Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Real-Time Estimation of the Risk of Death from Novel Coronavirus (COVID-19) Infection: Inference Using Exported Cases</title>
<author><name sortKey="Jung, Sung Mok" sort="Jung, Sung Mok" uniqKey="Jung S" first="Sung-Mok" last="Jung">Sung-Mok Jung</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akhmetzhanov, Andrei R" sort="Akhmetzhanov, Andrei R" uniqKey="Akhmetzhanov A" first="Andrei R." last="Akhmetzhanov">Andrei R. Akhmetzhanov</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayashi, Katsuma" sort="Hayashi, Katsuma" uniqKey="Hayashi K" first="Katsuma" last="Hayashi">Katsuma Hayashi</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Linton, Natalie M" sort="Linton, Natalie M" uniqKey="Linton N" first="Natalie M." last="Linton">Natalie M. Linton</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yichi" sort="Yang, Yichi" uniqKey="Yang Y" first="Yichi" last="Yang">Yichi Yang</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yuan, Baoyin" sort="Yuan, Baoyin" uniqKey="Yuan B" first="Baoyin" last="Yuan">Baoyin Yuan</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kinoshita, Ryo" sort="Kinoshita, Ryo" uniqKey="Kinoshita R" first="Ryo" last="Kinoshita">Ryo Kinoshita</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nishiura, Hiroshi" sort="Nishiura, Hiroshi" uniqKey="Nishiura H" first="Hiroshi" last="Nishiura">Hiroshi Nishiura</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2-jcm-09-00523">Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32075152</idno>
<idno type="pmc">7074479</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074479</idno>
<idno type="RBID">PMC:7074479</idno>
<idno type="doi">10.3390/jcm9020523</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000910</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000910</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Real-Time Estimation of the Risk of Death from Novel Coronavirus (COVID-19) Infection: Inference Using Exported Cases</title>
<author><name sortKey="Jung, Sung Mok" sort="Jung, Sung Mok" uniqKey="Jung S" first="Sung-Mok" last="Jung">Sung-Mok Jung</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akhmetzhanov, Andrei R" sort="Akhmetzhanov, Andrei R" uniqKey="Akhmetzhanov A" first="Andrei R." last="Akhmetzhanov">Andrei R. Akhmetzhanov</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayashi, Katsuma" sort="Hayashi, Katsuma" uniqKey="Hayashi K" first="Katsuma" last="Hayashi">Katsuma Hayashi</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Linton, Natalie M" sort="Linton, Natalie M" uniqKey="Linton N" first="Natalie M." last="Linton">Natalie M. Linton</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yichi" sort="Yang, Yichi" uniqKey="Yang Y" first="Yichi" last="Yang">Yichi Yang</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yuan, Baoyin" sort="Yuan, Baoyin" uniqKey="Yuan B" first="Baoyin" last="Yuan">Baoyin Yuan</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kobayashi, Tetsuro" sort="Kobayashi, Tetsuro" uniqKey="Kobayashi T" first="Tetsuro" last="Kobayashi">Tetsuro Kobayashi</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kinoshita, Ryo" sort="Kinoshita, Ryo" uniqKey="Kinoshita R" first="Ryo" last="Kinoshita">Ryo Kinoshita</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nishiura, Hiroshi" sort="Nishiura, Hiroshi" uniqKey="Nishiura H" first="Hiroshi" last="Nishiura">Hiroshi Nishiura</name>
<affiliation><nlm:aff id="af1-jcm-09-00523">Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2-jcm-09-00523">Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical Medicine</title>
<idno type="eISSN">2077-0383</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The exported cases of 2019 novel coronavirus (COVID-19) infection that were confirmed outside China provide an opportunity to estimate the cumulative incidence and confirmed case fatality risk (cCFR) in mainland China. Knowledge of the cCFR is critical to characterize the severity and understand the pandemic potential of COVID-19 in the early stage of the epidemic. Using the exponential growth rate of the incidence, the present study statistically estimated the cCFR and the basic reproduction number—the average number of secondary cases generated by a single primary case in a naïve population. We modeled epidemic growth either from a single index case with illness onset on 8 December 2019 (Scenario 1), or using the growth rate fitted along with the other parameters (Scenario 2) based on data from 20 exported cases reported by 24 January 2020. The cumulative incidence in China by 24 January was estimated at 6924 cases (95% confidence interval [CI]: 4885, 9211) and 19,289 cases (95% CI: 10,901, 30,158), respectively. The latest estimated values of the cCFR were 5.3% (95% CI: 3.5%, 7.5%) for Scenario 1 and 8.4% (95% CI: 5.3%, 12.3%) for Scenario 2. The basic reproduction number was estimated to be 2.1 (95% CI: 2.0, 2.2) and 3.2 (95% CI: 2.7, 3.7) for Scenarios 1 and 2, respectively. Based on these results, we argued that the current COVID-19 epidemic has a substantial potential for causing a pandemic. The proposed approach provides insights in early risk assessment using publicly available data.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name>
</author>
<author><name sortKey="Guan, X" uniqKey="Guan X">X. Guan</name>
</author>
<author><name sortKey="Wu, P" uniqKey="Wu P">P. Wu</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name>
</author>
<author><name sortKey="Tong, Y" uniqKey="Tong Y">Y. Tong</name>
</author>
<author><name sortKey="Ren, R" uniqKey="Ren R">R. Ren</name>
</author>
<author><name sortKey="Leung, K S M" uniqKey="Leung K">K.S.M. Leung</name>
</author>
<author><name sortKey="Lau, E H Y" uniqKey="Lau E">E.H.Y. Lau</name>
</author>
<author><name sortKey="Wong, J Y" uniqKey="Wong J">J.Y. Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, J" uniqKey="Cui J">J. Cui</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F. Li</name>
</author>
<author><name sortKey="Shi, Z L" uniqKey="Shi Z">Z.L. Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Ren, L" uniqKey="Ren L">L. Ren</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name>
</author>
<author><name sortKey="Fan, G" uniqKey="Fan G">G. Fan</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name>
</author>
<author><name sortKey="Gu, X" uniqKey="Gu X">X. Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name>
</author>
<author><name sortKey="Yuan, S" uniqKey="Yuan S">S. Yuan</name>
</author>
<author><name sortKey="Kok, K H" uniqKey="Kok K">K.H. Kok</name>
</author>
<author><name sortKey="To, K K W" uniqKey="To K">K.K.W. To</name>
</author>
<author><name sortKey="Chu, H" uniqKey="Chu H">H. Chu</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Xing, J" uniqKey="Xing J">J. Xing</name>
</author>
<author><name sortKey="Xing, F" uniqKey="Xing F">F. Xing</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Yip, C C" uniqKey="Yip C">C.C. Yip</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
<author><name sortKey="Jung, S" uniqKey="Jung S">S. Jung</name>
</author>
<author><name sortKey="Linton, N M" uniqKey="Linton N">N.M. Linton</name>
</author>
<author><name sortKey="Kinoshita, R" uniqKey="Kinoshita R">R. Kinoshita</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Hayashi, K" uniqKey="Hayashi K">K. Hayashi</name>
</author>
<author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T. Kobayashi</name>
</author>
<author><name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author><name sortKey="Akhmetzhanov, A R" uniqKey="Akhmetzhanov A">A.R. Akhmetzhanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghani, A C" uniqKey="Ghani A">A.C. Ghani</name>
</author>
<author><name sortKey="Donnelly, C A" uniqKey="Donnelly C">C.A. Donnelly</name>
</author>
<author><name sortKey="Cox, D R" uniqKey="Cox D">D.R. Cox</name>
</author>
<author><name sortKey="Griffin, J T" uniqKey="Griffin J">J.T. Griffin</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name>
</author>
<author><name sortKey="Lam, T H" uniqKey="Lam T">T.H. Lam</name>
</author>
<author><name sortKey="Ho, L M" uniqKey="Ho L">L.M. Ho</name>
</author>
<author><name sortKey="Chan, W S" uniqKey="Chan W">W.S. Chan</name>
</author>
<author><name sortKey="Anderson, R M" uniqKey="Anderson R">R.M. Anderson</name>
</author>
<author><name sortKey="Hedley, A J" uniqKey="Hedley A">A.J. Hedley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
<author><name sortKey="Klinkenberg, D" uniqKey="Klinkenberg D">D. Klinkenberg</name>
</author>
<author><name sortKey="Roberts, M" uniqKey="Roberts M">M. Roberts</name>
</author>
<author><name sortKey="Heesterbeek, J A" uniqKey="Heesterbeek J">J.A. Heesterbeek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garske, T" uniqKey="Garske T">T. Garske</name>
</author>
<author><name sortKey="Legrand, J" uniqKey="Legrand J">J. Legrand</name>
</author>
<author><name sortKey="Donnelly, C A" uniqKey="Donnelly C">C.A. Donnelly</name>
</author>
<author><name sortKey="Ward, H" uniqKey="Ward H">H. Ward</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S. Cauchemez</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name>
</author>
<author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name>
</author>
<author><name sortKey="Ghani, A C" uniqKey="Ghani A">A.C. Ghani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, R N" uniqKey="Thompson R">R.N. Thompson</name>
</author>
<author><name sortKey="Gilligan, C A" uniqKey="Gilligan C">C.A. Gilligan</name>
</author>
<author><name sortKey="Cunniffe, N J" uniqKey="Cunniffe N">N.J. Cunniffe</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Linton, N M" uniqKey="Linton N">N.M. Linton</name>
</author>
<author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T. Kobayashi</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Hayashi, K" uniqKey="Hayashi K">K. Hayashi</name>
</author>
<author><name sortKey="Akhmetzhanov, A R" uniqKey="Akhmetzhanov A">A.R. Akhmetzhanov</name>
</author>
<author><name sortKey="Jung, S" uniqKey="Jung S">S. Jung</name>
</author>
<author><name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author><name sortKey="Kinoshita, R" uniqKey="Kinoshita R">R. Kinoshita</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M. Lipsitch</name>
</author>
<author><name sortKey="Cohen, T" uniqKey="Cohen T">T. Cohen</name>
</author>
<author><name sortKey="Cooper, B" uniqKey="Cooper B">B. Cooper</name>
</author>
<author><name sortKey="Robins, J M" uniqKey="Robins J">J.M. Robins</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S. Ma</name>
</author>
<author><name sortKey="James, L" uniqKey="James L">L. James</name>
</author>
<author><name sortKey="Gopalakrishna, G" uniqKey="Gopalakrishna G">G. Gopalakrishna</name>
</author>
<author><name sortKey="Chew, S K" uniqKey="Chew S">S.K. Chew</name>
</author>
<author><name sortKey="Tan, C C" uniqKey="Tan C">C.C. Tan</name>
</author>
<author><name sortKey="Samore, M H" uniqKey="Samore M">M.H. Samore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
<author><name sortKey="Dushoff, J" uniqKey="Dushoff J">J. Dushoff</name>
</author>
<author><name sortKey="Bolker, B M" uniqKey="Bolker B">B.M. Bolker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kucharski, A J" uniqKey="Kucharski A">A.J. Kucharski</name>
