Macrophages and the Viral Dissemination Super Highway
Identifieur interne : 000768 ( Pmc/Corpus ); précédent : 000767; suivant : 000769Macrophages and the Viral Dissemination Super Highway
Auteurs : Arielle Klepper ; Andrea D. BranchSource :
- EC microbiology ; 2015.
Abstract
Monocytes and macrophages are key components of the innate immune system yet they are often the victims of attack by infectious agents. This review examines the significance of viral infection of macrophages. The central hypothesis is that macrophage tropism enhances viral dissemination and persistence, but these changes may come at the cost of reduced replication in cells other than macrophages.
Url:
PubMed: 26949751
PubMed Central: 4774560
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PMC:4774560Le document en format XML
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101664549</journal-id><journal-id journal-id-type="pubmed-jr-id">44165</journal-id><journal-id journal-id-type="nlm-ta">EC Microbiol</journal-id><journal-title-group><journal-title>EC microbiology</journal-title></journal-title-group></journal-meta><article-meta><article-id pub-id-type="pmid">26949751</article-id><article-id pub-id-type="pmc">4774560</article-id><article-id pub-id-type="manuscript">NIHMS756060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Macrophages and the Viral Dissemination Super Highway</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Klepper</surname><given-names>Arielle</given-names></name></contrib><contrib contrib-type="author"><name><surname>Branch</surname><given-names>Andrea D</given-names></name><xref ref-type="corresp" rid="CR1">*</xref></contrib><aff id="A1">Division of Liver Diseases, Department of Medicine, Mount Sinai Medical Center, USA</aff></contrib-group><author-notes><corresp id="CR1"><label>*</label>Corresponding Author: Andrea D Branch, Professor of Medicine, Division of Liver Diseases, Department of Medicine, Mount Sinai Medical Center, New York, 10029, USA.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>3</month><year>2016</year></pub-date><volume>2</volume><issue>3</issue><fpage>328</fpage><lpage>336</lpage><abstract><p id="P1">Monocytes and macrophages are key components of the innate immune system yet they are often the victims of attack by infectious agents. This review examines the significance of viral infection of macrophages. The central hypothesis is that macrophage tropism enhances viral dissemination and persistence, but these changes may come at the cost of reduced replication in cells other than macrophages.</p></abstract><kwd-group><kwd>Feline corona viruses</kwd><kwd>Macrophages</kwd><kwd>Lymphocytic choriomeningitis virus</kwd><kwd>Human cytomegalovirus</kwd><kwd>ssRNA</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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