Demyelination in mice resulting from infection with a mutant of Semliki Forest virus
Identifieur interne : 000166 ( Pmc/Corpus ); précédent : 000165; suivant : 000167Demyelination in mice resulting from infection with a mutant of Semliki Forest virus
Auteurs : B. J. Sheahan ; P. N. Barrett ; G. J. AtkinsSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1981.
Abstract
Twelve of 34 weanling mice (35%) developed lesions in the brain and spinal cord following i.p. infection with 102 p.f.u. of a mutant of Semliki Forest virus (SFV). Six of 12 mice examined 13 days post infection (p.i.) showed meningo-encephalomyelitis with focal spongiform lesions in the grey and white matter. The spongiform lesions were characterised by necrosis of putative oligodendrocytes, myelinic vacuolation and mononuclear cell infiltration. Only one of six mice examined 21 days p.i. and one of six mice examined 28 days p.i. showed lesions which comprised reactive and dystrophic changes in the white matter. Spongiform lesions and pycnotic nuclei were not seen at these times. Viral nucleocapsids were seen in the early stages of the disease in putative necrotic oligodendrocytes. Mature virus particles were not seen. This was in contrast to mice infected with virulent wild-type SFV when lesions were more severe and were accompanied by large numbers of immature and mature virus particles. It is suggested that the demyelination in mice infected with mutant SFV results primarily from selective destruction of oligodendrocytes by the mutant virus.
Url:
DOI: 10.1007/BF00689993
PubMed: 6259872
PubMed Central: 7086517
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PMC:7086517Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Demyelination in mice resulting from infection with a mutant of Semliki Forest virus</title><author><name sortKey="Sheahan, B J" sort="Sheahan, B J" uniqKey="Sheahan B" first="B. J." last="Sheahan">B. J. Sheahan</name><affiliation><nlm:aff id="Aff1">Department of Veterinary Pathology and Microbiology, Veterinary College of Ireland, Ballsbridge, Dublin 4, Ireland</nlm:aff></affiliation></author><author><name sortKey="Barrett, P N" sort="Barrett, P N" uniqKey="Barrett P" first="P. N." last="Barrett">P. N. Barrett</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.8217.c</institution-id><institution-id institution-id-type="ISNI">0000000419369705</institution-id><institution>Department of Microbiology, Moyne Institute,</institution><institution>Trinity College,</institution></institution-wrap>Dublin 2, Ireland</nlm:aff></affiliation></author><author><name sortKey="Atkins, G J" sort="Atkins, G J" uniqKey="Atkins G" first="G. J." last="Atkins">G. J. Atkins</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.8217.c</institution-id><institution-id institution-id-type="ISNI">0000000419369705</institution-id><institution>Department of Microbiology, Moyne Institute,</institution><institution>Trinity College,</institution></institution-wrap>Dublin 2, Ireland</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6259872</idno><idno type="pmc">7086517</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086517</idno><idno type="RBID">PMC:7086517</idno><idno type="doi">10.1007/BF00689993</idno><date when="1981">1981</date><idno type="wicri:Area/Pmc/Corpus">000166</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Demyelination in mice resulting from infection with a mutant of Semliki Forest virus</title><author><name sortKey="Sheahan, B J" sort="Sheahan, B J" uniqKey="Sheahan B" first="B. J." last="Sheahan">B. J. Sheahan</name><affiliation><nlm:aff id="Aff1">Department of Veterinary Pathology and Microbiology, Veterinary College of Ireland, Ballsbridge, Dublin 4, Ireland</nlm:aff></affiliation></author><author><name sortKey="Barrett, P N" sort="Barrett, P N" uniqKey="Barrett P" first="P. N." last="Barrett">P. N. Barrett</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.8217.c</institution-id><institution-id institution-id-type="ISNI">0000000419369705</institution-id><institution>Department of Microbiology, Moyne Institute,</institution><institution>Trinity College,</institution></institution-wrap>Dublin 2, Ireland</nlm:aff></affiliation></author><author><name sortKey="Atkins, G J" sort="Atkins, G J" uniqKey="Atkins G" first="G. J." last="Atkins">G. J. Atkins</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.8217.c</institution-id><institution-id institution-id-type="ISNI">0000000419369705</institution-id><institution>Department of Microbiology, Moyne Institute,</institution><institution>Trinity College,</institution></institution-wrap>Dublin 2, Ireland</nlm:aff></affiliation></author></analytic><series><title level="j">Acta Neuropathologica</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><date when="1981">1981</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Twelve of 34 weanling mice (35%) developed lesions in the brain and spinal cord following i.p. infection with 10<sup>2</sup> p.f.u. of a mutant of Semliki Forest virus (SFV). Six of 12 mice examined 13 days post infection (p.i.) showed meningo-encephalomyelitis with focal spongiform lesions in the grey and white matter. The spongiform lesions were characterised by necrosis of putative oligodendrocytes, myelinic vacuolation and mononuclear cell infiltration. Only one of six mice examined 21 days p.i. and one of six mice examined 28 days p.i. showed lesions which comprised reactive and dystrophic changes in the white matter. Spongiform lesions and pycnotic nuclei were not seen at these times. Viral nucleocapsids were seen in the early stages of the disease in putative necrotic oligodendrocytes. Mature virus particles were not seen. This was in contrast to mice infected with virulent wild-type SFV when lesions were more severe and were accompanied by large numbers of immature and mature virus particles. It is suggested that the demyelination in mice infected with mutant SFV results primarily from selective destruction of oligodendrocytes by the mutant virus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barrett, Pn" uniqKey="Barrett P">PN Barrett</name></author><author><name sortKey="Sheahan, Bj" uniqKey="Sheahan B">BJ Sheahan</name></author><author><name sortKey="Atkins, Gj" uniqKey="Atkins G">GJ Atkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blakemore, Wf" uniqKey="Blakemore W">WF Blakemore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradish, Cj" uniqKey="Bradish C">CJ Bradish</name></author><author><name sortKey="Allner, K" uniqKey="Allner K">K Allner</name></author><author><name sortKey="Maber, Hb" uniqKey="Maber H">HB Maber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bradish, Cj" uniqKey="Bradish 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Neuropathol</journal-id><journal-id journal-id-type="iso-abbrev">Acta Neuropathol</journal-id><journal-title-group><journal-title>Acta Neuropathologica</journal-title></journal-title-group><issn pub-type="ppub">0001-6322</issn><issn pub-type="epub">1432-0533</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">6259872</article-id><article-id pub-id-type="pmc">7086517</article-id><article-id pub-id-type="publisher-id">BF00689993</article-id><article-id pub-id-type="doi">10.1007/BF00689993</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Works</subject></subj-group></article-categories><title-group><article-title>Demyelination in mice resulting from infection with a mutant of Semliki Forest virus</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Sheahan</surname><given-names>B. J.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Barrett</surname><given-names>P. N.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Atkins</surname><given-names>G. J.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label>Department of Veterinary Pathology and Microbiology, Veterinary College of Ireland, Ballsbridge, Dublin 4, Ireland</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.8217.c</institution-id><institution-id institution-id-type="ISNI">0000000419369705</institution-id><institution>Department of Microbiology, Moyne Institute,</institution><institution>Trinity College,</institution></institution-wrap>Dublin 2, Ireland</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id><institution-id institution-id-type="ISNI">0000000119588658</institution-id><institution>Present Address: Institute of Virology and Immunobiology,</institution><institution>University of Würzburg,</institution></institution-wrap>Versbacher Str. 7, D-8700 Würzburg, Federal Republic of Germany</aff></contrib-group><pub-date pub-type="ppub"><year>1981</year></pub-date><volume>53</volume><issue>2</issue><fpage>129</fpage><lpage>136</lpage><history><date date-type="received"><day>21</day><month>7</month><year>1980</year></date><date date-type="accepted"><day>29</day><month>8</month><year>1980</year></date></history><permissions><copyright-statement>© Springer-Verlag 1981</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><title>Summary</title><p>Twelve of 34 weanling mice (35%) developed lesions in the brain and spinal cord following i.p. infection with 10<sup>2</sup> p.f.u. of a mutant of Semliki Forest virus (SFV). Six of 12 mice examined 13 days post infection (p.i.) showed meningo-encephalomyelitis with focal spongiform lesions in the grey and white matter. The spongiform lesions were characterised by necrosis of putative oligodendrocytes, myelinic vacuolation and mononuclear cell infiltration. Only one of six mice examined 21 days p.i. and one of six mice examined 28 days p.i. showed lesions which comprised reactive and dystrophic changes in the white matter. Spongiform lesions and pycnotic nuclei were not seen at these times. Viral nucleocapsids were seen in the early stages of the disease in putative necrotic oligodendrocytes. Mature virus particles were not seen. This was in contrast to mice infected with virulent wild-type SFV when lesions were more severe and were accompanied by large numbers of immature and mature virus particles. It is suggested that the demyelination in mice infected with mutant SFV results primarily from selective destruction of oligodendrocytes by the mutant virus.</p></abstract><kwd-group xml:lang="en"><title>Key words</title><kwd>Semliki Forest virus</kwd><kwd>Demyelinating diseases</kwd><kwd>Spongy degeneration</kwd><kwd>Oligodendrocytes</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 1981</meta-value></custom-meta></custom-meta-group></article-meta></front><back><fn-group><fn><p>The study was supported by the Medical Research Council of Ireland</p></fn></fn-group><ref-list id="Bib1"><title>References</title><ref id="CR1"><element-citation publication-type="journal"><person-group 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