Role of Homozygous DC-SIGNR 5/5 Tandem Repeat Polymorphism in HIV-1 Exposed Seronegative North Indian Individuals
Identifieur interne : 000944 ( Pmc/Checkpoint ); précédent : 000943; suivant : 000945Role of Homozygous DC-SIGNR 5/5 Tandem Repeat Polymorphism in HIV-1 Exposed Seronegative North Indian Individuals
Auteurs : Anurag Rathore [Inde] ; Animesh Chatterjee [Inde] ; P. Sivarama [Inde] ; Naohiko Yamamoto [Japon] ; Tapan N. Dhole [Inde]Source :
- Journal of Clinical Immunology [ 0271-9142 ] ; 2007.
Abstract
Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type lectins, DC-SIGN (present on dendritic cells and macrophages) and DC-SIGNR (present on endothelial cells in liver and lymph nodes) efficiently bind and transmit HIV-1 to susceptible cell
Url:
DOI: 10.1007/s10875-007-9131-x
PubMed: 17876530
PubMed Central: 7086598
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of Homozygous DC-SIGNR 5/5 Tandem Repeat Polymorphism in HIV-1 Exposed Seronegative North Indian Individuals</title><author><name sortKey="Rathore, Anurag" sort="Rathore, Anurag" uniqKey="Rathore A" first="Anurag" last="Rathore">Anurag Rathore</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Chatterjee, Animesh" sort="Chatterjee, Animesh" uniqKey="Chatterjee A" first="Animesh" last="Chatterjee">Animesh Chatterjee</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Sivarama, P" sort="Sivarama, P" uniqKey="Sivarama P" first="P." last="Sivarama">P. Sivarama</name><affiliation wicri:level="1"><nlm:aff id="Aff2">AIDS Counseling and Treatment Center, Belgaum, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>AIDS Counseling and Treatment Center, Belgaum</wicri:regionArea><wicri:noRegion>Belgaum</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naohiko" sort="Yamamoto, Naohiko" uniqKey="Yamamoto N" first="Naohiko" last="Yamamoto">Naohiko Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.27476.30</institution-id><institution-id institution-id-type="ISNI">000000010943978X</institution-id><institution>Department of International Health,</institution><institution>Nagoya University School of Medicine,</institution></institution-wrap>Nagoya, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Dhole, Tapan N" sort="Dhole, Tapan N" uniqKey="Dhole T" first="Tapan N." last="Dhole">Tapan N. Dhole</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17876530</idno><idno type="pmc">7086598</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086598</idno><idno type="RBID">PMC:7086598</idno><idno type="doi">10.1007/s10875-007-9131-x</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000273</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000273</idno><idno type="wicri:Area/Pmc/Curation">000273</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000273</idno><idno type="wicri:Area/Pmc/Checkpoint">000944</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000944</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of Homozygous DC-SIGNR 5/5 Tandem Repeat Polymorphism in HIV-1 Exposed Seronegative North Indian Individuals</title><author><name sortKey="Rathore, Anurag" sort="Rathore, Anurag" uniqKey="Rathore A" first="Anurag" last="Rathore">Anurag Rathore</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Chatterjee, Animesh" sort="Chatterjee, Animesh" uniqKey="Chatterjee A" first="Animesh" last="Chatterjee">Animesh Chatterjee</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Sivarama, P" sort="Sivarama, P" uniqKey="Sivarama P" first="P." last="Sivarama">P. Sivarama</name><affiliation wicri:level="1"><nlm:aff id="Aff2">AIDS Counseling and Treatment Center, Belgaum, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>AIDS Counseling and Treatment Center, Belgaum</wicri:regionArea><wicri:noRegion>Belgaum</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Naohiko" sort="Yamamoto, Naohiko" uniqKey="Yamamoto N" first="Naohiko" last="Yamamoto">Naohiko Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.27476.30</institution-id><institution-id institution-id-type="ISNI">000000010943978X</institution-id><institution>Department of International Health,</institution><institution>Nagoya University School of Medicine,</institution></institution-wrap>Nagoya, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya</wicri:regionArea></affiliation></author><author><name sortKey="Dhole, Tapan N" sort="Dhole, Tapan N" uniqKey="Dhole T" first="Tapan N." last="Dhole">Tapan N. Dhole</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Raebarelli Road, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Clinical Immunology</title><idno type="ISSN">0271-9142</idno><idno type="eISSN">1573-2592</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type lectins, DC-SIGN (present on dendritic cells and macrophages) and DC-SIGNR (present on endothelial cells in liver and lymph nodes) efficiently bind and transmit HIV-1 to susceptible cell <italic>in trans</italic>, thereby augmenting the infection. A potential association of the DC-SIGN and DC-SIGNR neck domain repeat polymorphism and risk of HIV-1 infection is currently under debate. To determine the influence of host genetic factors on HIV-1 resistance, we conducted genetic risk association study in HIV-1-exposed seronegative (<italic>n</italic> = 47) individuals, HIV-1 seronegative (<italic>n</italic> = 262) healthy control, and HIV-1-infected seropositive patients (<italic>n</italic> = 168) for polymorphism in neck domain of DC-SIGN and DC-SIGNR genes. The DC-SIGN and DC-SIGNR genotypes were identified by polymerase chain reaction method in DNA extracted from peripheral blood and confirmed by sequencing. Fisher exact or <italic>χ</italic><sup>2</sup> test was used for static analysis. DC-SIGN genotype and allele distribution was fairly similar in HIV-1-exposed seronegative, HIV-1 seropositive, and HIV-1 seronegative control. There was no statistical significance in the differences in the distribution of DC-SIGN genotypes. A total of 13 genotypes were found in DC-SIGNR neck repeat region polymorphism. Among all the genotypes, only 5/5 homozygous showed significant reduced risk of HIV-1 infection in HIV-1-exposed seronegative individuals (<italic>p</italic> = 0.009). A unique genotype 8/5 heterozygous was also found in HIV-1 seropositive individual, which is not reported elsewhere.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="O Rien, Sj" uniqKey="O Rien S">SJ O’Brien</name></author><author><name sortKey="Nelson, Gw" uniqKey="Nelson G">GW Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hogan, Cm" uniqKey="Hogan C">CM Hogan</name></author><author><name sortKey="Hammer, Sm" uniqKey="Hammer S">SM Hammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name></author><author><name sortKey="Paxton, Wa" uniqKey="Paxton W">WA Paxton</name></author><author><name sortKey="Choe, S" uniqKey="Choe S">S Choe</name></author><author><name sortKey="Ceradini, D" uniqKey="Ceradini D">D Ceradini</name></author><author><name sortKey="Martin, Sr" uniqKey="Martin S">SR Martin</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Immunol</journal-id><journal-title-group><journal-title>Journal of Clinical Immunology</journal-title></journal-title-group><issn pub-type="ppub">0271-9142</issn><issn pub-type="epub">1573-2592</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>Boston</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17876530</article-id><article-id pub-id-type="pmc">7086598</article-id><article-id pub-id-type="publisher-id">9131</article-id><article-id pub-id-type="doi">10.1007/s10875-007-9131-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Role of Homozygous DC-SIGNR 5/5 Tandem Repeat Polymorphism in HIV-1 Exposed Seronegative North Indian Individuals</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rathore</surname><given-names>Anurag</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chatterjee</surname><given-names>Animesh</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sivarama</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yamamoto</surname><given-names>Naohiko</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Dhole</surname><given-names>Tapan N.</given-names></name><address><phone>+91-522-2668100</phone><fax>+91-522-2668100</fax><email>tndhole@hotmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.263138.d</institution-id><institution-id institution-id-type="ISNI">0000000093467267</institution-id><institution>Department of Microbiology,</institution><institution>Sanjay Gandhi Post Graduate Institute of Medical Sciences,</institution></institution-wrap>Raebarelli Road, Lucknow, 226014 India</aff><aff id="Aff2"><label>2</label>AIDS Counseling and Treatment Center, Belgaum, India</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.27476.30</institution-id><institution-id institution-id-type="ISNI">000000010943978X</institution-id><institution>Department of International Health,</institution><institution>Nagoya University School of Medicine,</institution></institution-wrap>Nagoya, Japan</aff></contrib-group><pub-date pub-type="epub"><day>18</day><month>9</month><year>2007</year></pub-date><pub-date pub-type="ppub"><year>2008</year></pub-date><volume>28</volume><issue>1</issue><fpage>50</fpage><lpage>57</lpage><history><date date-type="received"><day>16</day><month>6</month><year>2007</year></date><date date-type="accepted"><day>21</day><month>8</month><year>2007</year></date></history><permissions><copyright-statement>© Springer Science+Business Media, LLC 2007</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>Despite multiple sexual exposures to HIV-1 virus, some individuals remain HIV-1 seronegative. Although several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (the 32-bp deletion, i.e., CCR5-Delta32 allele) is presently considered the most relevant one. The C-type lectins, DC-SIGN (present on dendritic cells and macrophages) and DC-SIGNR (present on endothelial cells in liver and lymph nodes) efficiently bind and transmit HIV-1 to susceptible cell <italic>in trans</italic>, thereby augmenting the infection. A potential association of the DC-SIGN and DC-SIGNR neck domain repeat polymorphism and risk of HIV-1 infection is currently under debate. To determine the influence of host genetic factors on HIV-1 resistance, we conducted genetic risk association study in HIV-1-exposed seronegative (<italic>n</italic> = 47) individuals, HIV-1 seronegative (<italic>n</italic> = 262) healthy control, and HIV-1-infected seropositive patients (<italic>n</italic> = 168) for polymorphism in neck domain of DC-SIGN and DC-SIGNR genes. The DC-SIGN and DC-SIGNR genotypes were identified by polymerase chain reaction method in DNA extracted from peripheral blood and confirmed by sequencing. Fisher exact or <italic>χ</italic><sup>2</sup> test was used for static analysis. DC-SIGN genotype and allele distribution was fairly similar in HIV-1-exposed seronegative, HIV-1 seropositive, and HIV-1 seronegative control. There was no statistical significance in the differences in the distribution of DC-SIGN genotypes. A total of 13 genotypes were found in DC-SIGNR neck repeat region polymorphism. Among all the genotypes, only 5/5 homozygous showed significant reduced risk of HIV-1 infection in HIV-1-exposed seronegative individuals (<italic>p</italic> = 0.009). A unique genotype 8/5 heterozygous was also found in HIV-1 seropositive individual, which is not reported elsewhere.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>DC-SIGN</kwd><kwd>DC-SIGNR</kwd><kwd>HIV-1</kwd><kwd>tandem repeats</kwd><kwd>genetic association</kwd><kwd>gene polymorphism</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media, LLC 2008</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li><li>Japon</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Rathore, Anurag" sort="Rathore, Anurag" uniqKey="Rathore A" first="Anurag" last="Rathore">Anurag Rathore</name></noRegion><name sortKey="Chatterjee, Animesh" sort="Chatterjee, Animesh" uniqKey="Chatterjee A" first="Animesh" last="Chatterjee">Animesh Chatterjee</name><name sortKey="Dhole, Tapan N" sort="Dhole, Tapan N" uniqKey="Dhole T" first="Tapan N." last="Dhole">Tapan N. Dhole</name><name sortKey="Sivarama, P" sort="Sivarama, P" uniqKey="Sivarama P" first="P." last="Sivarama">P. Sivarama</name></country><country name="Japon"><noRegion><name sortKey="Yamamoto, Naohiko" sort="Yamamoto, Naohiko" uniqKey="Yamamoto N" first="Naohiko" last="Yamamoto">Naohiko Yamamoto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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