Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors
Identifieur interne : 000281 ( Pmc/Corpus ); précédent : 000280; suivant : 000282Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors
Auteurs : D. Sulzer ; E. HoltzmanSource :
- Journal of Neurocytology [ 0300-4864 ] ; 1989.
Abstract
By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas of
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DOI: 10.1007/BF01474548
PubMed: 2478669
PubMed Central: 7089201
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</title><author><name sortKey="Sulzer, D" sort="Sulzer, D" uniqKey="Sulzer D" first="D." last="Sulzer">D. Sulzer</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Department of Biological Sciences,</institution><institution>Columbia University,</institution></institution-wrap>10027 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Holtzman, E" sort="Holtzman, E" uniqKey="Holtzman E" first="E." last="Holtzman">E. Holtzman</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Department of Biological Sciences,</institution><institution>Columbia University,</institution></institution-wrap>10027 New York, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2478669</idno><idno type="pmc">7089201</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089201</idno><idno type="RBID">PMC:7089201</idno><idno type="doi">10.1007/BF01474548</idno><date when="1989">1989</date><idno type="wicri:Area/Pmc/Corpus">000281</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000281</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</title><author><name sortKey="Sulzer, D" sort="Sulzer, D" uniqKey="Sulzer D" first="D." last="Sulzer">D. Sulzer</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Department of Biological Sciences,</institution><institution>Columbia University,</institution></institution-wrap>10027 New York, USA</nlm:aff></affiliation></author><author><name sortKey="Holtzman, E" sort="Holtzman, E" uniqKey="Holtzman E" first="E." last="Holtzman">E. Holtzman</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Department of Biological Sciences,</institution><institution>Columbia University,</institution></institution-wrap>10027 New York, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Neurocytology</title><idno type="ISSN">0300-4864</idno><idno type="eISSN">1573-7381</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas of<italic>Rana pipiens</italic> maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anderson, R G W" uniqKey="Anderson R">R. G. W. Anderson</name></author><author><name sortKey="Orci, L" uniqKey="Orci L">L. Orci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baguena Cervellera, R" uniqKey="Baguena Cervellera R">R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurocytol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurocytol</journal-id><journal-title-group><journal-title>Journal of Neurocytology</journal-title></journal-title-group><issn pub-type="ppub">0300-4864</issn><issn pub-type="epub">1573-7381</issn><publisher><publisher-name>Kluwer Academic Publishers</publisher-name><publisher-loc>Dordrecht</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">2478669</article-id><article-id pub-id-type="pmc">7089201</article-id><article-id pub-id-type="publisher-id">BF01474548</article-id><article-id pub-id-type="doi">10.1007/BF01474548</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sulzer</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Holtzman</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Department of Biological Sciences,</institution><institution>Columbia University,</institution></institution-wrap>10027 New York, USA</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.21729.3f</institution-id><institution-id institution-id-type="ISNI">0000000419368729</institution-id><institution>Present Address: New York State Psychiatric Institute,</institution><institution>Columbia University,</institution></institution-wrap>Box 62, 10032 New York, USA</aff></contrib-group><pub-date pub-type="ppub"><year>1989</year></pub-date><volume>18</volume><issue>4</issue><fpage>529</fpage><lpage>540</lpage><history><date date-type="received"><day>18</day><month>4</month><year>1989</year></date><date date-type="accepted"><day>18</day><month>5</month><year>1989</year></date></history><permissions><copyright-statement>© Chapman and Hall Ltd. 1989</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><title>Summary</title><p>By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas of<italic>Rana pipiens</italic> maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. 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