Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects
Identifieur interne : 000365 ( Pmc/Corpus ); précédent : 000364; suivant : 000366Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects
Auteurs : Mahendra Rai ; Kateryna Kon ; Avinash Ingle ; Nelson Duran ; Stefania Galdiero ; Massimiliano GaldieroSource :
- Applied Microbiology and Biotechnology [ 0175-7598 ] ; 2014.
Abstract
There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attention of scientists all over the world. The aim of the present review is to discuss broad-spectrum multifunctional activities of silver nanoparticles and stress their therapeutic potential as smart nanomedicine. Much emphasis has been dedicated to the antimicrobial and anticancer potential of silver nanoparticles showing their promising characteristics for treatment, prophylaxis and control of infections, as well as for diagnosis and treatment of different cancer types.
Url:
DOI: 10.1007/s00253-013-5473-x
PubMed: 24407450
PubMed Central: 7080016
Links to Exploration step
PMC:7080016Le document en format XML
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sortKey="Galdiero, Massimiliano" sort="Galdiero, Massimiliano" uniqKey="Galdiero M" first="Massimiliano" last="Galdiero">Massimiliano Galdiero</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.9841.4</institution-id><institution-id institution-id-type="ISNI">0000000122008888</institution-id><institution>Division of Microbiology, Department of Experimental Medicine,</institution><institution>II University of Naples,</institution></institution-wrap>Via De Crecchio 7, 80138 Naples, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.419473.c</institution-id><institution-id institution-id-type="ISNI">0000000417901315</institution-id><institution>CIRPEB University of Naples “Federico II” and Istituto di Biostrutture e Bioimmagini, CNR,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24407450</idno><idno type="pmc">7080016</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080016</idno><idno type="RBID">PMC:7080016</idno><idno type="doi">10.1007/s00253-013-5473-x</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000365</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects</title><author><name sortKey="Rai, Mahendra" sort="Rai, Mahendra" uniqKey="Rai M" first="Mahendra" last="Rai">Mahendra Rai</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.444309.e</institution-id><institution-id institution-id-type="ISNI">0000000106908229</institution-id><institution>Department of Biotechnology,</institution><institution>Sant Gadge Baba Amravati University,</institution></institution-wrap>Amravati, 444 602 Maharashtra India</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.411087.b</institution-id><institution-id institution-id-type="ISNI">0000000107232494</institution-id><institution>Biological Chemistry Laboratory, Instituto de Química,</institution><institution>Universidade Estadual de Campinas,</institution></institution-wrap>Campinas, SP Brazil</nlm:aff></affiliation></author><author><name sortKey="Kon, Kateryna" sort="Kon, Kateryna" uniqKey="Kon K" first="Kateryna" last="Kon">Kateryna Kon</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.445504.4</institution-id><institution>Department of Microbiology, Virology and Immunology,</institution><institution>Kharkiv National Medical University,</institution></institution-wrap>Kharkiv, Ukraine</nlm:aff></affiliation></author><author><name sortKey="Ingle, Avinash" sort="Ingle, Avinash" uniqKey="Ingle A" first="Avinash" last="Ingle">Avinash Ingle</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.444309.e</institution-id><institution-id institution-id-type="ISNI">0000000106908229</institution-id><institution>Department of Biotechnology,</institution><institution>Sant Gadge Baba Amravati University,</institution></institution-wrap>Amravati, 444 602 Maharashtra India</nlm:aff></affiliation></author><author><name sortKey="Duran, Nelson" sort="Duran, Nelson" uniqKey="Duran N" first="Nelson" last="Duran">Nelson Duran</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.412368.a</institution-id><institution-id institution-id-type="ISNI">0000000406438839</institution-id><institution>Centre of Natural and Human Science and Universidade Federal do ABC,</institution></institution-wrap>Santo Andre, SP Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.411087.b</institution-id><institution-id institution-id-type="ISNI">0000000107232494</institution-id><institution>Biological Chemistry Laboratory, Instituto de Química,</institution><institution>Universidade Estadual de Campinas,</institution></institution-wrap>Campinas, SP Brazil</nlm:aff></affiliation></author><author><name sortKey="Galdiero, Stefania" sort="Galdiero, Stefania" uniqKey="Galdiero S" first="Stefania" last="Galdiero">Stefania Galdiero</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.4691.a</institution-id><institution-id institution-id-type="ISNI">000000010790385X</institution-id><institution>Department of Pharmacy,</institution><institution>University of Naples “Federico II”,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.419473.c</institution-id><institution-id institution-id-type="ISNI">0000000417901315</institution-id><institution>CIRPEB University of Naples “Federico II” and Istituto di Biostrutture e Bioimmagini, CNR,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Galdiero, Massimiliano" sort="Galdiero, Massimiliano" uniqKey="Galdiero M" first="Massimiliano" last="Galdiero">Massimiliano Galdiero</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.9841.4</institution-id><institution-id institution-id-type="ISNI">0000000122008888</institution-id><institution>Division of Microbiology, Department of Experimental Medicine,</institution><institution>II University of Naples,</institution></institution-wrap>Via De Crecchio 7, 80138 Naples, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.419473.c</institution-id><institution-id institution-id-type="ISNI">0000000417901315</institution-id><institution>CIRPEB University of Naples “Federico II” and Istituto di Biostrutture e Bioimmagini, CNR,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</nlm:aff></affiliation></author></analytic><series><title level="j">Applied Microbiology and Biotechnology</title><idno type="ISSN">0175-7598</idno><idno type="eISSN">1432-0614</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attention of scientists all over the world. The aim of the present review is to discuss broad-spectrum multifunctional activities of silver nanoparticles and stress their therapeutic potential as smart nanomedicine. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Appl Microbiol Biotechnol</journal-id><journal-id journal-id-type="iso-abbrev">Appl. Microbiol. Biotechnol</journal-id><journal-title-group><journal-title>Applied Microbiology and Biotechnology</journal-title></journal-title-group><issn pub-type="ppub">0175-7598</issn><issn pub-type="epub">1432-0614</issn><publisher><publisher-name>Springer Berlin Heidelberg</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24407450</article-id><article-id pub-id-type="pmc">7080016</article-id><article-id pub-id-type="publisher-id">5473</article-id><article-id pub-id-type="doi">10.1007/s00253-013-5473-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Mini-Review</subject></subj-group></article-categories><title-group><article-title>Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rai</surname><given-names>Mahendra</given-names></name><address><phone>+91-721-2662206</phone><fax>+91-721-2662135</fax><email>mahendrarai@sgbau.ac.in</email><email>mkrai123@rediffmail.com</email><email>pmkrai@hotmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kon</surname><given-names>Kateryna</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ingle</surname><given-names>Avinash</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Duran</surname><given-names>Nelson</given-names></name><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Galdiero</surname><given-names>Stefania</given-names></name><xref ref-type="aff" rid="Aff5">5</xref><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Galdiero</surname><given-names>Massimiliano</given-names></name><xref ref-type="aff" rid="Aff6">6</xref><xref ref-type="aff" rid="Aff7">7</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.444309.e</institution-id><institution-id institution-id-type="ISNI">0000000106908229</institution-id><institution>Department of Biotechnology,</institution><institution>Sant Gadge Baba Amravati University,</institution></institution-wrap>Amravati, 444 602 Maharashtra India</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.445504.4</institution-id><institution>Department of Microbiology, Virology and Immunology,</institution><institution>Kharkiv National Medical University,</institution></institution-wrap>Kharkiv, Ukraine</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.412368.a</institution-id><institution-id institution-id-type="ISNI">0000000406438839</institution-id><institution>Centre of Natural and Human Science and Universidade Federal do ABC,</institution></institution-wrap>Santo Andre, SP Brazil</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.411087.b</institution-id><institution-id institution-id-type="ISNI">0000000107232494</institution-id><institution>Biological Chemistry Laboratory, Instituto de Química,</institution><institution>Universidade Estadual de Campinas,</institution></institution-wrap>Campinas, SP Brazil</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.4691.a</institution-id><institution-id institution-id-type="ISNI">000000010790385X</institution-id><institution>Department of Pharmacy,</institution><institution>University of Naples “Federico II”,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="GRID">grid.9841.4</institution-id><institution-id institution-id-type="ISNI">0000000122008888</institution-id><institution>Division of Microbiology, Department of Experimental Medicine,</institution><institution>II University of Naples,</institution></institution-wrap>Via De Crecchio 7, 80138 Naples, Italy</aff><aff id="Aff7"><label>7</label><institution-wrap><institution-id institution-id-type="GRID">grid.419473.c</institution-id><institution-id institution-id-type="ISNI">0000000417901315</institution-id><institution>CIRPEB University of Naples “Federico II” and Istituto di Biostrutture e Bioimmagini, CNR,</institution></institution-wrap>Via Mezzocannone 16, 80134 Naples, Italy</aff></contrib-group><pub-date pub-type="epub"><day>10</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="ppub"><year>2014</year></pub-date><volume>98</volume><issue>5</issue><fpage>1951</fpage><lpage>1961</lpage><history><date date-type="received"><day>7</day><month>9</month><year>2013</year></date><date date-type="rev-recd"><day>13</day><month>12</month><year>2013</year></date><date date-type="accepted"><day>14</day><month>12</month><year>2013</year></date></history><permissions><copyright-statement>© Springer-Verlag Berlin Heidelberg 2014</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>There are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attention of scientists all over the world. The aim of the present review is to discuss broad-spectrum multifunctional activities of silver nanoparticles and stress their therapeutic potential as smart nanomedicine. Much emphasis has been dedicated to the antimicrobial and anticancer potential of silver nanoparticles showing their promising characteristics for treatment, prophylaxis and control of infections, as well as for diagnosis and treatment of different cancer types.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Silver nanoparticles</kwd><kwd>Bioactivity</kwd><kwd>Antimicrobial</kwd><kwd>Antiarthropod</kwd><kwd>Anticancer</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag Berlin Heidelberg 2014</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1" sec-type="introduction"><title>Introduction</title><p>Multi-drug resistance is a growing problem in the treatment of infectious diseases. The extensive use of broad-spectrum antibiotics has led to resistance to classical antimicrobial agents for many bacterial human pathogens and has posed a major threat to the global health care. The problem of resistance emergence, perfectly depicted by the prevalence of more than 25 % among invasive staphylococcal isolates (methicillin resistant <italic>Staphylococcus aureus</italic>) in some countries (Johnson <xref ref-type="bibr" rid="CR43">2011</xref>), is not an exclusive prerogative of bacteria, in fact other noxious human pathogens are actually almost deprived of an efficient drug for their control. Resistance to the commonly used antimalarial drug chloroquine among <italic>Plasmodium falciparum</italic> has also reached nearly 25 % resistance (Fall et al. <xref ref-type="bibr" rid="CR25">2013</xref>), emergence of fluconazole-resistant <italic>Candida albicans</italic> strains and intrinsically resistant species including <italic>Candida glabrata</italic> and <italic>Candida krusei</italic> progressively reduce efficacy of the most popular antimycotic fluconazole, and emergence of resistant viral strains, particularly of HIV, creates great problems in anti-retroviral therapy (Johnson et al. <xref ref-type="bibr" rid="CR44">2013</xref>). The similar situation has recently been observed for insect vectors able to spread several infections: ticks, mosquitoes and lice demonstrated resistance to available anti-arthropod agents (Jayaseelan et al. <xref ref-type="bibr" rid="CR39">2012</xref>). Thus, there is an urgent need to search for new alternatives for the treatment and control of infectious diseases, and silver nanoparticles (AgNPs) are now being considered as a potential source of novel antimicrobial agents, which offer several advantages such as broad-spectrum activity and lower tendency to induce resistance (Rai et al. <xref ref-type="bibr" rid="CR76">2009</xref>).</p><p>Owing to their unique chemical and physical properties (Table <xref rid="Tab1" ref-type="table">1</xref>) and high surface area-to-volume ratio, AgNPs possess many important biological activities (Duran and Marcato <xref ref-type="bibr" rid="CR19">2013</xref>; Rai and Ingle <xref ref-type="bibr" rid="CR75">2012</xref>) in particular, nano-silver has found its application in the treatment of wounds (Rigo et al. <xref ref-type="bibr" rid="CR78">2013</xref>), burns (Elliott <xref ref-type="bibr" rid="CR24">2010</xref>), in water-disinfecting systems (Zhang et al. <xref ref-type="bibr" rid="CR100">2012</xref>), in development of nano-containing materials for bone implants (Marsich et al. <xref ref-type="bibr" rid="CR58">2013</xref>), dental materials (Zhang et al. <xref ref-type="bibr" rid="CR101">2013</xref>) and as antibacterials (Dar et al. <xref ref-type="bibr" rid="CR14">2013</xref>), antivirals (Fayaz et al. <xref ref-type="bibr" rid="CR26">2012</xref>), anti-protozoals (Adhikari et al. <xref ref-type="bibr" rid="CR3">2013</xref>), anti-arthropods (Subarani et al. <xref ref-type="bibr" rid="CR93">2013</xref>) and anticancerous agents (Jeyaraj et al. <xref ref-type="bibr" rid="CR40">2013a</xref>, <xref ref-type="bibr" rid="CR41">b</xref>). One of the main problems in anticancer treatments is the continuous growth of tumour cells resistant to a broad range of anticancer agents (Abraham et al. <xref ref-type="bibr" rid="CR2">2012</xref>). The documented activity of AgNPs against different types of cancer cell lines, including multi-drug resistant cells, makes them a promising alternative to known anticancer agents (Conde et al. <xref ref-type="bibr" rid="CR13">2012</xref>).<table-wrap id="Tab1"><label>Table 1</label><caption><p>Shape and size of biologically (from some fungi and plants) and chemically synthesized silver nanoparticles</p></caption><table frame="hsides" rules="groups"><thead><tr><th>S.N.</th><th>Name of fungi and plants</th><th>Size (nm)</th><th>Shape</th><th>Reference</th></tr></thead><tbody><tr><td colspan="5">Fungi</td></tr><tr><td> 1</td><td><italic>Fusarium culmorum</italic></td><td>5–25</td><td>Spherical</td><td>Bawaskar et al. (<xref ref-type="bibr" rid="CR9">2010</xref>)</td></tr><tr><td> 2</td><td><italic>Phoma glomerata</italic></td><td>60–80</td><td>Spherical</td><td>Birla et al. (<xref ref-type="bibr" rid="CR11">2009</xref>)</td></tr><tr><td> 3</td><td><italic>Cryphonectria</italic> sp.</td><td>30–70</td><td>Spherical</td><td>Dar et al. (<xref ref-type="bibr" rid="CR14">2013</xref>)</td></tr><tr><td> 4</td><td><italic>Fusarium oxysporum</italic></td><td>40.3 ± 3.5 </td><td>Spherical</td><td>De-Lima et al. (<xref ref-type="bibr" rid="CR17">2013</xref>)</td></tr><tr><td> 5</td><td>53 isolates of different fungi</td><td>5–50</td><td>Spherical</td><td>Devi and Joshi (<xref ref-type="bibr" rid="CR18">2012</xref>)</td></tr><tr><td> 6</td><td><italic>Opuntia ficus-indica</italic></td><td>12</td><td>Spherical</td><td>Gade et al. (<xref ref-type="bibr" rid="CR27">2010</xref>)</td></tr><tr><td> 7</td><td><italic>Alternaria alternata</italic></td><td>20–60</td><td>Spherical</td><td>Gajbhiye et al. (<xref ref-type="bibr" rid="CR29">2009</xref>)</td></tr><tr><td> 8</td><td><italic>Fusarium solani</italic></td><td>5–35</td><td>Spherical</td><td>Ingle et al. (<xref ref-type="bibr" rid="CR34">2009</xref>)</td></tr><tr><td> 9</td><td><italic>Aspergillus niger</italic>
</td><td>3–30</td><td>Spherical</td><td>Jaidev and Narasimha (<xref ref-type="bibr" rid="CR36">2010</xref>)</td></tr><tr><td> 10</td><td><italic>Pestalotia</italic> sp.</td><td>10–40</td><td>Spherical</td><td>Raheman et al. (<xref ref-type="bibr" rid="CR74">2011</xref>)</td></tr><tr><td> 11</td><td><italic>Cochliobolus lunatus</italic></td><td>3–21</td><td>Spherical</td><td>Salunkhe et al. (<xref ref-type="bibr" rid="CR83">2011</xref>)</td></tr><tr><td colspan="5">Plants</td></tr><tr><td> 1</td><td><italic>Phytolacca decandra</italic></td><td>91</td><td>Spherical</td><td>Bhattacharyya et al. (<xref ref-type="bibr" rid="CR10">2012</xref>)</td></tr><tr><td> 2</td><td><italic>Murraya koenigii</italic></td><td>40–80</td><td>Spherical</td><td>Bonde et al. (<xref ref-type="bibr" rid="CR12">2012</xref>)</td></tr><tr><td> 3</td><td><italic>Sesbania grandiflora</italic></td><td>22</td><td>Spherical</td><td>Jeyaraj et al. (<xref ref-type="bibr" rid="CR40">2013a</xref>)</td></tr><tr><td> 4</td><td><italic>Podophyllum hexandrum</italic>
</td><td>14</td><td>Spherical</td><td>Jeyaraj et al. (<xref ref-type="bibr" rid="CR41">2013b</xref>)</td></tr><tr><td> 5</td><td><italic>Ocimum canum</italic></td><td>60–150</td><td>Rod</td><td>Jayaseelan and Rahuman (<xref ref-type="bibr" rid="CR38">2012</xref>)</td></tr><tr><td> 6</td><td><italic>Catharanthus roseus</italic></td><td>35–55</td><td>Spherical</td><td>Ponarulselvam et al. (<xref ref-type="bibr" rid="CR70">2012</xref>)</td></tr><tr><td> 7</td><td><italic>Vitex negundo</italic></td><td>30</td><td>Spherical</td><td>Prabhu et al. (<xref ref-type="bibr" rid="CR71">2013</xref>)</td></tr><tr><td> 8</td><td><italic>Vinca rosea</italic></td><td>25–47</td><td>Spherical</td><td>Subarani et al. (<xref ref-type="bibr" rid="CR93">2013</xref>)</td></tr><tr><td colspan="5">Chemical approaches</td></tr><tr><td> 1</td><td>Using plasma gas</td><td>10-80</td><td>Spherical</td><td>Roger et al. (<xref ref-type="bibr" rid="CR79">2008</xref>)</td></tr><tr><td> 2</td><td>Using PEG</td><td>11.23</td><td>Spherical</td><td>Shameli et al. (<xref ref-type="bibr" rid="CR87">2012</xref>)</td></tr></tbody></table></table-wrap></p><p>Although the antibacterial properties of AgNPs are relatively well-known and have been exploited in many practical applications, their activities against other type of pathogens such as arthropod vectors of infections and different types of cancer cells have been evaluated only in recent years and there are still many open questions which require attention and further research.</p><p>The aim of the present review is to discuss the broad-spectrum bioactivities of AgNPs including their effects on different types of pathogenic micro- and macroorganisms, such as bacteria, viruses, fungi, protozoans and arthropods, as well as on tumour cells, to provide possible explanation of their mechanism of action, and to develop strategy for future studies in this area.</p></sec><sec id="Sec2"><title>Antibacterial activity of silver nanoparticles</title><p>Antimicrobial properties of nano-silver have been known for many centuries but their evaluation on scientific basis has only started in 2000s years. Sondi and Salopek-Sondi (<xref ref-type="bibr" rid="CR89">2004</xref>) were among the first to describe AgNPs activity against <italic>Escherichia coli</italic> and to propose a likely explanation of observed effects. The authors revealed formation of “pits” in bacterial cell wall and accumulation of AgNPs in the cellular membrane which led to an increase of its permeability and eventually to the death of bacterial cells. Also, they attempted to understand their mechanism of action. Presently, there are three main explanations that have been proposed to describe the antibacterial activity: (1) direct interaction of AgNPs with the bacterial cell membrane, causing subsequent membrane damage and complexation with components located inside the cells (Sondi and Salopek-Sondi <xref ref-type="bibr" rid="CR89">2004</xref>); (2) interaction with thiol (−SH) groups and production of reactive oxygen species (ROS) (Banerjee et al. <xref ref-type="bibr" rid="CR7">2010</xref>); (3) release of silver ions which inhibit respiratory enzymes and also generate ROS (Pal et al. <xref ref-type="bibr" rid="CR67">2007</xref>).</p><p>Devi and Joshi (<xref ref-type="bibr" rid="CR18">2012</xref>) screened 53 strains of different fungi for the mycosynthesis of AgNPs and also reported significant efficacy against <italic>S. aureus</italic>, <italic>Streptococcus pyogenes</italic>, <italic>Salmonella enterica</italic> and <italic>Enterococcus faecalis</italic>. Moreover, the mycosynthesized nanoparticles also showed potent antibacterial activity and synergistic effect with erythromycin, methicillin, chloramphenicol and ciprofloxacin against <italic>Klebsiella pneumoniae</italic> and <italic>Enterobacter aerogenes</italic> (Bawaskar et al. <xref ref-type="bibr" rid="CR9">2010</xref>) and with antibiotics gentamycin, ampicillin, tetracycline and streptomycin against <italic>E. coli</italic>, <italic>S. aureus</italic> and <italic>Pseudomonas aeruginosa</italic> (Bonde et al. <xref ref-type="bibr" rid="CR12">2012</xref>).</p><p>Size-dependent activity of AgNPs was reported in many articles with smaller NPs having higher activity; this result may be explained by a relative increase in contact surface area (Liu et al. <xref ref-type="bibr" rid="CR55">2010</xref>). Shameli et al. (<xref ref-type="bibr" rid="CR87">2012</xref>) demonstrated the antibacterial activity of different sizes of AgNPs in PEG against Gram-positive (<italic>S. aureus</italic>) and Gram-negative (<italic>Salmonella typhimurium</italic>) bacteria by the disc diffusion method. They reported the significant inhibition in growth of both these pathogens and concluded that the antibacterial activities of silver nanoparticles in PEG can be modified by controlling the size of nanoparticles because the activity of AgNPs decreases with the increase in the particle size.</p><p>All these factors that influence activity of AgNPs (concentration, size, shape, UV radiation and combination with different antibiotics) should be taken into account during synthesis processes and clinical use of AgNPs. Similarly, some other studies carried out by Birla et al. (<xref ref-type="bibr" rid="CR11">2009</xref>), Gade et al. (<xref ref-type="bibr" rid="CR27">2010</xref>), Ingle et al. (<xref ref-type="bibr" rid="CR33">2008</xref>, <xref ref-type="bibr" rid="CR34">2009</xref>), Raheman et al. (<xref ref-type="bibr" rid="CR74">2011</xref>), etc., had already proved the antibacterial potential of silver nanoparticles.</p></sec><sec id="Sec3"><title>Antifungal activity of silver nanoparticles</title><p>Antifungal activity of AgNPs is less studied compared to antibacterial activity. This is clearly illustrated by the number of publications: the PubMed search on studies devoted to antibacterial activity of AgNPs revealed 590 published articles (up to May 2013), while number of antifungal studies was only 70, some of which are discussed below. Kim et al. (<xref ref-type="bibr" rid="CR49">2008</xref>) studied the activity of chemically synthesized AgNPs against 44 strains of six fungal species viz. <italic>Candida albicans</italic>, <italic>C. tropicalis</italic>, <italic>C. glabrata</italic>, <italic>C. parapsilosis</italic>, <italic>C. krusei</italic> and <italic>Trichophyton mentagrophytes</italic>. AgNPs showed potent activity against different strains of <italic>T. mentagrophytes</italic> and <italic>Candida</italic> sp.</p><p>Gajbhiye et al. (<xref ref-type="bibr" rid="CR29">2009</xref>) reported effectiveness of biosynthesized silver nanoparticles against <italic>Phoma glomerata</italic>, <italic>P. herbarum</italic>, <italic>Fusarium semitectum</italic>, <italic>Trichoderma</italic> sp. and <italic>C. albicans</italic>. Further, they also reported the synergistic effects in combination with fluconazole. Jo et al. (<xref ref-type="bibr" rid="CR42">2009</xref>) studied the activity of both silver ions and nanoparticles against two plant-pathogenic fungi, <italic>Bipolaris sorokiniana</italic> and <italic>Magnaporthe grisea</italic>. Antifungal activity of AgNPs in combination with different heterocyclic compounds like thiazolidine, phthalazine, pyrazolo, tetrazolo, hydrazide and pyridazine derivatives were studied against <italic>Aspergillus flavus</italic> and <italic>C. albicans</italic>. The results confirmed enhanced activity of AgNPs in combination with heterocyclic compounds as compared to heterocyclic compounds alone (Kandile et al. <xref ref-type="bibr" rid="CR46">2010</xref>). Similarly, Jaidev and Narasimha (<xref ref-type="bibr" rid="CR36">2010</xref>) reported comparative activity of AgNPs against <italic>Staphylococcus</italic> sp., <italic>Bacillus</italic> sp., <italic>E. coli</italic> and <italic>Aspergillus niger</italic>. They reported higher zone of inhibition (1.2 cm) in case of <italic>A. niger</italic> confirming the maximum activity as compared to <italic>Staphylococcus</italic> sp. (0.9 cm), <italic>Bacillus</italic> sp. (0.8 cm) and <italic>E. coli</italic> (0.8 cm).</p><p>Nasrollahi et al. (<xref ref-type="bibr" rid="CR65">2011</xref>) investigated antifungal activity of chemically synthesized AgNPs against <italic>C. albicans</italic> and <italic>Saccharomyces cerevisiae</italic>. Their results confirmed the potential activity of AgNPs as compared to standard antifungal agents (viz. amphotericin B and fluconazole). The changes on membrane reactions of yeasts have been elucidated by scanning electron microscopy. Savithramma et al. (<xref ref-type="bibr" rid="CR85">2011</xref>) synthesized silver nanoparticles using extract of <italic>Boswellia ovalifoliolata</italic>, <italic>Shorea tumbuggaia</italic> and <italic>Svensonia hyderobadensis</italic>) and evaluated their antifungal activity against <italic>A. flavus</italic>, <italic>A. niger</italic>, <italic>Curvularia</italic> sp., <italic>Fusarium</italic> sp. and <italic>Rhizopus</italic> sp. The results showed that all the three nanoparticles synthesized from different medicinal plants have significant activity against all the tested fungi. Among these, nanoparticles synthesized from <italic>Svensonia hyderobadensis</italic> showed higher activity as compared to AgNPs synthesized using two other plants.</p><p>Kaur et al. (<xref ref-type="bibr" rid="CR47">2012</xref>) studied potential antifungal activity of silver and chitosan nanoparticles against <italic>Rhizoctonia solani</italic>, <italic>A. flavus</italic>, and <italic>Alternaria alternata</italic> from chickpea seeds. In another study, Tile and Bholay (<xref ref-type="bibr" rid="CR96">2012</xref>) reported significant activity of AgNPs against <italic>C. albicans</italic>, <italic>Trichophyton rubrum</italic> and <italic>Aspergillus fumigatus</italic>.</p><p>In an extensive study, Xu et al. (<xref ref-type="bibr" rid="CR99">2013</xref>) evaluated AgNPs and natamycin against 216 strains of fungi from patients suffering from severe keratitis. These included 112 isolates of <italic>Fusarium</italic>, 82 isolates of <italic>Aspergillus</italic> and 10 <italic>Alternaria</italic> isolates. The authors reported that AgNPs demonstrated higher activity compared to natamycin. Recently, Dar et al. (<xref ref-type="bibr" rid="CR14">2013</xref>) reported the remarkable antimicrobial activity of AgNPs synthesized from <italic>Cryphonectria</italic> sp. against <italic>S. aureus</italic>, <italic>E. coli</italic>, <italic>Salmonella typhi</italic> and <italic>C. albicans</italic>, concluding that AgNPs can be used as potential antifungal agents. In spite of various reports on antifungal activity of AgNPs, a precise mechanism of such effect has not been reported. One of possible explanations is destruction of membrane integrity of fungi and inhibition of normal budding process in yeasts (Kim et al. <xref ref-type="bibr" rid="CR50">2009</xref>). Similarly, in bacteria, disturbances in membrane penetration may also lead to internalization of nanoparticles and subsequent intracellular effects including ROS generation, interaction with -SH groups, inhibition of protein synthesis and interaction with phosphorus-containing molecules, such as DNA.</p></sec><sec id="Sec4"><title>Antiviral activity of silver nanoparticles</title><p>AgNPs have received tremendous attention for their antibacterial activities, but the antiviral properties of metal nanoparticles remain an undeveloped area (Galdiero et al. <xref ref-type="bibr" rid="CR31">2013</xref>). Nowadays, effective and safe antiviral therapies are available and this has led to a significant improvement of the life for a large numbers of patients; nevertheless, viruses still represent one of the leading causes of the disease and death worldwide. Moreover, emerging and re-emerging viral diseases are a major threat to human and veterinary health. We have witnessed examples occurring approximately one each year, with the majority are viruses originating from an animal reservoir as a consequence of their ability to switch to a new host. The best known examples are SARS corona virus, West Nile virus, monkey pox virus, Hantavirus, Nipah virus, Hendravirus, Chikungunya virus and, last but not least, the threat of pandemic influenza viruses, most recently of avian or swine origin. Of the many factors responsible, changes to the local ecosystems that disturb the balance between pathogen and principal host species is one of the major drivers, together with increasing urbanization and changes in human behaviour (Howard and Fletcher <xref ref-type="bibr" rid="CR32">2012</xref>).</p><p>Therefore, there is a greater need to develop new and unique treatment options with antiviral agents, which can also overcome the problem of antiviral resistance. AgNPs are emerging as one of the options for the management of viral diseases due to their potential antiviral activity (Galdiero et al. <xref ref-type="bibr" rid="CR30">2011</xref>), and an important application of AgNPs is the treatment of viral diseases that require maintenance of circulating drug concentration or long lasting therapeutic regimens. AgNPs are active on a broad range of viruses and present a lower possibility of developing resistance compared to conventional antivirals.</p><p>The ideal antiviral agent should display a broad-spectrum action against many viral species/strains to be used as first aid compounds against unforeseen viral epidemics or pandemics and is greatly needed in the antiviral agents arsenal. Therefore, AgNPs have received considerable attention due to their particular intrinsic properties, especially since they have shown antiviral efficacy against several viruses regardless of the specific family. Nevertheless, different nanoparticles have different properties as a consequence of its production method (size, shape, capping agent and level of dispersity) and the available data from literature are quite heterogeneous and of difficult categorization. Three key aspects can be extrapolated from the studies conducted so far on the antiviral properties of AgNPs: (1) AgNPs have demonstrated antiviral activity against a number of viruses infecting both prokaryotic (De-Gusseme et al. <xref ref-type="bibr" rid="CR15">2010</xref>; Narasimha <xref ref-type="bibr" rid="CR64">2012</xref>) and eukaryotic organisms, making them a true broad-spectrum antiviral agent; (2) viral inhibition depends on the size of AgNPs (generally small AgNPs, 25 nm or less, resulted more active in viral infectivity inhibition) (Lara et al. <xref ref-type="bibr" rid="CR52">2010a</xref>; Speshock et al. <xref ref-type="bibr" rid="CR90">2010</xref>); (3) early infection might be the general time frame where AgNPs exert their antiviral activity impacting the rest of the viral replication cycle (Baram-Pinto et al. <xref ref-type="bibr" rid="CR8">2009</xref>; Trefry and Wooley <xref ref-type="bibr" rid="CR97">2013</xref>).</p><p>However, a precise mechanism of AgNP antiviral activity and an exact stage of infection at which AgNPs exert antiviral activity have yet to be determined. The possible general mechanism (Fig. <xref rid="Fig1" ref-type="fig">1</xref>) for the antiviral activity of silver nanoparticles can be derived by the available literature (see references throughout the section). Several studies have analysed the behaviour of naked (without a capping agent) AgNPs in inhibition of different viruses, namely hepatitis B virus (HBV) (Lu et al. <xref ref-type="bibr" rid="CR56">2008</xref>), influenza virus (Mehrbod et al. <xref ref-type="bibr" rid="CR59">2009</xref>; Xiang et al. <xref ref-type="bibr" rid="CR98">2011</xref>), human parainfluenza virus type 3 (HPIV-3) (Gaikwad et al. <xref ref-type="bibr" rid="CR28">2013</xref>), Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) (Gaikwad et al. <xref ref-type="bibr" rid="CR28">2013</xref>; Sun et al. <xref ref-type="bibr" rid="CR94">2005</xref>), Coxsackievirus B3 (Salem et al. <xref ref-type="bibr" rid="CR82">2012</xref>), tacaribe virus (TCRV) (Speshock et al. <xref ref-type="bibr" rid="CR90">2010</xref>), Vaccinia virus (Trefry and Wooley <xref ref-type="bibr" rid="CR97">2013</xref>) and monkeypox virus (MPV) (Roger et al. <xref ref-type="bibr" rid="CR79">2008</xref>). A general plot of the activity of naked nanoparticles against these viruses is difficult to draw as a consequence of different AgNPs production procedures and their different sizes. In fact, though being able to inhibit Coxakievirus B3 infectivity with a dose–response effect (Salem et al. <xref ref-type="bibr" rid="CR82">2012</xref>), the nanoparticles derived from <italic>Ricinus communis</italic> aqueous extracts measured up to 1,000 nm, therefore, could be barely considered nanoparticles. Other AgNPs produced by fungi were more contained in size (size range 5–20 nm) and showed a consistent ability to reduce infectivity of HSV-1/2 and HPIV-3 (Gaikwad et al. <xref ref-type="bibr" rid="CR28">2013</xref>). Production of antiviral AgNPs from different fungi is a feasible method, but some of the fungi strains resulted in production of silver nanoparticles with considerable toxicity. Nanoparticles produced in <italic>Fusarium oxysporum</italic>, <italic>Curvularia</italic> sp. and <italic>Chaetomium indicum</italic> presented low toxicity levels and promising antiviral activity.<fig id="Fig1"><label>Fig. 1</label><caption><p>Mechanism of antiviral effect of AgNPs on different stages of virus replication: <italic>1</italic>—interaction with viral surface, <italic>2</italic>—interference with viral attachment, <italic>3</italic>—inhibition of virus penetration into the cell, <italic>4</italic>—interaction with viral genome, <italic>5</italic>—inhibition of genome replication, <italic>6</italic>—inhibition of protein synthesis, <italic>7</italic>—inhibition of assembly and release of virions</p></caption><graphic xlink:href="253_2013_5473_Fig1_HTML" id="MO1"></graphic></fig></p><p>Lu et al. (<xref ref-type="bibr" rid="CR56">2008</xref>) demonstrated that larger nanoparticles (800 nm) presented high level of cytotoxicity in cell culture-based assays, but smaller nanoparticles only showed minor toxicity, in fact, HBV could be efficiently inhibited by 10 and 50 nm nanoparticles where the activity was probably due to specific interactions between the nanoparticles and the double-stranded DNA of HBV and/or direct binding with viral particles and consequent prevention of virions from entering into host cells. In this study, antiviral testing and cytotoxicity assays were performed using HepAD38, a stably transfected hepatoblastoma cell line that secretes HBV-like particles and express high levels of HBV DNA into the supernatant. Similarly, influenza virus can be efficiently inhibited by AgNPs of average size of 10 nm (Xiang et al. <xref ref-type="bibr" rid="CR98">2011</xref>). Naked AgNPs could provide a strong protection against influenza virus infections without the risk of cell toxicity (Mehrbod et al. <xref ref-type="bibr" rid="CR59">2009</xref>; Xiang et al. <xref ref-type="bibr" rid="CR98">2011</xref>). Another study is focused on TCRV of the Arenaviridae family and has shown an excellent activity of 10 nm particles compared to 25 nm particles (Speshock et al. <xref ref-type="bibr" rid="CR90">2010</xref>). AgNPs seem to interact with TCRV prior to cellular exposure resulting in either prevention of the viral particle internalization by interfering with cellular receptor binding or may favour the internalization of the AgNP together with the virus and produce an inhibitory effect on viral replication interfering with the TCRV RNA-dependent RNA polymerase.</p><p>The overall picture shows a tendency of the smaller size nanoparticles to be more incisive in reducing infectivity regardless of the viral species and to exert a minor cytotoxicity. Capping agent(s) added to naked silver nanoparticles (polyvinylpyrrolidone, citrate and polyethylene glycol, etc.) have also been proven to be biologically compatible and reduce infectivity; however, they may render the AgNPs less efficacious. In fact, a polysaccharide coating protects the cell from the toxic effects of the AgNPs, but it also reduces its activity against TCRV (Speshock et al. <xref ref-type="bibr" rid="CR90">2010</xref>). Indeed, the same capping agent proved to be very efficacious against MPV, where polysaccharide-coated AgNPs of 10 nm were highly effective in reducing MPV-induced plaque formation in vitro at concentrations ranging from 12.5 to 100 μg/mL (Roger et al. <xref ref-type="bibr" rid="CR79">2008</xref>).</p><p>Other examples of coated AgNPs are offered in several studies having as antiviral target human immunodeficiency virus type-1 (HIV-1) (Lara et al. <xref ref-type="bibr" rid="CR52">2010a</xref>, <xref ref-type="bibr" rid="CR53">b</xref>, <xref ref-type="bibr" rid="CR54">2011</xref>; Sun et al. <xref ref-type="bibr" rid="CR94">2005</xref>), HSV (Baram-Pinto et al. <xref ref-type="bibr" rid="CR8">2009</xref>) and respiratory syncytial virus (RSV) (Sun et al. <xref ref-type="bibr" rid="CR95">2008</xref>). AgNPs with a surface coating of poly(N-vinyl-2-pyrrolidone) (PVP) within the range of 1–10 nm proved to be the most efficacious nanoparticles to inhibit replication of HIV in a dose-dependent manner (Elechiguerra et al. <xref ref-type="bibr" rid="CR23">2005</xref>). AgNPs were able to inhibit a number of HIV-1 isolates (including laboratory strains, clinical isolates, macrophage [M]-tropic and T lymphocyte [T]-tropic strains, and resistant strains) suggesting they may be broad-spectrum anti-HIV-1 agents (Lara et al. <xref ref-type="bibr" rid="CR52">2010a</xref>). In fact, PVP-coated silver nanoparticles have been tested as a topical vaginal microbicide endowed with virucidal activity to prevent transmission of HIV-1 infection using an in vitro human cervical tissue-based organ culture that simulates in vivo conditions (Lara et al. <xref ref-type="bibr" rid="CR53">2010b</xref>) or as coating for polyurethane condoms to directly inactivate infectious microorganisms (Fayaz et al. <xref ref-type="bibr" rid="CR26">2012</xref>). Both studies proved to sensibly inactivate HIV infectivity. The precise mechanism of action is not completely understood, but several data point to a direct interaction of AgNPs with surface glycoproteins and interference with binding and fusion events of viral penetration into susceptible cells. Furthermore, AgNPs are able to inhibit post-entry stages of the HIV-1 life cycle; in fact, the antiviral activity can also be maintained when the silver nanoparticles were added after the cell had been already infected with HIV. In this event, AgNPs might inhibit post-entry stages of infection by blocking other functional HIV-1 proteins or reducing reverse transcription or proviral transcription rates by directly binding to the RNA or DNA molecules. Also, RSV can be efficiently inhibited by PVP-coated AgNPs (Sun et al. <xref ref-type="bibr" rid="CR95">2008</xref>), probably by binding of nanoparticles to the viral surface through a possible interaction with entry glycoproteins that are evenly distributed on the envelope of the RSV virion. A different capping agent, namely mercaptoethanesulfonate (Baram-Pinto et al. <xref ref-type="bibr" rid="CR8">2009</xref>), has been used as capping agent for AgNPs tested against HSV-1. Sulfonate-capped AgNPs inhibit HSV-1 infection by blocking the attachment and thereby the entrance of the virus into the cells and/or by preventing the cell-to-cell spread of the virus. Their anti-HSV-1 activity depends from their ability to mimic heparan sulphate (the cellular primary receptor for HSV) and thus compete for the binding of the virus to the cell and is amplified by the presence of the inner core of nanosilver.</p><p>The exploitation of AgNPs as antivirals is still in its infancy, and further studies are warranted to elucidate the mechanism(s) of action, which may render possible antiviral development of AgNPs to fill the vital niche of a broad-spectrum antiviral agent.</p></sec><sec id="Sec5"><title>Anti-protozoal activity of silver nanoparticles</title><p>Oocyst-producing water-borne intestinal protozoa, such as <italic>Giardia lamblia</italic> and especially <italic>Cryptosporidium parvum</italic>, are resistant to traditional deactivation procedures including size-exclusion filters and chlorine treatments (Korich et al. <xref ref-type="bibr" rid="CR51">1990</xref>). Both the pathogens cause gastrointestinal infections throughout the world. Furthermore, infection of <italic>Cryptosporidium parvum</italic> in immune-compromised individuals can be life-threatening; thus, search for new methods of deactivation of these pathogens at ultra-low detection level has great importance.</p><p>An interesting in vivo study was carried out by Said et al. (<xref ref-type="bibr" rid="CR81">2012</xref>) who compared the activity of AgNPs, chitosan NPs and curcumin NPs against <italic>G. lamblia</italic> in experiments on rats. The maximum efficacy was achieved by combining all three types of nanoparticles (AgNPs, chitosan NPs and curcumin NPs) compared to when they were used separately. Experiments are being performed to verify the effectiveness of AgNPs against <italic>Cryptosporidium parvum</italic> (Abebe <xref ref-type="bibr" rid="CR1">2012</xref>; Su et al. <xref ref-type="bibr" rid="CR92">2012</xref>). The study by Abebe (<xref ref-type="bibr" rid="CR1">2012</xref>) is directed to assess disinfection effect of AgNPs on <italic>Cryptosporidium parvum</italic> and to develop an effective system of water filtration. However, final results of both experimental studies have not yet been published.</p><p>Another important protozoal infection is leishmaniasis, which is one of the main neglected tropical infections of the world with occurrence in 88 countries and an estimated number of 500,000 cases of visceral form and 1.5 million cases of cutaneous leishmaniasis (Marr et al. <xref ref-type="bibr" rid="CR57">2012</xref>). Drug resistance compromises present treatment options and absence of effective vaccination warrants to search for new compounds with anti-leishmanial activity. Nanotechnology is implied in two different directions: the development of nano-liposomal formulations containing conventional anti-leishmanial drugs, for instance, antimonial and amphotericin B liposomes (Duran et al. <xref ref-type="bibr" rid="CR20">2009</xref>), and the use of nanoparticles of metals or metal oxides, including AgNPs, Ag<sub>2</sub>O and TiO<sub>2</sub> nanoparticles (Allahverdiyev et al. <xref ref-type="bibr" rid="CR4">2011a</xref>, <xref ref-type="bibr" rid="CR5">b</xref>, <xref ref-type="bibr" rid="CR6">c</xref>).</p><p>Leishmania parasites are sensitive to ROS (Murray <xref ref-type="bibr" rid="CR62">1981</xref>); however, during multiplication in macrophages they block enzymatic mechanisms responsible for ROS production and thus evade destruction (Shio and Olivier <xref ref-type="bibr" rid="CR88">2010</xref>). One of the first works on anti-leishmanial activity of AgNPs did not find significant differences in reducing proliferation of <italic>Leishmania major</italic> by AgNPs and controls in in vitro experiments, and also there was no significant decrease in lesion sizes and amastigote counts in the in vivo experiment on BALB/c mice; however, nanosilver-treated mice demonstrated significant decrease in secondary infection. Therefore, it was concluded that AgNPs are effective to control the secondary infection in localized cutaneous leishmaniasis (Mohebali et al. <xref ref-type="bibr" rid="CR61">2009</xref>). Similar results regarding lesion sizes and splenic parasite load were obtained by Nilforoushzadeh et al. (<xref ref-type="bibr" rid="CR66">2012</xref>); there were no significant differences in these parameters in groups treated using chemically produced AgNPs compared with the control group without treatment.</p><p>However, Rossi-Bergmann et al. (<xref ref-type="bibr" rid="CR80">2012</xref>) reported promising activity of biosynthesized (using <italic>F. oxysporum</italic>) AgNPs against <italic>Leishmania amazonensis</italic> promastigotes in vitro and in vivo. Further, they also compared activity of biologically and chemically produced AgNPs. It was observed that in in vitro experiments biologically produced AgNPs were four times more potent than chemically produced AgNPs; moreover, in the in vivo model they were even more effective.</p><p>In another recent study, in vitro effect of AgNPs on morphological properties, growth, proliferation, metabolic activity, infectivity and infection index (percentage of infected macrophages multiplied by the average number of amastigotes per macrophage) of <italic>Leishmania tropica</italic> was evaluated depending on presence or absence of UV irradiation (Allahverdiyev et al. <xref ref-type="bibr" rid="CR5">2011b</xref>). AgNPs inhibited all biological activities of <italic>L. tropica</italic> and, moreover, this effect was enhanced under UV light. Observed enhancing effect of UV light on anti-leishmanial activity of AgNPs was attributed to the ability of AgNPs to release silver ions. Loosing infectious ability by <italic>Leishmania</italic> under the action of AgNPs, especially noted together with UV light, was explained by interaction of AgNPs with parasitic surface lipophosphoglycan and glycoprotein molecules that are responsible for infectivity. Such findings are important not only in the treatment of leishmaniasis but also in the control of its spread by application of AgNPs on sandfly vectors carrying infective promastigotes. Interestingly, amastigotes appeared to be more sensitive than promastigotes, even to low concentrations of AgNPs that are non-harmful for macrophages, such as 1–10 mg/L. This was supposed to be a result of macrophages action, which after exposure to AgNPs may enhance production of lytic enzymes or nitric oxide, and also this effect may be caused by losing ability of amastigotes to affect negatively the ROS production.</p><p>One of the most common protozoal vector-borne diseases with prevalence in tropical and subtropical regions and over one million global deaths per year is malaria (Kamareddine <xref ref-type="bibr" rid="CR45">2012</xref>). Rapid growth in resistance of plasmodia to antimalarial drugs stimulates continuous search for innovative approaches against malarial parasites, and also for methods to control the spread of the mosquito vector.</p><p>Among different agents, AgNPs have also been evaluated against plasmodia in several works that demonstrated promising results. Panneerselvam et al. (<xref ref-type="bibr" rid="CR68">2011</xref>) reported activity of AgNPs (average size of approximately 55 nm) produced biologically using <italic>Andrographis paniculata</italic> Nees (Acanthaceae) against <italic>P. falciparum</italic>. Ponarulselvam et al. (<xref ref-type="bibr" rid="CR70">2012</xref>) reported activity of AgNPs (average size of approximately 35–55 nm) produced using aqueous leaves extract of <italic>Catharanthus roseus</italic> against <italic>P. falciparum</italic>. An ongoing study of Murugan et al. (<xref ref-type="bibr" rid="CR63">2013</xref>) demonstrates high activity of AgNPs bio-reduced in 5 % <italic>Cassia occidentalis</italic> leaf broth against chloroquine-sensitive and chloroquine-resistant strains of <italic>P. falciparum</italic> and malaria vector <italic>Anopheles stephensi</italic>. However, there is no explanation of anti-plasmodial effects in any published studies.</p></sec><sec id="Sec6"><title>Anti-arthropod activity of AgNPs</title><p>In recent years, there has been increasing incidence of many vector-borne pathogens in new geographical regions (Kilpatrick and Randolph <xref ref-type="bibr" rid="CR48">2012</xref>). Resistance to insecticidal agents was found among all types of arthropod vectors. Ticks were found to be resistant to acaricides; moreover, present acaricidal substances have serious drawbacks, such as contamination of environment, milk and meat products (Jayaseelan and Rahuman <xref ref-type="bibr" rid="CR38">2012</xref>). The same happens with insecticide resistance in mosquitoes and lice (Raghavendra et al. <xref ref-type="bibr" rid="CR73">2011</xref>; Durand et al. <xref ref-type="bibr" rid="CR22">2012</xref>). Owing to this, interest of scientists has been devoted to the search for anti-arthropod potential in different types of antiparasitic agents, including AgNPs (Adhikari et al. <xref ref-type="bibr" rid="CR3">2013</xref>). Many recently published studies report significant acaricidal, larvicidal and lousicidal properties in biologically produced AgNPs, proving that they represent an innovative approach to control arthropods and prevent spread of vector-borne diseases.</p><p>In spite of the fact that many published studies proved anti-arthropodal effect of AgNPs, there is still no clear scientific explanation of it. The possible larvicidal activity of AgNPs was hypothesized to be caused by penetration of nanoparticles through larvae membrane (Salunkhe et al. <xref ref-type="bibr" rid="CR83">2011</xref>); however, further studies are necessary in order to reveal the precise mechanism of anti-arthropod activity of AgNPs.</p></sec><sec id="Sec7"><title>Silver nanoparticles in cancer</title><p>The early detection and treatment of cancer are the basic problems faced by the cancer specialists and hence this area has attracted a great attention. One important point in the effectiveness of anti-cancer drugs is related to the possibility of reaching the target site in sufficient concentration and to the efficient activity without causing damage to healthy tissues and cells (Misra et al. <xref ref-type="bibr" rid="CR60">2010</xref>; Seigneuric et al. <xref ref-type="bibr" rid="CR86">2010</xref>).</p><p>In this direction, nanotechnology represents, at the moment, one of the new technologies with possibility to enhance the diagnosis and treatment of cancer. This could be achieved through new imaging agents, multifunctional targeted devices capable of bypassing biological barriers to deliver therapeutic agents directly to the biological target involved in cancer, nano-biosensors for predicting the disease and minimizing the growth of cancer cells and reducing the cost of treatments (Jain <xref ref-type="bibr" rid="CR37">2010</xref>; Qiao et al. <xref ref-type="bibr" rid="CR72">2010</xref>). Metallic nanoparticles, in this area, appear as important agents, since they are used in several biomedical applications, such as highly sensitive diagnostic assays and biosensors (Rai et al. <xref ref-type="bibr" rid="CR77">2012</xref>), thermal, and radiotherapy enhancement (Qiao et al. <xref ref-type="bibr" rid="CR72">2010</xref>), as well as drug and gene delivery with relatively low toxicity (Bhattacharyya et al. <xref ref-type="bibr" rid="CR10">2012</xref>; Conde et al. <xref ref-type="bibr" rid="CR13">2012</xref>). It is known that AgNPs interact with cells and intracellular macromolecules like proteins and DNA, probably through ROS, showing apoptotic bodies and necrotic cell death due to the cytotoxicity of biogenic AgNPs, although all of these possibilities are still under studies (Duran et al. <xref ref-type="bibr" rid="CR21">2010</xref>; Jeyaraj et al. <xref ref-type="bibr" rid="CR40">2013a</xref>, <xref ref-type="bibr" rid="CR41">b</xref>). Several factors influence toxicity of AgNPs, such as dose, time and size of the particles. Against MCF-7 cell culture, it was found that toxicity is dose-dependent and causes cellular damage in Human Epidermoid Larynx (Hep-2) cell line through ROS formation (Jacob et al. <xref ref-type="bibr" rid="CR35">2012</xref>). Biologically synthesized AgNPs from the leaf of <italic>Suaeda monoica</italic> on Hep-2 cells exhibited dose-dependent toxicity at the concentration studied (Satyavani et al. <xref ref-type="bibr" rid="CR84">2012</xref>).</p><p>AgNPs biogenically synthesized from <italic>Podophyllum hexandrum</italic> leaf extract showed a cytotoxicity and apoptotic effect, probably through caspace-cascade activation and loses of mitochondrial integrity (Jeyaraj et al. <xref ref-type="bibr" rid="CR41">2013b</xref>). Piao et al. (<xref ref-type="bibr" rid="CR69">2011</xref>) reported that hydroxyl radicals released by the AgNPs attack cellular components including DNA, lipids and proteins to cause various kinds of oxidative damages. Jeyaraj et al. (<xref ref-type="bibr" rid="CR40">2013a</xref>) using biogenic AgNPs from <italic>Sesbania grandiflora</italic> leaf extract also showed cytotoxic effect against MCF-7 cell lines inducing cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis. The authors suggested that in order to progress to clinical cancer treatment it is necessary to study the formulation and clinical trials to establish the nanodrug to treat cancer cells.</p><p>In a recent study, biogenic AgNPs from <italic>Vitex negundo</italic> leaf extract showed inhibition of proliferation of human colon cancer cell line HCT15. These results indicate that AgNPs may exert antiproliferative effects on colon cancer cell line by suppressing its growth, arresting the G0/G1-phase, reducing DNA synthesis and inducing apoptosis (Prabhu et al. <xref ref-type="bibr" rid="CR71">2013</xref>). Inoculation of Dalton’s lymphoma ascites cells in mice produced a tumour progression in the animals, whereas in the presence of AgNPs a substantial decrease in cancer cell numbers in tumour mice was observed through histopathologic analysis. Apparently, the effect of AgNPs in increasing mean survival time and life span depends on their ability to reduce tumour cell viability and induce cytotoxicity (Sriram et al. <xref ref-type="bibr" rid="CR91">2010</xref>). The hematologic parameters examined in the controls, tumour controls and tumour-treated mice showed the effect of AgNPs in reducing white blood cell and platelet counts in tumour-bearing mice compared with controls. These data highlight the non-toxic effect of AgNPs, which did not induce any alteration in hematologic parameters for treated mice in comparison with controls and, at the same time, led to effective control of white blood cells that possess the immunologic constituents of ascitic fluid. This was corroborated recently by De-Lima et al. (<xref ref-type="bibr" rid="CR16">2012</xref>, <xref ref-type="bibr" rid="CR17">2013</xref>) in cytotoxic and genotoxic biogenic AgNPs studies.</p></sec><sec id="Sec8" sec-type="conclusion"><title>Conclusions and future prospects</title><p>AgNPs demonstrated broad-spectrum activity against different types of causative agents of infectious diseases, and also against their arthropod vectors, which makes it possible to apply AgNPs not only for treatment purposes but also for control of infections (Fig. <xref rid="Fig2" ref-type="fig">2</xref>). Recent studies have been directed to address several questions: (1) methods of synthesis of AgNPs with optimal properties enhancing their antimicrobial effect and minimizing potential adverse toxic impact on human or animal cells; (2) detection of possible targets among microorganisms, against which AgNPs can be potentially applied either alone or in combination with conventional antimicrobial agents; (3) detection of possible candidates among arthropod vectors transmitting infections taking into account the stages of their life cycle which can be easily and effectively targeted; (4) producing clinically and environmentally applicable forms containing AgNPs, such as antimicrobial coatings against microorganisms or repellent substances against their arthropod vectors. Many aspects in these global goals still remain unsolved and studies in the nearest future may help in overcoming present to-date barriers. Studies on combined use of AgNPs with other antimicrobial agents may solve problem of toxicity and prevent possible risk of resistance development. Further investigations should also be devoted to the assessment of influence of biological fluids, oxygen pressure and other chemical and biological factors on bioactivity and biocompatibility of AgNPs. Mechanism of antimicrobial and anti-arthropod effect should be deeply evaluated, as understanding of all molecular events in action of AgNPs may open up new perspectives in their application and new possibilities of creating beneficial combinations with other biologically active agents.<fig id="Fig2"><label>Fig. 2</label><caption><p>AgNPs in the treatment and control of infectious diseases: antimicrobial properties of AgNPs make them useful in the treatment and prophylaxis of infections (<italic>upper part</italic> of diagram), while anti-arthropod properties can be used in the control of spread of infections by affecting arthropod vectors (down part of diagram)</p></caption><graphic xlink:href="253_2013_5473_Fig2_HTML" id="MO2"></graphic></fig></p><p>Broad-spectrum bioactivities of AgNPs make them promising agents not only in fighting infections but also in tackling serious problem of tumours and, particularly, multi-drug-resistant cancer cells. 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