</author>
<author><name sortKey="Russell, T W" uniqKey="Russell T">T.W. Russell</name>
</author>
<author><name sortKey="Diamond, C" uniqKey="Diamond C">C. Diamond</name>
</author>
<author><name sortKey="Funk, S" uniqKey="Funk S">S. Funk</name>
</author>
<author><name sortKey="Eggo, R M" uniqKey="Eggo R">R.M. Eggo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, R N" uniqKey="Thompson R">R.N. Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boldog, P" uniqKey="Boldog P">P. Boldog</name>
</author>
<author><name sortKey="Tekeli, T" uniqKey="Tekeli T">T. Tekeli</name>
</author>
<author><name sortKey="Vizi, Z" uniqKey="Vizi Z">Z. Vizi</name>
</author>
<author><name sortKey="Denes, A" uniqKey="Denes A">A. Denes</name>
</author>
<author><name sortKey="Bartha, F" uniqKey="Bartha F">F. Bartha</name>
</author>
<author><name sortKey="Rost, G" uniqKey="Rost G">G. Rost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donnelly, C A" uniqKey="Donnelly C">C.A. Donnelly</name>
</author>
<author><name sortKey="Ghani, A C" uniqKey="Ghani A">A.C. Ghani</name>
</author>
<author><name sortKey="Leung, G M" uniqKey="Leung G">G.M. Leung</name>
</author>
<author><name sortKey="Hedley, A J" uniqKey="Hedley A">A.J. Hedley</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S. Riley</name>
</author>
<author><name sortKey="Abu Raddad, L J" uniqKey="Abu Raddad L">L.J. Abu-Raddad</name>
</author>
<author><name sortKey="Ho, L M" uniqKey="Ho L">L.-M. Ho</name>
</author>
<author><name sortKey="Thach, T Q" uniqKey="Thach T">T.-Q. Thach</name>
</author>
<author><name sortKey="Chau, P" uniqKey="Chau P">P. Chau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K. Mizumoto</name>
</author>
<author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M. Saitoh</name>
</author>
<author><name sortKey="Chowell, G" uniqKey="Chowell G">G. Chowell</name>
</author>
<author><name sortKey="Miyamatsu, Y" uniqKey="Miyamatsu Y">Y. Miyamatsu</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Majumder, M S" uniqKey="Majumder M">M.S. Majumder</name>
</author>
<author><name sortKey="Kluberg, S A" uniqKey="Kluberg S">S.A. Kluberg</name>
</author>
<author><name sortKey="Mekaru, S R" uniqKey="Mekaru S">S.R. Mekaru</name>
</author>
<author><name sortKey="Brownstein, J S" uniqKey="Brownstein J">J.S. Brownstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K. Mizumoto</name>
</author>
<author><name sortKey="Endo, A" uniqKey="Endo A">A. Endo</name>
</author>
<author><name sortKey="Chowell, G" uniqKey="Chowell G">G. Chowell</name>
</author>
<author><name sortKey="Miyamatsu, Y" uniqKey="Miyamatsu Y">Y. Miyamatsu</name>
</author>
<author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M. Saitoh</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H. Nishiura</name>
</author>
<author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T. Kobayashi</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Hayashi, K" uniqKey="Hayashi K">K. Hayashi</name>
</author>
<author><name sortKey="Miyama, T" uniqKey="Miyama T">T. Miyama</name>
</author>
<author><name sortKey="Kinoshita, R" uniqKey="Kinoshita R">R. Kinoshita</name>
</author>
<author><name sortKey="Linton, N M" uniqKey="Linton N">N.M. Linton</name>
</author>
<author><name sortKey="Jung, S M" uniqKey="Jung S">S.-M. Jung</name>
</author>
<author><name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A. Suzuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name>
</author>
<author><name sortKey="Ran, J" uniqKey="Ran J">J. Ran</name>
</author>
<author><name sortKey="Musa, S S" uniqKey="Musa S">S.S. Musa</name>
</author>
<author><name sortKey="Yang, G" uniqKey="Yang G">G. Yang</name>
</author>
<author><name sortKey="Lou, Y" uniqKey="Lou Y">Y. Lou</name>
</author>
<author><name sortKey="Gao, D" uniqKey="Gao D">D. Gao</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name>
</author>
<author><name sortKey="He, D" uniqKey="He D">D. He</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Read, J M" uniqKey="Read J">J.M. Read</name>
</author>
<author><name sortKey="Bridgen, J R" uniqKey="Bridgen J">J.R. Bridgen</name>
</author>
<author><name sortKey="Cummings, D A" uniqKey="Cummings D">D.A. Cummings</name>
</author>
<author><name sortKey="Ho, A" uniqKey="Ho A">A. Ho</name>
</author>
<author><name sortKey="Jewell, C P" uniqKey="Jewell C">C.P. Jewell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C. Fraser</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S. Riley</name>
</author>
<author><name sortKey="Anderson, R M" uniqKey="Anderson R">R.M. Anderson</name>
</author>
<author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, R N" uniqKey="Thompson R">R.N. Thompson</name>
</author>
<author><name sortKey="Gilligan, C A" uniqKey="Gilligan C">C.A. Gilligan</name>
</author>
<author><name sortKey="Cunniffe, N J" uniqKey="Cunniffe N">N.J. Cunniffe</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J Clin Med</journal-id>
<journal-id journal-id-type="publisher-id">jcm</journal-id>
<journal-title-group><journal-title>Journal of Clinical Medicine</journal-title>
</journal-title-group>
<issn pub-type="epub">2077-0383</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32075152</article-id>
<article-id pub-id-type="pmc">7074479</article-id>
<article-id pub-id-type="doi">10.3390/jcm9020523</article-id>
<article-id pub-id-type="publisher-id">jcm-09-00523</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Real-Time Estimation of the Risk of Death from Novel Coronavirus (COVID-19) Infection: Inference Using Exported Cases</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-0787-4515</contrib-id>
<name><surname>Jung</surname>
<given-names>Sung-mok</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-3269-7351</contrib-id>
<name><surname>Akhmetzhanov</surname>
<given-names>Andrei R.</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayashi</surname>
<given-names>Katsuma</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-5464-0076</contrib-id>
<name><surname>Linton</surname>
<given-names>Natalie M.</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Yichi</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yuan</surname>
<given-names>Baoyin</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kobayashi</surname>
<given-names>Tetsuro</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-0116-4598</contrib-id>
<name><surname>Kinoshita</surname>
<given-names>Ryo</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-0941-8537</contrib-id>
<name><surname>Nishiura</surname>
<given-names>Hiroshi</given-names>
</name>
<xref ref-type="aff" rid="af1-jcm-09-00523">1</xref>
<xref ref-type="aff" rid="af2-jcm-09-00523">2</xref>
<xref rid="c1-jcm-09-00523" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-jcm-09-00523"><label>1</label>
Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido 060-8638, Japan;<email>seductmd@med.hokudai.ac.jp</email>
(S.-m.J.);<email>akhmetzhanov@gmail.com</email>
(A.R.A.);<email>katsuma5miffy@gmail.com</email>
(K.H.);<email>nlinton@gmail.com</email>
(N.M.L.);<email>lukeyang1993@eis.hokudai.ac.jp</email>
(Y.Y.);<email>baoyinyuan@gmail.com</email>
(B.Y.);<email>tootsieroll2910@gmail.com</email>
(T.K.);<email>kinoshitaryo@gmail.com</email>
(R.K.)</aff>
<aff id="af2-jcm-09-00523"><label>2</label>
Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan</aff>
<author-notes><corresp id="c1-jcm-09-00523"><label>*</label>
Correspondence: <email>nishiurah@med.hokudai.ac.jp</email>
; Tel.: +81-11-706-5066</corresp>
</author-notes>
<pub-date pub-type="epub"><day>14</day>
<month>2</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><month>2</month>
<year>2020</year>
</pub-date>
<volume>9</volume>
<issue>2</issue>
<elocation-id>523</elocation-id>
<history><date date-type="received"><day>29</day>
<month>1</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>12</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 by the authors.</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>The exported cases of 2019 novel coronavirus (COVID-19) infection that were confirmed outside China provide an opportunity to estimate the cumulative incidence and confirmed case fatality risk (cCFR) in mainland China. Knowledge of the cCFR is critical to characterize the severity and understand the pandemic potential of COVID-19 in the early stage of the epidemic. Using the exponential growth rate of the incidence, the present study statistically estimated the cCFR and the basic reproduction number—the average number of secondary cases generated by a single primary case in a naïve population. We modeled epidemic growth either from a single index case with illness onset on 8 December 2019 (Scenario 1), or using the growth rate fitted along with the other parameters (Scenario 2) based on data from 20 exported cases reported by 24 January 2020. The cumulative incidence in China by 24 January was estimated at 6924 cases (95% confidence interval [CI]: 4885, 9211) and 19,289 cases (95% CI: 10,901, 30,158), respectively. The latest estimated values of the cCFR were 5.3% (95% CI: 3.5%, 7.5%) for Scenario 1 and 8.4% (95% CI: 5.3%, 12.3%) for Scenario 2. The basic reproduction number was estimated to be 2.1 (95% CI: 2.0, 2.2) and 3.2 (95% CI: 2.7, 3.7) for Scenarios 1 and 2, respectively. Based on these results, we argued that the current COVID-19 epidemic has a substantial potential for causing a pandemic. The proposed approach provides insights in early risk assessment using publicly available data.</p>
</abstract>
<kwd-group><kwd>mortality</kwd>
<kwd>censoring</kwd>
<kwd>travel</kwd>
<kwd>migration</kwd>
<kwd>importation</kwd>
<kwd>emerging infectious diseases</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec sec-type="intro" id="sec1-jcm-09-00523"><title>1. Introduction</title>
<p>Since 8 December 2019, clusters of pneumonia cases of unknown etiology have emerged in Wuhan City, Hubei Province, China [<xref rid="B1-jcm-09-00523" ref-type="bibr">1</xref>
,<xref rid="B2-jcm-09-00523" ref-type="bibr">2</xref>
]. Virological investigation suggests that the causative agent of this pneumonia is a novel coronavirus (COVID-19) [<xref rid="B3-jcm-09-00523" ref-type="bibr">3</xref>
]. As of 27 January 2020, a total of 4515 cases including 106 deaths were confirmed [<xref rid="B4-jcm-09-00523" ref-type="bibr">4</xref>
]. Forty-one cases of COVID-19 infections were also reported outside China, in other Asian countries, the United States, France, Australia, and Canada.</p>
<p>A local market selling seafood and wildlife in Wuhan was visited by many cases in the initial cluster, indicating that a common-source zoonotic exposure may have been the main mode of transmission [<xref rid="B5-jcm-09-00523" ref-type="bibr">5</xref>
]. However, even after shutting down the market, the number of cases continued to grow across China and several instances of household transmission were reported [<xref rid="B6-jcm-09-00523" ref-type="bibr">6</xref>
]. It is now speculated that sustained human-to-human transmission aided in the establishment of the epidemic [<xref rid="B7-jcm-09-00523" ref-type="bibr">7</xref>
] and that reported case counts greatly underestimated the actual number of infections in China [<xref rid="B8-jcm-09-00523" ref-type="bibr">8</xref>
].</p>
