SARS coronavirus Accessory Proteins
Identifieur interne : 000645 ( Pmc/Corpus ); précédent : 000644; suivant : 000646SARS coronavirus Accessory Proteins
Auteurs : Krishna Narayanan ; Cheng Huang ; Shinji MakinoSource :
- Virus research [ 0168-1702 ] ; 2007.
Abstract
The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory proteins might play an important role in modulating the host response to virus infection and thereby, contribute to pathogenesis. In this review, we have compiled the current knowledge about SARS-CoV accessory proteins, obtained from studies in cell culture systems, reverse genetics and animal models, to shed some light into the possible role of these proteins in the propagation and virulence of SARS-CoV in its natural host. We conclude by providing some questions for future studies that will greatly advance our knowledge about the biological significance and contributions of the accessory proteins in the development of SARS in humans.
Url:
DOI: 10.1016/j.virusres.2007.10.009
PubMed: 18045721
PubMed Central: 2720074
Links to Exploration step
PMC:2720074Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS coronavirus Accessory Proteins</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name></author><author><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18045721</idno><idno type="pmc">2720074</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720074</idno><idno type="RBID">PMC:2720074</idno><idno type="doi">10.1016/j.virusres.2007.10.009</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000645</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000645</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS coronavirus Accessory Proteins</title><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name></author><author><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name></author></analytic><series><title level="j">Virus research</title><idno type="ISSN">0168-1702</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory proteins might play an important role in modulating the host response to virus infection and thereby, contribute to pathogenesis. In this review, we have compiled the current knowledge about SARS-CoV accessory proteins, obtained from studies in cell culture systems, reverse genetics and animal models, to shed some light into the possible role of these proteins in the propagation and virulence of SARS-CoV in its natural host. We conclude by providing some questions for future studies that will greatly advance our knowledge about the biological significance and contributions of the accessory proteins in the development of SARS in humans.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8410979</journal-id><journal-id journal-id-type="pubmed-jr-id">7967</journal-id><journal-id journal-id-type="nlm-ta">Virus Res</journal-id><journal-title>Virus research</journal-title><issn pub-type="ppub">0168-1702</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18045721</article-id><article-id pub-id-type="pmc">2720074</article-id><article-id pub-id-type="doi">10.1016/j.virusres.2007.10.009</article-id><article-id pub-id-type="manuscript">NIHMS44318</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>SARS coronavirus Accessory Proteins</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Narayanan</surname><given-names>Krishna</given-names></name><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Cheng</given-names></name></contrib><contrib contrib-type="author"><name><surname>Makino</surname><given-names>Shinji</given-names></name></contrib><aff id="A1">Departments of Microbiology and Immunology, the University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019</aff></contrib-group><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Krishna Narayanan, Department of Microbiology and Immunology, the University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019. Phone: (409) 772-8172, Fax: (409) 772-5065, E-mail: <email>krnaraya@utmb.edu</email>. Cheng Huang, Department of Microbiology and Immunology, the University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1019, Phone: (409) 772-8172, E-mail: <email>chhuang@utmb.edu</email>. Shinji Makino; Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, TX 77555- 1019. Phone: (409) 772- 2323, E- mail: <email>shmakino@utmb.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2007</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>8</month><year>2009</year></pub-date><volume>133</volume><issue>1</issue><fpage>113</fpage><lpage>121</lpage><abstract><p id="P2">The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory proteins might play an important role in modulating the host response to virus infection and thereby, contribute to pathogenesis. In this review, we have compiled the current knowledge about SARS-CoV accessory proteins, obtained from studies in cell culture systems, reverse genetics and animal models, to shed some light into the possible role of these proteins in the propagation and virulence of SARS-CoV in its natural host. We conclude by providing some questions for future studies that will greatly advance our knowledge about the biological significance and contributions of the accessory proteins in the development of SARS in humans.</p></abstract><kwd-group><kwd>RNA viruses</kwd><kwd>SARS coronavirus</kwd><kwd>SARS-CoV</kwd><kwd>Accessory proteins</kwd></kwd-group><contract-num rid="AI1">R01 AI029984-16</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000645 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000645 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:2720074
|texte= SARS coronavirus Accessory Proteins
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:18045721" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |