Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)
Identifieur interne : 000316 ( Pmc/Corpus ); précédent : 000315; suivant : 000317Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)
Auteurs : L. A. Baltina ; R. M. Kondratenko ; L. A. Baltina ; O. A. Plyasunova ; A. G. Pokrovskii ; G. A. TolstikovSource :
- Pharmaceutical Chemistry Journal [ 0091-150X ] ; 2009.
Abstract
The review is devoted to the problem of creating new antiviral drugs based on glycyrrhizic acid (GA), the major triterpene glycoside extracted from roots of common and Ural licorice (
Url:
DOI: 10.1007/s11094-010-0348-2
PubMed: NONE
PubMed Central: 7089237
Links to Exploration step
PMC:7089237Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)</title><author><name sortKey="Baltina, L A" sort="Baltina, L A" uniqKey="Baltina L" first="L. A." last="Baltina">L. A. Baltina</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Kondratenko, R M" sort="Kondratenko, R M" uniqKey="Kondratenko R" first="R. M." last="Kondratenko">R. M. Kondratenko</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.411540.5</institution-id><institution>Bashkir State Medical University,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Baltina, L A" sort="Baltina, L A" uniqKey="Baltina L" first="L. A." last="Baltina">L. A. Baltina</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Plyasunova, O A" sort="Plyasunova, O A" uniqKey="Plyasunova O" first="O. A." last="Plyasunova">O. A. Plyasunova</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.419755.b</institution-id><institution>State Research Center of Virology and Biotechnology Vector,</institution></institution-wrap>Kol’tsovo, Novosibirsk Oblast Russia</nlm:aff></affiliation></author><author><name sortKey="Pokrovskii, A G" sort="Pokrovskii, A G" uniqKey="Pokrovskii A" first="A. G." last="Pokrovskii">A. G. Pokrovskii</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.419755.b</institution-id><institution>State Research Center of Virology and Biotechnology Vector,</institution></institution-wrap>Kol’tsovo, Novosibirsk Oblast Russia</nlm:aff></affiliation></author><author><name sortKey="Tolstikov, G A" sort="Tolstikov, G A" uniqKey="Tolstikov G" first="G. A." last="Tolstikov">G. A. Tolstikov</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7089237</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089237</idno><idno type="RBID">PMC:7089237</idno><idno type="doi">10.1007/s11094-010-0348-2</idno><idno type="pmid">NONE</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000316</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)</title><author><name sortKey="Baltina, L A" sort="Baltina, L A" uniqKey="Baltina L" first="L. A." last="Baltina">L. A. Baltina</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Kondratenko, R M" sort="Kondratenko, R M" uniqKey="Kondratenko R" first="R. M." last="Kondratenko">R. M. Kondratenko</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.411540.5</institution-id><institution>Bashkir State Medical University,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Baltina, L A" sort="Baltina, L A" uniqKey="Baltina L" first="L. A." last="Baltina">L. A. Baltina</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author><author><name sortKey="Plyasunova, O A" sort="Plyasunova, O A" uniqKey="Plyasunova O" first="O. A." last="Plyasunova">O. A. Plyasunova</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.419755.b</institution-id><institution>State Research Center of Virology and Biotechnology Vector,</institution></institution-wrap>Kol’tsovo, Novosibirsk Oblast Russia</nlm:aff></affiliation></author><author><name sortKey="Pokrovskii, A G" sort="Pokrovskii, A G" uniqKey="Pokrovskii A" first="A. G." last="Pokrovskii">A. G. Pokrovskii</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.419755.b</institution-id><institution>State Research Center of Virology and Biotechnology Vector,</institution></institution-wrap>Kol’tsovo, Novosibirsk Oblast Russia</nlm:aff></affiliation></author><author><name sortKey="Tolstikov, G A" sort="Tolstikov, G A" uniqKey="Tolstikov G" first="G. A." last="Tolstikov">G. A. Tolstikov</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</nlm:aff></affiliation></author></analytic><series><title level="j">Pharmaceutical Chemistry Journal</title><idno type="ISSN">0091-150X</idno><idno type="eISSN">1573-9031</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The review is devoted to the problem of creating new antiviral drugs based on glycyrrhizic acid (GA), the major triterpene glycoside extracted from roots of common and Ural licorice (<italic>Glycyrrhiza glabra</italic> L. and <italic>G. uralensis</italic> Fisher, respectively). Published data on the natural GA sources, antiviral activity of GA and its derivatives, clinical applications of GA-based drugs, and the properties of GA-containing biologically active nutrient additives are summarized. Possible mechanisms of the antiviral activity of GA and its derivatives are examined. It is shown that chemical modification of GA is a promising way of designing new highly active antiviral drugs for the prophylaxis and treatment of HIV, hepatitis B and C, corona-virus, and herpes simplex virus infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ershov, Fi" uniqKey="Ershov F">FI Ershov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Matthee, G" uniqKey="Matthee G">G Matthee</name></author><author><name sortKey="Wright, Ad" uniqKey="Wright A">AD Wright</name></author><author><name sortKey="Konig, Gm" uniqKey="Konig G">GM Konig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corbett, Jw" uniqKey="Corbett J">JW Corbett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imamichi, T" uniqKey="Imamichi T">T 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Pharm Chem J</journal-id><journal-id journal-id-type="iso-abbrev">Pharm Chem J</journal-id><journal-title-group><journal-title>Pharmaceutical Chemistry Journal</journal-title></journal-title-group><issn pub-type="ppub">0091-150X</issn><issn pub-type="epub">1573-9031</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>Boston</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7089237</article-id><article-id pub-id-type="publisher-id">348</article-id><article-id pub-id-type="doi">10.1007/s11094-010-0348-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Search for New Drugs</subject></subj-group></article-categories><title-group><article-title>Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Baltina</surname><given-names>L. A.</given-names></name><address><email>baltina@anrb.ru</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kondratenko</surname><given-names>R. M.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Baltina</surname><given-names>L. A.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Plyasunova</surname><given-names>O. A.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pokrovskii</surname><given-names>A. G.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tolstikov</surname><given-names>G. A.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.4886.2</institution-id><institution-id institution-id-type="ISNI">0000000121929124</institution-id><institution>Institute of Organic Chemistry, UfaScientific Center,</institution><institution>Russian Academy of Sciences,</institution></institution-wrap>Ufa, Bashkortostan Russia</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.411540.5</institution-id><institution>Bashkir State Medical University,</institution></institution-wrap>Ufa, Bashkortostan Russia</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.419755.b</institution-id><institution>State Research Center of Virology and Biotechnology Vector,</institution></institution-wrap>Kol’tsovo, Novosibirsk Oblast Russia</aff></contrib-group><pub-date pub-type="epub"><day>4</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="ppub"><year>2009</year></pub-date><volume>43</volume><issue>10</issue><fpage>539</fpage><lpage>548</lpage><history><date date-type="received"><day>20</day><month>2</month><year>2006</year></date></history><permissions><copyright-statement>© Springer Science+Business Media, Inc. 2009</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The review is devoted to the problem of creating new antiviral drugs based on glycyrrhizic acid (GA), the major triterpene glycoside extracted from roots of common and Ural licorice (<italic>Glycyrrhiza glabra</italic> L. and <italic>G. uralensis</italic> Fisher, respectively). Published data on the natural GA sources, antiviral activity of GA and its derivatives, clinical applications of GA-based drugs, and the properties of GA-containing biologically active nutrient additives are summarized. Possible mechanisms of the antiviral activity of GA and its derivatives are examined. It is shown that chemical modification of GA is a promising way of designing new highly active antiviral drugs for the prophylaxis and treatment of HIV, hepatitis B and C, corona-virus, and herpes simplex virus infections.</p></abstract><kwd-group xml:lang="en"><title>Key words</title><kwd>licorice root</kwd><kwd>glycyrrhizic acid</kwd><kwd>antiviral activity</kwd><kwd>antiviral drugs</kwd><kwd>biologically active nutrient additives</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media, Inc. 2009</meta-value></custom-meta></custom-meta-group></article-meta></front><back><fn-group><fn><p>Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 43, No. 10, pp. 3–12, October, 2009.</p></fn></fn-group><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Ershov</surname><given-names>FI</given-names></name></person-group><source>Antiviral Preparations</source><year>1998</year><publisher-loc>Moscow</publisher-loc><publisher-name>Meditsina</publisher-name></element-citation></ref><ref id="CR2"><label>2.</label><mixed-citation publication-type="other">F. 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