<p>Early assessment of the severity of infection and transmissibility can help quantify the pandemic potential of COVID-19 and anticipate the likely number of deaths by the end of the epidemic. One important epidemiological measure of severity is case fatality risk (CFR), which can be measured using three different approaches, by estimating (i) the proportion of the cumulative number of deaths out of the cumulative number of cases at a point in time, (ii) the ratio of the cumulative number of deaths to the cumulative number of infected individuals whose clinical outcome is known (i.e., the deceased or recovered), and (iii) the risk of death among confirmed cases, explicitly accounting for the time from illness onset to death [<xref rid="B9-jcm-09-00523" ref-type="bibr">9</xref>
]. Estimating the CFR using the ratio of deaths to confirmed cases (cCFR), with an adjustment of the time delay from illness onset to death (i.e., method (iii)), can provide insight into severity of the disease, because the naïve CFR based on method (i) tends to be an underestimate due to the real-time nature of the growth of fatal cases. For example, during the early stage of an epidemic, failing to right-censor cases with respect to the time delay from illness onset to death may lead to underestimation of the CFR. This is because death due to infection may yet occur following case identification [<xref rid="B9-jcm-09-00523" ref-type="bibr">9</xref>
,<xref rid="B10-jcm-09-00523" ref-type="bibr">10</xref>
,<xref rid="B11-jcm-09-00523" ref-type="bibr">11</xref>
]. </p>
<p>When the CFR denominator only includes confirmed cases it is referred to as the cCFR [<xref rid="B10-jcm-09-00523" ref-type="bibr">10</xref>
] and may overestimate the actual CFR among all infected individuals due to under-ascertainment of infections in the population. Nonetheless, the cCFR is still a valuable measure of the upper bound of the CFR among all symptomatic cases (sCFR), particularly in circumstances of high uncertainty, such as the emergence of a new human pathogen (i.e., COVID-19).</p>
<p>The basic reproduction number (<inline-formula><mml:math id="mm1"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, the average number of secondary cases generated by a single primary case in a fully susceptible population, represents an epidemiological measurement of the transmissibility, helping us to quantify the pandemic potential of COVID-19. Here, we define a pandemic as the worldwide spread of a newly emerged disease, in which the number of simultaneously infected individuals exceeds the capacity for treatment [<xref rid="B12-jcm-09-00523" ref-type="bibr">12</xref>
]. Using the growth rate of the estimated cumulative incidence from exportation cases and accounting for the time delay from illness onset to death, the present study aims to estimate the cCFR of COVID-19 in real-time.</p>
</sec>
<sec sec-type="methods" id="sec2-jcm-09-00523"><title>2. Methods</title>
<sec id="sec2dot1-jcm-09-00523"><title>2.1. Epidemiological Data</title>
<p>Information on exported COVID-19 cases who were confirmed in other countries and deaths due to COVID-19 infection in China were retrieved from the first announcement date of the current outbreak (i.e., 31 December 2019) through 24 January 2020. The cutoff time of 24 January was specifically selected to reflect the governmental ban on public transportation from Wuhan (including flights) which was invoked on 23 January 2020 [<xref rid="B13-jcm-09-00523" ref-type="bibr">13</xref>
]. All data were collected either from government websites or from media quoting government announcements. Our data include 51 cases diagnosed outside China who had illness onset through 24 January and were reported by 9 February 2020 and the dates of illness onset and death among 41 deceased cases in China.</p>
</sec>
<sec id="sec2dot2-jcm-09-00523"><title>2.2. Estimation of the Delay Distributions</title>
<p>The observed incidence <italic>i</italic>
(<italic>t</italic>
) by date of illness onset <italic>t</italic>
is modeled using an exponential growth model with the rate <italic>r</italic>
: <inline-formula><mml:math id="mm2"><mml:mrow><mml:mrow><mml:mi>i</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:msup><mml:mi>e</mml:mi>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mi>t</mml:mi>
</mml:mrow>
</mml:msup>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, where <italic>i</italic>
<sub>0</sub>
is the expected number of infected cases at time <italic>t</italic>
= 0. The cumulative incidence <italic>I</italic>
(t) is an integral of <italic>i</italic>
(<italic>t</italic>
) over the time interval from zero to <italic>t</italic>
that can be written as <inline-formula><mml:math id="mm3"><mml:mrow><mml:mrow><mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:msubsup><mml:mstyle mathsize="140%" displaystyle="true"><mml:mo>∫</mml:mo>
</mml:mstyle>
<mml:mn>0</mml:mn>
<mml:mi>t</mml:mi>
</mml:msubsup>
<mml:mi>i</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>s</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mi mathvariant="normal">d</mml:mi>
<mml:mi>s</mml:mi>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:msup><mml:mi>e</mml:mi>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mi>t</mml:mi>
</mml:mrow>
</mml:msup>
<mml:mo>−</mml:mo>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>/</mml:mo>
<mml:mi>r</mml:mi>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
. The cumulative incidence is adjusted to the date of report by the factor <italic>u</italic>
dependent on the parameters of the delay distribution. For the estimation of time delay distribution from illness onset to death, we accounted for right truncation and modeled and used a lognormal distribution with parameters adopted from an earlier study [<xref rid="B14-jcm-09-00523" ref-type="bibr">14</xref>
]. Let <inline-formula><mml:math id="mm4"><mml:mrow><mml:mrow><mml:mi>f</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>t</mml:mi>
<mml:mo>;</mml:mo>
<mml:mi>θ</mml:mi>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
be the lognormal distribution with parameters <inline-formula><mml:math id="mm5"><mml:mrow><mml:mrow><mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:msub><mml:mi>a</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>b</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
. Then, the cumulative incidence <italic>I(t)</italic>
by date of report <italic>t</italic>
can be adjusted to the time from illness onset to death and report by simply multiplying it by the factor <inline-formula><mml:math id="mm6"><mml:mrow><mml:mrow><mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, which is a consequence of the exponentially growing epidemic [<xref rid="B10-jcm-09-00523" ref-type="bibr">10</xref>
]. The factor <italic>u</italic>
is defined by the following integral:<disp-formula id="FD1-jcm-09-00523"><label>(1)</label>
<mml:math id="mm7"><mml:mrow><mml:mrow><mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:msubsup><mml:mstyle mathsize="140%" displaystyle="true"><mml:mo>∫</mml:mo>
</mml:mstyle>
<mml:mn>0</mml:mn>
<mml:mo>∞</mml:mo>
</mml:msubsup>
<mml:mi>exp</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mo>−</mml:mo>
<mml:mi>r</mml:mi>
<mml:mi>s</mml:mi>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mi>f</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>s</mml:mi>
<mml:mo>;</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mi>d</mml:mi>
<mml:mi>s</mml:mi>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
</p>
<p>The adjusted cumulative incidence then obeys <inline-formula><mml:math id="mm8"><mml:mrow><mml:mrow><mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:mo> </mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
. The cumulative number of deaths <italic>D</italic>
(<italic>t</italic>
) reported by date <italic>t</italic>
is the result of Binomial sampling:<disp-formula id="FD2-jcm-09-00523"><label>(2)</label>
<mml:math id="mm9"><mml:mrow><mml:mrow><mml:mi>D</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mtext> </mml:mtext>
<mml:mo>~</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>binom</mml:mi>
</mml:mrow>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>size</mml:mi>
<mml:mo>=</mml:mo>
<mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>prob</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
</p>
<p>Let <inline-formula><mml:math id="mm10"><mml:mrow><mml:mrow><mml:msub><mml:mi>a</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
and <inline-formula><mml:math id="mm11"><mml:mrow><mml:mrow><mml:msub><mml:mi>b</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
be the shape and inverse scale of the gamma distribution modeling the distribution of time interval from illness onset to the report for observed exported cases. The cumulative incidence in China can be then adjusted by the multiplicative factor <inline-formula><mml:math id="mm12"><mml:mrow><mml:mrow><mml:mover accent="true"><mml:mi>u</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:msub><mml:mi>a</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>b</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
. The number of exported cases <italic>E</italic>
(<italic>t</italic>
) can then be sampled from another Binomial distribution:<disp-formula id="FD3-jcm-09-00523"><label>(3)</label>
<mml:math id="mm13"><mml:mrow><mml:mrow><mml:mi>E</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mtext> </mml:mtext>
<mml:mo>~</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>binom</mml:mi>
</mml:mrow>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>size</mml:mi>
<mml:mo>=</mml:mo>
<mml:mover accent="true"><mml:mi>u</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>prob</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>p</mml:mi>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
where <italic>p</italic>
describes the probability of finding a traveler from Wuhan among all travelers from China subject to the detection time window of the virus <italic>T</italic>
= 12.5 days [<xref rid="B8-jcm-09-00523" ref-type="bibr">8</xref>
]. Given that the total volume of inbound passengers from China is <italic>M</italic>
= 5.56 million passengers per year, the fraction of Wuhan travelers is <inline-formula><mml:math id="mm14"><mml:mrow><mml:mi>ϕ</mml:mi>
</mml:mrow>
</mml:math>
</inline-formula>
= 0.021%, and the population of Wuhan is <italic>n</italic>
= 11 million, the probability <italic>p</italic>
is given by
<disp-formula id="FD4-jcm-09-00523"><label>(4)</label>
<mml:math id="mm15"><mml:mrow><mml:mrow><mml:mi>p</mml:mi>
<mml:mo>=</mml:mo>
<mml:mfrac><mml:mrow><mml:mi>ϕ</mml:mi>
<mml:mi>M</mml:mi>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mrow><mml:mn>365</mml:mn>
<mml:mi>n</mml:mi>
</mml:mrow>
</mml:mfrac>
<mml:mo>≈</mml:mo>
<mml:mn>0.0036</mml:mn>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
</p>
</sec>
<sec id="sec2dot3-jcm-09-00523"><title>2.3. Statistical Inference</title>
<p>First, we fitted the delay distribution of the time from illness onset to report <inline-formula><mml:math id="mm16"><mml:mrow><mml:mrow><mml:mi mathvariant="sans-serif">Δ</mml:mi>
<mml:msub><mml:mi>T</mml:mi>
<mml:mrow><mml:mi>e</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>k</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
(<inline-formula><mml:math id="mm17"><mml:mrow><mml:mrow><mml:mi>k</mml:mi>
<mml:mo>≤</mml:mo>
<mml:msub><mml:mi>K</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
) to the gamma distribution. We define the log-likelihood as follows:<disp-formula id="FD5-jcm-09-00523"><label>(5)</label>
<mml:math id="mm18"><mml:mrow><mml:mrow><mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo stretchy="false">(</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mrow><mml:mo stretchy="false">|</mml:mo>
<mml:mtext> </mml:mtext>
<mml:mi mathvariant="sans-serif">Δ</mml:mi>
</mml:mrow>
<mml:msub><mml:mi>T</mml:mi>
<mml:mrow><mml:mi>e</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>k</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mo stretchy="false">)</mml:mo>
<mml:mo>=</mml:mo>
<mml:munder><mml:mstyle mathsize="140%" displaystyle="true"><mml:mo>∑</mml:mo>
</mml:mstyle>
<mml:mi>k</mml:mi>
</mml:munder>
<mml:mi>log</mml:mi>
<mml:mo stretchy="false">(</mml:mo>
<mml:mi>gamma</mml:mi>
<mml:mo stretchy="false">(</mml:mo>
<mml:mi mathvariant="sans-serif">Δ</mml:mi>
<mml:msub><mml:mi>T</mml:mi>
<mml:mrow><mml:mi>e</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>k</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mtext> </mml:mtext>
<mml:mo stretchy="false">|</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>shape</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>a</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>scale</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>b</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
that is maximized to find the mean values of the parameters <inline-formula><mml:math id="mm19"><mml:mrow><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>θ</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>a</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:msub><mml:mover accent="true"><mml:mi>b</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, used in the following step. </p>
<p>Second, we fitted the observed counts of exported cases and deaths by considering two other likelihoods respective to each process:<disp-formula id="FD6-jcm-09-00523"><label>(6)</label>
<mml:math id="mm20"><mml:mrow><mml:mrow><mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi>E</mml:mi>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
<mml:mo> </mml:mo>
<mml:mo stretchy="false">|</mml:mo>
<mml:mtext> </mml:mtext>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>E</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mtext> </mml:mtext>
<mml:msub><mml:mi>t</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>≤</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>≤</mml:mo>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:munderover><mml:mstyle mathsize="140%" displaystyle="true"><mml:mo>∑</mml:mo>
</mml:mstyle>
<mml:mrow><mml:mi>t</mml:mi>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>t</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mi>T</mml:mi>
</mml:munderover>
<mml:mi>log</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>binom</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>E</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mtext> </mml:mtext>
<mml:mo stretchy="false">|</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>size</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mover accent="true"><mml:mi>u</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mover accent="true"><mml:mi>θ</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>prob</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>p</mml:mi>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
<disp-formula id="FD7-jcm-09-00523"><label>(7)</label>
<mml:math id="mm21"><mml:mrow><mml:mrow><mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi>D</mml:mi>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
<mml:mo> </mml:mo>
<mml:mo stretchy="false">|</mml:mo>
<mml:mo> </mml:mo>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>D</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mtext> </mml:mtext>
<mml:msub><mml:mi>t</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
<mml:mo>≤</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>≤</mml:mo>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:munderover><mml:mstyle mathsize="140%" displaystyle="true"><mml:mo>∑</mml:mo>
</mml:mstyle>
<mml:mrow><mml:mi>t</mml:mi>
<mml:mo>=</mml:mo>
<mml:msub><mml:mi>t</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mi>T</mml:mi>
</mml:munderover>
<mml:mi>log</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>binom</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>D</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mtext> </mml:mtext>
<mml:mo stretchy="false">|</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>size</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mrow><mml:mtext> </mml:mtext>
<mml:mi>prob</mml:mi>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
where <inline-formula><mml:math id="mm22"><mml:mrow><mml:mrow><mml:msub><mml:mi>t</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
and <inline-formula><mml:math id="mm23"><mml:mrow><mml:mrow><mml:msub><mml:mi>t</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
are the times at which the first exportation event and the first death are observed. The total log-likelihood is given by the sum of two log-likelihoods:<disp-formula id="FD8-jcm-09-00523"><label>(8)</label>
<mml:math id="mm24"><mml:mrow><mml:mrow><mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi mathvariant="sans-serif">Σ</mml:mi>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:msub><mml:mi>θ</mml:mi>
<mml:mi mathvariant="sans-serif">Σ</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mi>CFR</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
<mml:mo stretchy="false">|</mml:mo>
<mml:mi>D</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
<mml:mi>E</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>=</mml:mo>
<mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi>E</mml:mi>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
<mml:mtext> </mml:mtext>
<mml:mo stretchy="false">|</mml:mo>
<mml:mi>E</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>+</mml:mo>
<mml:mi>l</mml:mi>
<mml:mi>o</mml:mi>
<mml:mi>g</mml:mi>
<mml:msub><mml:mi>L</mml:mi>
<mml:mi>D</mml:mi>
</mml:msub>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
<mml:mo stretchy="false">|</mml:mo>
<mml:mi>D</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
which is then maximized to determine the best-fit parameters <inline-formula><mml:math id="mm25"><mml:mrow><mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
.</p>
<p>We considered two possible scenarios to fit to the data. In the first scenario (referred to as “Scenario 1”), the parameter <inline-formula><mml:math id="mm26"><mml:mrow><mml:mrow><mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
is fixed at one on the date of illness onset for the first COVID-19 confirmed case (i.e., 8 December 2019), providing a fixed starting point for the exponential growth of the cumulative incidence. Although 8 December 2019 is assumed as the starting point for exponential growth of the cumulative incidence in Scenario 1, there is still uncertainty using this date as a proxy for the beginning of exponential growth due to inconsistencies in reported illness onset for the earliest reported cases [<xref rid="B2-jcm-09-00523" ref-type="bibr">2</xref>
,<xref rid="B5-jcm-09-00523" ref-type="bibr">5</xref>
]. Therefore, we conducted a sensitivity analysis where the start date for exponential growth was varied between 1 December and 10 December 2019. In the second scenario (referred to as “Scenario 2”), all parameters <inline-formula><mml:math id="mm27"><mml:mrow><mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>i</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:mi>C</mml:mi>
<mml:mi>F</mml:mi>
<mml:mi>R</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
are variable, and calculation begins on the date the first exported case was observed (i.e., 13 January 2020). For both scenarios, we conducted sensitivity analyses that estimated the growth rate, cumulative incidence, and cCFR value using different cut-off times, values of the detection window <italic>T</italic>
, and sizes of the catchment population of the Wuhan International airport <italic>n</italic>
.</p>
<p>The value of the basic reproduction number <inline-formula><mml:math id="mm28"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
for the COVID-19 epidemic was calculated as
<disp-formula id="FD9-jcm-09-00523"><label>(9)</label>
<mml:math id="mm29"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:mn>1</mml:mn>
<mml:mo>+</mml:mo>
<mml:mi>r</mml:mi>
<mml:msub><mml:mi>S</mml:mi>
<mml:mtext> </mml:mtext>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</disp-formula>
where <italic>r</italic>
is the estimated growth rate for each scenario and <italic>S</italic>
is the mean serial interval for successive COVID-19 infections. The value of the serial interval was adopted from a published study [<xref rid="B2-jcm-09-00523" ref-type="bibr">2</xref>
], and a gamma distribution was fitted to six known infector-infectee pairs (mean = 7.5 days, standard deviation [SD] = 3.4 days).</p>
<p>In our analysis, we employed Markov chain Monte Carlo (MCMC) simulations with eight chains of 4250 samples each, with 2500 samples used for the tuning stage, leveraging the No-U-Turn sampler (NUTS) part of the Python PyMC3 package. However, one of the input variables for the Binomial distribution <inline-formula><mml:math id="mm30"><mml:mrow><mml:mrow><mml:mover accent="true"><mml:mi>u</mml:mi>
<mml:mo>˜</mml:mo>
</mml:mover>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
or <inline-formula><mml:math id="mm31"><mml:mrow><mml:mrow><mml:mi>u</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mrow><mml:mi>r</mml:mi>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>)</mml:mo>
</mml:mrow>
<mml:mo>⋅</mml:mo>
<mml:mi>I</mml:mi>
<mml:mrow><mml:mo>(</mml:mo>
<mml:mi>t</mml:mi>
<mml:mo>)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
was modeled with a continuous variable in our approach. We used the gamma distribution, matching the first two moments to obtain the transformation of the discrete Binomial distribution to its continuous approximation [<xref rid="B15-jcm-09-00523" ref-type="bibr">15</xref>
,<xref rid="B16-jcm-09-00523" ref-type="bibr">16</xref>
]. We avoided joint estimation of all parameters <inline-formula><mml:math id="mm32"><mml:mrow><mml:mrow><mml:mrow><mml:mo>{</mml:mo>
<mml:mrow><mml:msub><mml:mi>θ</mml:mi>
<mml:mi mathvariant="sans-serif">Σ</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
<mml:mo>,</mml:mo>
<mml:msub><mml:mi>θ</mml:mi>
<mml:mi>d</mml:mi>
</mml:msub>
</mml:mrow>
<mml:mo>}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
due to heterogeneity in the aggregated data—a similar issue is discussed in [<xref rid="B10-jcm-09-00523" ref-type="bibr">10</xref>
]. Instead, we implemented sequential fitting, wherein first we considered only the likelihood <inline-formula><mml:math id="mm33"><mml:mrow><mml:mrow><mml:msub><mml:mi>L</mml:mi>
