Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.</title><author><name sortKey="Waite, D J" sort="Waite, D J" uniqKey="Waite D" first="D. J." last="Waite">D. J. Waite</name></author><author><name sortKey="Appel, M C" sort="Appel, M C" uniqKey="Appel M" first="M. C." last="Appel">M. C. Appel</name></author><author><name sortKey="Handler, E S" sort="Handler, E S" uniqKey="Handler E" first="E. S." last="Handler">E. S. Handler</name></author><author><name sortKey="Mordes, J P" sort="Mordes, J P" uniqKey="Mordes J" first="J. P." last="Mordes">J. P. Mordes</name></author><author><name sortKey="Rossini, A A" sort="Rossini, A A" uniqKey="Rossini A" first="A. A." last="Rossini">A. A. Rossini</name></author><author><name sortKey="Greiner, D L" sort="Greiner, D L" uniqKey="Greiner D" first="D. L." last="Greiner">D. L. Greiner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">8669488</idno><idno type="pmc">1861642</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1861642</idno><idno type="RBID">PMC:1861642</idno><date when="1996">1996</date><idno type="wicri:Area/Pmc/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.</title><author><name sortKey="Waite, D J" sort="Waite, D J" uniqKey="Waite D" first="D. J." last="Waite">D. J. Waite</name></author><author><name sortKey="Appel, M C" sort="Appel, M C" uniqKey="Appel M" first="M. C." last="Appel">M. C. Appel</name></author><author><name sortKey="Handler, E S" sort="Handler, E S" uniqKey="Handler E" first="E. S." last="Handler">E. S. Handler</name></author><author><name sortKey="Mordes, J P" sort="Mordes, J P" uniqKey="Mordes J" first="J. P." last="Mordes">J. P. Mordes</name></author><author><name sortKey="Rossini, A A" sort="Rossini, A A" uniqKey="Rossini A" first="A. A." last="Rossini">A. A. Rossini</name></author><author><name sortKey="Greiner, D L" sort="Greiner, D L" uniqKey="Greiner D" first="D. L." last="Greiner">D. L. Greiner</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>RT6 is a cell surface alloantigen that identifies a regulatory subset of peripheral T cells in the rat. Diabetes-prone BB rats are deficient in peripheral RT6+ T cells and develop spontaneous autoimmune insulin-dependent diabetes mellitus. Diabetes-resistant BB rats have normal numbers of RT6+ T cells, and insulin-dependent diabetes mellitus can be induced in these animals by in vivo depletion of peripheral RT6+ cells. Athymic rats are also severely deficient in peripheral RT6+ T cells. Although very different with respect to the peripheral RT6+ cell compartment, normal, athymic, and diabetes-prone BB rats all generate RT6+ intestinal epithelial lymphocytes (IELs). The goal of these studies was to analyze the ontogeny of RT6+ IELs and peripheral lymphoid cells by in situ immunohistochemistry. We observed the following. 1) RT6+ IELs appear before alpha(beta) T-cell-receptor- expressing IELs in diabetes-prone BB, diabetes-resistant BB, and athymic WAG rats. 2) In vivo depletion of peripheral RT6+ T cells in diabetes-resistant BB rats using a cytotoxic monoclonal antibody is not accompanied by depletion of RT6+ IELs. 3) A population of RT6+ T-cell-receptor-negative IELs is present in normal, euthymic diabetes-resistant BB rats, constitutes a larger percentage of the euthymic but lymphopenic diabetes-prone BB rat IEL population, and is the predominant IEL phenotype in athymic WAG rats. These results suggest that RT6+ cells are composed of both thymus-dependent and thymus-independent cell subsets that have different developmental characteristics and may differ in function.