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<title xml:lang="en">Is the ferret a suitable species for studying perinatal brain injury?</title>
<author>
<name sortKey="Empie, Kristen" sort="Empie, Kristen" uniqKey="Empie K" first="Kristen" last="Empie">Kristen Empie</name>
</author>
<author>
<name sortKey="Rangarajan, Vijayeta" sort="Rangarajan, Vijayeta" uniqKey="Rangarajan V" first="Vijayeta" last="Rangarajan">Vijayeta Rangarajan</name>
</author>
<author>
<name sortKey="Juul, Sandra E" sort="Juul, Sandra E" uniqKey="Juul S" first="Sandra E." last="Juul">Sandra E. Juul</name>
</author>
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<idno type="pmid">26102988</idno>
<idno type="pmc">4793918</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793918</idno>
<idno type="RBID">PMC:4793918</idno>
<idno type="doi">10.1016/j.ijdevneu.2015.06.005</idno>
<date when="2015">2015</date>
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<title xml:lang="en" level="a" type="main">Is the ferret a suitable species for studying perinatal brain injury?</title>
<author>
<name sortKey="Empie, Kristen" sort="Empie, Kristen" uniqKey="Empie K" first="Kristen" last="Empie">Kristen Empie</name>
</author>
<author>
<name sortKey="Rangarajan, Vijayeta" sort="Rangarajan, Vijayeta" uniqKey="Rangarajan V" first="Vijayeta" last="Rangarajan">Vijayeta Rangarajan</name>
</author>
<author>
<name sortKey="Juul, Sandra E" sort="Juul, Sandra E" uniqKey="Juul S" first="Sandra E." last="Juul">Sandra E. Juul</name>
</author>
</analytic>
<series>
<title level="j">International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience</title>
<idno type="ISSN">0736-5748</idno>
<idno type="eISSN">1873-474X</idno>
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<date when="2015">2015</date>
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<div type="abstract" xml:lang="en">
<p id="P1">Complications of prematurity often disrupt normal brain development and/or cause direct damage to the developing brain, resulting in poor neurodevelopmental outcomes. Physiologically relevant animal models of perinatal brain injury can advance our understanding of these influences and thereby provide opportunities to develop therapies and improve long-term outcomes. While there are advantages to currently available small animal models, there are also significant drawbacks that have limited translation of research findings to humans. Large animal models such as newborn pig, sheep and nonhuman primates have complex brain development more similar to humans, but these animals are expensive, and developmental testing of sheep and piglets is limited. Ferrets (
<italic>Mustela putorius furo)</italic>
are born lissencephalic and undergo postnatal cortical folding to form complex gyrencephalic brains. This review examines whether ferrets might provide a novel intermediate animal model of neonatal brain disease that has the benefit of a gyrified, altricial brain in a small animal. It summarizes attributes of ferret brain growth and development that make it an appealing animal in which to model perinatal brain injury. We postulate that because of their innate characteristics, ferrets have great potential in neonatal neurodevelopmental studies.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
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<journal-meta>
<journal-id journal-id-type="nlm-journal-id">8401784</journal-id>
<journal-id journal-id-type="pubmed-jr-id">99</journal-id>
<journal-id journal-id-type="nlm-ta">Int J Dev Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">Int. J. Dev. Neurosci.</journal-id>
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<journal-title>International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience</journal-title>
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<issn pub-type="ppub">0736-5748</issn>
<issn pub-type="epub">1873-474X</issn>
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<article-id pub-id-type="pmid">26102988</article-id>
<article-id pub-id-type="pmc">4793918</article-id>
<article-id pub-id-type="doi">10.1016/j.ijdevneu.2015.06.005</article-id>
<article-id pub-id-type="manuscript">NIHMS766170</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
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<title-group>
<article-title>Is the ferret a suitable species for studying perinatal brain injury?</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Empie</surname>
<given-names>Kristen</given-names>
</name>
<xref rid="FN2" ref-type="author-notes">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rangarajan</surname>
<given-names>Vijayeta</given-names>
</name>
<xref rid="FN2" ref-type="author-notes">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Juul</surname>
<given-names>Sandra E.</given-names>
</name>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<aff id="A1">Department of Neonatology, University of Washington, Seattle, USA</aff>
</contrib-group>
<author-notes>
<corresp id="FN1">
<label>*</label>
Corresponding author at: Department of Pediatrics, Division of Neonatology, University of Washington Box 356320, Seattle, Washington. Fax: +1 206 543 8926.
<email>sjuul@uw.edu</email>
(S.E. Juul)</corresp>
<fn id="FN2" fn-type="equal">
<label>1</label>
<p>Equivalent first authors.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>9</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>20</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub">
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>16</day>
<month>3</month>
<year>2016</year>
</pub-date>
<volume>45</volume>
<fpage>2</fpage>
<lpage>10</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.ijdevneu.2015.06.005</pmc-comment>
<abstract>
<p id="P1">Complications of prematurity often disrupt normal brain development and/or cause direct damage to the developing brain, resulting in poor neurodevelopmental outcomes. Physiologically relevant animal models of perinatal brain injury can advance our understanding of these influences and thereby provide opportunities to develop therapies and improve long-term outcomes. While there are advantages to currently available small animal models, there are also significant drawbacks that have limited translation of research findings to humans. Large animal models such as newborn pig, sheep and nonhuman primates have complex brain development more similar to humans, but these animals are expensive, and developmental testing of sheep and piglets is limited. Ferrets (
<italic>Mustela putorius furo)</italic>
are born lissencephalic and undergo postnatal cortical folding to form complex gyrencephalic brains. This review examines whether ferrets might provide a novel intermediate animal model of neonatal brain disease that has the benefit of a gyrified, altricial brain in a small animal. It summarizes attributes of ferret brain growth and development that make it an appealing animal in which to model perinatal brain injury. We postulate that because of their innate characteristics, ferrets have great potential in neonatal neurodevelopmental studies.</p>
</abstract>
<kwd-group>
<kwd>Neurodevelopment</kwd>
<kwd>Perinatal brain injury</kwd>
<kwd>Ferrets</kwd>
<kwd>Animal model</kwd>
<kwd>Neurogenesis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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