<mml:mi>e</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, then we fit the likelihood <inline-formula><mml:math id="mm34"><mml:mrow><mml:mrow><mml:msub><mml:mi>L</mml:mi>
<mml:mi mathvariant="sans-serif">Σ</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
using the mean values of the estimated parameters obtained in the previous round. Finally, we verified the obtained fit by calculating pointwise estimates using maximum likelihood estimation with confidence intervals derived as profile likelihood-based intervals. We found that both approaches were at complete agreement in their results.</p>
</sec>
</sec>
<sec sec-type="results" id="sec3-jcm-09-00523"><title>3. Results</title>
<p><xref ref-type="fig" rid="jcm-09-00523-f001">Figure 1</xref>
A,B show the mean and SD of the time from illness onset to reporting and death, respectively. Employing the gamma distribution, the mean time from illness onset to reporting was estimated at 7.1 days (95% confidence interval [CI]: 5.9, 8.4). The mean time from illness onset to death—adopted from a previous study [<xref rid="B14-jcm-09-00523" ref-type="bibr">14</xref>
]—was estimated at 20.2 days (95% CI: 15.1, 29.5), which led to a lognormal distribution with a location parameter of 2.84 and a scale parameter of 0.52.</p>
<p>Subsequently, the cumulative incidence was estimated from exported case data by fitting an exponentially growing incidence curve for both Scenarios 1 and 2 (<xref ref-type="fig" rid="jcm-09-00523-f002">Figure 2</xref>
). As of 24 January 2020, 20 exported cases were reported, and the cumulative incidence in China was estimated at 6924 cases (95% CI: 4885, 9211) in Scenario 1 and 19,289 cases (95% CI: 10,901, 30,158) in Scenario 2. <xref rid="jcm-09-00523-t001" ref-type="table">Table 1</xref>
shows the real-time update of the estimated cumulative incidence. The exponential growth rates (<italic>r</italic>
), derived from the growth rate of cumulative incidence, were estimated at 0.15 per day (95% CI: 0.14, 0.15) and 0.29 per day (95% CI: 0.22, 0.36) in Scenarios 1 and 2, respectively.</p>
<p><xref ref-type="fig" rid="jcm-09-00523-f002">Figure 2</xref>
C,D show the estimated cCFR value accounting for the time delay from illness onset to death under Scenarios 1 and 2, respectively. A total of 41 confirmed deaths were reported as of 24 January 2020, the cCFR value was estimated at 5.3% (95% CI: 3.5%, 7.5%) for Scenario 1 and 8.4% (95% CI: 5.3%, 12.3%) for Scenario 2, respectively.</p>
<p>We estimated the basic reproduction number for the COVID-19 infection, using the estimated exponential growth (<italic>r</italic>
) and accounting for possible variations of the mean serial interval (<xref ref-type="fig" rid="jcm-09-00523-f003">Figure 3</xref>
). Assuming that the mean serial interval was 7.5 days [<xref rid="B2-jcm-09-00523" ref-type="bibr">2</xref>
], the basic reproduction number was estimated at 2.10 (95% CI: 2.04, 2.16) and 3.19 (95% CI: 2.66, 3.69) for Scenarios 1 and 2, respectively. However, as the mean serial interval varies, the estimates can range from 1.6 to 2.6 and 2.2 to 4.2 for Scenarios 1 and 2, respectively.</p>
<p>To address the uncertainty in the unobserved date of illness onset of the index case in Scenario 1, cCFR was estimated by varying the starting date of the exponential growth in the incidence by placing the single index case between 1 and 10 December 2019 (<xref ref-type="app" rid="app1-jcm-09-00523">Figure S1 and Table S1</xref>
). When we assumed the date of illness onset of the index case was 1 December 2019, the estimated incidence in China and the cCFR on 24 January 2020 were estimated at 4718 (95% CI: 3328, 6278) and 5.3% (95% CI: 3.5, 7.6). The sensitivity analyses for varied cutoff dates between 15 and 24 January 2020 were conducted. Depending on the number of time points, the estimates of the cumulative incidence and cCFR have similar values in Scenario 1 (<xref ref-type="app" rid="app1-jcm-09-00523">Figure S2</xref>
) but slightly decreased in Scenario 2, when the cutoff date was earlier (<xref ref-type="app" rid="app1-jcm-09-00523">Figure S3</xref>
). In addition, considering the uncertainty of two fixed parameters (i.e., detection time window and catchment population in Wuhan airport), sensitivity was assessed by varying those parameters. As the catchment population increases and the detection window time decreases, estimated cCFR on 24 January 2020 gets smaller due to increased number of incidence in China (<xref ref-type="app" rid="app1-jcm-09-00523">Tables S2 and S3</xref>
).</p>
</sec>
<sec sec-type="discussion" id="sec4-jcm-09-00523"><title>4. Discussion</title>
<p>The present study estimated the risk of death among confirmed cases while addressing ascertainment bias by using data from cases diagnosed outside mainland China and a right-censored likelihood for modeling the count of deceased cases. The estimated cCFR value was 5.3% (95% CI: 3.5, 7.5) when the date of illness onset for the index case was fixed <italic>a priori</italic>
at 8 December 2019 (Scenario 1), and 8.4% (95% CI: 5.3%, 12.3%) when the timing of the exponential growth of the epidemic was fitted to data alongside with other model parameters (Scenario 2). The estimated value of <italic>u</italic>
in Scenario 2, which adjusts the time delay from illness onset to death, was smaller than that in Scenario 1 due to the larger value of the growth rate of incidence, while the estimated cCFR value as of 24 January 2020 was larger in Scenario 2 compared with Scenario 1. Depending on the available data, the estimate of the cCFR (i.e., the delay-adjusted risk of death among confirmed cases) may vary in time and show some fluctuations. In addition to that, we estimated the value of the basic reproduction number <inline-formula><mml:math id="mm35"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
in the range of 1.6–2.6 for Scenario 1 and 2.2–4.2 for Scenario 2. From either estimate, we conclude that COVID-19 has substantial potential to spread via human-to-human transmission. However, <italic>R</italic>
<sub>0</sub>
> 1 does not guarantee that a single exported (and untraced) case would immediately lead to a major epidemic in the destination country as government responses such as border control, isolation of suspected cases, and intensive surveillance should serve to reduce opportunities for transmission to occur [<xref rid="B17-jcm-09-00523" ref-type="bibr">17</xref>
,<xref rid="B18-jcm-09-00523" ref-type="bibr">18</xref>
,<xref rid="B19-jcm-09-00523" ref-type="bibr">19</xref>
].</p>
<p>Our cCFR estimates of 5.3% and 8.4% indicate that the severity of COVID-19 is not as high as that of other diseases caused by coronaviruses, including severe acute respiratory syndrome (SARS), which had an estimated CFR of 17% in Hong Kong [<xref rid="B9-jcm-09-00523" ref-type="bibr">9</xref>
,<xref rid="B10-jcm-09-00523" ref-type="bibr">10</xref>
,<xref rid="B20-jcm-09-00523" ref-type="bibr">20</xref>
], and Middle East respiratory syndrome, which had an estimated CFR of 20% in South Korea [<xref rid="B21-jcm-09-00523" ref-type="bibr">21</xref>
]. Nonetheless, considering the overall magnitude of the ongoing epidemic, a 5%–8% risk of death is by no means insignificant. In addition to quantifying the overall risk of death, future research must identify groups at risk of death (e.g., the elderly and people with underlying comorbidities) [<xref rid="B22-jcm-09-00523" ref-type="bibr">22</xref>
,<xref rid="B23-jcm-09-00523" ref-type="bibr">23</xref>
]. Moreover, considering that about 9% of all infected individuals are ascertained and reported [<xref rid="B24-jcm-09-00523" ref-type="bibr">24</xref>
], the infection fatality risk (IFR), i.e., the risk of death among all infected individuals, would be on the order of 0.5% to 0.8%.</p>
<p>Our estimated <inline-formula><mml:math id="mm36"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
range of 1.6–4.2 for COVID-19 is consistent with other preliminary estimates posted on public domains [<xref rid="B25-jcm-09-00523" ref-type="bibr">25</xref>
,<xref rid="B26-jcm-09-00523" ref-type="bibr">26</xref>
,<xref rid="B27-jcm-09-00523" ref-type="bibr">27</xref>
,<xref rid="B28-jcm-09-00523" ref-type="bibr">28</xref>
], and is comparable to the <inline-formula><mml:math id="mm37"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
of SARS, which was in the range of 2–5 during the 2003 outbreak in Singapore [<xref rid="B15-jcm-09-00523" ref-type="bibr">15</xref>
]. Between our two estimates, the latter scenario yielded a greater value than the former, and there was an increasingly improved ascertainment in early January 2020. The virus was identified and sequenced on 7 January 2020 and subsequently the primer was widely distributed, allowing for rapid laboratory identification of cases and contributing to a time-dependent increase in the number of confirmed cases out of China. Consequently, Scenario 2, which was fully dependent on the growth rate of exported cases, could have overestimated the intrinsic growth rate of cases. Considering the estimated value of <inline-formula><mml:math id="mm38"><mml:mrow><mml:mrow><mml:msub><mml:mi>R</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:math>
</inline-formula>
, the possibility of presymptomatic transmission in the ongoing epidemic is a critical question, as it would have a substantial impact on public health response to the epidemic (e.g., whether the contact tracing should be prioritized or not) as well as overall predictability of the epidemic during the containment stage [<xref rid="B29-jcm-09-00523" ref-type="bibr">29</xref>
,<xref rid="B30-jcm-09-00523" ref-type="bibr">30</xref>
].</p>
<p>From the technical side, it should be emphasized that our proposed approach can be especially useful during the early stage of an epidemic when local surveillance is affected by substantial ascertainment bias and export and death data are available and better ascertained. Nonetheless, caution must be used when implementing similar estimations for the COVID-19 epidemic, as all flights from Wuhan airport were grounded as of 23 January 2020 [<xref rid="B13-jcm-09-00523" ref-type="bibr">13</xref>
] and this intervention abruptly changed the human migration network. Despite the decrease in the outbound flow of travelers from Wuhan, there is a substantial risk that the next epidemic wave will originate from other cities.</p>
<p>There are five main limitations in the present study. First, our results present an estimate for the cCFR which only addresses fatality among confirmed cases. More precise IFR estimates that include infected individuals other than confirmed cases can only be estimated using additional data (e.g., seroepidemiological data or outpatient clinic visits). It should be noted that not only the denominator but also the numerator values are subject to better estimation (e.g. excess mortality estimate). Second, our study relied on limited empirical data that were extracted from publicly available data sources. Thus, future studies with greater sample size and precision are needed. Nonetheless, we believe that this study will improve the situational assessment of the ongoing epidemic. Third, our assumed date of illness onset for the index case in Scenario 1 is based on initial reports of the earliest onset date for a case, and the continued exponential growth with the rate <italic>r</italic>
is the authors’ extrapolation. However, we conducted a sensitivity analysis and ensured that the resulting statistical estimates would not greatly vary from our main results. Fourth, there is an uncertainty in the detection window time <italic>T</italic>
. Since the epidemiological investigations are being actively implemented outside China, we believe that the sum of the incubation period and the infectious period can be a plausible estimation of the detection time window. Fifth, heterogeneous aspects of death (e.g. age and risk groups) need to be addressed in the future studies.</p>
<p>In conclusion, the present study has estimated cCFR to be on the order of 5%–8% and <italic>R<sub>0</sub>
</italic>
to be 1.6–4.2, endorsing the notion that COVID-19 infection in the ongoing epidemic possesses the potential to become a pandemic. The proposed approach can also help direct risk assessment in other settings with the use of publicly available datasets.</p>
</sec>
</body>
<back><app-group><app id="app1-jcm-09-00523"><title>Supplementary Materials</title>
<p>The following are available online at <uri xlink:href="https://www.mdpi.com/2077-0383/9/2/523/s1">https://www.mdpi.com/2077-0383/9/2/523/s1</uri>
, Figure S1: Sensitivity analysis with varying the start point of exponential growth in cumulative incidence from 1 to 10 December 2019, Figure S2: Sensitivity analysis with varying the cutoff date from 15 to 24 January 2020 in estimation Scenario 1, Figure S3: Sensitivity analysis with varying the cutoff date from 15 to 24 January 2020 in estimation Scenario 2, Table S1: Sensitivity analysis with varying the start point of exponential growth in cumulative incidence from 1 to 10 December 2019 in estimation Scenario 1, Table S2: Sensitivity analysis with varying the catchment population size in Wuhan airport, Table S3: Sensitivity analysis with varying the detection time window.</p>
<supplementary-material content-type="local-data" id="jcm-09-00523-s001"><media xlink:href="jcm-09-00523-s001.pdf"><caption><p>Click here for additional data file.</p>
</caption>
</media>
</supplementary-material>
</app>
</app-group>
<notes><title>Author Contributions</title>
<p>S.-m.J., A.R.A., and H.N. conceived the study and participated in the study design. All authors assisted in collecting the data. S.-m.J. and A.R.A. analyzed the data and S.-m.J., A.R.A., K.H. and H.N. drafted the manuscript. All authors have read and agreed to the published version of the manuscript. </p>
</notes>
<notes><title>Funding</title>
<p>H.N. received funding from the Japan Agency for Medical Research and Development (AMED) [grant number: JP18fk0108050]; the Japan Society for the Promotion of Science (JSPS) KAKENHI [grant numbers, H.N.: 17H04701, 17H05808, 18H04895 and 19H01074; R.K.: 18J21587], the Inamori Foundation, and the Japan Science and Technology Agency (JST) CREST program [grant number: JPMJCR1413]. S.M.J. and N.M.L. receive graduate study scholarships from the Ministry of Education, Culture, Sports, Science and Technology, Japan. B.Y. wishes to thank China Scholarship Council.</p>
</notes>
<notes notes-type="COI-statement"><title>Conflicts of Interest</title>
<p>The authors declare no conflict of interest.</p>
</notes>
<ref-list><title>References</title>
<ref id="B1-jcm-09-00523"><label>1.</label>
<element-citation publication-type="web"><person-group person-group-type="author"><collab>World Health Organization</collab>
</person-group>
<article-title>Novel Coronavirus—China Disease Outbreak News</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/">https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-02-09">(accessed on 9 February 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B2-jcm-09-00523"><label>2.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Guan</surname>
<given-names>X.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>P.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>X.</given-names>
</name>
<name><surname>Zhou</surname>
<given-names>L.</given-names>
</name>
<name><surname>Tong</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Ren</surname>
<given-names>R.</given-names>
</name>
<name><surname>Leung</surname>
<given-names>K.S.M.</given-names>
</name>
<name><surname>Lau</surname>
<given-names>E.H.Y.</given-names>
</name>
<name><surname>Wong</surname>
<given-names>J.Y.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia</article-title>
<source>N. Engl. J. Med.</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1056/NEJMoa2001316</pub-id>
<pub-id pub-id-type="pmid">31995857</pub-id>
</element-citation>
</ref>
<ref id="B3-jcm-09-00523"><label>3.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cui</surname>
<given-names>J.</given-names>
</name>
<name><surname>Li</surname>
<given-names>F.</given-names>
</name>
<name><surname>Shi</surname>
<given-names>Z.L.</given-names>
</name>
</person-group>
<article-title>Origin and evolution of pathogenic coronaviruses</article-title>
<source>Nat. Rev. Microbiol.</source>
<year>2019</year>
<volume>17</volume>
<fpage>181</fpage>
<lpage>192</lpage>
<pub-id pub-id-type="doi">10.1038/s41579-018-0118-9</pub-id>
<pub-id pub-id-type="pmid">30531947</pub-id>
</element-citation>
</ref>
<ref id="B4-jcm-09-00523"><label>4.</label>
<element-citation publication-type="gov"><person-group person-group-type="author"><collab>Center for Disease Control and Prevention</collab>
</person-group>
<article-title>2019 Novel Coronavirus, Wuhan, China</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/coronavirus/COVID-19/about/transmission.html">https://www.cdc.gov/coronavirus/COVID-19/about/transmission.html</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-24">(accessed on 24 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B5-jcm-09-00523"><label>5.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname>
<given-names>C.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Li</surname>
<given-names>X.</given-names>
</name>
<name><surname>Ren</surname>
<given-names>L.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>L.</given-names>
</name>
<name><surname>Fan</surname>
<given-names>G.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Gu</surname>
<given-names>X.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China</article-title>
<source>Lancet</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1016/S0140-6736(20)30183-5</pub-id>
</element-citation>
</ref>
<ref id="B6-jcm-09-00523"><label>6.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname>
<given-names>J.F.W.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>S.</given-names>
</name>
<name><surname>Kok</surname>
<given-names>K.H.</given-names>
</name>
<name><surname>To</surname>
<given-names>K.K.W.</given-names>
</name>
<name><surname>Chu</surname>
<given-names>H.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>J.</given-names>
</name>
<name><surname>Xing</surname>
<given-names>J.</given-names>
</name>
<name><surname>Xing</surname>
<given-names>F.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Yip</surname>
<given-names>C.C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster</article-title>
<source>Lancet</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1016/S0140-6736(20)30154-9</pub-id>
</element-citation>
</ref>
<ref id="B7-jcm-09-00523"><label>7.</label>
<element-citation publication-type="web"><person-group person-group-type="author"><collab>World Health Organization</collab>
</person-group>
<article-title>Novel Coronavirus (COVID-19) Situation Report-3</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-COVID-19.pdf?sfvrsn=d6d23643_4">https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-COVID-19.pdf?sfvrsn=d6d23643_4</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-23">(accessed on 23 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B8-jcm-09-00523"><label>8.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>S.</given-names>
</name>
<name><surname>Linton</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>Kinoshita</surname>
<given-names>R.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Hayashi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kobayashi</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>B.</given-names>
</name>
<name><surname>Akhmetzhanov</surname>
<given-names>A.R.</given-names>
</name>
</person-group>
<article-title>The extent of transmission of novel coronavirus in Wuhan, China, 2020</article-title>
<source>J. Clin. Med.</source>
<year>2020</year>
<volume>9</volume>
<elocation-id>330</elocation-id>
<pub-id pub-id-type="doi">10.3390/jcm9020330</pub-id>
</element-citation>
</ref>
<ref id="B9-jcm-09-00523"><label>9.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ghani</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Donnelly</surname>
<given-names>C.A.</given-names>
</name>
<name><surname>Cox</surname>
<given-names>D.R.</given-names>
</name>
<name><surname>Griffin</surname>
<given-names>J.T.</given-names>
</name>
<name><surname>Fraser</surname>
<given-names>C.</given-names>
</name>
<name><surname>Lam</surname>
<given-names>T.H.</given-names>
</name>
<name><surname>Ho</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Chan</surname>
<given-names>W.S.</given-names>
</name>
<name><surname>Anderson</surname>
<given-names>R.M.</given-names>
</name>
<name><surname>Hedley</surname>
<given-names>A.J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Methods for estimating the case fatality ratio for a novel, emerging infectious disease</article-title>
<source>Am. J. Epidemiol.</source>
<year>2005</year>
<volume>16</volume>
<fpage>479</fpage>
<lpage>486</lpage>
<pub-id pub-id-type="doi">10.1093/aje/kwi230</pub-id>
</element-citation>
</ref>
<ref id="B10-jcm-09-00523"><label>10.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
<name><surname>Klinkenberg</surname>
<given-names>D.</given-names>
</name>
<name><surname>Roberts</surname>
<given-names>M.</given-names>
</name>
<name><surname>Heesterbeek</surname>
<given-names>J.A.</given-names>
</name>
</person-group>
<article-title>Early epidemiological assessment of the virulence of emerging infectious diseases: A case study of an influenza pandemic</article-title>
<source>PLoS ONE</source>
<year>2009</year>
<volume>4</volume>
<elocation-id>e6852</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0006852</pub-id>
<pub-id pub-id-type="pmid">19718434</pub-id>
</element-citation>
</ref>
<ref id="B11-jcm-09-00523"><label>11.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garske</surname>
<given-names>T.</given-names>
</name>
<name><surname>Legrand</surname>
<given-names>J.</given-names>
</name>
<name><surname>Donnelly</surname>
<given-names>C.A.</given-names>
</name>
<name><surname>Ward</surname>
<given-names>H.</given-names>
</name>
<name><surname>Cauchemez</surname>
<given-names>S.</given-names>
</name>
<name><surname>Fraser</surname>
<given-names>C.</given-names>
</name>
<name><surname>Ferguson</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>Ghani</surname>
<given-names>A.C.</given-names>
</name>
</person-group>
<article-title>Assessing the severity of the novel influenza A/H1N1 pandemic</article-title>
<source>BMJ</source>
<year>2009</year>
<volume>339</volume>
<fpage>b2840</fpage>
<pub-id pub-id-type="doi">10.1136/bmj.b2840</pub-id>
<pub-id pub-id-type="pmid">19602714</pub-id>
</element-citation>
</ref>
<ref id="B12-jcm-09-00523"><label>12.</label>
<element-citation publication-type="web"><person-group person-group-type="author"><name><surname>Thompson</surname>
<given-names>R.N.</given-names>
</name>
<name><surname>Gilligan</surname>
<given-names>C.A.</given-names>
</name>
<name><surname>Cunniffe</surname>
<given-names>N.J.</given-names>
</name>
</person-group>
<article-title>When Does A Minor Outbreak Become A Major Epidemic? Linking the Risk from Invading Pathogens to Practical Definitions of A Major Epidemic</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.biorxiv.org/content/10.1101/768853v2">https://www.biorxiv.org/content/10.1101/768853v2</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-02-09">(accessed on 9 February 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B13-jcm-09-00523"><label>13.</label>
<element-citation publication-type="web"><person-group person-group-type="author"><collab>BBC NEWS</collab>
</person-group>
<article-title>Coronavirus: Wuhan Shuts Public Transport over Outbreak</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.bbc.com/news/world-asia-china-51215348">https://www.bbc.com/news/world-asia-china-51215348</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-28">(accessed on 28 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B14-jcm-09-00523"><label>14.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Linton</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>Kobayashi</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Hayashi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Akhmetzhanov</surname>
<given-names>A.R.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>S.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>B.</given-names>
</name>
<name><surname>Kinoshita</surname>
<given-names>R.</given-names>
</name>
<name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>Epidemiological characteristics of novel coronavirus infection: A statistical analysis of publicly available case data</article-title>
<source>J. Clin. Med.</source>
<year>2020</year>
<comment>in press</comment>
</element-citation>
</ref>
<ref id="B15-jcm-09-00523"><label>15.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lipsitch</surname>
<given-names>M.</given-names>
</name>
<name><surname>Cohen</surname>
<given-names>T.</given-names>
</name>
<name><surname>Cooper</surname>
<given-names>B.</given-names>
</name>
<name><surname>Robins</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Ma</surname>
<given-names>S.</given-names>
</name>
<name><surname>James</surname>
<given-names>L.</given-names>
</name>
<name><surname>Gopalakrishna</surname>
<given-names>G.</given-names>
</name>
<name><surname>Chew</surname>
<given-names>S.K.</given-names>
</name>
<name><surname>Tan</surname>
<given-names>C.C.</given-names>
</name>
<name><surname>Samore</surname>
<given-names>M.H.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Transmission dynamics and control of severe acute respiratory syndrome</article-title>
<source>Science</source>
<year>2003</year>
<volume>300</volume>
<fpage>1966</fpage>
<lpage>1970</lpage>
<pub-id pub-id-type="doi">10.1126/science.1086616</pub-id>
<pub-id pub-id-type="pmid">12766207</pub-id>
</element-citation>
</ref>
<ref id="B16-jcm-09-00523"><label>16.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname>
<given-names>M.</given-names>
</name>
<name><surname>Dushoff</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bolker</surname>
<given-names>B.M.</given-names>
</name>
</person-group>
<article-title>Fitting mechanistic epidemic models to data: A comparison of simple Markov chain Monte Carlo approaches. Stat</article-title>
<source>Methods Med. Res.</source>
<year>2018</year>
<volume>27</volume>
<fpage>1956</fpage>
<lpage>1967</lpage>
<pub-id pub-id-type="doi">10.1177/0962280217747054</pub-id>
<pub-id pub-id-type="pmid">29846150</pub-id>
</element-citation>
</ref>
<ref id="B17-jcm-09-00523"><label>17.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kucharski</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Russell</surname>
<given-names>T.W.</given-names>
</name>
<name><surname>Diamond</surname>
<given-names>C.</given-names>
</name>
<collab>CMMID nCoV Working Group</collab>
<name><surname>Funk</surname>
<given-names>S.</given-names>
</name>
<name><surname>Eggo</surname>
<given-names>R.M.</given-names>
</name>
</person-group>
<article-title>Early dynamics of transmission and control of COVID-19: A mathematical modelling study</article-title>
<source>medRxiv</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1101/2020.01.31.20019901</pub-id>
</element-citation>
</ref>
<ref id="B18-jcm-09-00523"><label>18.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thompson</surname>
<given-names>R.N.</given-names>
</name>
</person-group>
<article-title>2019–2020 Wuhan coronavirus outbreak: Intense surveillance is vital for preventing sustained transmission in new locations</article-title>
<source>biorxiv</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1101/2020.01.24.919159</pub-id>
</element-citation>
</ref>
<ref id="B19-jcm-09-00523"><label>19.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Boldog</surname>
<given-names>P.</given-names>
</name>
<name><surname>Tekeli</surname>
<given-names>T.</given-names>
</name>
<name><surname>Vizi</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Denes</surname>
<given-names>A.</given-names>
</name>
<name><surname>Bartha</surname>
<given-names>F.</given-names>
</name>
<name><surname>Rost</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Risk assessment of novel coronavirus COVID-19 outbreaks outside China</article-title>
<source>J. Clin. Med.</source>
<year>2020</year>
<volume>9</volume>
<elocation-id>571</elocation-id>
<pub-id pub-id-type="doi">10.3390/jcm9020571</pub-id>
<pub-id pub-id-type="pmid">32093043</pub-id>
</element-citation>
</ref>
<ref id="B20-jcm-09-00523"><label>20.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Donnelly</surname>
<given-names>C.A.</given-names>
</name>
<name><surname>Ghani</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Leung</surname>
<given-names>G.M.</given-names>
</name>
<name><surname>Hedley</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Fraser</surname>
<given-names>C.</given-names>
</name>
<name><surname>Riley</surname>
<given-names>S.</given-names>
</name>
<name><surname>Abu-Raddad</surname>
<given-names>L.J.</given-names>
</name>
<name><surname>Ho</surname>
<given-names>L.-M.</given-names>
</name>
<name><surname>Thach</surname>
<given-names>T.-Q.</given-names>
</name>
<name><surname>Chau</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong</article-title>
<source>Lancet</source>
<year>2003</year>
<volume>361</volume>
<fpage>1761</fpage>
<lpage>1766</lpage>
<pub-id pub-id-type="doi">10.1016/S0140-6736(03)13410-1</pub-id>
<pub-id pub-id-type="pmid">12781533</pub-id>
</element-citation>
</ref>
<ref id="B21-jcm-09-00523"><label>21.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mizumoto</surname>
<given-names>K.</given-names>
</name>
<name><surname>Saitoh</surname>
<given-names>M.</given-names>
</name>
<name><surname>Chowell</surname>
<given-names>G.</given-names>
</name>
<name><surname>Miyamatsu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea, 2015</article-title>
<source>Int. J. Infect. Dis.</source>
<year>2015</year>
<volume>39</volume>
<fpage>7</fpage>
<lpage>9</lpage>
<pub-id pub-id-type="doi">10.1016/j.ijid.2015.08.005</pub-id>
<pub-id pub-id-type="pmid">26275845</pub-id>
</element-citation>
</ref>
<ref id="B22-jcm-09-00523"><label>22.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Majumder</surname>
<given-names>M.S.</given-names>
</name>
<name><surname>Kluberg</surname>
<given-names>S.A.</given-names>
</name>
<name><surname>Mekaru</surname>
<given-names>S.R.</given-names>
</name>
<name><surname>Brownstein</surname>
<given-names>J.S.</given-names>
</name>
</person-group>
<article-title>Mortality risk factors for Middle East Respiratory Syndrome outbreak, South Korea, 2015</article-title>
<source>Emerg. Infect. Dis.</source>
<year>2015</year>
<volume>21</volume>
<fpage>2088</fpage>
<lpage>2090</lpage>
<pub-id pub-id-type="doi">10.3201/eid2111.151231</pub-id>
<pub-id pub-id-type="pmid">26488869</pub-id>
</element-citation>
</ref>
<ref id="B23-jcm-09-00523"><label>23.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mizumoto</surname>
<given-names>K.</given-names>
</name>
<name><surname>Endo</surname>
<given-names>A.</given-names>
</name>
<name><surname>Chowell</surname>
<given-names>G.</given-names>
</name>
<name><surname>Miyamatsu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Saitoh</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea, 2015</article-title>
<source>BMC Med.</source>
<year>2015</year>
<volume>13</volume>
<elocation-id>228</elocation-id>
<pub-id pub-id-type="doi">10.1186/s12916-015-0468-3</pub-id>
<pub-id pub-id-type="pmid">26420593</pub-id>
</element-citation>
</ref>
<ref id="B24-jcm-09-00523"><label>24.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nishiura</surname>
<given-names>H.</given-names>
</name>
<name><surname>Kobayashi</surname>
<given-names>T.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Hayashi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Miyama</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kinoshita</surname>
<given-names>R.</given-names>
</name>
<name><surname>Linton</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>S.-M.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>B.</given-names>
</name>
<name><surname>Suzuki</surname>
<given-names>A.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The rate of under ascertainment of novel coronavirus (COVID-19) infection: Estimation using Japanese passengers data on evacuation flights</article-title>
<source>J. Clin. Med.</source>
<year>2020</year>
<volume>9</volume>
<elocation-id>419</elocation-id>
<pub-id pub-id-type="doi">10.3390/jcm9020419</pub-id>
</element-citation>
</ref>
<ref id="B25-jcm-09-00523"><label>25.</label>
<element-citation publication-type="web"><person-group person-group-type="author"><name><surname>Zhao</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ran</surname>
<given-names>J.</given-names>
</name>
<name><surname>Musa</surname>
<given-names>S.S.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>G.</given-names>
</name>
<name><surname>Lou</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Gao</surname>
<given-names>D.</given-names>
</name>
<name><surname>Yang</surname>
<given-names>L.</given-names>
</name>
<name><surname>He</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Preliminary Estimation of the Basic Reproduction Number of Novel Coronavirus (COVID-19) in China, from 2019 to 2020: A Data-Driven Analysis in the Early Phase of the Outbreak</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.biorxiv.org/content/10.1101/2020.01.23.916395v1">https://www.biorxiv.org/content/10.1101/2020.01.23.916395v1</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-29">(accessed on 29 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B26-jcm-09-00523"><label>26.</label>
<element-citation publication-type="web"><article-title>Imperial College London-MRC Centre for Global Infectious Disease Analysis. News/Wuhan Coronavirus</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/">https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-28">(accessed on 28 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B27-jcm-09-00523"><label>27.</label>
<element-citation publication-type="web"><article-title>The University of Hong Kong-HKUMed WHO Collaborating Centre for Infectious Disease Epidemiology and Control. Nowcasting and Forecasting the Wuhan COVID-19 Outbreak</article-title>
<comment>Available online: <ext-link ext-link-type="uri" xlink:href="https://www.med.hku.hk/news/press/HKUMed-WHO-Collaborating-Centre-for-Infectious-Disease-Epidemiology-and-Control-releases%20real-time-nowcast-on-the-likely-extent-of-the-Wuhan-coronavirus">https://www.med.hku.hk/news/press/HKUMed-WHO-Collaborating-Centre-for-Infectious-Disease-Epidemiology-and-Control-releases%20real-time-nowcast-on-the-likely-extent-of-the-Wuhan-coronavirus</ext-link>
</comment>
<date-in-citation content-type="access-date" iso-8601-date="2020-01-28">(accessed on 28 January 2020)</date-in-citation>
</element-citation>
</ref>
<ref id="B28-jcm-09-00523"><label>28.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Read</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Bridgen</surname>
<given-names>J.R.</given-names>
</name>
<name><surname>Cummings</surname>
<given-names>D.A.</given-names>
</name>
<name><surname>Ho</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jewell</surname>
<given-names>C.P.</given-names>
</name>
</person-group>
<article-title>Novel Coronavirus COVID-19: Early Estimation of Epidemiological Parameters and Epidemic Predictions</article-title>
<source>medRxiv</source>
<year>2020</year>
<pub-id pub-id-type="doi">10.1101/2020.01.23.20018549v2</pub-id>
</element-citation>
</ref>
<ref id="B29-jcm-09-00523"><label>29.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fraser</surname>
<given-names>C.</given-names>
</name>
<name><surname>Riley</surname>
<given-names>S.</given-names>
</name>
<name><surname>Anderson</surname>
<given-names>R.M.</given-names>
</name>
<name><surname>Ferguson</surname>
<given-names>N.M.</given-names>
</name>
</person-group>
<article-title>Factors that make an infectious disease outbreak controllable</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2004</year>
<volume>101</volume>
<fpage>6146</fpage>
<lpage>6151</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0307506101</pub-id>
<pub-id pub-id-type="pmid">15071187</pub-id>
</element-citation>
</ref>
<ref id="B30-jcm-09-00523"><label>30.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thompson</surname>
<given-names>R.N.</given-names>
</name>
<name><surname>Gilligan</surname>
<given-names>C.A.</given-names>
</name>
<name><surname>Cunniffe</surname>
<given-names>N.J.</given-names>
</name>
</person-group>
<article-title>Detecting presymptomatic infection is necessary to forecast major epidemics in the earliest stages of infectious disease outbreaks</article-title>
<source>PLoS Comput. Biol.</source>
<year>2016</year>
<volume>12</volume>
<elocation-id>e1004836</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pcbi.1004836</pub-id>
<pub-id pub-id-type="pmid">27046030</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
<floats-group><fig id="jcm-09-00523-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Estimates of the mean and standard deviation (SD) of the time from illness onset to reporting and death cases, accounting for right truncation, with novel coronavirus (COVID-19) infection in China, 2020. Inference of A and B was conducted among (<bold>A</bold>
) exported cases observed in other countries and (<bold>B</bold>
) deceased cases in China. (<bold>A</bold>
) Frequency distribution of the time from illness onset to reporting among exported cases employing a gamma distribution with a mean of 7.1 days (95% confidence interval [CI]: 5.9, 8.4) and SD of 4.4 days (95% CI: 3.5, 5.7). (<bold>B</bold>
) Frequency distribution of the time from illness onset to death with a mean of 19.9 days (95% CI: 14.9, 29.0) (shown in black) and SD of 11.4 days (95% CI: 6.5, 21.6) employing a lognormal distribution and accounting for right truncation. For reference, the estimate of the mean and its 95% credible intervals without accounting for right truncation are shown in grey. The values for distribution of time from illness onset to death are adopted from an earlier study [<xref rid="B14-jcm-09-00523" ref-type="bibr">14</xref>
]. The blue bars show empirically observed data collected from governmental reports (as of 24 January 2020).</p>
</caption>
<graphic xlink:href="jcm-09-00523-g001"></graphic>
</fig>
<fig id="jcm-09-00523-f002" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Cumulative incidence and the confirmed case fatality risk of the novel coronavirus (COVID-19) outbreak in China, 2020. (<bold>A</bold>
,<bold>B</bold>
) Observed and estimated cumulative number of cases in China by the date of report. An exponential growth curve was extrapolated using the exported case data. Scenario 1 extrapolated the exponential growth from December to first case on 8 December 2019, while Scenario 2 started the estimation of the exponential growth only from 13 January 2020. The black line and shaded area represent median and 95% credible interval of the cumulative incidence in China, respectively. The blue bars show the cumulative number of reported cases from the government of mainland China. The cumulative number of reported cases was not used for fitting, but it was shown for comparison between the cumulative number of reported and estimated cases in China. There is a decrease in the cumulative number of reported cases in early January, because only 41 cases tested positive for the novel coronavirus among the reported 59 cases on 10 January 2020. Left-top panels on both <bold>A</bold>
and <bold>B</bold>
show the cumulative numbers of exported cases observed in other countries and the cumulative number of deaths in China, represented by dark and light green bars, respectively. (<bold>C</bold>
,<bold>D</bold>
) Confirmed case fatality risk (cCFR) by the date of reporting. Each value of cCFR was estimated as the ratio of cumulative number of estimated incidence to death at time <italic>t</italic>
. The points and error bars represent the median and its 95% credible interval of the cCFR. All 95% credible intervals were derived from Markov chain Monte Carlo simulations.</p>
</caption>
<graphic xlink:href="jcm-09-00523-g002"></graphic>
</fig>
<fig id="jcm-09-00523-f003" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Basic reproduction number of novel coronavirus (COVID-19) infections in China, 2020. Black lines and grey shades represent the median and 95% credible intervals of the basic reproduction number. Panel <bold>A</bold>
shows the result of Scenario 1, in which an exponential growth started from the assumed illness onset date of index case, while Panel <bold>B</bold>
shows the result from exponential growth from the first exported case (Scenario 2). The 95% credible intervals were derived from Markov chain Monte Carlo method.</p>
</caption>
<graphic xlink:href="jcm-09-00523-g003"></graphic>
</fig>
<table-wrap id="jcm-09-00523-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">jcm-09-00523-t001_Table 1</object-id>
<label>Table 1</label>
<caption><p>Exportation events and estimated incidence in China, 2020.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Importing Locations</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Date of Report (2020)</th>
<th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Cumulative Count</th>
<th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">Estimated Incidence in China (95% CI)</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Scenario 1</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Scenario 2</th>
</tr>
</thead>
<tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">Thailand</td>
<td align="center" valign="middle" rowspan="1" colspan="1">13 January</td>
<td align="center" valign="middle" rowspan="1" colspan="1">1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">1828 (1397 2288)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">1369 (1003 1782)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Japan</td>
<td align="center" valign="middle" rowspan="1" colspan="1">16 January</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2120 (1605 2672)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">1829 (1392 2309)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Thailand</td>
<td align="center" valign="middle" rowspan="1" colspan="1">17 January</td>
<td align="center" valign="middle" rowspan="1" colspan="1">3</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2458 (1845 3119)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2444 (1894 3033)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">South Korea</td>
<td align="center" valign="middle" rowspan="1" colspan="1">20 January </td>
<td align="center" valign="middle" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" rowspan="1" colspan="1">3832 (2802 4962)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5882 (4252 7629)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Taiwan, United States</td>
<td align="center" valign="middle" rowspan="1" colspan="1">21 January </td>
<td align="center" valign="middle" rowspan="1" colspan="1">6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">4443 (3220 5792)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">7901 (5425, 10,662)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Thailand</td>
<td align="center" valign="middle" rowspan="1" colspan="1">22 January </td>
<td align="center" valign="middle" rowspan="1" colspan="1">8</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5151 (3700 6761)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">10,626 (6897, 15,003)</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Singapore, Vietnam</td>
<td align="center" valign="middle" rowspan="1" colspan="1">23 January </td>
<td align="center" valign="middle" rowspan="1" colspan="1">11</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5972 (4252 7892)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">14,308 (8661, 21,250)</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Japan, Nepal, South Korea, Singapore, Thailand, United States</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">24 January </td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6924 (4885 9211)</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">19,289 (10,901, 30,158)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>CI, confidence interval (the 95% CI was derived from the Markov chain Monte Carlo method). Scenario 1 indicates the estimated exponential growth rate with the assumed illness onset date of the first COVID-19 case (i.e., 8 December 2019), while Scenario 2 presents the estimated exponential growth rate from the date of first exportation event (i.e., 13 January 2020).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000910 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000910 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |