Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals
Identifieur interne : 000318 ( Pmc/Corpus ); précédent : 000317; suivant : 000319Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals
Auteurs : Nilesh P. Teli ; Michael P. TimkoSource :
- Plant Cell, Tissue and Organ Culture [ 0167-6857 ] ; 2004.
Abstract
In recent years there has been a dramatic increase in the application of plant biotechnology for the production of a variety of commercially valuable simple and complex biological molecules (biologics) for use in human and animal healthcare. Transgenic whole plants and plant cell culture systems have been developed that have the capacity to economically produce large-scale quantities of antibodies and antibody fragments, antigens and/or vaccine epitopes, metabolic enzymes, hormones, (neuro)peptides and a variety of biologically active complexes and secondary metabolites for direct use as therapeutic agents or diagnostic tools in the medical healthcare industry. As the products of genetically modified plants make their way from concept to commercialization the associated risks and acceptance by the public has been become a focal point. In this paper, we summarize the recent advances made in the use of transgenic plants and plant cell cultures as biological factories for the production of human therapeutics and biopharmaceuticals and discuss the long-term potential of `molecular farming' as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community.
Url:
DOI: 10.1007/s11240-004-0653-0
PubMed: NONE
PubMed Central: 7089434
Links to Exploration step
PMC:7089434Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals</title><author><name sortKey="Teli, Nilesh P" sort="Teli, Nilesh P" uniqKey="Teli N" first="Nilesh P." last="Teli">Nilesh P. Teli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Timko, Michael P" sort="Timko, Michael P" uniqKey="Timko M" first="Michael P." last="Timko">Michael P. Timko</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7089434</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089434</idno><idno type="RBID">PMC:7089434</idno><idno type="doi">10.1007/s11240-004-0653-0</idno><idno type="pmid">NONE</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000318</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000318</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals</title><author><name sortKey="Teli, Nilesh P" sort="Teli, Nilesh P" uniqKey="Teli N" first="Nilesh P." last="Teli">Nilesh P. Teli</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Timko, Michael P" sort="Timko, Michael P" uniqKey="Timko M" first="Michael P." last="Timko">Michael P. Timko</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Plant Cell, Tissue and Organ Culture</title><idno type="ISSN">0167-6857</idno><idno type="eISSN">1573-5044</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In recent years there has been a dramatic increase in the application of plant biotechnology for the production of a variety of commercially valuable simple and complex biological molecules (biologics) for use in human and animal healthcare. Transgenic whole plants and plant cell culture systems have been developed that have the capacity to economically produce large-scale quantities of antibodies and antibody fragments, antigens and/or vaccine epitopes, metabolic enzymes, hormones, (neuro)peptides and a variety of biologically active complexes and secondary metabolites for direct use as therapeutic agents or diagnostic tools in the medical healthcare industry. As the products of genetically modified plants make their way from concept to commercialization the associated risks and acceptance by the public has been become a focal point. In this paper, we summarize the recent advances made in the use of transgenic plants and plant cell cultures as biological factories for the production of human therapeutics and biopharmaceuticals and discuss the long-term potential of `molecular farming' as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ap Rees, T" uniqKey="Ap Rees T">T Ap Rees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arakawa, T" uniqKey="Arakawa T">T Arakawa</name></author><author><name sortKey="Chong, Dkx" uniqKey="Chong D">DKX Chong</name></author><author><name sortKey="Slattery, Cw" uniqKey="Slattery C">CW Slattery</name></author><author><name sortKey="Langridge, Whr" uniqKey="Langridge W">WHR 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Cell Tissue Organ Cult</journal-id><journal-id journal-id-type="iso-abbrev">Plant Cell Tissue Organ Cult</journal-id><journal-title-group><journal-title>Plant Cell, Tissue and Organ Culture</journal-title></journal-title-group><issn pub-type="ppub">0167-6857</issn><issn pub-type="epub">1573-5044</issn><publisher><publisher-name>Kluwer Academic Publishers</publisher-name><publisher-loc>Dordrecht</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7089434</article-id><article-id pub-id-type="publisher-id">DO00000653</article-id><article-id pub-id-type="doi">10.1007/s11240-004-0653-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Recent developments in the use of transgenic plants for the production of human therapeutics and biopharmaceuticals</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Teli</surname><given-names>Nilesh P.</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Timko</surname><given-names>Michael P.</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.27755.32</institution-id><institution-id institution-id-type="ISNI">000000009136933X</institution-id><institution>Department of Biology,</institution><institution>University of Virginia,</institution></institution-wrap>Gilmer Hall 044, VA USA</aff></contrib-group><pub-date pub-type="ppub"><year>2004</year></pub-date><volume>79</volume><issue>2</issue><fpage>125</fpage><lpage>145</lpage><permissions><copyright-statement>© Kluwer Academic Publishers 2004</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>In recent years there has been a dramatic increase in the application of plant biotechnology for the production of a variety of commercially valuable simple and complex biological molecules (biologics) for use in human and animal healthcare. Transgenic whole plants and plant cell culture systems have been developed that have the capacity to economically produce large-scale quantities of antibodies and antibody fragments, antigens and/or vaccine epitopes, metabolic enzymes, hormones, (neuro)peptides and a variety of biologically active complexes and secondary metabolites for direct use as therapeutic agents or diagnostic tools in the medical healthcare industry. As the products of genetically modified plants make their way from concept to commercialization the associated risks and acceptance by the public has been become a focal point. In this paper, we summarize the recent advances made in the use of transgenic plants and plant cell cultures as biological factories for the production of human therapeutics and biopharmaceuticals and discuss the long-term potential of `molecular farming' as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community.</p></abstract><kwd-group xml:lang="en"><kwd>edible vaccines</kwd><kwd>molecular farming</kwd><kwd>plantibodies</kwd><kwd>secondary metabolites</kwd><kwd>therapeutic proteins</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Kluwer Academic Publishers 2004</meta-value></custom-meta></custom-meta-group></article-meta></front><back><ref-list id="Bib1"><title>References</title><ref id="CR1"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ap Rees</surname><given-names>T</given-names></name></person-group><article-title>Prospects of manipulating plant metabolism</article-title><source>Trends Biotechnol.</source><year>1995</year><volume>13</volume><fpage>375</fpage><lpage>378</lpage></element-citation></ref><ref id="CR2"><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arakawa</surname><given-names>T</given-names></name><name><surname>Chong</surname><given-names>DKX</given-names></name><name><surname>Slattery</surname><given-names>CW</given-names></name><name><surname>Langridge</surname><given-names>WHR</given-names></name></person-group><article-title>Improvements in human health through production of human milk proteins in transgenic food plants</article-title><source>Adv. 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