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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins.</title>
<author><name sortKey="Risco, C" sort="Risco, C" uniqKey="Risco C" first="C" last="Risco">C. Risco</name>
</author>
<author><name sortKey="Ant N, I M" sort="Ant N, I M" uniqKey="Ant N I" first="I M" last="Ant N">I M Ant N</name>
</author>
<author><name sortKey="Enjuanes, L" sort="Enjuanes, L" uniqKey="Enjuanes L" first="L" last="Enjuanes">L. Enjuanes</name>
</author>
<author><name sortKey="Carrascosa, J L" sort="Carrascosa, J L" uniqKey="Carrascosa J" first="J L" last="Carrascosa">J L Carrascosa</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">8676505</idno>
<idno type="pmc">190415</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC190415</idno>
<idno type="RBID">PMC:190415</idno>
<date when="1996">1996</date>
<idno type="wicri:Area/Pmc/Corpus">000479</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000479</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins.</title>
<author><name sortKey="Risco, C" sort="Risco, C" uniqKey="Risco C" first="C" last="Risco">C. Risco</name>
</author>
<author><name sortKey="Ant N, I M" sort="Ant N, I M" uniqKey="Ant N I" first="I M" last="Ant N">I M Ant N</name>
</author>
<author><name sortKey="Enjuanes, L" sort="Enjuanes, L" uniqKey="Enjuanes L" first="L" last="Enjuanes">L. Enjuanes</name>
</author>
<author><name sortKey="Carrascosa, J L" sort="Carrascosa, J L" uniqKey="Carrascosa J" first="J L" last="Carrascosa">J L Carrascosa</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="1996">1996</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Coronaviruses are enveloped RNA viruses involved in a variety of pathologies that affect animals and humans. Existing structural models of these viruses propose a helical nucleocapsid under the virion envelope as the unique internal structure. In the present work, we have analyzed the structure of the transmissible gastroenteritis coronavirus. The definition of its organization supports a new structural model for coronaviruses, since a spherical, probably icosahedral, internal core has been characterized. Disruption of these cores induces the release of N-protein-containing helical nucleocapsids. Immunogold mapping and protein analysis of purified cores showed that they consist of M and N proteins, M being the main core shell component. This surprising finding, together with the fact that M protein molecules are also located in the virion envelope, indicates that a reconsideration of the assembly and maturation of coronaviruses, as well as a study of potential M-protein subclasses, is needed.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-title>Journal of Virology</journal-title>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">8676505</article-id>
<article-id pub-id-type="pmc">190415</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Risco</surname>
<given-names>C</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Antón</surname>
<given-names>I M</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Enjuanes</surname>
<given-names>L</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Carrascosa</surname>
<given-names>J L</given-names>
</name>
</contrib>
</contrib-group>
<aff>Macromolecular Structure Department, Centro Nacional de Biotechnologiá, Consejo Superior de Investigaciones Científicas, Campus Universidad Autónoma, Madrid, Spain.</aff>
<pub-date pub-type="ppub"><month>7</month>
<year>1996</year>
</pub-date>
<volume>70</volume>
<issue>7</issue>
<fpage>4773</fpage>
<lpage>4777</lpage>
<abstract><p>Coronaviruses are enveloped RNA viruses involved in a variety of pathologies that affect animals and humans. Existing structural models of these viruses propose a helical nucleocapsid under the virion envelope as the unique internal structure. In the present work, we have analyzed the structure of the transmissible gastroenteritis coronavirus. The definition of its organization supports a new structural model for coronaviruses, since a spherical, probably icosahedral, internal core has been characterized. Disruption of these cores induces the release of N-protein-containing helical nucleocapsids. Immunogold mapping and protein analysis of purified cores showed that they consist of M and N proteins, M being the main core shell component. This surprising finding, together with the fact that M protein molecules are also located in the virion envelope, indicates that a reconsideration of the assembly and maturation of coronaviruses, as well as a study of potential M-protein subclasses, is needed.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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