Bilirubin encephalopathy in a domestic shorthair cat with increased osmotic fragility and cholangiohepatitis
Identifieur interne : 000746 ( Pmc/Corpus ); précédent : 000745; suivant : 000747Bilirubin encephalopathy in a domestic shorthair cat with increased osmotic fragility and cholangiohepatitis
Auteurs : Elena T. Contreras ; Urs Giger ; Jennifer L. Malmberg ; Jessica M. Quimby ; Paula A. SchafferSource :
- Veterinary pathology [ 0300-9858 ] ; 2015.
Abstract
A 7-month-old female domestic shorthair (DSH) cat was diagnosed with chronic regenerative hemolytic anemia characterized by increased osmotic fragility (OF) of unknown etiology. At 13 months of age, the cat was evaluated for acute collapse. The cat was icteric with severe hyperbilirubinemia but no hematocrit changes. Severe obtundation and lateral recumbency progressed to tetraparesis and loss of proprioception in all four limbs, and a cerebellar or brainstem lesion was suspected. Post-mortem examination revealed suppurative cholangiohepatitis and acute neuronal necrosis in the nuclei of the brainstem and cerebellum, consistent with bilirubin encephalopathy. This is the first known occurrence of cholangiohepatitis and bilirubin encephalopathy in an adult cat with chronic hemolytic anemia. Although rare, bilirubin encephalopathy should be considered as a possible sequela to hyperbilirubinemia in adult patients. It remains unknown whether increased OF was related to the cholangiohepatopathy.
Url:
DOI: 10.1177/0300985815603433
PubMed: 26354310
PubMed Central: 4785093
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Malmberg</name><affiliation><nlm:aff id="A3">Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</nlm:aff></affiliation></author><author><name sortKey="Quimby, Jessica M" sort="Quimby, Jessica M" uniqKey="Quimby J" first="Jessica M." last="Quimby">Jessica M. Quimby</name><affiliation><nlm:aff id="A1">Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</nlm:aff></affiliation></author><author><name sortKey="Schaffer, Paula A" sort="Schaffer, Paula A" uniqKey="Schaffer P" first="Paula A." last="Schaffer">Paula A. Schaffer</name><affiliation><nlm:aff id="A2">Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26354310</idno><idno type="pmc">4785093</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785093</idno><idno type="RBID">PMC:4785093</idno><idno type="doi">10.1177/0300985815603433</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000746</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000746</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bilirubin encephalopathy in a domestic shorthair cat with increased osmotic fragility and cholangiohepatitis</title><author><name sortKey="Contreras, Elena T" sort="Contreras, Elena T" uniqKey="Contreras E" first="Elena T." last="Contreras">Elena T. Contreras</name><affiliation><nlm:aff id="A1">Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</nlm:aff></affiliation></author><author><name sortKey="Giger, Urs" sort="Giger, Urs" uniqKey="Giger U" first="Urs" last="Giger">Urs Giger</name><affiliation><nlm:aff id="A2">Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:aff></affiliation></author><author><name sortKey="Malmberg, Jennifer L" sort="Malmberg, Jennifer L" uniqKey="Malmberg J" first="Jennifer L." last="Malmberg">Jennifer L. Malmberg</name><affiliation><nlm:aff id="A3">Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</nlm:aff></affiliation></author><author><name sortKey="Quimby, Jessica M" sort="Quimby, Jessica M" uniqKey="Quimby J" first="Jessica M." last="Quimby">Jessica M. Quimby</name><affiliation><nlm:aff id="A1">Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</nlm:aff></affiliation></author><author><name sortKey="Schaffer, Paula A" sort="Schaffer, Paula A" uniqKey="Schaffer P" first="Paula A." last="Schaffer">Paula A. Schaffer</name><affiliation><nlm:aff id="A2">Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Veterinary pathology</title><idno type="ISSN">0300-9858</idno><idno type="eISSN">1544-2217</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A 7-month-old female domestic shorthair (DSH) cat was diagnosed with chronic regenerative hemolytic anemia characterized by increased osmotic fragility (OF) of unknown etiology. At 13 months of age, the cat was evaluated for acute collapse. The cat was icteric with severe hyperbilirubinemia but no hematocrit changes. Severe obtundation and lateral recumbency progressed to tetraparesis and loss of proprioception in all four limbs, and a cerebellar or brainstem lesion was suspected. Post-mortem examination revealed suppurative cholangiohepatitis and acute neuronal necrosis in the nuclei of the brainstem and cerebellum, consistent with bilirubin encephalopathy. This is the first known occurrence of cholangiohepatitis and bilirubin encephalopathy in an adult cat with chronic hemolytic anemia. Although rare, bilirubin encephalopathy should be considered as a possible sequela to hyperbilirubinemia in adult patients. It remains unknown whether increased OF was related to the cholangiohepatopathy.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0312020</journal-id><journal-id journal-id-type="pubmed-jr-id">7984</journal-id><journal-id journal-id-type="nlm-ta">Vet Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Vet. Pathol.</journal-id><journal-title-group><journal-title>Veterinary pathology</journal-title></journal-title-group><issn pub-type="ppub">0300-9858</issn><issn pub-type="epub">1544-2217</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26354310</article-id><article-id pub-id-type="pmc">4785093</article-id><article-id pub-id-type="doi">10.1177/0300985815603433</article-id><article-id pub-id-type="manuscript">NIHMS725321</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Bilirubin encephalopathy in a domestic shorthair cat with increased osmotic fragility and cholangiohepatitis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Contreras</surname><given-names>Elena T.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Giger</surname><given-names>Urs</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Malmberg</surname><given-names>Jennifer L.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Quimby</surname><given-names>Jessica M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Schaffer</surname><given-names>Paula A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</aff><aff id="A2"><label>2</label>Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.</aff><aff id="A3"><label>3</label>Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.</aff><author-notes><corresp id="cor1">Corresponding author: Elena T. Contreras, DVM, Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W Drake Road, Fort Collins, CO 80523, USA. <email>elena.contreras@colostate.edu</email></corresp><fn id="FN1" fn-type="conflict"><p id="P14">Declaration of Conflicting Interests</p><p id="P15">The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>09</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2017</year></pub-date><volume>53</volume><issue>3</issue><fpage>629</fpage><lpage>632</lpage><pmc-comment>elocation-id from pubmed: 10.1177/0300985815603433</pmc-comment>
<abstract><p id="P1">A 7-month-old female domestic shorthair (DSH) cat was diagnosed with chronic regenerative hemolytic anemia characterized by increased osmotic fragility (OF) of unknown etiology. At 13 months of age, the cat was evaluated for acute collapse. The cat was icteric with severe hyperbilirubinemia but no hematocrit changes. Severe obtundation and lateral recumbency progressed to tetraparesis and loss of proprioception in all four limbs, and a cerebellar or brainstem lesion was suspected. Post-mortem examination revealed suppurative cholangiohepatitis and acute neuronal necrosis in the nuclei of the brainstem and cerebellum, consistent with bilirubin encephalopathy. This is the first known occurrence of cholangiohepatitis and bilirubin encephalopathy in an adult cat with chronic hemolytic anemia. Although rare, bilirubin encephalopathy should be considered as a possible sequela to hyperbilirubinemia in adult patients. It remains unknown whether increased OF was related to the cholangiohepatopathy.</p></abstract><kwd-group><kwd>feline</kwd><kwd>hemolytic anemia</kwd><kwd>hereditary disorders</kwd><kwd>hyperbilirubinemia</kwd><kwd>kernicterus</kwd><kwd>liver disease</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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