Causation and disease: effect of technology on postulates of causation.
Identifieur interne : 000505 ( Pmc/Corpus ); précédent : 000504; suivant : 000506Causation and disease: effect of technology on postulates of causation.
Auteurs : A. S. EvansSource :
- The Yale Journal of Biology and Medicine [ 0044-0086 ] ; 1991.
Abstract
This paper reviews the technical developments in microbiology that led to the discovery of new infectious agents and the effect of these discoveries on establishing proof of causation. In bacteriology, these advances included the light microscope, bacterial stains, bacterial cultures, and the methods used to isolate clones. In virology, they involved the use of filters to separate viruses from bacteria, the electron microscope, the use of laboratory animals, embryonated eggs, tissue cultures to identify or grow the agent, and the recent development of molecular techniques to detect the presence of antigen in tissues. In immunology, they were based on the discovery of antibodies and of the immune response.
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PubMed: 1814063
PubMed Central: 2589507
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Yale J Biol Med</journal-id><journal-id journal-id-type="pmc">yjbm</journal-id><journal-title>The Yale Journal of Biology and Medicine</journal-title><issn pub-type="ppub">0044-0086</issn><issn pub-type="epub">1551-4056</issn><publisher><publisher-name>Yale Journal of Biology and Medicine</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">1814063</article-id><article-id pub-id-type="pmc">2589507</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Causation and disease: effect of technology on postulates of causation.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Evans</surname><given-names>A. S.</given-names></name></contrib></contrib-group><aff>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut.</aff><pub-date pub-type="ppub"><season>Sep-Oct</season><year>1991</year></pub-date><volume>64</volume><issue>5</issue><fpage>513</fpage><lpage>528</lpage><abstract><p>This paper reviews the technical developments in microbiology that led to the discovery of new infectious agents and the effect of these discoveries on establishing proof of causation. In bacteriology, these advances included the light microscope, bacterial stains, bacterial cultures, and the methods used to isolate clones. In virology, they involved the use of filters to separate viruses from bacteria, the electron microscope, the use of laboratory animals, embryonated eggs, tissue cultures to identify or grow the agent, and the recent development of molecular techniques to detect the presence of antigen in tissues. In immunology, they were based on the discovery of antibodies and of the immune response.</p></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="yjbm00059-0088.tif" xlink:title="scanned-page" xlink:role="513" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0089.tif" xlink:title="scanned-page" xlink:role="514" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0090.tif" xlink:title="scanned-page" xlink:role="515" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0091.tif" xlink:title="scanned-page" xlink:role="516" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0092.tif" xlink:title="scanned-page" xlink:role="517" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0093.tif" xlink:title="scanned-page" xlink:role="518" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0094.tif" xlink:title="scanned-page" xlink:role="519" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0095.tif" xlink:title="scanned-page" xlink:role="520" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0096.tif" xlink:title="scanned-page" xlink:role="521" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0097.tif" xlink:title="scanned-page" xlink:role="522" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0098.tif" xlink:title="scanned-page" xlink:role="523" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0099.tif" xlink:title="scanned-page" xlink:role="524" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0100.tif" xlink:title="scanned-page" xlink:role="525" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0101.tif" xlink:title="scanned-page" xlink:role="526" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0102.tif" xlink:title="scanned-page" xlink:role="527" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="yjbm00059-0103.tif" xlink:title="scanned-page" xlink:role="528" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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