, Jun Sik" uniqKey="Kang J" first="Jun Sik" last="Kang">Jun Sik Kang</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<author><name sortKey="Jhun, Byung Woo" sort="Jhun, Byung Woo" uniqKey="Jhun B" first="Byung Woo" last="Jhun">Byung Woo Jhun</name>
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<author><name sortKey="Yoon, Hee" sort="Yoon, Hee" uniqKey="Yoon H" first="Hee" last="Yoon">Hee Yoon</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
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<author><name sortKey="Lim, Seong Mi" sort="Lim, Seong Mi" uniqKey="Lim S" first="Seong Mi" last="Lim">Seong Mi Lim</name>
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<author><name sortKey="Ko, Eunsil" sort="Ko, Eunsil" uniqKey="Ko E" first="Eunsil" last="Ko">Eunsil Ko</name>
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<author><name sortKey="Park, Joo Hyun" sort="Park, Joo Hyun" uniqKey="Park J" first="Joo Hyun" last="Park">Joo Hyun Park</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<author><name sortKey="Hwang, Sung Yeon" sort="Hwang, Sung Yeon" uniqKey="Hwang S" first="Sung Yeon" last="Hwang">Sung Yeon Hwang</name>
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<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
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<author><name sortKey="Lee, Se Uk" sort="Lee, Se Uk" uniqKey="Lee S" first="Se Uk" last="Lee">Se Uk Lee</name>
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<author><name sortKey="Lee, Tae Rim" sort="Lee, Tae Rim" uniqKey="Lee T" first="Tae Rim" last="Lee">Tae Rim Lee</name>
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<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
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<author><name sortKey="Cha, Won Chul" sort="Cha, Won Chul" uniqKey="Cha W" first="Won Chul" last="Cha">Won Chul Cha</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<author><name sortKey="Shin, Tae Gun" sort="Shin, Tae Gun" uniqKey="Shin T" first="Tae Gun" last="Shin">Tae Gun Shin</name>
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<author><name sortKey="Sim, Min Seob" sort="Sim, Min Seob" uniqKey="Sim M" first="Min Seob" last="Sim">Min Seob Sim</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<author><name sortKey="Jo, Ik Joon" sort="Jo, Ik Joon" uniqKey="Jo I" first="Ik Joon" last="Jo">Ik Joon Jo</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Utility of Preliminary Patient Evaluation in a Febrile Respiratory Infectious Disease Unit outside the Emergency Department</title>
<author><name sortKey="Kang, Jun Sik" sort="Kang, Jun Sik" uniqKey="Kang J" first="Jun Sik" last="Kang">Jun Sik Kang</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jhun, Byung Woo" sort="Jhun, Byung Woo" uniqKey="Jhun B" first="Byung Woo" last="Jhun">Byung Woo Jhun</name>
<affiliation><nlm:aff id="A2">Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yoon, Hee" sort="Yoon, Hee" uniqKey="Yoon H" first="Hee" last="Yoon">Hee Yoon</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
.</nlm:aff>
</affiliation>
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<author><name sortKey="Lim, Seong Mi" sort="Lim, Seong Mi" uniqKey="Lim S" first="Seong Mi" last="Lim">Seong Mi Lim</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
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<author><name sortKey="Ko, Eunsil" sort="Ko, Eunsil" uniqKey="Ko E" first="Eunsil" last="Ko">Eunsil Ko</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
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<author><name sortKey="Park, Joo Hyun" sort="Park, Joo Hyun" uniqKey="Park J" first="Joo Hyun" last="Park">Joo Hyun Park</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
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<author><name sortKey="Hwang, Sung Yeon" sort="Hwang, Sung Yeon" uniqKey="Hwang S" first="Sung Yeon" last="Hwang">Sung Yeon Hwang</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
.</nlm:aff>
</affiliation>
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<author><name sortKey="Lee, Se Uk" sort="Lee, Se Uk" uniqKey="Lee S" first="Se Uk" last="Lee">Se Uk Lee</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Tae Rim" sort="Lee, Tae Rim" uniqKey="Lee T" first="Tae Rim" last="Lee">Tae Rim Lee</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cha, Won Chul" sort="Cha, Won Chul" uniqKey="Cha W" first="Won Chul" last="Cha">Won Chul Cha</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shin, Tae Gun" sort="Shin, Tae Gun" uniqKey="Shin T" first="Tae Gun" last="Shin">Tae Gun Shin</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sim, Min Seob" sort="Sim, Min Seob" uniqKey="Sim M" first="Min Seob" last="Sim">Min Seob Sim</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jo, Ik Joon" sort="Jo, Ik Joon" uniqKey="Jo I" first="Ik Joon" last="Jo">Ik Joon Jo</name>
<affiliation><nlm:aff id="A1">Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
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<series><title level="j">Journal of Korean Medical Science</title>
<idno type="ISSN">1011-8934</idno>
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<front><div type="abstract" xml:lang="en"><p>A febrile respiratory infectious disease unit (FRIDU) with a negative pressure ventilation system was constructed outside the emergency department (ED) of the Samsung Medical Center in 2015, to screen for patients with contagious diseases requiring isolation. We evaluated the utility of the FRIDU during 1 year of operation. We analyzed 1,562 patients who were hospitalized after FRIDU screening between August 2015 and July 2016. The level of isolation recommended during their screening at the FRIDU was compared with the level deemed appropriate given their final diagnosis. Of the 1,562 patients screened at the FRIDU, 198 (13%) were isolated, 194 (12%) were reverse isolated, and 1,170 (75%) were not isolated. While hospitalized, 97 patients (6%) were confirmed to have a contagious disease requiring isolation, such as tuberculosis; 207 patients (13%) were confirmed to be immunocompromised and to require reverse isolation, mainly due to neutropenia; and the remaining 1,258 patients (81%) did not require isolation. The correlation coefficient for isolation consistency was 0.565 (<italic>P</italic>
< 0.001). The sensitivity and negative predictive value of FRIDU screening for diagnosing contagious disease requiring isolation are 76% and 98%, respectively. No serious nosocomial outbreaks of contagious diseases occurred. During FRIDU screening, 114 patients were admitted to the resuscitation zone due to clinical instability, and three of these patients died. The initial isolation levels resulting from FRIDU screening were moderately well correlated with the isolation levels required by the final diagnosis, demonstrating the utility of pre-hospitalization screening units. However, the risks of deterioration during the screening process remain challenges.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id>
<journal-id journal-id-type="publisher-id">JKMS</journal-id>
<journal-title-group><journal-title>Journal of Korean Medical Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">1011-8934</issn>
<issn pub-type="epub">1598-6357</issn>
<publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28776351</article-id>
<article-id pub-id-type="pmc">5546975</article-id>
<article-id pub-id-type="doi">10.3346/jkms.2017.32.9.1534</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
<subj-group subj-group-type="subheading"><subject>Emergency & Critical Care Medicine</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>The Utility of Preliminary Patient Evaluation in a Febrile Respiratory Infectious Disease Unit outside the Emergency Department</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-5889-3161</contrib-id>
<name><surname>Kang</surname>
<given-names>Jun Sik</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-6348-8731</contrib-id>
<name><surname>Jhun</surname>
<given-names>Byung Woo</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-1297-9813</contrib-id>
<name><surname>Yoon</surname>
<given-names>Hee</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-9247-7081</contrib-id>
<name><surname>Lim</surname>
<given-names>Seong Mi</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-5959-5545</contrib-id>
<name><surname>Ko</surname>
<given-names>Eunsil</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-6382-0642</contrib-id>
<name><surname>Park</surname>
<given-names>Joo Hyun</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-1352-3009</contrib-id>
<name><surname>Hwang</surname>
<given-names>Sung Yeon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-4201-2272</contrib-id>
<name><surname>Lee</surname>
<given-names>Se Uk</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1860-8236</contrib-id>
<name><surname>Lee</surname>
<given-names>Tae Rim</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-2778-2992</contrib-id>
<name><surname>Cha</surname>
<given-names>Won Chul</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-9657-1040</contrib-id>
<name><surname>Shin</surname>
<given-names>Tae Gun</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-6645-3684</contrib-id>
<name><surname>Sim</surname>
<given-names>Min Seob</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-8098-1862</contrib-id>
<name><surname>Jo</surname>
<given-names>Ik Joon</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,<country>Korea</country>
.</aff>
<aff id="A2"><label>2</label>
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul,<country>Korea</country>
.</aff>
<aff id="A3"><label>3</label>
Department of Emergency Medicine, Kangwon National University College of Medicine, Chuncheon,<country>Korea</country>
.</aff>
<author-notes><corresp>Address for Correspondence: Hee Yoon, MD. Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea. <email>wildhi.yoon@gmail.com</email>
</corresp>
<fn id="FN1" fn-type="equal"><p><sup>*</sup>
Jun Sik Kang and Byung Woo Jhun contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>03</day>
<month>7</month>
<year>2017</year>
</pub-date>
<volume>32</volume>
<issue>9</issue>
<fpage>1534</fpage>
<lpage>1541</lpage>
<history><date date-type="received"><day>12</day>
<month>4</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>28</day>
<month>5</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2017 The Korean Academy of Medical Sciences.</copyright-statement>
<copyright-year>2017</copyright-year>
<license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>A febrile respiratory infectious disease unit (FRIDU) with a negative pressure ventilation system was constructed outside the emergency department (ED) of the Samsung Medical Center in 2015, to screen for patients with contagious diseases requiring isolation. We evaluated the utility of the FRIDU during 1 year of operation. We analyzed 1,562 patients who were hospitalized after FRIDU screening between August 2015 and July 2016. The level of isolation recommended during their screening at the FRIDU was compared with the level deemed appropriate given their final diagnosis. Of the 1,562 patients screened at the FRIDU, 198 (13%) were isolated, 194 (12%) were reverse isolated, and 1,170 (75%) were not isolated. While hospitalized, 97 patients (6%) were confirmed to have a contagious disease requiring isolation, such as tuberculosis; 207 patients (13%) were confirmed to be immunocompromised and to require reverse isolation, mainly due to neutropenia; and the remaining 1,258 patients (81%) did not require isolation. The correlation coefficient for isolation consistency was 0.565 (<italic>P</italic>
< 0.001). The sensitivity and negative predictive value of FRIDU screening for diagnosing contagious disease requiring isolation are 76% and 98%, respectively. No serious nosocomial outbreaks of contagious diseases occurred. During FRIDU screening, 114 patients were admitted to the resuscitation zone due to clinical instability, and three of these patients died. The initial isolation levels resulting from FRIDU screening were moderately well correlated with the isolation levels required by the final diagnosis, demonstrating the utility of pre-hospitalization screening units. However, the risks of deterioration during the screening process remain challenges.</p>
</abstract>
<abstract abstract-type="graphical"><title>Graphical Abstract</title>
<p><graphic xlink:href="jkms-32-1534-abf001.jpg" position="float" orientation="portrait"></graphic>
</p>
</abstract>
<kwd-group kwd-group-type="author"><kwd>Febrile</kwd>
<kwd>Respiratory</kwd>
<kwd>Infectious</kwd>
<kwd>Emergency</kwd>
<kwd>Isolation</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec sec-type="intro"><title>INTRODUCTION</title>
<p>Infectious diseases have historically affected the development and advancement of human societies. During the early- and mid-20th century, mortality associated with infectious diseases declined dramatically due to advances in medicine and public health; however, they remain a major public health burden worldwide. Recent data presented by the World Health Organization indicated that more than a quarter of the estimated 59 million deaths that occur globally each year are associated with infectious disease (<xref rid="B1" ref-type="bibr">1</xref>
<xref rid="B2" ref-type="bibr">2</xref>
).</p>
<p>Acute respiratory illnesses are the leading cause of death from infectious diseases around the world, and occasional outbreaks of particularly virulent strains are potential public health disasters. In 2002, a few cases of a life-threatening respiratory disease caused by corona virus in China (<xref rid="B3" ref-type="bibr">3</xref>
<xref rid="B4" ref-type="bibr">4</xref>
), ultimately resulted in a global epidemic of severe acute respiratory syndrome. Recently, a large outbreak of fatal Middle East respiratory syndrome-coronavirus (MERS-CoV) occurred following a single patient exposure in the emergency department (ED) of our institution, a tertiary-care hospital in Korea, which resulted in significant public health and economic burden (<xref rid="B5" ref-type="bibr">5</xref>
<xref rid="B6" ref-type="bibr">6</xref>
).</p>
<p>EDs are one of the major gateways to hospital entry and have substantial burdens associated with infectious disease-related visits (<xref rid="B7" ref-type="bibr">7</xref>
<xref rid="B8" ref-type="bibr">8</xref>
<xref rid="B9" ref-type="bibr">9</xref>
<xref rid="B10" ref-type="bibr">10</xref>
). Thus, accurate categorization of patients is required, and determination of the initial isolation level is one of the most difficult issues faced by ED physicians, especially when treating patients with a suspected contagious respiratory illness (<xref rid="B11" ref-type="bibr">11</xref>
<xref rid="B12" ref-type="bibr">12</xref>
<xref rid="B13" ref-type="bibr">13</xref>
). After the 2015 outbreak of fatal MERS-CoV at our institution (<xref rid="B5" ref-type="bibr">5</xref>
<xref rid="B14" ref-type="bibr">14</xref>
), a febrile respiratory infectious disease unit (FRIDU) with a negative pressure ventilation system was separately constructed outside the ED; to prevent the spread of contagious diseases within the hospital, this unit triages and determines isolation levels for all emergency patients prior to their admission to the ED or hospital. However, data on the utility of such screening units are limited.</p>
<p>We compared patients' initial FRIDU-determined isolation level with the level associated with their final diagnosis and assessed the limitations of the screening system. We hope this study will help efforts to integrate isolation strategies into ED contagious disease management procedures.</p>
</sec>
<sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title>
<sec><title>Study design, subjects, and institution</title>
<p>We performed a retrospective cohort analysis of patients with febrile illness who were hospitalized after FRIDU screening. All patients visited the emergency center were triaged outside the ED between August 2015 and July 2016. The records of 4,128 adult patients with febrile illness who entered the FRIDU after initial triage were reviewed. Finally, the 1,562 patients who were hospitalized after FRIDU screening were included in the analysis (<xref ref-type="fig" rid="F1">Figs. 1</xref>
and <xref ref-type="fig" rid="F2">2</xref>
).</p>
<fig id="F1" fig-type="figure" orientation="portrait" position="float"><label>Fig. 1</label>
<caption><p>Study patients flow through the FRIDU.</p>
<p>FRIDU = febrile respiratory infectious disease unit, ED = emergency department, ICU = intensive care unit, GW = general ward.</p>
</caption>
<graphic xlink:href="jkms-32-1534-g001"></graphic>
</fig>
<fig id="F2" fig-type="figure" orientation="portrait" position="float"><label>Fig. 2</label>
<caption><p>FRIDU and triage. (<bold>A</bold>
) The outside view of FRIDU and triage. (<bold>B</bold>
) The inside view of FRIDU and triage.</p>
<p>FRIDU = febrile respiratory infectious disease unit, ED = emergency department, A = anteroom, T = toilet, R1–R6 = room 1–room 6, Lab1–3 = laboratory 1–3, D = doctor's examination, N = nurse's triage, R = reception.</p>
</caption>
<graphic xlink:href="jkms-32-1534-g002"></graphic>
</fig>
<p>Samsung Medical Center is a modern 1,989-bed university-affiliated tertiary hospital providing referral care in Korea and about 200 patients are seen in the ED each day. In ED for adult, there are 58 beds were spaced roughly 1.5–2.0 m apart with curtains or wall in between and ambulatory zone with 24 chairs for stable patients.</p>
</sec>
<sec><title>Facilities in the triage room and FRIDU outside ED</title>
<p>The triage room is in the front of the FRIDU, which is located outside the ED (<xref ref-type="fig" rid="F2">Fig. 2A</xref>
), and includes an administration area, a nurses' triage area, and a doctor's examination room (<xref ref-type="fig" rid="F2">Fig. 2B</xref>
). There are also 6 isolation rooms with negative pressure ventilation systems, each with a high-efficiency particulate air filter with an airtight backdraft damper (15–30 air changes per hour). An anteroom is located in front of every isolation room, and the inter-room pressure difference is −4.5 to −17 Pa. Portable radiological and ultrasound examinations, blood sample kits, polymerase chain reaction (PCR) tests for respiratory viruses, and sputum examination kits were available in every isolation and laboratory room. Oxygen supply systems (nasal prong, facial mask, etc.), devices for airway management and central vascular access, mechanical ventilation, and remote vital sign monitors were also provided.</p>
</sec>
<sec><title>Patient management, criteria for FRIDU screening, and determination of isolation level</title>
<p>All emergency center patients were triaged in the FRIDU triage room outside the ED. After that, patients who had any of the following conditions were screened for contagious diseases in the FRIDU before entering the ED or being admitted to the hospital: 1) fever ≥ 37.5°C (99.5°F) and respiratory symptoms including cough, sputum, or dyspnea (modified Medical Research Council ≥ II), 2) history of travel to high-risk countries within 2–4 weeks, regardless of fever or respiratory symptoms (e.g., Middle East for MERS-CoV or West Africa for Ebola) by the Centers for Disease Control and Prevention guidance, or 3) signs and symptoms suggesting airborne disease, such as chickenpox or tuberculosis. When a patient was determined to be clinically deteriorated at the FRIDU, the patient was moved to the resuscitation zone equipped with a portable negative pressure ventilation system or isolated in a single room with a door in the ED.</p>
<p>After FRIDU screening, patients were categorized according to the following three isolation levels based on the attending ED physician's diagnosis: 1) suspected of having a contagious disease requiring isolation (e.g., patients with influenza or pulmonary tuberculosis), 2) immunocompromised status requiring reverse isolation (e.g., patients with neutropenia), or 3) not requiring isolation (e.g., patients with a urinary tract infection). After the initial diagnostic work up, some patients requiring hospitalization were directly admitted from the FRIDU without entering the ED; some were hospitalized or discharged after entering the ED and receiving additional medical examinations; and some were discharged, referred elsewhere, or followed by the outpatient clinic without entering the ED or being hospitalized.</p>
</sec>
<sec><title>Statistical analysis</title>
<p>Data on categorical variables are presented as numbers and percentages, and data on continuous variables are presented as means ± standard deviations. Data on continuous variables were compared using a 2-sample t-test and the data were normally distributed. Data on categorical variables were compared by χ<sup>2</sup>
or Fisher's exact test. The consistency of the isolation levels assigned based on the FRIDU screening and that associated with the final diagnosis was assessed using a correlation coefficient (kappa). Univariate and multivariate analyses with logistic regression were performed to evaluate factors associated with being diagnosed with a contagious disease by the FRIDU screening. Statistical analyses were performed using PASW software (ver. 22.0; SPSS Inc., Chicago, IL, USA), and a 2-sided <italic>P</italic>
value < 0.05 was considered statistically significant.</p>
</sec>
<sec><title>Ethics statement</title>
<p>The Institutional Review Board of the Samsung Medical Center approved this study and permitted the review and publication of patient records (IRB registration number 2016-08-166). The requirement for informed consent by individual patients was waived due to the retrospective design of the study.</p>
</sec>
</sec>
<sec sec-type="results"><title>RESULTS</title>
<sec><title>Study patients</title>
<p>In total, 59,546 patients visited the emergency center during the one year and were triaged in the FRIDU outside the ED. After initial triage, 4,128 adult patients with febrile illness were screened at FRIDU and 1,422 patients were discharged, referred elsewhere, or followed by the outpatient clinic without entering the ED. Four hundred three patients were directly hospitalized without entering the ED and 114 patients were admitted to the resuscitation zone due to clinical instability during FRIDU screening; of these, 29 patients were later discharged or referred elsewhere. Of the 2,189 patients who entered the ED after FRIDU screening, 1,115 were discharged, referred elsewhere, or followed by the outpatient clinic without hospitalization based on the ED physician's decision. Finally, the 1,562 patients with febrile illness who were hospitalized after FRIDU screening were included in the analysis (<xref ref-type="fig" rid="F1">Fig. 1</xref>
).</p>
</sec>
<sec><title>Clinical characteristics of study patients</title>
<p>In total, 1,562 patients with febrile illness who were hospitalized after FRIDU screening were included in the analysis. Characteristics of study patients are shown in <xref ref-type="table" rid="T1">Table 1</xref>
. Based on FRIDU screening, 198 patients (13%) were isolated (isolation), 194 patients (12%) were reverse isolated (reverse isolation), and 1,170 patients (75%) did not require isolation (non-isolation). More than 40% of isolation patients were relatively elderly (≥ 65 years), and they were more likely to have chronic heart disease (16%) (<italic>P</italic>
= 0.001) or chronic pulmonary disease (24%) (<italic>P</italic>
< 0.001) compared with the other two groups. The amount of time spent in the FRIDU was longest for the isolation group. Among reverse isolation patients, 73% had active hemato-oncologic malignancy (<italic>P</italic>
< 0.001), 87% had fever (<italic>P</italic>
< 0.001), and 32% had relatively severe diseases as indicated by the Emergency Severity Index score or Korean Triage and Acuity Scale (modified version of the Canadian Triage and Acuity Scale) ≤ 2 (<italic>P</italic>
= 0.002) (<xref ref-type="supplementary-material" rid="S1">Supplementary Table 1</xref>
). Each of these indicators was the highest in the reverse isolation group.</p>
<table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label>
<caption><title>Characteristics of patients hospitalized with acute febrile illness via ED after FRIDU screening</title>
</caption>
<alternatives><graphic xlink:href="jkms-32-1534-i001"></graphic>
<table frame="hsides" rules="rows"><col width="35.08%" span="1"></col>
<col width="16.23%" span="1"></col>
<col width="16.23%" span="1"></col>
<col width="16.23%" span="1"></col>
<col width="16.23%" span="1"></col>
<thead><tr><th valign="top" align="left" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)">Characteristic</th>
<th valign="top" align="center" rowspan="1" colspan="3" style="background-color:rgb(200,199,223)">Isolation level in hospitalization based on FRIDU screening</th>
<th valign="top" align="center" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)"><italic>P</italic>
value</th>
</tr>
<tr><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Isolation (n = 198)</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Reverse isolation (n = 194)</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Non-isolation (n = 1,170)</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Age ≥ 65, yr</td>
<td valign="top" align="center" rowspan="1" colspan="1">82 (41)</td>
<td valign="top" align="center" rowspan="1" colspan="1">54 (28)</td>
<td valign="top" align="center" rowspan="1" colspan="1">531 (45)</td>
<td valign="top" align="right" rowspan="1" colspan="1">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Gender (male)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">104 (53)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">89 (46)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">639 (55)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.075</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">History of overseas travel (< 1 mon)</td>
<td valign="top" align="center" rowspan="1" colspan="1">6 (3)</td>
<td valign="top" align="center" rowspan="1" colspan="1">2 (1)</td>
<td valign="top" align="center" rowspan="1" colspan="1">29 (3)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.347</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Underlying comorbidity</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Chronic heart disease</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">32 (16)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">8 (4)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">133 (11)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Chronic kidney disease</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">26 (13)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">30 (16)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">111 (10)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.022</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Chronic pulmonary disease</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">47 (24)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">7 (4)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">226 (19)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Active hemato-oncologic malignancy</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">66 (33)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">142 (73)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">549 (47)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Major surgery (< 1 mon)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1 (1)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1 (1)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">19 (2)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.361</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Transplant state</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">24 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">62 (32)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">68 (6)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Presenting symptoms or signs</td>
<td valign="top" align="center" rowspan="1" colspan="1"></td>
<td valign="top" align="center" rowspan="1" colspan="1"></td>
<td valign="top" align="center" rowspan="1" colspan="1"></td>
<td valign="top" align="right" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Fever (temporal temperature ≥ 37.5℃)</td>
<td valign="top" align="center" rowspan="1" colspan="1">125 (63)</td>
<td valign="top" align="center" rowspan="1" colspan="1">168 (87)</td>
<td valign="top" align="center" rowspan="1" colspan="1">858 (73)</td>
<td valign="top" align="right" rowspan="1" colspan="1">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Respiratory symptom</td>
<td valign="top" align="center" rowspan="1" colspan="1">176 (89)</td>
<td valign="top" align="center" rowspan="1" colspan="1">169 (87)</td>
<td valign="top" align="center" rowspan="1" colspan="1">1,017 (87)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.753</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Gastrointestinal symptom</td>
<td valign="top" align="center" rowspan="1" colspan="1">11 (6)</td>
<td valign="top" align="center" rowspan="1" colspan="1">23 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1">180 (15)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Genitourinary symptom</td>
<td valign="top" align="center" rowspan="1" colspan="1">3 (2)</td>
<td valign="top" align="center" rowspan="1" colspan="1">10 (5)</td>
<td valign="top" align="center" rowspan="1" colspan="1">59 (5)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.062</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Dermatologic symptom</td>
<td valign="top" align="center" rowspan="1" colspan="1">14 (7)</td>
<td valign="top" align="center" rowspan="1" colspan="1">0 (0)</td>
<td valign="top" align="center" rowspan="1" colspan="1">27 (2)</td>
<td valign="top" align="right" rowspan="1" colspan="1">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">KTAS or ESI score ≤ 2</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">50 (25)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">62 (32)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">246 (21)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.002</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">KTAS or ESI score ≤ 3</td>
<td valign="top" align="center" rowspan="1" colspan="1">178 (90)</td>
<td valign="top" align="center" rowspan="1" colspan="1">178 (92)</td>
<td valign="top" align="center" rowspan="1" colspan="1">1,025 (88)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.194</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Stay time in FRIDU ≥ 3, hr</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">166 (84)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">96 (80)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">542 (46)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Stay time in FRIDU, min</td>
<td valign="top" align="center" rowspan="1" colspan="1">528 ± 500</td>
<td valign="top" align="center" rowspan="1" colspan="1">221 ± 204</td>
<td valign="top" align="center" rowspan="1" colspan="1">260 ± 957</td>
<td valign="top" align="right" rowspan="1" colspan="1">< 0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Stay time in ED, min</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">725 ± 664</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">763 ± 862</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">891 ± 876</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.011</td>
</tr>
</tbody>
</table>
</alternatives>
<table-wrap-foot><p>Data are presented as number (percentage) or mean ± standard deviation.</p>
<p>ED = emergency department, FRIDU = febrile respiratory infectious disease unit, KTAS = Korean Triage and Acuity Scale, ESI = Emergency Severity Index.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec><title>Isolation level by final diagnosis</title>
<p>The appropriate isolation levels for the final diagnoses confirmed during hospitalization are shown in <xref ref-type="table" rid="T2">Table 2</xref>
. Of 1,562 patients, 97 (6%) were confirmed to have a contagious disease requiring isolation, such as influenza (n = 63), pulmonary tuberculosis (n = 24), disseminated zoster (n = 6), chicken pox (n = 3), or suspicious viral pneumonia (n = 1). An additional 207 patients (13%) with immunocompromised status required reverse isolation, mainly due to neutropenia (n = 180) or transplant status (n = 26). The remaining 1,258 patients (81%) did not require isolation. Among these, pneumonia (n = 456) was the most common diagnosis, followed by urinary tract infection (n = 89), and hepatobiliary infection (n = 82).</p>
<table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label>
<caption><title>Isolation levels according to final diagnosis confirmed during hospitalization of study patients</title>
</caption>
<alternatives><graphic xlink:href="jkms-32-1534-i002"></graphic>
<table frame="hsides" rules="rows"><col width="69.93%" span="1"></col>
<col width="30.07%" span="1"></col>
<thead><tr><th valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Final diagnosis</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">No. (%)</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Contagious disease requiring isolation</td>
<td valign="top" align="center" rowspan="1" colspan="1">97 (6)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Influenza</td>
<td valign="top" align="center" rowspan="1" colspan="1">63/97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Pulmonary tuberculosis</td>
<td valign="top" align="center" rowspan="1" colspan="1">24/97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Disseminated zoster</td>
<td valign="top" align="center" rowspan="1" colspan="1">6/97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Chicken pox</td>
<td valign="top" align="center" rowspan="1" colspan="1">3/97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Suspicious viral pneumonia</td>
<td valign="top" align="center" rowspan="1" colspan="1">1/97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Immunocompromised status requiring reverse isolation</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">207 (13)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Neutropenia (neutrophil count < 500/µL)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">180/207</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Transplant state</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">26/207</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Etc.</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1/207</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">No need to isolate</td>
<td valign="top" align="center" rowspan="1" colspan="1">1,258 (81)</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Pneumonia</td>
<td valign="top" align="center" rowspan="1" colspan="1">456/1,258</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Urinary tract infection</td>
<td valign="top" align="center" rowspan="1" colspan="1">89/1,258</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Hepatobiliary infection</td>
<td valign="top" align="center" rowspan="1" colspan="1">82/1,258</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Others</td>
<td valign="top" align="center" rowspan="1" colspan="1">631/1,258</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Total</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1,562 (100)</td>
</tr>
</tbody>
</table>
</alternatives>
</table-wrap>
</sec>
<sec><title>Consistency of isolation levels based on FRIDU screening and final diagnosis</title>
<p>We compared the isolation levels based on the initial FRIDU screening with that associated with the final diagnosis to evaluate their consistency, as shown in <xref ref-type="table" rid="T3">Table 3</xref>
. The isolation level was consistent for 1,309 (83%) patients; of these, 74 required isolation, 143 required reverse isolation, and 1,092 did not require isolation. The correlation coefficient for isolation consistency was 0.565 (<italic>P</italic>
< 0.001).</p>
<table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label>
<caption><title>Consistency of isolation levels based on FRIDU screening and final diagnosis</title>
</caption>
<alternatives><graphic xlink:href="jkms-32-1534-i003"></graphic>
<table frame="hsides" rules="rows"><col width="41.92%" span="1"></col>
<col width="15.4%" span="1"></col>
<col width="15.4%" span="1"></col>
<col width="15.4%" span="1"></col>
<col width="11.87%" span="1"></col>
<thead><tr><th valign="top" align="left" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)">Final diagnosis</th>
<th valign="top" align="center" rowspan="1" colspan="3" style="background-color:rgb(200,199,223)">Isolation level in hospitalization based on FRIDU screening</th>
<th valign="top" align="center" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)">Total</th>
</tr>
<tr><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Isolation</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Reverse isolation</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Non-isolation</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Contagious disease requiring isolation</td>
<td valign="top" align="right" rowspan="1" colspan="1">74</td>
<td valign="top" align="right" rowspan="1" colspan="1">5</td>
<td valign="top" align="right" rowspan="1" colspan="1">18</td>
<td valign="top" align="right" rowspan="1" colspan="1">97</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Immunocompromised status requiring reverse isolation</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">4</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">143</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">60</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">207</td>
</tr>
<tr><td valign="top" align="justify" rowspan="1" colspan="1">No need to isolate</td>
<td valign="top" align="right" rowspan="1" colspan="1">120</td>
<td valign="top" align="right" rowspan="1" colspan="1">46</td>
<td valign="top" align="right" rowspan="1" colspan="1">1,092</td>
<td valign="top" align="right" rowspan="1" colspan="1">1,258</td>
</tr>
<tr><td valign="top" align="justify" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Total</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">198</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">194</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1,170</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">1,562</td>
</tr>
</tbody>
</table>
</alternatives>
<table-wrap-foot><p>Data are presented as number. Correlation coefficient kappa value = 0.565, <italic>P</italic>
< 0.001.</p>
<p>FRIDU = febrile respiratory infectious disease unit.</p>
</table-wrap-foot>
</table-wrap>
<p>The remaining 253 patients were inconsistently isolated. Of these, 166 did not ultimately require isolation but were initially isolated (n = 120) or reverse isolated (n = 46). Of the other 87 patients, 23 had contagious diseases but were inappropriately reverse isolated (n = 5) or not isolated (n = 18), and 64 patients had immunocompromised status but were inappropriately isolated (n = 4) or not isolated (n = 60) (<xref ref-type="table" rid="T4">Table 4</xref>
).</p>
<table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label>
<caption><title>Patients who were confirmed to have contagious disease requiring isolation or immunocompromised status but, who were applied inappropriate isolation level after hospitalization</title>
</caption>
<alternatives><graphic xlink:href="jkms-32-1534-i004"></graphic>
<table frame="hsides" rules="rows"><col width="42.51%" span="1"></col>
<col width="19.16%" span="1"></col>
<col width="19.16%" span="1"></col>
<col width="19.16%" span="1"></col>
<thead><tr><th valign="top" align="left" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)">Final diagnosis</th>
<th valign="top" align="center" rowspan="1" colspan="3" style="background-color:rgb(200,199,223)">No. of Inappropriate isolation</th>
</tr>
<tr><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Isolation</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Reverse isolation</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Non-isolation</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Contagious disease (n = 23)</td>
<td valign="top" align="center" rowspan="1" colspan="1">0</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
<td valign="top" align="center" rowspan="1" colspan="1">18</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Pulmonary tuberculosis (n = 5)</td>
<td valign="top" align="center" rowspan="1" colspan="1">-</td>
<td valign="top" align="center" rowspan="1" colspan="1">0</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Influenza (n = 18)</td>
<td valign="top" align="center" rowspan="1" colspan="1">-</td>
<td valign="top" align="center" rowspan="1" colspan="1">5</td>
<td valign="top" align="center" rowspan="1" colspan="1">13</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Immunocompromised status (n = 64)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">4</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">60</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Neutropenic fever (n = 60)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">2</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">-</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">58</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Transplanted patient (n = 4)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">2</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">-</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">2</td>
</tr>
</tbody>
</table>
</alternatives>
</table-wrap>
<p>We additionally categorized study patients into 2 groups (isolation vs. reverse isolation and non-isolation), the sensitivity and negative predictive value (NPV) of FRIDU screening for diagnosing contagious disease requiring isolation are 76% (confidence interval [CI], 67%–84%) and 98% (CI, 97%–99%), respectively.</p>
</sec>
<sec><title>Risk factors for predicting contagiousness at FRIDU screening</title>
<p>We additionally used univariate and multivariate analyses with a logistic regression model to determine the factors related to being diagnosed with a contagious disease at the initial FRIDU screening (<xref ref-type="supplementary-material" rid="S2">Supplementary Table 2</xref>
). The variables used were old age (≥ 65 years), gender (male), chronic kidney disease, transplant history, fever (≥ 37.5°C), and leukocytosis (>10,000/μL). Transplant history (odds ratio [OR], 2.294; <italic>P</italic>
= 0.003), fever (OR, 0.616; <italic>P</italic>
= 0.030), and leukocytosis (OR, 0.315; <italic>P</italic>
= 0.005) were significantly associated with an initial diagnosis of a contagious disease.</p>
</sec>
<sec><title>Deterioration during FRIDU screening</title>
<p>Of 4,128 patients who were screened in the FRIDU, 114 patients were admitted to the resuscitation area due to clinical instability during FRIDU screening; three of these patients died in the ED. One of the 3 underwent cardiac arrest in the FRIDU and was moved to the resuscitation zone in the ED while cardiopulmonary resuscitation was performed. Twenty-nine of the 114 patients were discharged or referred elsewhere in the resuscitation area (<xref ref-type="fig" rid="F1">Fig. 1</xref>
) and were excluded from the analysis due to limited clinical and laboratory data. The 85 hospitalized patients who deteriorated during FRIDU screening are described in <xref ref-type="table" rid="T5">Table 5</xref>
.</p>
<table-wrap id="T5" orientation="portrait" position="float"><label>Table 5</label>
<caption><title>Characteristics of patients who deteriorated during FRIDU screening</title>
</caption>
<alternatives><graphic xlink:href="jkms-32-1534-i005"></graphic>
<table frame="hsides" rules="rows"><col width="36%" span="1"></col>
<col width="22.33%" span="1"></col>
<col width="22.33%" span="1"></col>
<col width="19.33%" span="1"></col>
<thead><tr><th valign="top" align="left" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)">Characteristics</th>
<th valign="top" align="center" rowspan="1" colspan="2" style="background-color:rgb(200,199,223)">Final diagnosis</th>
<th valign="top" align="center" rowspan="2" colspan="1" style="background-color:rgb(200,199,223)"><italic>P</italic>
value</th>
</tr>
<tr><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Contagious disease (n = 17)</th>
<th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(200,199,223)">Non-contagious disease (n = 68)</th>
</tr>
</thead>
<tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Age ≥ 65, yr</td>
<td valign="top" align="center" rowspan="1" colspan="1">9 (53)</td>
<td valign="top" align="center" rowspan="1" colspan="1">35 (52)</td>
<td valign="top" align="right" rowspan="1" colspan="1">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Gender (male)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">10 (59)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">27 (40)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Underlying comorbidity (≥ 1)</td>
<td valign="top" align="center" rowspan="1" colspan="1">13 (77)</td>
<td valign="top" align="center" rowspan="1" colspan="1">54 (79)</td>
<td valign="top" align="right" rowspan="1" colspan="1">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Presenting symptoms</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Hemoptysis</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">4 (24)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">7 (10)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.197</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Fever (≥ 37.5℃)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">10 (59)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">54 (79)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.281</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Dyspnea (MMRC ≥ II)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">17 (100)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">49 (72)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.032</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Tachypnea (> 30 breaths/min)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">8 (47)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">34 (50)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Tachycardia (> 100 beats/min)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">15 (88)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">55 (81)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Initial oxygen requirement</td>
<td valign="top" align="center" rowspan="1" colspan="1">16 (94)</td>
<td valign="top" align="center" rowspan="1" colspan="1">38 (56)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.014</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Laboratory findings</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Leukocytosis (> 10,000/μL)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">9 (53)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">28 (41)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">> 0.999</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> Neutropenia (< 500/μL)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">2 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">16 (24)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.722</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)"> C-reactive protein, mg/dL</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">14 ± 10</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">12 ± 10</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.542</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Cause of deterioration</td>
<td valign="top" align="center" rowspan="1" colspan="1"></td>
<td valign="top" align="center" rowspan="1" colspan="1"></td>
<td valign="top" align="right" rowspan="1" colspan="1"></td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Septic shock</td>
<td valign="top" align="center" rowspan="1" colspan="1">2 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1">25 (37)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.201</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Respiratory failure</td>
<td valign="top" align="center" rowspan="1" colspan="1">11 (64)</td>
<td valign="top" align="center" rowspan="1" colspan="1">22 (32)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Heart failure</td>
<td valign="top" align="center" rowspan="1" colspan="1">2 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1">8 (12)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.343</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1"> Unknown</td>
<td valign="top" align="center" rowspan="1" colspan="1">2 (12)</td>
<td valign="top" align="center" rowspan="1" colspan="1">13 (19)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.114</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">Intensive care unit admission</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">3 (18)</td>
<td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">47 (69)</td>
<td valign="top" align="right" rowspan="1" colspan="1" style="background-color:rgb(225,224,237)">0.004</td>
</tr>
<tr><td valign="top" align="left" rowspan="1" colspan="1">Survival</td>
<td valign="top" align="center" rowspan="1" colspan="1">14 (82)</td>
<td valign="top" align="center" rowspan="1" colspan="1">61 (90)</td>
<td valign="top" align="right" rowspan="1" colspan="1">0.197</td>
</tr>
</tbody>
</table>
</alternatives>
<table-wrap-foot><p>Data are presented as number (percentage) or mean ± standard deviation.</p>
<p>FRIDU = febrile respiratory infectious disease unit, MMRC = modified Medical Research Council.</p>
</table-wrap-foot>
</table-wrap>
<p>Of the 85 patients, 17 (20%) had contagious diseases and 37 (44%) were male. Most patients had fever (n = 64, 75%) and/or dyspnea (n = 66, 78%). Twenty-seven patients (32%) had septic shock, 33 (38%) had respiratory failure, 10 (12%) had heart failure, and 15 (18%) had an illness with an unknown cause.</p>
</sec>
</sec>
<sec sec-type="discussion"><title>DISCUSSION</title>
<p>The most important findings of our study were that the isolation levels determined based on initial FRIDU screening were moderately well correlated with the isolation levels required by the final diagnoses. And FRIDU screening had high NPV for diagnosing contagious disease requiring isolation, demonstrating the utility of pre-hospitalization screening units. Of 97 patients diagnosed with contagious diseases requiring isolation, 74 patients were isolated and 5 patients were reverse isolated, and all of the 5 patients had had both neutropenia and influenza. Of 18 patents who were non-isolated, 16 had a negative result of influenza antigen test at initial FRIDU but they subsequently were confirmed to have respiratory virus infection during hospitalization by PCR test. Additionally, 143 of 207 immunocompromised patients were reverse isolated based on FRIDU screening. Actually, more than two-thirds of the 60 immunocompromised patients, who were categorized into non-isolation based on FRIDU screening, were observed in their own bed with curtain and reverse isolation notice, due to the lack of revere isolation room. Of them, patients who had respiratory symptoms such as cough, sputum mandatorily had to wear a surgical mask and were thoroughly trained for respiratory etiquette in our hospital. Moreover, given that no serious nosocomial outbreaks occurred during the study period, pre-hospitalization screening systems for contagious diseases could be a viable strategy for preventing nosocomial infections (<xref rid="B15" ref-type="bibr">15</xref>
<xref rid="B16" ref-type="bibr">16</xref>
).</p>
<p>We additionally evaluated risk factors for predicting contagious diseases at the screening level. Patients who were diagnosed with contagious diseases were more likely to have a transplant history, but, oddly, they were less likely to have fever or leukocytosis. These results imply that commonly used clinical parameters, such as fever or leukocytosis, may not be enough to accurately discriminate between contagious and non-infectious diseases. In our study, only 62 of 97 (64%) patients with a contagious disease had a fever and 89 (92%) had leukocytosis. Both of these proportions were significantly lower than those for the remaining patients with non-contagious diseases (<italic>P</italic>
= 0.031 for fever, <italic>P</italic>
= 0.008 for leukocytosis). However, a more general interpretation of these findings is limited in that our institution is one of the largest tertiary-referral centers in Korea, and our patients generally have relatively severe or complicated conditions.</p>
<p>There have been very few studies conducted on pre-hospital triage. During the 2009 influenza pandemic, an influenza-like illness scoring system was used to triage 1,840 ED patients with acute respiratory illness treated at a Mexican hospital (<xref rid="B17" ref-type="bibr">17</xref>
). In a study conducted in Qatar, a surveillance system protocol reduced the number of patients who needed to be tested for MERS-CoV at an ED (<xref rid="B18" ref-type="bibr">18</xref>
). However, to date, no data on the utility of screening systems outside the ED of tertiary medical centers have been collected at the pre-hospitalization stage, especially for all emergency center patients; thus, our study is unique and significant.</p>
<p>During the study period, we found several problems regarding the maintenance of our screening system, and these could be critical if inappropriately managed. The greatest concern was that some patients deteriorated during FRIDU screening, and 3 of the 114 patients who were moved to the resuscitation zone during our study period died in the ED. Although the medical facilities in the FRIDU are well established, special medical resources, such as computed tomography, were not available or applied late, and the screening process is focused on contagious diseases; hence, critically ill patients are at risk of clinical deterioration during the screening process.</p>
<p>The other major problem is that maintaining a separate screening system outside the ED requires considerable personnel and financial resources. During the study period, an average of 12 patients were screened daily in the FRIDU, which means that the screening process was activated every 2 hours, and the FRIDU required staffing 24 hours a day. For these reasons, the ideal tertiary hospital ED isolation system still may not be enough—although most hospitals are still far from the ideal. A study conducted in the United Kingdom in 2007 found that only 24% of 203 hospitals reviewed had isolation facilities available in the ED (<xref rid="B19" ref-type="bibr">19</xref>
). A recent evaluation of 48 infectious disease isolation facilities in 16 European countries found that only 18 facilities fulfilled the definition of a high-level isolation unit, and only 34 had all essential equipment for negative pressure (<xref rid="B20" ref-type="bibr">20</xref>
). Given that disasters such as the recent outbreak in Korea (<xref rid="B5" ref-type="bibr">5</xref>
) can affect not only public health but the economy (<xref rid="B6" ref-type="bibr">6</xref>
), we believe that a more efficient screening process is needed.</p>
<p>The present study had several limitations. First, the screening criteria for contagious diseases were not validated, especially regarding the definition of fever, which was very low (≥ 37.5°C). Second, mainly due to the retrospective design, we could not evaluate the degree to which the screening system was more effective than the previous system at preventing nosocomial outbreaks. Third, we analyzed just patients who were hospitalized after screening, so we could not know final diagnosis of the patients such as discharged, referred or followed by the outpatient clinic. Forth, our study population was not representative in terms of baseline clinical characteristics, such as comorbidity, because our study was conducted at a large tertiary-referral center.</p>
<p>To the best of our knowledge, this is the first study to demonstrate the utility of a contagious diseases screening unit outside an ED and hospital. We showed that the isolation level determined based on the FRIDU screening system was moderately well correlated with the isolation levels required by the final diagnosis, and no serious nosocomial outbreaks of contagious diseases occurred during the study period. However, the problems of clinical deterioration during screening and the financial and personnel costs remain. Therefore, further system-level studies on triage strategy are needed.</p>
</sec>
</body>
<back><fn-group><fn fn-type="COI-statement"><p><bold>DISCLOSURE:</bold>
The authors have no potential conflicts of interest to disclose.</p>
</fn>
<fn fn-type="con"><p><bold>AUTHOR CONTRIBUTION:</bold>
Conceptualization: Kang JS, Jhun BW, Yoon H. Investigation: Kang JS, Jhun BW, Yoon H, Lim SM, Ko E, Park JH, Hwang SY, Lee SU, Lee TR, Cha WC, Shin TG, Sim MS, Jo IJ. Supervision: Kang JS, Jhun BW, Yoon H. Writing - original draft: Kang JS, Jhun BW, Yoon H. Writing - review & editing: Kang JS, Jhun BW, Yoon H.</p>
</fn>
</fn-group>
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<sec sec-type="supplementary-material"><title>Supplementary Materials</title>
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<p>KTAS and ESI</p>
</caption>
<media mimetype="application" mime-subtype="pdf" xlink:href="jkms-32-1534-s001.pdf" orientation="portrait" id="d35e2310" position="anchor"></media>
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</record>
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