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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus.</title>
<author><name sortKey="La Posta, V J" sort="La Posta, V J" uniqKey="La Posta V" first="V J" last="La Posta">V J La Posta</name>
</author>
<author><name sortKey="Auperin, D D" sort="Auperin, D D" uniqKey="Auperin D" first="D D" last="Auperin">D D Auperin</name>
</author>
<author><name sortKey="Kamin Lewis, R" sort="Kamin Lewis, R" uniqKey="Kamin Lewis R" first="R" last="Kamin-Lewis">R. Kamin-Lewis</name>
</author>
<author><name sortKey="Cole, G A" sort="Cole, G A" uniqKey="Cole G" first="G A" last="Cole">G A Cole</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">7684468</idno>
<idno type="pmc">237696</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237696</idno>
<idno type="RBID">PMC:237696</idno>
<date when="1993">1993</date>
<idno type="wicri:Area/Pmc/Corpus">000476</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000476</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus.</title>
<author><name sortKey="La Posta, V J" sort="La Posta, V J" uniqKey="La Posta V" first="V J" last="La Posta">V J La Posta</name>
</author>
<author><name sortKey="Auperin, D D" sort="Auperin, D D" uniqKey="Auperin D" first="D D" last="Auperin">D D Auperin</name>
</author>
<author><name sortKey="Kamin Lewis, R" sort="Kamin Lewis, R" uniqKey="Kamin Lewis R" first="R" last="Kamin-Lewis">R. Kamin-Lewis</name>
</author>
<author><name sortKey="Cole, G A" sort="Cole, G A" uniqKey="Cole G" first="G A" last="Cole">G A Cole</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="1993">1993</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Recombinant vaccinia virus expressing the Lassa virus (LV) envelope glycoprotein precursor, V-LSGPC, was used to study the basis of LV-induced cross-protective immunity against the closely related arenavirus lymphocytic choriomeningitis virus (LCMV). C3H/HeJ mice primed with V-LSGPC developed neither circulating antibodies nor CD8+ cytotoxic T cells specific for LCMV, yet they resisted a normally lethal LCMV challenge. Spleen cells from such mice gave a proliferative response to LCMV in vitro that was inhibitable by anti-CD4 antibody. Synthetic peptides corresponding to predicted T-cell sites common to the envelope glycoprotein precursor (GP-C) of LV and that of LCMV were used to map the specificity of the proliferative response to an epitope located between amino acids 403 and 417 of LV GP-C. Several CD4+ T-cell clones specific for the 403-417 peptide were isolated and found to produce gamma interferon in response to both the peptide and LCMV. One of these clones, C9, was selected for further study. C9 lysed I-AK-bearing target cells, and when adoptively transferred to C3H/HeJ mice, it was capable of mediating both a peptide-specific delayed hypersensitivity reaction and resistance to lethal LCMV challenge. These collective findings demonstrate, for the first time, that CD4+ T cells can play a major role in arenavirus-specific cross-protective immunity.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-title>Journal of Virology</journal-title>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">7684468</article-id>
<article-id pub-id-type="pmc">237696</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T-cell clone specific for an envelope glycoprotein epitope of Lassa virus.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>La Posta</surname>
<given-names>V J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Auperin</surname>
<given-names>D D</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kamin-Lewis</surname>
<given-names>R</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cole</surname>
<given-names>G A</given-names>
</name>
</contrib>
</contrib-group>
<aff>Department of Microbiology and Immunology, University of Maryland, Baltimore 21201.</aff>
<pub-date pub-type="ppub"><month>6</month>
<year>1993</year>
</pub-date>
<volume>67</volume>
<issue>6</issue>
<fpage>3497</fpage>
<lpage>3506</lpage>
<abstract><p>Recombinant vaccinia virus expressing the Lassa virus (LV) envelope glycoprotein precursor, V-LSGPC, was used to study the basis of LV-induced cross-protective immunity against the closely related arenavirus lymphocytic choriomeningitis virus (LCMV). C3H/HeJ mice primed with V-LSGPC developed neither circulating antibodies nor CD8+ cytotoxic T cells specific for LCMV, yet they resisted a normally lethal LCMV challenge. Spleen cells from such mice gave a proliferative response to LCMV in vitro that was inhibitable by anti-CD4 antibody. Synthetic peptides corresponding to predicted T-cell sites common to the envelope glycoprotein precursor (GP-C) of LV and that of LCMV were used to map the specificity of the proliferative response to an epitope located between amino acids 403 and 417 of LV GP-C. Several CD4+ T-cell clones specific for the 403-417 peptide were isolated and found to produce gamma interferon in response to both the peptide and LCMV. One of these clones, C9, was selected for further study. C9 lysed I-AK-bearing target cells, and when adoptively transferred to C3H/HeJ mice, it was capable of mediating both a peptide-specific delayed hypersensitivity reaction and resistance to lethal LCMV challenge. These collective findings demonstrate, for the first time, that CD4+ T cells can play a major role in arenavirus-specific cross-protective immunity.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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