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 1</label><graphic xlink:href="amjpathol00042-0319-a" xlink:role="2046"></graphic></fig><fig id="F2"><label>Figure 2</label><graphic xlink:href="amjpathol00042-0321-a" xlink:role="2048"></graphic></fig><fig id="F3"><label>Figure 3</label><graphic xlink:href="amjpathol00042-0323-a" xlink:role="2050"></graphic></fig><fig id="F4"><label>Figure 4</label><graphic xlink:href="amjpathol00042-0324-a" xlink:role="2051"></graphic></fig><fig id="F5"><label>Figure 5</label><graphic xlink:href="amjpathol00042-0325-a" xlink:role="2052"></graphic></fig><fig id="F6"><label>Figure 6</label><graphic xlink:href="amjpathol00042-0326-a" xlink:role="2053"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-title>The American Journal of Pathology</journal-title><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn></journal-meta><article-meta><article-id pub-id-type="pmid">8669488</article-id><article-id pub-id-type="pmc">1861642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Ontogeny and immunohistochemical localization of thymus-dependent and thymus-independent RT6+ cells in the rat.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Waite</surname><given-names>D. J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Appel</surname><given-names>M. C.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Handler</surname><given-names>E. S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mordes</surname><given-names>J. P.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rossini</surname><given-names>A. A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Greiner</surname><given-names>D. L.</given-names></name></contrib></contrib-group><aff>Department of Medicine, Diabetes Division, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA.</aff><pub-date pub-type="ppub"><month>6</month><year>1996</year></pub-date><volume>148</volume><issue>6</issue><fpage>2043</fpage><lpage>2056</lpage><abstract><p>RT6 is a cell surface alloantigen that identifies a regulatory subset of peripheral T cells in the rat. Diabetes-prone BB rats are deficient in peripheral RT6+ T cells and develop spontaneous autoimmune insulin-dependent diabetes mellitus. Diabetes-resistant BB rats have normal numbers of RT6+ T cells, and insulin-dependent diabetes mellitus can be induced in these animals by in vivo depletion of peripheral RT6+ cells. Athymic rats are also severely deficient in peripheral RT6+ T cells. Although very different with respect to the peripheral RT6+ cell compartment, normal, athymic, and diabetes-prone BB rats all generate RT6+ intestinal epithelial lymphocytes (IELs). The goal of these studies was to analyze the ontogeny of RT6+ IELs and peripheral lymphoid cells by in situ immunohistochemistry. We observed the following. 1) RT6+ IELs appear before alpha(beta) T-cell-receptor- expressing IELs in diabetes-prone BB, diabetes-resistant BB, and athymic WAG rats. 2) In vivo depletion of peripheral RT6+ T cells in diabetes-resistant BB rats using a cytotoxic monoclonal antibody is not accompanied by depletion of RT6+ IELs. 3) A population of RT6+ T-cell-receptor-negative IELs is present in normal, euthymic diabetes-resistant BB rats, constitutes a larger percentage of the euthymic but lymphopenic diabetes-prone BB rat IEL population, and is the predominant IEL phenotype in athymic WAG rats. These results suggest that RT6+ cells are composed of both thymus-dependent and thymus-independent cell subsets that have different developmental characteristics and may differ in function.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 1</label><graphic xlink:href="amjpathol00042-0319-a" xlink:role="2046"></graphic></fig><fig id="F2"><label>Figure 2</label><graphic xlink:href="amjpathol00042-0321-a" xlink:role="2048"></graphic></fig><fig id="F3"><label>Figure 3</label><graphic xlink:href="amjpathol00042-0323-a" xlink:role="2050"></graphic></fig><fig id="F4"><label>Figure 4</label><graphic xlink:href="amjpathol00042-0324-a" xlink:role="2051"></graphic></fig><fig id="F5"><label>Figure 5</label><graphic xlink:href="amjpathol00042-0325-a" xlink:role="2052"></graphic></fig><fig id="F6"><label>Figure 6</label><graphic xlink:href="amjpathol00042-0326-a" xlink:role="2053"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000420 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000420 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |