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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats</title><author><name sortKey="Wren Dail, Melissa A" sort="Wren Dail, Melissa A" uniqKey="Wren Dail M" first="Melissa A" last="Wren-Dail">Melissa A. Wren-Dail</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dauchy, Robert T" sort="Dauchy, Robert T" uniqKey="Dauchy R" first="Robert T" last="Dauchy">Robert T. Dauchy</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Blask, David E" sort="Blask, David E" uniqKey="Blask D" first="David E" last="Blask">David E. Blask</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hill, Steven M" sort="Hill, Steven M" uniqKey="Hill S" first="Steven M" last="Hill">Steven M. Hill</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ooms, Tara G" sort="Ooms, Tara G" uniqKey="Ooms T" first="Tara G" last="Ooms">Tara G. Ooms</name><affiliation><nlm:aff wicri:cut="; and" id="aff3">Section of Laboratory Animal Medicine, IIT Research Institute, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Dupepe, Lynell M" sort="Dupepe, Lynell M" uniqKey="Dupepe L" first="Lynell M" last="Dupepe">Lynell M. Dupepe</name><affiliation><nlm:aff id="aff2">Comparative Medicine, Tulane University School of Medicine, New Orleans, Louisiana</nlm:aff></affiliation></author><author><name sortKey="Bohm, Rudolf P" sort="Bohm, Rudolf P" uniqKey="Bohm R" first="Rudolf P" last="Bohm">Rudolf P. Bohm</name><affiliation><nlm:aff id="aff4">Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28381314</idno><idno type="pmc">5402733</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402733</idno><idno type="RBID">PMC:5402733</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000689</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000689</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats</title><author><name sortKey="Wren Dail, Melissa A" sort="Wren Dail, Melissa A" uniqKey="Wren Dail M" first="Melissa A" last="Wren-Dail">Melissa A. Wren-Dail</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dauchy, Robert T" sort="Dauchy, Robert T" uniqKey="Dauchy R" first="Robert T" last="Dauchy">Robert T. Dauchy</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Blask, David E" sort="Blask, David E" uniqKey="Blask D" first="David E" last="Blask">David E. Blask</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hill, Steven M" sort="Hill, Steven M" uniqKey="Hill S" first="Steven M" last="Hill">Steven M. Hill</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ooms, Tara G" sort="Ooms, Tara G" uniqKey="Ooms T" first="Tara G" last="Ooms">Tara G. Ooms</name><affiliation><nlm:aff wicri:cut="; and" id="aff3">Section of Laboratory Animal Medicine, IIT Research Institute, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Dupepe, Lynell M" sort="Dupepe, Lynell M" uniqKey="Dupepe L" first="Lynell M" last="Dupepe">Lynell M. Dupepe</name><affiliation><nlm:aff id="aff2">Comparative Medicine, Tulane University School of Medicine, New Orleans, Louisiana</nlm:aff></affiliation></author><author><name sortKey="Bohm, Rudolf P" sort="Bohm, Rudolf P" uniqKey="Bohm R" first="Rudolf P" last="Bohm">Rudolf P. Bohm</name><affiliation><nlm:aff id="aff4">Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana</nlm:aff></affiliation></author></analytic><series><title level="j">Comparative Medicine</title><idno type="ISSN">1532-0820</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO<sub>2</sub> anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO<sub>2</sub> (70% CO<sub>2</sub>, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague–Dawley rats (Crl:SD; <italic>n</italic> = 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod. After 1 wk of acclimation, a series of 6 low-volume blood draws were collected by cardiocentesis under anesthesia using isoflurane (10 min or less) compared with CO<sub>2</sub> (1 min or less) at a single circadian time point every 4 d (0400, 0800, 1200, 1600, 2000, or 2400) over 3 wk to assess arterial blood glucose, lactic acid, and potassium and plasma melatonin, leptin, insulin, total fatty acids, and corticosterone concentrations. Results revealed that plasma levels (mean ± SEM) of melatonin were low (11 ± 1 pg/mL) during the light phase in both groups but were significantly lower during the dark phase in the isoflurane group (48 ± 6 pg/mL) compared with the CO<sub>2</sub> group (162 ± 18 pg/mL). In addition, prominent circadian rhythms of arterial plasma levels of corticosterone, glucose, total fatty acids, lactic acid, and potassium were altered in the isoflurane group compared with the CO<sub>2</sub> group. These findings demonstrate that the normal circadian rhythms of endocrine physiology and metabolism observed during brief CO<sub>2</sub> anesthesia in rats are markedly disrupted by isoflurane anesthesia.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Comp Med</journal-id><journal-id journal-id-type="iso-abbrev">Comp. Med</journal-id><journal-id journal-id-type="publisher-id">cm</journal-id><journal-title-group><journal-title>Comparative Medicine</journal-title></journal-title-group><issn pub-type="ppub">1532-0820</issn><publisher><publisher-name>American Association for Laboratory Animal Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28381314</article-id><article-id pub-id-type="pmc">5402733</article-id><article-id pub-id-type="publisher-id">2017000138</article-id><article-categories><subj-group subj-group-type="heading"><subject>Rat Models</subject></subj-group></article-categories><title-group><article-title>Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wren-Dail</surname><given-names>Melissa A</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Dauchy</surname><given-names>Robert T</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blask</surname><given-names>David E</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hill</surname><given-names>Steven M</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ooms</surname><given-names>Tara G</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dupepe</surname><given-names>Lynell M</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bohm</surname><given-names>Rudolf P</given-names><suffix>Jr</suffix></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><aff id="aff1">Departments of<label>1</label>Structural and Cellular Biology and</aff><aff id="aff2"><label>2</label>Comparative Medicine, Tulane University School of Medicine, New Orleans, Louisiana</aff><aff id="aff3"><label>3</label>Section of Laboratory Animal Medicine, IIT Research Institute, Chicago, Illinois; and</aff><aff id="aff4"><label>4</label>Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Corresponding author: Email: <email>mwren@tulane.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>4</month><year>2017</year></pub-date><pub-date pub-type="epub"><month>4</month><year>2017</year></pub-date><volume>67</volume><issue>2</issue><fpage>138</fpage><lpage>146</lpage><history><date date-type="received"><day>17</day><month>5</month><year>2016</year></date><date date-type="rev-recd"><day>01</day><month>7</month><year>2016</year></date><date date-type="accepted"><day>13</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement>© American Association for Laboratory Animal Science</copyright-statement><copyright-year>2017</copyright-year></permissions><abstract><p>Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO<sub>2</sub> anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO<sub>2</sub> (70% CO<sub>2</sub>, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague–Dawley rats (Crl:SD; <italic>n</italic> = 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod. After 1 wk of acclimation, a series of 6 low-volume blood draws were collected by cardiocentesis under anesthesia using isoflurane (10 min or less) compared with CO<sub>2</sub> (1 min or less) at a single circadian time point every 4 d (0400, 0800, 1200, 1600, 2000, or 2400) over 3 wk to assess arterial blood glucose, lactic acid, and potassium and plasma melatonin, leptin, insulin, total fatty acids, and corticosterone concentrations. Results revealed that plasma levels (mean ± SEM) of melatonin were low (11 ± 1 pg/mL) during the light phase in both groups but were significantly lower during the dark phase in the isoflurane group (48 ± 6 pg/mL) compared with the CO<sub>2</sub> group (162 ± 18 pg/mL). In addition, prominent circadian rhythms of arterial plasma levels of corticosterone, glucose, total fatty acids, lactic acid, and potassium were altered in the isoflurane group compared with the CO<sub>2</sub> group. These findings demonstrate that the normal circadian rhythms of endocrine physiology and metabolism observed during brief CO<sub>2</sub> anesthesia in rats are markedly disrupted by isoflurane anesthesia.</p></abstract><kwd-group><title>Abbreviation</title><kwd>TFA, total fatty acids</kwd></kwd-group><counts><page-count count="9"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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