Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rat Strains Differ in Susceptibility to <italic>Ureaplasma parvum</italic>-Induced Urinary Tract Infection and Struvite Stone Formation<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Reyes, Leticia" sort="Reyes, Leticia" uniqKey="Reyes L" first="Leticia" last="Reyes">Leticia Reyes</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Reinhard, Mary" sort="Reinhard, Mary" uniqKey="Reinhard M" first="Mary" last="Reinhard">Mary Reinhard</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="O Donell, L J" sort="O Donell, L J" uniqKey="O Donell L" first="L. J." last="O'Donell">L. J. O'Donell</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Stevens, Janet" sort="Stevens, Janet" uniqKey="Stevens J" first="Janet" last="Stevens">Janet Stevens</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Brown, Mary B" sort="Brown, Mary B" uniqKey="Brown M" first="Mary B." last="Brown">Mary B. Brown</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16982825</idno><idno type="pmc">1698052</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698052</idno><idno type="RBID">PMC:1698052</idno><idno type="doi">10.1128/IAI.00984-06</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000453</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000453</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rat Strains Differ in Susceptibility to <italic>Ureaplasma parvum</italic>-Induced Urinary Tract Infection and Struvite Stone Formation<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Reyes, Leticia" sort="Reyes, Leticia" uniqKey="Reyes L" first="Leticia" last="Reyes">Leticia Reyes</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Reinhard, Mary" sort="Reinhard, Mary" uniqKey="Reinhard M" first="Mary" last="Reinhard">Mary Reinhard</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="O Donell, L J" sort="O Donell, L J" uniqKey="O Donell L" first="L. J." last="O'Donell">L. J. O'Donell</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Stevens, Janet" sort="Stevens, Janet" uniqKey="Stevens J" first="Janet" last="Stevens">Janet Stevens</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author><author><name sortKey="Brown, Mary B" sort="Brown, Mary B" uniqKey="Brown M" first="Mary B." last="Brown">Mary B. Brown</name><affiliation><nlm:aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</nlm:aff></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of <italic>Ureaplasma parvum</italic>. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1α (IL-1α), and IL-1β. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-id journal-id-type="publisher-id">iai</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16982825</article-id><article-id pub-id-type="pmc">1698052</article-id><article-id pub-id-type="publisher-id">0984-06</article-id><article-id pub-id-type="doi">10.1128/IAI.00984-06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Bacterial Infections</subject></subj-group></article-categories><title-group><article-title>Rat Strains Differ in Susceptibility to <italic>Ureaplasma parvum</italic>-Induced Urinary Tract Infection and Struvite Stone Formation<xref ref-type="fn" rid="fn1">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Reyes</surname><given-names>Leticia</given-names></name><xref ref-type="aff" rid="aff0"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Reinhard</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>O'Donell</surname><given-names>L. J.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Stevens</surname><given-names>Janet</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Mary B.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib></contrib-group><aff id="aff0">University of Florida, College of Veterinary Medicine, Department of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, Florida 32610-0880</aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: University of Florida, College of Veterinary Medicine, Dept. of Infectious Disease and Pathology, P.O. Box 110880, Gainesville, FL 32610-0880. Phone: (352) 392-4700, ext. 3990. Fax: (352) 846-2781. E-mail: <email>lreyes@ufl.edu</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>18</day><month>9</month><year>2006</year></pub-date><volume>74</volume><issue>12</issue><fpage>6656</fpage><lpage>6664</lpage><history><date date-type="received"><day>20</day><month>6</month><year>2006</year></date><date date-type="rev-recd"><day>20</day><month>7</month><year>2006</year></date><date date-type="accepted"><day>11</day><month>9</month><year>2006</year></date></history><copyright-statement>Copyright © 2006, American Society for Microbiology</copyright-statement><copyright-year>2006</copyright-year><self-uri xlink:title="pdf" xlink:href="zii01206006656.pdf"></self-uri><abstract><p>Individuals with struvite uroliths are susceptible to recurrent urinary tract infections (UTI), sepsis, and renal disease. Unfortunately, little is known about the host-specific factors that predispose to this disease. In order to develop a rodent model that can address this problem, we inoculated female Fischer 344 (F344), Lewis (LEW), Sprague-Dawley (SD), and Wistar (WIS) rats with a host-adapted strain of <italic>Ureaplasma parvum</italic>. Animals were necropsied at 2 weeks postinoculation; 100% of F344, 42% of SD, 10% of LEW, and 10% of WIS rats remained infected. Severe bladder lesions and struvite calculi were seen in 64% of F344 rats; in other rat strains, bladder lesions were mild or absent. F344 rats with struvite uroliths had the highest urinary levels of proinflammatory cytokines, such as GRO/KC, interleukin-1α (IL-1α), and IL-1β. F344 rats without struvite stones at necropsy had milder bladder lesions and significantly lower urinary levels of proinflammatory cytokines but a more prominent inflammatory response than did other rat strains. Based on our results, struvite stone formation is linked to a robust inflammatory response that does not resolve UTI but instead promotes damage to surrounding tissues.</p></abstract></article-meta><notes><fn-group><fn><p><italic>Editor:</italic> R. P. Morrison</p></fn></fn-group></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000453 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000453 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |